Product Name

  • Name

    1-Ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridinecarboxamide

  • EINECS 249-433-9
  • CAS No. 29097-12-9
  • Article Data2
  • CAS DataBase
  • Density 1.33g/cm3
  • Solubility
  • Melting Point
  • Formula C9H12 N2 O3
  • Boiling Point 430.323 °C at 760 mmHg
  • Molecular Weight 196.206
  • Flash Point 214.052 °C
  • Transport Information
  • Appearance Off-white powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 29097-12-9 (1-Ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridinecarboxamide)
  • Hazard Symbols
  • Synonyms Nicotinamide,1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo- (8CI);1-Ethyl-2-hydroxy-4-methyl-5-carbamoyl-6-pyridinone;1-Ethyl-3-(aminocarbonyl)-4-methyl-6-hydroxy-2-pyridone;1-Ethyl-6-hydroxy-4-methyl-2-pyridone-3-carboxamide;3-(Aminocarbonyl)-1-ethyl-6-hydroxy-4-methyl-2(1H)-pyridone;3-Carbamoyl-1-ethyl-6-hydroxy-4-methyl-2-pyridone;5-Carbamoyl-1-ethyl-2-hydroxy-4-methyl-6-pyridone;
  • PSA 85.32000
  • LogP 0.68140

Synthetic route

C26H19N5O18S5
698352-78-2

C26H19N5O18S5

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C35H28N8O21S5

C35H28N8O21S5

Conditions
ConditionsYield
Stage #1: C26H19N5O18S5 With hydrogenchloride; aminosulfonic acid; sodium nitrite In water at 0 - 10℃; for 2h;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With lithium hydroxide In water at 0 - 10℃; pH=5 - 7;		75%
1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

3-azido-3-ethyl-1,3-benzothiazolium-tetrafluoroborat

3-azido-3-ethyl-1,3-benzothiazolium-tetrafluoroborat

Natrium-5-carbamoyl-3-<2-(5-carbamoyl-1-ethyl-1,2,3,6-tetrahydro-4-methyl-2,6-dioxopyridin-3-yliden)hydrazino>-1-ethyl-1,6-dihydro-4-methyl-6-oxopyridin-2-olat

Natrium-5-carbamoyl-3-<2-(5-carbamoyl-1-ethyl-1,2,3,6-tetrahydro-4-methyl-2,6-dioxopyridin-3-yliden)hydrazino>-1-ethyl-1,6-dihydro-4-methyl-6-oxopyridin-2-olat

Conditions
ConditionsYield
With sodium carbonate In methanol; water at 0℃; for 5h; pH 8;43%
C26H19N5O15S4
698352-37-3

C26H19N5O15S4

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C35H28N8O18S4

C35H28N8O18S4

Conditions
ConditionsYield
Stage #1: C26H19N5O15S4 With hydrogenchloride; aminosulfonic acid; sodium nitrite In water at 0 - 10℃; for 2h; pH=9;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With lithium hydroxide In water at 0 - 10℃; pH=9 - 10;		10%
1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

sodium salt of 1-ethyl-3-carbamoyl-4-methyl-5-methylsulfonyl-6-hydroxy-pyrid-2-one
71552-63-1

sodium salt of 1-ethyl-3-carbamoyl-4-methyl-5-methylsulfonyl-6-hydroxy-pyrid-2-one

Conditions
ConditionsYield
With sodium hydroxide; sodium chloride In water
4,4'-diamino-2,2'-biphenyldisulfonic acid
117-61-3

4,4'-diamino-2,2'-biphenyldisulfonic acid

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C32H32N6O12S2

C32H32N6O12S2

Conditions
ConditionsYield
Stage #1: 4,4'-diamino-2,2'-biphenyldisulfonic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water for 2.5h; pH=7 - 8; Cooling with ice;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With sodium hydroxide In water for 3h; pH=8 - 9; Cooling with ice;
4,4'-diamino-2,2'-biphenyldisulfonic acid
117-61-3

4,4'-diamino-2,2'-biphenyldisulfonic acid

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C48H66N8O10S2

C48H66N8O10S2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium nitrite; sodium hydroxide; hydrogenchloride / water / 2.5 h / pH 7 - 8 / Cooling with ice
1.2: 3 h / pH 8 - 9 / Cooling with ice
2.1: thionyl chloride / N,N-dimethyl-formamide; chloroform / 5 h / 50 °C
2.2: 20 °C
View Scheme
2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate
2494-89-5

2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate

2-amino-1-benzenesulfonic acid
88-21-1

2-amino-1-benzenesulfonic acid

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C23H22N6O12S3(2-)*2Na(1+)

C23H22N6O12S3(2-)*2Na(1+)

Conditions
ConditionsYield
Stage #1: 2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 2h;
Stage #2: 2-amino-1-benzenesulfonic acid With sodium carbonate In water at 10 - 15℃; for 5h;
Stage #3: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one Further stages;
...Expand
2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate
2494-89-5

2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate

1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

sodium 2-amino-5-aminomethylnaphthalene-1-sulfonate

sodium 2-amino-5-aminomethylnaphthalene-1-sulfonate

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C31H28ClN9O12S3(2-)*2Na(1+)

