2-(2-Chloroethoxy)acetamide supplier

Name
2-(2-Chloroethoxy)Acetamide
EINECS
CAS No. 36961-64-5
Article Data2
CAS DataBase
Density 1.216 g/cm³
Solubility
Melting Point 72-75 °C
Formula C₄H₈ClNO₂
Boiling Point 289.3 °C at 760 mmHg
Molecular Weight 137.566
Flash Point 128.8 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (2-Chloroethoxy)acetamide;2-(2-Chloroethoxy)acetamide;
PSA 52.32000
LogP 0.42740

Synthetic route

: 123-85-3
2-(2-hydroxyethoxy)-acetamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

Conditions

Conditions	Yield
With pyridine; thionyl chloride In chloroform; water	91%

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 83881-37-2, 163837-41-0, 163837-43-2
2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

Conditions

Conditions	Yield
Stage #1: N-(4-chlorobenzhydryl)piperazine With tetrabutylammomium bromide; potassium carbonate In water at 25℃; Stage #2: 2-(2-chloroethoxy)acetamide In water at 80℃;	95%
With potassium iodide; sodium chloride; sodium carbonate; sodium sulfate In di-isopropyl ether; water; toluene	79.6%

: 120-43-4
4-ethoxycarbonylpiperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: ethyl 4-(2-carbamoylmethoxyethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium iodide; sodium carbonate In isopropyl alcohol; toluene	82%

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

A dihydrochloride of 2-[2-[4-[(4-chlorophenyl) phenylmethyl-1-piperazinyl]ethoxy]acetamide: dihydrochloride of 2-[2-[4-[(4-chlorophenyl) phenylmethyl-1-piperazinyl]ethoxy]acetamide

B: 83881-37-2, 163837-41-0, 163837-43-2
2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide

Conditions

Conditions	Yield
With potassium iodide; sodium chloride; sodium carbonate In para-xylene; water; toluene	A 78.8% B n/a

...Expand

: 841-77-0
diphenylmethylpiperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

A: 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]-acetamide

B 2-[2-[4-Diphenylmethyl)-1-piperazinyl]ethoxy]-acetamide dihydrochloride: 2-[2-[4-Diphenylmethyl)-1-piperazinyl]ethoxy]-acetamide dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene; water; benzene	A 73% B n/a

...Expand

: 110-85-0
piperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 142-64-3
piperazine dihydrochloride

: 197968-56-2
2-[2-(1-piperazinyl)ethoxy]acetamide

Conditions

Conditions	Yield
With ammonium hydroxide In methanol; ethanol; dichloromethane; water; butanone	57.1%

...Expand

: 110-85-0
piperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 197968-56-2
2-[2-(1-piperazinyl)ethoxy]acetamide

Conditions

Conditions	Yield
With ammonium hydroxide In toluene	39%

: 36961-64-5
2-(2-chloroethoxy)acetamide

: (+)-1-<(4-chlorophenyl)phenylmethyl>piperazine

: (+)-2-(2-<4-<(4-chlorophenyl)phenylmethyl>-1-piperazinyl>ethoxy)acetamide

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In toluene

: 36961-64-5
2-(2-chloroethoxy)acetamide

: (-)-1-<(4-chlorophenyl)phenylmethyl>piperazine

: (-)-2-(2-<4-<(4-chlorophenyl)phenylmethyl>-1-piperazinyl>ethoxy)acetamide

Conditions

Conditions	Yield
With sodium carbonate; potassium iodide In toluene

: 120-43-4
4-ethoxycarbonylpiperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: ethyl (2-carbamoylmethoxyethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium iodide; sodium carbonate In ethyl acetate; isopropyl alcohol; toluene

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 1-[2-(3,5-Bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazine

: 2-(2-{4-[2-(3,5-bis-trifluoromethyl-benzyloxy)-1-phenyl-ethyl]-piperazin-1-yl}-ethoxy)-acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 346417-35-4
1-{(S)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazine

: 346415-25-6
2-[2-(4-{(S)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-ethoxy]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 551943-94-3
1-{(S)-2-[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazine

: 346417-73-0
2-[2-(4-{(S)-2-[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-ethoxy]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 551943-93-2
1-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazine

: 346417-74-1
2-[2-(4-{(R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-ethoxy]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 551943-95-4
1-{(R)-2-[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazine

: 346417-75-2
2-[2-(4-{(R)-2-[(S)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethyl}-piperazin-1-yl)-ethoxy]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 197968-98-2
(2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy)acetamide

Conditions

Conditions	Yield
With sodium carbonate In xylene at 140℃; for 4h; Heating / reflux;

: 67-56-1
methanol

: 2759-28-6
1-phenylmethylpiperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 2-(4-benzyl-1-piperazinyl)ethoxyacetamide

Conditions

Conditions	Yield
With potassium iodide; sodium carbonate In dichloromethane; water; butanone

...Expand

: 110-91-8
morpholine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 7440-44-0
pyrographite

: 2-(2-morpholinoethoxy)acetamide hydrochloride

Conditions

Conditions	Yield
With sodium iodide In hydrogenchloride; toluene

...Expand

: potassium phthalimidate

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 2-(2-phthalimidoethoxy)acetamide

Conditions

Conditions	Yield
In N-methyl-acetamide

: 36961-64-5
2-(2-chloroethoxy)acetamide

: 439858-21-6
(S)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

: [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-(2-chloroethoxy)acetamide; 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine With potassium carbonate; potassium iodide In N,N-dimethyl-formamide; toluene at 25 - 110℃; Stage #2: With hydrogenchloride In Isopropyl acetate; N,N-dimethyl-formamide; acetone; toluene at 10 - 15℃; pH=1 - 2;

: 1198162-46-7
(-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine

: 36961-64-5
2-(2-chloroethoxy)acetamide

: (+)-Cetirizine dihydrochloride

Conditions

Conditions	Yield
Stage #1: (-)-1-[(4-chloro-phenyl)-phenyl-methyl]-4-(4-methoxy-benzyl)piperazine; 2-(2-chloroethoxy)acetamide With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 25 - 110℃; Stage #2: With hydrogenchloride In ipa pH=1 - 2;

2-(2-Chloroethoxy)acetamide Specification

The 2-(2-Chloroethoxy)acetamide with the CAS number 36961-64-5 is also called Acetamide,2-(2-chloroethoxy)-. Its molecular formula is C₄H₈ClNO₂. This chemical is a kind of organics. It should be stored in dry and cool environment.

The properties of the chemical are: (1)ACD/LogP: -0.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.73; (4)ACD/LogD (pH 7.4): -0.73; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 9.58; (8)ACD/KOC (pH 7.4): 9.58; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 29.54 Å²; (13)Index of Refraction: 1.455; (14)Molar Refractivity: 30.73 cm³; (15)Molar Volume: 113.1 cm³; (16)Polarizability: 12.18×10^-24cm³; (17)Surface Tension: 39.4 dyne/cm; (18)Enthalpy of Vaporization: 52.86 kJ/mol; (19)Vapour Pressure: 0.00222 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: NC(=O)COCCCl
(2)InChI: InChI=1/C4H8ClNO2/c5-1-2-8-3-4(6)7/h1-3H2,(H2,6,7)
(3)InChIKey: KQHRCXCLILUNBX-UHFFFAOYAD

Product Name

2-(2-Chloroethoxy)Acetamide

Synthetic route

2-(2-Chloroethoxy)acetamide Specification

Related Products

Hot Products