2,3-Dichlorobenzaldehyde supplier

Name
2,3-Dichlorobenzaldehyde
EINECS 228-711-3
CAS No. 6334-18-5
Article Data27
CAS DataBase
Density 1.4 g/cm³
Solubility Practically insoluble in water
Melting Point 64-67 °C(lit.)
Formula C₇H₄Cl₂O
Boiling Point 242.9 °C at 760 mmHg
Molecular Weight 175.014
Flash Point 99.2 °C
Transport Information UN 3261 8/PG 2
Appearance white crystalline powder
Safety 26-36/37/39-45-37/39
Risk Codes 34-36/37/38
Molecular Structure
Hazard Symbols Xi, C
Synonyms Benzaldehyde, 2,3-dichloro-;2,3-Dichlorobenzaldehyde (2,3-DCBA);
PSA 17.07000
LogP 2.80590

Synthetic route

: N'-(2,3-dichloro-benzylidene)-N,N-dimethyl-hydrazine

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With silica gel; iron(III) chloride for 0.01h; microwave irradiation;	89%
With K5 In acetonitrile at 20℃; for 0.75h;	84%

: 4414-54-4
2,3-dichlorobenzaldehyde oxime

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With quinolinium monofluorochromate(VI) In acetonitrile for 5h; Oxidation; Heating;	85%
With caro's acid; silica gel for 0.03h; deoximation; Irradiation;	80%

: 2-(2,3-dichloro-phenyl)-[1,3]dithiolane

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In methanol; water Heating;	80%

: 38594-42-2
2,3-dichlorobenzyl alcohol

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With eosin y In dimethyl sulfoxide at 80℃; for 24h; Irradiation;	53%
With copper(l) iodide; di-tert-butyl peroxide; (E)-N-((Z)-4-((2,6-dimethylphenyl)amino)pent-3-en-2-ylidene)-2,6-dimethylaniline In N,N-dimethyl-formamide at 90℃; for 6h; Sealed tube; Inert atmosphere;	93 %Chromat.
With hydrogen bromide; dihydrogen peroxide In 1,4-dioxane at 25℃; for 7h; Temperature;	48.19 g

: 17257-79-3
3,4-epoxy-2-pentanone

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 6334-18-5
2,3-dichlorobenzylaldehyde

B: 4,5-Dichloro-benzene-1,3-dicarbaldehyde

Conditions

Conditions	Yield
With trichlorophosphate Product distribution; RT, 30 min, heating, 4-4.5 h; different epoxy ketones;	A 18% B 30%
With trichlorophosphate RT, 30 min, heating, 4-4.5 h;	A 18% B 30%

...Expand

: 32768-54-0
2,3-dichlorotoluene

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With sodium molybdate; dihydrogen peroxide; cobalt(II) acetate; acetic acid; sodium bromide at 90℃; Temperature;	29%
With bromine at 180 - 200℃; Erhitzen des Reaktionsgemisches mit konz. Schwefelsaeure auf 100-140grad;
(i) Br2, (UV-irradiation), (ii) aq. H2SO4; Multistep reaction;
Multi-step reaction with 3 steps 1: 2,2'-azobis(isobutyronitrile); bromine / 1,2-dichloro-ethane / 75 °C 2: water; sodium carbonate / 8 h / Reflux 3: dihydrogen peroxide; hydrogen bromide / 1,4-dioxane / 7 h / 25 °C View Scheme

: 6705-49-3
7-oxabicyclo[4.1.0]heptan-2-one

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 6334-18-5
2,3-dichlorobenzylaldehyde

B: 2-chloroisophthalaldehyde

Conditions

Conditions	Yield
With trichlorophosphate RT, 30 min, heating, 4-4.5 h;	A 13% B 24%

...Expand

: 111011-80-4
2-acetonyl-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane

: 1,2-dichloro-3-(dimorpholinomethyl)benzene

A: 6334-18-5
2,3-dichlorobenzylaldehyde

B: 115578-90-0
(E)-2,2-dimethyl-1,3-propanediyl α-acetyl-2,3-dichlorostyrylphosphonate

