• Name

  1-Chloro-3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

• EINECS 800-102-2
• CAS No. 3601-89-6
• Article Data10
• CAS DataBase
• Density 1.283 g/cm³
• Solubility
• Melting Point 109 °C dec.
• Formula C₂₁H₂₁ClO₅
• Boiling Point 518.4 °C at 760 mmHg
• Molecular Weight 388.848
• Flash Point 185.6 °C
• Transport Information
• Appearance Crystalline solid
• Safety 26-36
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms D-erythro-Pentofuranosylchloride, 2-deoxy-, bis(4-methylbenzoate) (9CI);D-erythro-Pentofuranosylchloride, 2-deoxy-, di-p-toluate (7CI,8CI);Ribofuranosyl chloride, 2-deoxy-,di-p-toluate, D- (6CI);2-Deoxy-3,5-di-O-p-toluoyl-D-erythro-pentofuranosylchloride;3,5-Di-O-p-toluoyl-2-deoxy-D-ribofuranosyl chloride;
• PSA 61.83000
• LogP 4.03960

Synthetic route

30161-97-8

5-aminothaizolo<4,5-d>pyrimidine-2,7(3H,6H)-dione

3601-89-6

1-chloro-2-deoxy-3,5-di-O-p-toluoyl-D-erythro-pentofuranose

124737-27-5, 135505-31-6

5-amino-3-(2-deoxy-3,5-di-O-toluoyl-D-erythro-pentofuranosyl)thiazolo<4,5-d>pyrimidine-2,7-dione

Conditions

Conditions	Yield
With trimethylsilyl fluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane 1.) reflux, 3 h, 2.) 110 deg C, 30 min; Yield given. Multistep reaction;

3601-89-6

1-chloro-2-deoxy-3,5-di-O-p-toluoyl-D-erythro-pentofuranose

124737-22-0

5-amino-3-(2-deoxy-β-D-erythro-pentofuranosyl)thiazolo<4,5-d>pyrimidine-2,7-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) trimethylsilyl fluoromethanesulfonate, hexamethyldisilazane (HMDS) / 1.) reflux, 3 h, 2.) 110 deg C, 30 min 2: 42 percent / NaOMe / methanol / 8 h / Ambient temperature View Scheme

1-Chloro-3,5-di-O-toluoyl-2-deoxy-D-ribofuranose Specification