1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide supplier

Name
1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide
EINECS 217-579-2
CAS No. 1892-57-5
Article Data12
CAS DataBase
Density 0.86 g/cm³
Solubility Soluble in water.
Melting Point 115 ºC
Formula C₈H₁₇N₃
Boiling Point 197.7 °C at 760 mmHg
Molecular Weight 155.243
Flash Point 73.4 °C
Transport Information UN 2735 8/PG 3
Appearance COA
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide;1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide;1-Ethyl-3-(dimethylaminopropyl)carbodiimide;1-Ethyl-3-(N,N-dimethylamino)propylcarbodiimide;1,3-Propanediamine,N'-(ethylcarbonimidoyl)-N,N-dimethyl- (9CI);Carbodiimide,[3-(dimethylamino)propyl]ethyl- (6CI,7CI,8CI);1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide;3-(3-Dimethylaminopropyl)-1-ethylcarbodiimide;EDAC;N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide;
PSA 27.96000
LogP 1.13190

Synthetic route

: 32897-26-0
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
With triethylamine; p-toluenesulfonyl chloride In dichloromethane for 4h; Heating;	60%

: 1-(3-dimethylamino-propyl)-3-ethyl-thiourea

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
With dicarbonyl(cyclopentadienyl)methyliron(II); Triethoxysilane In tetrahydrofuran; 1,3,5-trimethyl-benzene at 60℃; for 24h; Schlenk technique; Inert atmosphere;	46%
With sodium hypochlorite; ethylenediaminetetraacetic acid at 30℃; Reagent/catalyst; Temperature;
With bis(trichloromethyl) carbonate In Petroleum ether at 15 - 45℃; for 3h; Temperature;	213.6 g

: 542-85-8
Ethyl isothiocyanate

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
(i) Et2O, (ii) HgO, benzene; Multistep reaction;
(i) Et2O, (ii) HgO, CH2Cl2; Multistep reaction;

: 109-55-7
1-amino-3-(dimethylamino)propane

: 109-90-0
ethyl isocyanate

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
(i), (ii) TsCl; Multistep reaction;

: 109-55-7
1-amino-3-(dimethylamino)propane

(+-)-ethoxycarbonylamino-phenyl-acetic acid ethyl ester: (+-)-ethoxycarbonylamino-phenyl-acetic acid ethyl ester

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether / 2 h / Ambient temperature 2: 60 percent / triethylamine, toluenesulfonyl chloride / CH2Cl2 / 4 h / Heating View Scheme

: 25952-53-8
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
With potassium carbonate In trifluoromethylbenzene (BTF); water

: 18997-72-3
N-(3-Dimethylamino-propyl)-dithiocarbamidsaeure

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 3 h / 10 - 15 °C 2: dichloromethane / 1 h / 10 - 15 °C 3: sodium hypochlorite; ethylenediaminetetraacetic acid / 30 °C View Scheme

: 27421-70-1
3-(dimethylamino)propyl isothiocyanate

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dichloromethane / 1 h / 10 - 15 °C 2: sodium hypochlorite; ethylenediaminetetraacetic acid / 30 °C View Scheme

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 2 h / 10 - 20 °C 2: chloroformic acid ethyl ester; triethylamine / dichloromethane / 3 h / 10 - 15 °C 3: dichloromethane / 1 h / 10 - 15 °C 4: sodium hypochlorite; ethylenediaminetetraacetic acid / 30 °C View Scheme

: 1271-42-7
ferrocenecarboxylic acid

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 2592-95-2
benzotriazol-1-ol

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: Fe(C5H5)(C5H4)CONHCH(CH2OH)COOCH3

Conditions

Conditions	Yield
With CuCl In N,N-dimethyl-formamide	99%

...Expand

: 36507-55-8
morphine-6-hemisuccinate

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: EDC-morphine-6-hemisuccinate

Conditions

Conditions	Yield
With hydrogenchloride In water at 37℃; for 2h; pH=5.5;	98%

: L-aspartic acid di-tert-butyl ester hydrochloride

: 42417-65-2
Z-MeVal-OH

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 80029-43-2, 123333-53-9
1-hydroxybenzotriazol-hydrate

: N-[N-(benzyloxycarbonyl)-N-methylvalyl]-L-aspartic acid di-tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	98%

...Expand

hyaluronic acid sodium salt from bacterial source (100 kDa): hyaluronic acid sodium salt from bacterial source (100 kDa)

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

hyaluronyl N-[3-(dimethylamino)propyl]-N’-ethylimidocarbamate, content of isoureido residues 100%: hyaluronyl N-[3-(dimethylamino)propyl]-N’-ethylimidocarbamate, content of isoureido residues 100%

