1,4-Cyclohexanedione supplier

Name
1,4-Cyclohexanedione
EINECS 211-306-0
CAS No. 637-88-7
Article Data110
CAS DataBase
Density 1.128 g/cm³
Solubility
Melting Point 77-78.5 °C(lit.)
Formula C₆H₈O₂
Boiling Point 226.66 °C at 760 mmHg
Molecular Weight 112.128
Flash Point 82.157 °C
Transport Information
Appearance tan or yellow crystalline powder
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 1,4-Dioxocyclohexane;Tetrahydroquinone;Cyclohexan-1,4-dione;1,4-Cyclohexane Dione;1,4-Cyclohexanedione(CAS:637-88-7);
PSA 34.14000
LogP 0.69860

Synthetic route

: 106-51-4
p-benzoquinone

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With aluminium trichloride; zinc In tetrahydrofuran for 0.4h; Ambient temperature;	100%
With formic acid In toluene at 120℃; for 10h; Inert atmosphere; chemoselective reaction;	57%
With hydrogen; tetra-(n-butyl)ammonium iodide In water at 110℃; under 15001.5 Torr; for 24h; chemoselective reaction;	57%
With ruthenium; hydrogen at 80℃; under 37503.8 Torr; for 1h; Reagent/catalyst; Ionic liquid; chemoselective reaction;

: 10553-38-5
1,4-cyclohexanedione bis(dimethyl acetal)

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
In 1,4-dioxane; water; dimethyl sulfoxide for 12h; Heating;	98.2%

: 556-48-9
1,4-Cyclohexanediol

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 1h; Milling;	97%
With ruthenium(IV) oxide; sodium dihydrogenphosphate; sodium chloride In water at 10 - 15℃; electrooxidation;	94%
With m-iodosylbenzoic acid; ruthenium trichloride In water; acetonitrile at 20℃; for 10h;	84%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With barium(II) chloride In water at 19.85 - 179.85℃; under 7575.61 Torr; for 0.666667h;	96%
With CuCl2*2H2O In acetonitrile for 0.5h; Ambient temperature;	95%
With trifluoroacetic acid In dichloromethane at 25℃; for 12h;	90%

: 556-48-9
1,4-Cyclohexanediol

A: 13482-22-9
4-hydroxycyclohexanone

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sodium bromate; sodium hydrogensulfite In water; acetonitrile at 20℃; for 6h; Oxidation;	A 1% B 93%
With sodium bromate; sodium hydrogensulfite In water; acetonitrile at 20℃; for 2h; Oxidation;	A 78% B 10%
With 2O34W9Zn(12-)W(6+)3Zn(2+)*2H2O; dihydrogen peroxide In water; acetonitrile at 135℃; under 2250.23 Torr; for 0.25h; Microwave irradiation;	A n/a B 58%

: 67-51-6
3,5-dimethyl-1H-pyrazole

4-hydroxycyclohexane mono-ketal: 4-hydroxycyclohexane mono-ketal

A: 4746-97-8
cyclohexanedione monoethylene ketal

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
In dichloromethane; ethyl acetate	A 91% B n/a

...Expand

: 26757-29-9
1,4-Cyclohexandion-bis-(dimethylhydrazon)

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In acetic acid; acetonitrile at 0 - 20℃; Product distribution; oxidative cleavage;	88%

: 13482-22-9
4-hydroxycyclohexanone

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane for 2h; Ambient temperature;	87%

: 87377-98-8, 87398-13-8, 190020-19-0
(Z,Z)-1,4-Cyclohexandion-bis

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane for 12h; Ambient temperature;	87%

: 183-97-1
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With tetrachlorosilane In dichloromethane at 20℃; for 0.5h;	85%

: Co{(N4C19H6(CH3)8)(CH2CH2COOC3H7)4(CH2COOC3H7)3}(CH2CHC(O)CH2CH2C(O))(1+)

