1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride supplier

Name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
EINECS
CAS No. 23007-85-4
Article Data1
CAS DataBase
Density g/cm³
Solubility
Melting Point 249.0 to 254.0 °C
Formula C12H15 N . Cl H
Boiling Point 258.6°Cat760mmHg
Molecular Weight 209.719
Flash Point 105.8°C
Transport Information UN 2811
Appearance
Safety A poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Risk Codes R25;R39/23/24/25
Molecular Structure
Hazard Symbols
Synonyms Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (8CI,9CI); 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinehydrochloride
PSA 3.24000
LogP 3.14540

Synthetic route

: 1445-73-4
1-Methyl-4-piperidone

: 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dibutyl ether; tetrahydrofuran / -78 - 20 °C 2: hydrogenchloride / water / 5 h / Reflux View Scheme

: 591-51-5
phenyllithium

: 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dibutyl ether; tetrahydrofuran / -78 - 20 °C 2: hydrogenchloride / water / 5 h / Reflux View Scheme

: 4972-68-3
1-methyl-4-phenyl-piperidin-4-ol

: 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 5h; Reflux;

: 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

: 95969-40-7
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide

Conditions

Conditions	Yield
Stage #1: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride With sodium ethanolate In ethanol at 0℃; Stage #2: With dihydrogen peroxide In ethanol; water at 50℃;	100%

: 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

: 207395-42-4
1-(N-formyl-N-methyl)amino-3-phenylpropan-2-one

Conditions

Conditions	Yield
With potassium permanganate In acetone at 20℃; for 2h;	85%

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties

IUPAC Name: 1-Methyl-4-phenyl-3,6-dihydro-2H-pyridine hydrochloride
Synonyms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinium chloride ; 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine hydrochloride ; Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (1:1) ; Pyridine, 1,2,5,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride
Product Categories: Heterocyclic Compounds;Neurochemicals
CAS NO:23007-85-4
Molecular Formula of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) :C₁₂H₁₆ClN
Molecular Weight of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) : 209.72
Molecular structure of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) :
Flash Point: 105.8 °C
Enthalpy of Vaporization: 49.62 kJ/mol
Boiling Point: 258.6 °C at 760 mmHg
Vapour Pressure: 0.0136 mmHg at 25°C
Appearance:White Solid

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Uses

1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) is used as a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	150mg/kg (150mg/kg)		Annales Pharmaceutiques Francaises. Vol. 12, Pg. 241, 1954.
mouse	LD50	subcutaneous	53800ug/kg (53.8mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 247, Pg. 531, 1988.
rat	LD50	intraperitoneal	72mg/kg (72mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Bulletin of Experimental Biology and Medicine Vol. 105, Pg. 470, 1988.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Safety Profile

A poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Hazard Codes Toxic T
Risk Statements 39-23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
Safety Statements 45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR 2811
RTECS UT8358950
HazardClass 6.1(b)
PackingGroup III

Product Name

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Synthetic route

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Toxicity Data With Reference

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Safety Profile

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