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 2h; pH=4.7 - 4.8;	98%

: 55147-78-9
bis(bis(trimethylsilyl)amido)tin(II)

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1362855-87-5
[(C2H5NC(N(Si(CH3)3)2)N(CH2)3N(CH3)2)2Sn]

Conditions

Conditions	Yield
In diethyl ether (Ar); C2H5NCN(CH2)3N(CH3)2 in Et2O added to a soln. of Sn compd. at roomtemp., stirred for 0.5 h; filtered, evapd. (vac.); obtained oily; elem. anal.;	96%

: 2386-47-2
butane-1-sulfonic acid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide n-butylsulfonate

Conditions

Conditions	Yield
at 15 - 25℃; for 1h; Large scale;	95.8%

: 75-75-2
methanesulfonic acid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methanesulfonate

Conditions

Conditions	Yield
at 15 - 25℃; for 1h; Large scale;	95.5%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

25-hydroxyvitamin D3-3-hemisuccinate: 25-hydroxyvitamin D3-3-hemisuccinate

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 38862-25-8
methacrylic acid N-hydroxysuccinimide ester

Conditions

Conditions	Yield
With sodium sulfate In dichloromethane	94%

...Expand

: 2886-33-1
dibenzyl L-aspartate toluene-4-sulphonate

: 88950-64-5
1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1415763-45-9
1-[(tert-butoxycarbonyl)amino]cyclopropanecarbonyl-L-aspartic acid dibenzyl ester

Conditions

Conditions	Yield
With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane	94%

...Expand

: 6140-88-1
hexadecane-1-sulfonic acid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cetyl sulfonate

Conditions

Conditions	Yield
at 15 - 25℃; for 1h; Large scale;	94%

: 4530-18-1
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

: [Ru(η(5)-C5Me5)(phenylalanine methyl ester)]Cl

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: [Ru(η(5)-C5Me5)(PhCH2CH(NHCOOBu(t))CONHCH(CO2H)CH2Ph)]Cl

Conditions

Conditions	Yield
With triethylamine In dichloromethane addn. of 1 equiv. protected phenylalanine ester to Ru-complex, then addn. of Et3N and carbodiimide derivative, stirring at -50°C for 12 h; addn. of water, citric acid and Na2CO3, solvent removal; elem. anal.;	92%

...Expand

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 13629-22-6
fluoren-9-ylidene-hydrazine

: 1445265-19-9
EtNHC(NNfluoren)NHCH2CH2CH2NMe2

Conditions

Conditions	Yield
With [Ti(pentamethylcyclopentadienyl)(N(xylyl)C4H6N)(tert-butylimido)(tert-butylamine)] In 1,4-dioxane at 80℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	92%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 25952-53-8
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

Conditions

Conditions	Yield
With triethylamine hydrochloride In acetonitrile at 15℃; for 1h; Temperature;	92%

: 677722-99-5, 847675-62-1, 297176-74-0
(Sp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: N-[3-(dimethylamino)propyl]-N'-ethyl-N-[(Sp)-2-(diphenylphosphino)ferrocenecarbonyl]urea

Conditions

Conditions	Yield
In dichloromethane (Ar); carbodiimide was added to soln. of Fe complex in CH2Cl2; stirred at room temp. for 20 h; evapd. (vac.); chromd. (silica gel, CH2Cl2/MeOH, 10/1 to 5/1); evapd. (vac.);	91%

: 55147-78-9
bis(bis(trimethylsilyl)amido)tin(II)

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1362855-81-9
(C2H5NC(N(Si(CH3)3)2)N(CH2)3N(CH3)2)SnN(SiMe3)2

Conditions

Conditions	Yield
In diethyl ether (Ar); a soln. of C2H5NCN(CH2)3N(CH3)2 added to a soln. of Sn compd. at room temp., stirred for 2 h; filtered, evapd. (vac.); obtained oily; elem. anal.;	91%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 610-30-0
2,4-dinitrobenzoic acid

: (3-(3-(dimethylamino)propyl)-1-ethyl-6-nitro-2,4-dioxo-1,3-diazaspiro[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions

Conditions	Yield
Stage #1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	91%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: biotinyl-bromoacetyl hydrazide

: 1-ethyl-3-{3-[(biotinylhydrazinocarbonylmethyl)dimethylammonio]propyl}carbodiimide bromide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Ambient temperature;	90%

: [bis(trimethylsilyl)amino]tin chloride dimer

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1362855-85-3
[(C2H5NC(N(Si(CH3)3)2)N(CH2)3N(CH3)2)SnCl]

Conditions

Conditions	Yield
In diethyl ether (Ar); C2H5NCN(CH2)3N(CH3)2 in Et2O added to a suspn. of Sn compd. at room temp., stirred; filtered, evapd. (vac.); obtained oily; elem. anal.;	90%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 80-70-6
N,N,N',N'-tetramethylguanidine