A: 765-69-5
2-Methylcyclopentane-1,3-dione

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
In methanol Irradiation (UV/VIS); anaerobic irradiation 1h with visible light at 20°C; analyzing products by GLC;	A 69% B 19%
In water Irradiation (UV/VIS); anaerobic irradiation 1h with visible light in single-compartment vesicle of N,N-dihexadecyl-Nα-(6-(trimethylammonio)hexanoyl)-L-alaninamide bromide at 20°C; phosphate-borate buffer; analyzing products by GLC;	A 19% B 67%
In benzene Irradiation (UV/VIS); anaerobic irradiation 1h with visible light at 20°C; analyzing products by GLC;	A 57% B 28%

: 108-94-1
cyclohexanone

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With hydrogenchloride; tetrakis(tetrabutylammonium)decatungstate(VI); oxygen In dichloromethane; water; acetonitrile at 20℃; for 0.75h; Flow reactor; Irradiation;	67%
With methanol; dihydrogen peroxide; vanadia
With water at 20℃; under 750.075 Torr; for 48h; Catalytic behavior; Electrolysis;	Ca.97%Spectr.

: 183-97-1
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane

A: 4746-97-8
cyclohexanedione monoethylene ketal

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With formaldehyd; silica gel; iron(III) chloride at 20℃; for 0.416667h;	A 58% B 22 % Chromat.

: 280-53-5
2,3-dioxabicyclo<2.2.2>octane

A: 74-85-1
ethene

B: 638-37-9
butanedial

C: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
at 450℃; under 0.001 Torr; Product distribution; Mechanism;	A n/a B 56% C 42%

...Expand

: 280-53-5
2,3-dioxabicyclo<2.2.2>octane

A: 638-37-9
butanedial

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
at 450℃;	A 56% B 42%

: 15791-03-4
1,1,4,4-tetramethoxycyclohexa-2,5-diene

A: 10553-38-5
1,4-cyclohexanedione bis(dimethyl acetal)

B: 112465-66-4
4-methoxy-3-cyclohexenone dimethyl acetal

C: 637-88-7
1,4-Cyclohexanedione

D: 150-78-7
1,4-dimethoxybezene

Conditions

Conditions	Yield
With sodium methylate In methanol electrolysis cathodic reaction (R-Ni powder cathode, Pt plate anode, 300 mA, 2.4 V);	A 45% B 24% C 6% D 24%

...Expand

: 280-53-5
2,3-dioxabicyclo<2.2.2>octane

A: 638-37-9
butanedial

B: 931-71-5
cis-1,4-cyclohexanediol

C: 13482-22-9
4-hydroxycyclohexanone

D: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With cobalt(II) 5,10,15,20-tetraphenylporphyrin In chloroform at 60℃; for 11h; Further byproducts given;	A 21% B 28% C 17% D 5%

...Expand

: 13482-23-0
4-methoxycyclohexanone

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With calcium hypochlorite; acetic acid In water; acetonitrile at 0℃; regioselective reaction;	20%

: 108-93-0
cyclohexanol

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With H4Na12O66W19Zn5; sulfuric acid; oxygen In water at 25℃; under 750.075 Torr; for 0.75h; pH=1; Irradiation;	14%
Multi-step reaction with 2 steps 1: water / 48 h / 20 °C / 750.08 Torr / Electrolysis 2: water / 48 h / 20 °C / 750.08 Torr / Electrolysis View Scheme

: 787-07-5
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sulfuric acid
With water at 200℃;

: 787-07-5
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

A: bicyclohexylidene-2,5,4'-trione

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With hydrogenchloride

: 110-15-6
succinic acid

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
bei der Destillation des bernteinsauren Calciums;

: 19620-36-1
4-(propan-2-ylidene)cyclohexan-1-one

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With permanganate(VII) ion

: 861316-24-7
3,6-dioxo-cyclohexane-1,2-dicarbonitrile

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sulfuric acid

: 123-25-1
succinic acid diethyl ester

: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With fired clay at 260℃;
With fired clay at 400℃;