C31H28ClN9O12S3(2-)*2Na(1+)

Conditions
ConditionsYield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; sodium 2-amino-5-aminomethylnaphthalene-1-sulfonate With sodium carbonate In water at 0 - 5℃; for 2h; pH=2 - 2.5;
Stage #2: 2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate With sodium carbonate In water at 40 - 45℃; for 2h; pH=6 - 7;
Stage #3: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one Further stages;
...Expand
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

2-aminonaphthalenesulfonic acid
81-16-3

2-aminonaphthalenesulfonic acid

1,3-phenylenediamine-4-sulphonic acid sodium salt

1,3-phenylenediamine-4-sulphonic acid sodium salt

C28H25ClN6O9S2(2-)*2Na(1+)

C28H25ClN6O9S2(2-)*2Na(1+)

Conditions
ConditionsYield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 2-aminonaphthalenesulfonic acid In water at 0 - 5℃; for 5h; pH=4 - 5;
Stage #2: 1,3-phenylenediamine-4-sulphonic acid sodium salt In water at 25 - 30℃; for 6h; pH=6 - 7;
Stage #3: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one Further stages;
...Expand
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

1,3-phenylenediamine-4-sulphonic acid sodium salt

1,3-phenylenediamine-4-sulphonic acid sodium salt

C31H34Cl2N8O15S4(4-)*4Na(1+)

C31H34Cl2N8O15S4(4-)*4Na(1+)

Conditions
ConditionsYield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 2,2'-iminobis[ethanol] In water at 0 - 5℃; for 4h; pH=4 - 5;
Stage #2: 1,3-phenylenediamine-4-sulphonic acid sodium salt In water at 30 - 40℃; for 6h; pH=5 - 6;
Stage #3: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one Further stages;
...Expand
C10H8F2N4O3S
252291-80-8

C10H8F2N4O3S

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C19H17F2N7O6S

C19H17F2N7O6S

Conditions
ConditionsYield
Stage #1: C10H8F2N4O3S With hydrogenchloride; sodium nitrite In water at 2 - 5℃; for 2h;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With sodium hydroxide In water at 15℃; for 5h; pH=6;
C10H8F2N4O6S2

C10H8F2N4O6S2

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

C19H17F2N7O9S2

C19H17F2N7O9S2

Conditions
ConditionsYield
Stage #1: C10H8F2N4O6S2 With hydrogenchloride; sodium nitrite In water at 2℃; for 2h;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With sodium hydroxide In water at 15℃; for 5h; pH=6;
1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one
29097-12-9

1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one

2-amino-5-nitro-benzoic acid
616-79-5

2-amino-5-nitro-benzoic acid

C16H13N5O6

C16H13N5O6

Conditions
ConditionsYield
Stage #1: 2-amino-5-nitro-benzoic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water for 3.5h; Cooling with ice;
Stage #2: 1-ethyl-3-aminocarbonyl-4-methyl-6-hydroxypyrid-2-one With sodium hydroxide In water at 20℃; for 3h; pH=7.5 - 9.5;

1-Ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridinecarboxamide Specification

The 3-Pyridinecarboxamide,1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-, with the cas registry number 29097-12-9, has the systematic name of 1-ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide yellow spectra chemically-reactivedyes.

The characteristics of this chemical are as followings: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 2; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 5; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 3; (8)Polar Surface Area: 83.63 ; (9)Index of Refraction: 1.588; (10)Molar Refractivity: 49.684 cm3; (11)Molar Volume: 147.55 cm3; (12)Polarizability: 19.696×10-24 cm3; (13)Surface Tension: 58.656 dyne/cm; (14)Density: 1.33 g/cm3; (15)Flash Point: 214.052 °C; (16)Enthalpy of Vaporization: 79.179 kJ/mol; (17)Boiling Point: 430.323 °C at 760 mmHg.

Use of 3-Pyridinecarboxamide,1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-: 3-Pyridinecarboxamide,1-ethyl-1,2-dihydro-6-hydroxy-4-methyl-2-oxo- could react with 2-azido-3-ethyl-benzothiazolium; tetrafluoroborate to produce Natrium-5-carbamoyl-3-[2-(5-carbamoyl-1-ethyl-1,2,3,6-tetrahydro-4-methyl-2,6-dioxopyridin-3-yliden)hydrazino]-1-ethyl-1,6-dihydro-4-methyl-6-oxopyridin-2-olat. The reaction condition: reagent:Na2CO3; solution: methanol and H2O; reaction time: 5 hours; reaction temp.: 0 ℃; field: 43%; other condition: PH 8.

Addtionally, the following datas could be converted inte the molecular structure:
(1)SMILES:O=C1/C(=C(/C)\C=C(\O)N1CC)C(N)=O
(2)InChI:InChI=1/C9H12N2O3/c1-3-11-6(12)4-5(2)7(8(10)13)9(11)14/h4,12H,3H2,1-2H3,(H2,10,13)
(3)InChIKey:IVEOCYLKEXGIPE-UHFFFAOYAD

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