• Name

  3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride

• EINECS
• CAS No. 63971-25-5
• Article Data3
• CAS DataBase
• Density 1.197 g/cm³
• Solubility
• Melting Point
• Formula C₁₂H₂₁NO
• Boiling Point 269.4 °C at 760 mmHg
• Molecular Weight 195.305
• Flash Point 116.8 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1-Amino-3,5-dimethyl-7-hydroxyadamantane;1-AMINO-7-HYDROXY-3,5-DIMETHYLADAMANTANE;3-Amino-5,7-dimethyl-adamantan-1-ol;
• PSA 46.25000
• LogP 2.50930

Synthetic route

19982-07-1

1-acetamido-3,5-dimethyladamantane

A

351329-87-8

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide

B

10347-01-0

1,3-dihydroxy-5,7-dimethyladamantane

C

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
Stage #1: 1-acetamido-3,5-dimethyladamantane With nitric acid Stage #2: With acetic acid; urea In water	A 17% B 9% C n/a

...Expand

C22H38N2O5

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dichloromethane / 1 h / 20 °C 2: hydrogen / methanol / 12 h View Scheme

C12H22N2O*C2HF3O2

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
With hydrogen In methanol for 12h;

707-37-9

1,3-dimethyl-5-adamantanol

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrabutyl-ammonium chloride; methanol; cerium(III) chloride / acetonitrile / 16 h / 20 °C / Irradiation; Inert atmosphere; Sealed tube 2: dichloromethane / 1 h / 20 °C 3: hydrogen / methanol / 12 h View Scheme

41100-52-1

memantine hydrochloride

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 20℃; for 39h; Cooling with ice;	4.4 g

19982-07-1

1-acetamido-3,5-dimethyladamantane

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium hydroxide; butan-1-ol / 130 °C 1.2: pH 8 - 9 2.1: sulfuric acid; nitric acid / 39 h / 20 °C / Cooling with ice View Scheme

941-37-7

3,5-dimethyl-1-bromoadamantane

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 8 h / 130 °C 2.1: potassium hydroxide; butan-1-ol / 130 °C 2.2: pH 8 - 9 3.1: sulfuric acid; nitric acid / 39 h / 20 °C / Cooling with ice View Scheme

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

89139-48-0

3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanoic acid

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-3-(3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 70h; Inert atmosphere;	36%

3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanoic acid

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-3-(4-fluoro-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 70h; Inert atmosphere;	25%

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

82152-06-5

2-(3-Oxo-3h-benzo[d]isothiazol-2-yl)-acetic acid

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 70h; Inert atmosphere;	17%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 70h;	17%

85-44-9

phthalic anhydride

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

847278-49-3

C20H23NO3

Conditions

Conditions	Yield
at 30 - 100℃;

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

356572-08-2

1-hydroxy-3-amino-5,7-dimethyladamantane hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate	68.5 mg

63971-25-5

3-amino-5,7-dimethyladamantan-1-ol

1-nitro-7-hydroxy-3,5-dimethyladamantane

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane for 3h; Reflux;	3.8 g

1-Amino-7-hydroxy-3,5-dimethyladamantane Chemical Properties

1-Amino-7-hydroxy-3,5-dimethyladamantane Specification