: 110-87-2
3,4-dihydro-2H-pyran

: 556-48-9
1,4-Cyclohexanediol

A: 60739-53-9
4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With jones reagent; toluene-4-sulfonic acid 1) acetone, 1 h, ice-bath cooling, 2) CH2Cl2, 30 min, rt; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 280-53-5
2,3-dioxabicyclo<2.2.2>octane

A: 931-71-5
cis-1,4-cyclohexanediol

B: 13482-22-9
4-hydroxycyclohexanone

C: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In dichloromethane at 60℃; for 5h; Product distribution; other reagent;	A 39 % Chromat. B 44 % Chromat. C 4 % Chromat.

...Expand

: 610-92-4
2,5-dihydroxy-1,4-benzenedicarboxylic acid

A: 490-93-7
1,4-cyclohexanedione-2,5-dicarboxylic acid

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sodium hydroxide; sodium amalgam at 0℃; for 0.5h; Yield given;

: 108-94-1
cyclohexanone

A: 142-62-1
hexanoic acid

B: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sodium persulfate; iron(II) sulfate In water at 80℃; for 6h; Yield given. Yields of byproduct given;

: 108-94-1
cyclohexanone

A: 930-68-7
cyclohexenone

B: 4096-34-8
cyclohex-3-enone

C: 142-62-1
hexanoic acid

D: 637-88-7
1,4-Cyclohexanedione

Conditions

Conditions	Yield
With sodium persulfate; iron(II) sulfate In water Yield given. Yields of byproduct given;

...Expand

: 875535-43-6
4,5-bis(4-dodecyloxyphenylethynyl)benzene-1,2-dicarbaldehyde

: 637-88-7
1,4-Cyclohexanedione

: 2,3,9,10-tetrakis(4-dodecyloxyphenylethynyl)-6,13-pentacenequinone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 55℃;	100%

: potassium cyanide

: 98-88-4
benzoyl chloride

: 637-88-7
1,4-Cyclohexanedione

: 1196087-96-3
trans-1,4-di(phenylcarbonyl)aminocyclohexane-1,4-dinitrile

Conditions

Conditions	Yield
Stage #1: potassium cyanide; 1,4-Cyclohexanedione With ammonium chloride In water at 20℃; Strecker reaction; Cooling with ice; Inert atmosphere; Stage #2: benzoyl chloride With potassium carbonate In tetrahydrofuran; water at 20℃; for 72h; Inert atmosphere;	100%

...Expand

: 137-07-5
2-amino-benzenethiol

: 637-88-7
1,4-Cyclohexanedione

: 182-68-3
3H,3''H-dispiro{benzothiazole-2,1'-cyclohexane-4',2''-benzothiazole}

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	99%

: 637-88-7
1,4-Cyclohexanedione

: 556-48-9
1,4-Cyclohexanediol

Conditions

Conditions	Yield
With samarium diiodide; water In tetrahydrofuran at 20℃;	99%
With sodium tetrahydroborate; TiO(acac)2 In tetrahydrofuran for 0.17h; Heating;	93%
With sodium tetrahydroborate; Dowex1-x8 In tetrahydrofuran for 0.34h; Heating;	90%

: 932-41-2
2,3-diformylthiophene

: 637-88-7
1,4-Cyclohexanedione

: 143746-72-9
dithieno<2,3-b><6,7-d>-9,10-anthraquinone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 20℃; for 4h; Inert atmosphere;	99%
With potassium hydroxide In ethanol	93%
With potassium hydroxide In ethanol for 1h;	92.8%
With potassium hydroxide In ethanol at 20℃;	84%
With potassium hydroxide In ethanol; water

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 637-88-7
1,4-Cyclohexanedione

