Product Name

  • Name

    DOTHIEPIN HCL

  • EINECS 212-978-8
  • CAS No. 897-15-4
  • Article Data1
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 218-221ºC
  • Formula C19H21 N S . Cl H
  • Boiling Point 430.9 °C at 760 mmHg
  • Molecular Weight 331.909
  • Flash Point 214.4 °C
  • Transport Information
  • Appearance Crystalline powder
  • Safety Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: cardiomyopathy. Experimental teratogenic and reproductive effects. An antidepressant. When heated to decomposition it emits very toxic fumes of NOx, SOx and HCl.
  • Risk Codes R22 R36 R43 S25 S37/39 S45
  • Molecular Structure Molecular Structure of 897-15-4 (DOTHIEPIN HCL)
  • Hazard Symbols F,T,Xn
  • Synonyms 1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride (9CI);Dibenzo[b,e]thiepin-D11(6H),g-propylamine,N,N-dimethyl-, hydrochloride (7CI,8CI); Dibenzo[b,e]thiepin, 1-propanaminederiv.; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]thiepinhydrochloride; Altapin; Depresym; Dosulepin chloride; Dosulepin hydrochloride;Dothiepin hydrochloride; Prothiaden hydrochloride
  • PSA 28.54000
  • LogP 5.47770

Synthetic route

dothiepin
113-53-1, 25627-37-6, 25627-38-7

dothiepin

dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; ethanol
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

11-<3-(Methyl-ethoxycarbonylamino)-propyliden>-6,11-dihydro-dibenzothiepin
2025-60-7

11-<3-(Methyl-ethoxycarbonylamino)-propyliden>-6,11-dihydro-dibenzothiepin

Conditions
ConditionsYield
With sodium hydrogencarbonate In toluene for 6h; Heating;92%
dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

N-methyldibenzothiepin-Δ11(6H),γ-propylamine
1154-09-2

N-methyldibenzothiepin-Δ11(6H),γ-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating
2: 77 percent / KOH / butan-1-ol / 4 h / Heating
View Scheme
dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

3-thiepin-11-ylidene)propyl>-N-methylamino>propionic acid

3-thiepin-11-ylidene)propyl>-N-methylamino>propionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating
2: 77 percent / KOH / butan-1-ol / 4 h / Heating
3: ethanol / 2 h / Heating
4: NaOH / methanol / 0.5 h / Heating
View Scheme
dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid

3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating
2: 77 percent / KOH / butan-1-ol / 4 h / Heating
3: ethanol / 2 h / Heating
4: NaOH / methanol / 0.5 h / Heating
View Scheme
dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

ethyl 3-thiepin-11-ylidene)propyl>-N-methylamino>propionate

ethyl 3-thiepin-11-ylidene)propyl>-N-methylamino>propionate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating
2: 77 percent / KOH / butan-1-ol / 4 h / Heating
3: ethanol / 2 h / Heating
View Scheme
dosulepin hydrochloride
897-15-4

dosulepin hydrochloride

3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid ethyl ester

3-(Methyl-{3-[11H-10-thia-dibenzo[a,d]cyclohepten-(5Z)-ylidene]-propyl}-amino)-propionic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 1.) NaHCO3 / toluene / 6 h / Heating
2: 77 percent / KOH / butan-1-ol / 4 h / Heating
3: ethanol / 2 h / Heating
View Scheme

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride Chemical Properties

Chemical Name: Dothiepin HCL
IUPAC NAME: (3Z)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride ; 3E)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride ; (3Z)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine
CAS No.: 897-15-4
EINECS: 212-978-8
Molecular Formula: C19H22ClNS
Molecular Weight: 331.9 g/mol
Flash Point: 214.4 °C
Boiling Point: 430.9 °C at 760 mmHg
Following is the structure of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4):


Product Categories about 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4) is Antidepressant
The chemical synonymous of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride (CAS No.897-15-4) are Dothiepin Hcl ; Dothiepin Hydrochloride ; Dosulepin Hcl ; 11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo(B,E)Thiepinehydrochlorid ; 3-Dibenzo(B,E)Thiepin-11(6h)-Ylidene-N,N-Dimethyl-1-Propanaminhydrochlor ; Dosulepinchloride ; Dosulepinhydrochloride ; N,N-Dimethyldibenzo(B,E)Thiepin-Delta(Sup11(6h),Gamma)-Propylaminehydrochlo

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride Toxicity Data With Reference

1.    

orl-rat TDLo:440 mg/kg (MGN):REP

     OYYAA2    Oyo Yakuri. Pharmacometrics. 27 (1984),1103.
2.    

orl-wmn LDLo:40 mg/kg

     PGMJAO    Postgraduate Medical Journal. 60 (1984),442.
3.    

orl-cld TDLo:90 mg/kg:CVS

     PGMJAO    Postgraduate Medical Journal. 60 (1984),442.
4.    

orl-rat LD50:260 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
5.    

ipr-rat LD50:105 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),192.
6.    

scu-rat LD50:760 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
7.    

ivn-rat LD50:24 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
8.    

orl-mus LD50:209 mg/kg

     27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,88.
9.    

ipr-mus LD50:116 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),192.
     

 

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: cardiomyopathy. Experimental teratogenic and reproductive effects. An antidepressant. When heated to decomposition it emits very toxic fumes of NOx, SOx and HCl.

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