: 1542158-74-6
C13H30N6

Conditions

Conditions	Yield
at 120℃; for 0.0833333h; Inert atmosphere; Microwave irradiation; Green chemistry;	89%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 5149-08-6
1,1-bis(4-bromophenyl)hydrazine

: EtNHC{NN(p-BrC6H4)2}NHCH2CH2CH2NMe2

Conditions

Conditions	Yield
With [Ti(pentamethylcyclopentadienyl)(N(xylyl)C4H6N)(tert-butylimido)(tert-butylamine)] In toluene at 105℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	87%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 74-88-4
methyl iodide

: 138551-31-2
1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide methiodide

Conditions

Conditions	Yield
In diethyl ether for 48h; Ambient temperature;	85%
In dichloromethane at 15 - 25℃; for 1h; Large scale;	81.2%

: L-glutamic acid di-tert-butyl ester hydrochloride

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: N-({2-[(4-amidino-2-fluorophenoxy)carbonyl]-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl}acetyl)-L-glutamic acid bis(trifluoroacetate)

Conditions

Conditions	Yield
In pyridine; trifluoroacetic acid	83%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 74-88-4
methyl iodide

: 22572-40-3
3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide

Conditions

Conditions	Yield
In dichloromethane at 15 - 25℃; for 1h; Industrial scale;	81.2%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1415763-66-4
N-allyl-N-(3-{5-[(4-amidinophenoxy)carbonyl]-3-methylthiophen-2-yl}propanoyl)glycine trifluoroacetate

Conditions

Conditions	Yield
With trifluoroacetic acid In pyridine	81%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 66761-27-1
4-carboxy-3-hydroxyphenyl azide

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1293988-98-3
[2-(4-azido-2-hydroxy-benzoylamino)-ethyl]-carbamicacid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 4-carboxy-3-hydroxyphenyl azide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: N-BOC-1,2-diaminoethane In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;	75%

...Expand

: 52833-94-0
2-amino-5-bromonicotinicacid

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 2-amino-5-bromo-N-isopropylpyridine-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-amino-5-bromonicotinicacid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide With benzotriazol-1-ol In tetrahydrofuran at 0℃; for 0.25h; Stage #2: With isopropylamine In tetrahydrofuran at 20℃;	75%

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1415763-54-0
N-allyl-N-({2-[(2,2,2-trichloroethoxy)carbonyl]-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl}acetyl)-L-glutamic acid di-tert-butyl ester

Conditions

Conditions	Yield
With trifluoroacetic acid In pyridine	74%

: L-aspartic acid di-tert-butyl ester hydrochloride

: N-{[5-(4-amidinophenoxycarbonyl)furan-2-yl]methyl}-D-proline bis(trifluoroacetate)

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: N-(N-{[5-(4-amidinophenoxycarbonyl)furan-2-yl]methyl}-D-prolyl)-L-aspartic acid di-tert-butyl ester bis(trifluoroacetate)

Conditions

Conditions	Yield
With pyridine; trifluoroacetic acid	73%

...Expand

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: 1415763-00-6
N-allyl-N-[N-allyl-N-(3-{5-[(4-amidinophenoxy)carbonyl]-3-methylthiophen-2-yl}propanoyl)glycyl]-L-glutamic acid trifluoroacetate

Conditions

Conditions	Yield
With trifluoroacetic acid In pyridine	73%

: maleimide-PEG8-acid

: C69H88N10O19

: 1892-57-5
N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

: C95H130N12O31

Conditions

Conditions	Yield
In chloroform for 1.5h;	72%

...Expand

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Chemical Properties

IUPAC Name: 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine
The MF of 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide(1892-57-5): C₈H₁₇N₃
The MW of 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide(1892-57-5): 155.24
EINECS: 217-579-2
bp: 66-68°C 1mm
density: 0.877 g/mL at 20 °C(lit.)
refractive index: n20/D 1.461
Fp: 66-68°C/1mm
storage temp.: -20 °C
Sensitive: Air Sensitive
Vapour Pressure: 0.373 mmHg at 25°C
Categories: straight chain compounds
Synonyms: 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE;EDAC;EDCI;WATER-SOLUBLE CARBODIIMIDE;WSCD;WSCI;N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE
The Structure of 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide(1892-57-5):

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Safety Profile

Hazard Codes:

C
Risk Statements: 34
34: Causes burns
Safety Statements: 26-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
F: 1-3-10
F1 Sensitive to air and humidity.
F 3 Hygroscopic.
F 10 Keep under argon.
HazardClass: 8
PackingGroup: III

Product Name

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide

Synthetic route

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Chemical Properties

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Safety Profile

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