: (±)-(1,9-dioxa-4,12-diazadispiro[4.2.48.25]tetradecane-3,3,11,11-tetrayl)tetramethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 20℃; for 17h; Reflux; Dean-Stark;	99%

: 67-56-1
methanol

: 637-88-7
1,4-Cyclohexanedione

: 10553-38-5
1,4-cyclohexanedione bis(dimethyl acetal)

Conditions

Conditions	Yield
With trimethyl orthoformate at 20℃; for 0.5h;	98%
Ce(3+)-mont at 25℃; for 0.5h;	96%
With trimethyl orthoformate at 80℃; under 6000480 Torr; for 19h;	94%
With oxygen at 20℃; for 16h; UV-irradiation;	87%

: 95-54-5
1,2-diamino-benzene

: 637-88-7
1,4-Cyclohexanedione

: 54825-25-1
dispiro[2H-benzimidazole-2,1'-cyclohexane-4',2''-[2H]benzimidazole]

Conditions

Conditions	Yield
In ethanol for 10h; Heating;	98%

: 540-63-6
ethane-1,2-dithiol

: 637-88-7
1,4-Cyclohexanedione

: 311-37-5
1,4-cyclohexanedione diethylenethioacetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 6h; Reflux;	98%
With dimethylbromosulphonium bromide at 20℃; for 1h;	89%
With [silica-OSi(OMe)2C3H6(N2C3(CH3)H2)C4H8SO3H]HSO4 In water for 7h;	89%

: 124925-07-1
(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-(pyridin-2-ylsulfanyl)-6-((1S,2R)-1,2,3-triacetoxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 637-88-7
1,4-Cyclohexanedione

: C46H66N2O26

Conditions

Conditions	Yield
With samarium diiodide In tetrahydrofuran at 20℃; for 0.0833333h; Reformatsky reaction;	98%

: 1345541-45-8
4,5-dibutylthiophene-2,3-dicarbaldehyde

: 637-88-7
1,4-Cyclohexanedione

: 1345541-47-0
2,3,7,8-tetrabutylanthradithiophene-5,11-dione

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 3h; Inert atmosphere;	98%

: 637-88-7
1,4-Cyclohexanedione

: 6133-84-2, 6212-72-2, 10220-83-4
1,4-cyclohexanedioxime

Conditions

Conditions	Yield
Stage #1: 1,4-Cyclohexanedione With hydroxylamine hydrochloride In water at 0 - 20℃; for 0.5h; Stage #2: With potassium carbonate In water	98%

: 7677-24-9
trimethylsilyl cyanide

: 637-88-7
1,4-Cyclohexanedione

: C14H26N2O2Si2

Conditions

Conditions	Yield
With C29H38AlN4O2(1+)*CF3O3S(1-) In neat (no solvent) at 20℃; for 0.25h; Catalytic behavior; Inert atmosphere; Schlenk technique;	98%

: (R)-methyl 3-hydroxyhepta-5,6-dienoate

: 637-88-7
1,4-Cyclohexanedione

: C22H32O8

Conditions

Conditions	Yield
With (S)-(-)-SEGphos; palladium diacetate; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene at 85℃; for 14h; Reagent/catalyst; Solvent; Inert atmosphere;	98%
With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); palladium diacetate; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene at 85℃; for 14h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	98%

: 77-99-6
1,1,1-tri(hydroxymethyl)propane

: 637-88-7
1,4-Cyclohexanedione

: C18H32O6

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 90 - 112℃; for 10h; Reagent/catalyst; Solvent; Dean-Stark;	98%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 637-88-7
1,4-Cyclohexanedione

: 71647-43-3, 71647-44-4, 849618-78-6
1,4-di(ethoxycarbonyl-methylidyne) cyclohexane

Conditions

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1h; Stage #2: 1,4-Cyclohexanedione In tetrahydrofuran at 20℃; for 0.5h;	97%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In 1,2-dimethoxyethane at 0℃; for 1h; Stage #2: 1,4-Cyclohexanedione In 1,2-dimethoxyethane at 20℃; for 0.5h;	50%

: 542-92-7
cyclopenta-1,3-diene

: 637-88-7
1,4-Cyclohexanedione

: 5439-22-5
1,4:5,8-dimethano-1,4,4a,5,8,8a,9a,10a-octahydroanthracene-9,10-dione

Conditions

Conditions	Yield
In ethanol at -10 - 0℃; for 1h; Inert atmosphere;	96.8%

: 637-88-7
1,4-Cyclohexanedione

: 643-79-8
o-phthalic dicarboxaldehyde

: 3029-32-1
6,13-pentacenequinone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 4h; Inert atmosphere;	96%
With potassium hydroxide In methanol; water at 0 - 64℃; for 12h; Inert atmosphere;	86%
With water; potassium hydroxide In ethanol at 60℃; for 4h; Inert atmosphere;	85%

: 107-21-1
ethylene glycol

: 637-88-7
1,4-Cyclohexanedione

: 4746-97-8
cyclohexanedione monoethylene ketal

Conditions

Conditions	Yield
With triethylmethylammonium chloride at 50℃; for 1h; Temperature; Reagent/catalyst;	96%
With toluene-4-sulfonic acid In benzene at 100℃; for 1.5h;	35%
With toluene-4-sulfonic acid In benzene for 4h; Heating;

: 98-01-1
furfural

: 637-88-7
1,4-Cyclohexanedione

: 91344-69-3
2-(2-furanylmethyl)hydroquinone

Conditions

Conditions	Yield
With lithium chloride In various solvent(s) at 160 - 170℃; for 1h;	96%
With 1,3-dimethyl-2-imidazolidinone; lithium chloride at 165℃; for 1h;	70%
With lithium chloride In pyridine for 1h; Reflux;	33%

: 87-91-2
diethyl (2R,3R)-tartrate

: 637-88-7
1,4-Cyclohexanedione

: 216373-63-6
tetraethyl (2R,3R,10R,11R)-1,4,9,12-tetraoxadispiro[4.2.48.25]tetradecane-2,3,10,11-tetracarboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 30h; cyclocondensation; Heating;	96%
With toluene-4-sulfonic acid In toluene for 120h; Condensation; Heating;	92%
With boron trifluoride diethyl etherate In ethyl acetate at 0 - 20℃;	55%
With boron trifluoride diethyl etherate In ethyl acetate at 0℃;

: 637-88-7
1,4-Cyclohexanedione

: 13482-22-9
4-hydroxycyclohexanone

Conditions

Conditions	Yield
With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; triethylamine In acetonitrile at 20℃;	96%
With Candida parapsilosis ATCC 7330 whole cells In ethanol; water at 25℃; for 8h; pH=6.8; Microbiological reaction; regioselective reaction;	63%
With sodium tetrahydroborate In methanol at -20℃;	60%
With keto reductases from Lactobacillus kefir; nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In aq. phosphate buffer at 30℃; for 12h; pH=7; Reagent/catalyst; pH-value; Enzymatic reaction;

: 1013662-53-7
C16H18O3Si2

: 637-88-7
1,4-Cyclohexanedione

: 1013662-54-8
C38H36O4Si4

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 60℃;	96%

: 64-17-5
ethanol

: 637-88-7
1,4-Cyclohexanedione

: 78070-34-5
1,4-cyclohexanedione bis(diethyl acetal)

Conditions

Conditions	Yield
With orthoformic acid triethyl ester at 20℃; for 0.5h;	96%

: 19050-62-5
N-(2-phenylethyl)-2-aminobenzamide

: 637-88-7
1,4-Cyclohexanedione

: 1221177-08-7
C36H36N4O2

Conditions

Conditions	Yield
With iodine at 50℃; for 5h; Ionic liquid; Combinatorial reaction / High throughput screening (HTS);	96%

: 28144-70-9
anthranilic acid amide

: 637-88-7
1,4-Cyclohexanedione

: 1221177-03-2
C20H20N4O2

Conditions

Conditions	Yield
With iodine at 50℃; for 4h; Ionic liquid; Combinatorial reaction / High throughput screening (HTS);	96%
With bis(glycerol)boric acid; bis(glycerol)boric acid at 60℃; for 0.833333h; Green chemistry;	87%
With 1-methyl-3-[3-(triethoxysilyl)propyl]-1H-imidazol-3-ium hydrogen sulfate, immobilized on the surface of Fe3O4SiO2 magnetic nanoparticles In ethanol for 0.333333h; Catalytic behavior; Reflux; Green chemistry;	84%

1,4-Cyclohexanedione Chemical Properties

The Molecular Structure of 1,4-Cyclohexanedione (CAS NO.637-88-7):

Empirical Formula: C₆H₈O₂
Molecular Weight: 112.1265
Nominal Mass: 112 Da
Average Mass: 112.1265 Da
Monoisotopic Mass: 112.052429 Da
Index of Refraction: 1.473
Molar Refractivity: 27.93 cm³
Molar Volume: 99.4 cm³
Surface Tension: 40.5 dyne/cm
Density: 1.127 g/cm³
Flash Point: 82.2 °C
Enthalpy of Vaporization: 46.32 kJ/mol
Boiling Point: 226.7 °C at 760 mmHg
Vapour Pressure: 0.0809 mmHg at 25°C
Melting Point: 76-80°C
IUPAC Name: cyclohexane-1,4-dione
Appearance: tan or yellow crystalline powder
Synonyms: 1,4-Cyclohexanedion;1,4-Dioxocyclohexane;Tetrahydroquinone;Tetrahydro-p-benzoquinone;1,4-Cyclohexandione;1,4-Tetrahydroquinone;Cyclohexane-1,4-dione;CHD
Product Categories: ketone;Pharmaceutical Intermediate;C3 to C6;Carbonyl Compounds;Ketones

1,4-Cyclohexanedione History

1,4-Cyclohexanedione (CAS NO.637-88-7) is prepared in two steps from diesters of succinic acid. For example under basic conditions, the diethyl ester condenses to give 2,5-dicarbethoxy-1,4-cyclohexanedione. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.

1,4-Cyclohexanedione Uses

1,4-Cyclohexanedione (CAS NO.637-88-7) is used as a building block in the synthesis of more complex molecules.

1,4-Cyclohexanedione Production

1,4-Cyclohexanedione (CAS NO.637-88-7) is prepared in two steps from diesters of succinic acid.Under basic conditions, the diethyl ester condenses to give 2,5-dicarbethoxy-1,4-cyclohexanedione. This intermediate can be hydrolysed and decarboxylated to afford the desired dione.

1,4-Cyclohexanedione Safety Profile

Hazard Codes: Xi
Safety Statements: 22-24/25
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
WGK Germany: 3
F: 8
Hazard Note: Irritant
HS Code: 29142900
Do not breathe the dust of 1,4-Cyclohexanedione (CAS NO.637-88-7). Avoid 1,4-Cyclohexanedione (CAS NO.637-88-7) contact with skin and with eyes.

1,4-Cyclohexanedione Specification

1,4-Cyclohexanedione (CAS NO.637-88-7) is the organic compound. This colourless solid is one of the three isomeric cyclohexanediones. This particular diketone is used as a building block in the synthesis of more complex molecules.

Product Name

1,4-Cyclohexanedione

Synthetic route

1,4-Cyclohexanedione Chemical Properties

1,4-Cyclohexanedione History

1,4-Cyclohexanedione Uses

1,4-Cyclohexanedione Production

1,4-Cyclohexanedione Safety Profile

1,4-Cyclohexanedione Specification

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