C: (Z)-2,2-dimethyl-1,3-propanediyl α-acetyl-2,3-dichlorostyrylphosphonate

Conditions

Conditions	Yield
With trifluoroacetic acid 1) toluene, 2) r.t., 1.0 h; Yield given. Multistep reaction. Title compound not separated from byproducts;	A 11% B n/a C n/a
With chloroacetic acid In toluene for 3h; Ambient temperature; Yield given. Title compound not separated from byproducts;	A 7% B n/a C n/a

...Expand

: 75-17-2
formaldoxime

: 608-27-5
2,3-dichloroaniline

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
(i) aq. HCl, NaNO2, (ii) /BRN= 1697325/, CuSO4, Na2SO4, NaOAc, (iii) acid; Multistep reaction;
With hydrogenchloride; sodium acetate; copper(II) sulfate; sodium nitrite Yield given. Multistep reaction;
Multistep reaction;

: 29027-17-6
2-chloro-3-methylaniline

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl 2: bromine / 180 - 200 °C / Erhitzen des Reaktionsgemisches mit konz. Schwefelsaeure auf 100-140grad View Scheme

: 288-43-7
1,2,3-oxadiazole

: 1820-80-0
3-aminopyrazole

: 6287-38-3
3,4-dichlorobenzaldehyde

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With sodium bicarbonate In N-methyl-acetamide; hexane; water; ethyl acetate

...Expand

: 95-50-1
1,2-dichloro-benzene

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 57915-78-3
1-(bromomethyl)-2,3-dichlorobenzene

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: eosin y; oxygen / dimethyl sulfoxide / 12 h / 25 °C / Irradiation 2: eosin y / dimethyl sulfoxide / 24 h / 80 °C / Irradiation View Scheme

: 576-24-9
2,3-dichlorophenol

A: 5145-42-6
2,3-dichloro-1,4-benzoquinone

B: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With C84H80CoN16O8; C84H80CuN16O8; dihydrogen peroxide at 75℃; for 3h; Catalytic behavior; Reagent/catalyst; Temperature;

: C7H4Cl2O4S

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
In water; benzene

: 2,3‑dichlorobenzylidene bromide

: 6334-18-5
2,3-dichlorobenzylaldehyde

Conditions

Conditions	Yield
With hydrogen bromide In water; dimethyl sulfoxide at 140℃; Temperature; Flow reactor;

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 22483-09-6
2,2-dimethoxyethylamine

: 57987-75-4
N-<(2,3-dichlorophenyl)methylene>-2,2-dimethoxyethanamine

Conditions

Conditions	Yield
In toluene for 1.5h; Heating;	100%
In toluene for 0.5h; Heating;	100%
for 0.333333h; Heating;

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 22483-09-6
2,2-dimethoxyethylamine

: 57987-75-4
2,3-dichloro-N-(2,2-dimethoxyethyl)benzylidenamine

Conditions

Conditions	Yield
In benzene Heating;	100%
In toluene

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 38594-42-2
2,3-dichlorobenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	100%
With sodium borohydrid In methanol; sodium hydroxide	92%
With sodium tetrahydroborate In methanol
With sodium tetrahydroborate; water In acetonitrile

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 100427-51-8
1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate

: 2-[1-(2,3-Dichloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl ester; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In chloroform Ambient temperature;	100%

: 61-54-1
tryptamine

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 331852-79-0
C17H14Cl2N2

Conditions

Conditions	Yield
With trifluoroacetic acid In 1,1-dichloroethane Reflux;	100%

: 17857-14-6
(3-carboxypropyl)(triphenyl)phosphonium bromide

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 847948-69-0
5-(2,3-dichloro-phenyl)-pent-4-enoic acid

Conditions

Conditions	Yield
Stage #1: (3-carboxypropyl)(triphenyl)phosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 1.5h; Wittig Reaction; Stage #2: 2,3-dichlorobenzylaldehyde In tetrahydrofuran at 0 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water	100%

: 1123-49-5
3,5-dimethyl-4-nitroisoxazole

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1025644-92-1
C12H8Cl2N2O3

Conditions

Conditions	Yield
With pyrrolidine In neat (no solvent) at 20℃; for 0.05h; Aldol Condensation;	100%
With piperidine In acetonitrile for 4h; Knoevenagel condensation; Reflux;

: 92151-73-0
2-phenylethynylphenol

: 6334-18-5
2,3-dichlorobenzylaldehyde

A: 1839-72-1
2-phenylbenzofuran

B: 1352954-81-4
C21H14Cl2O2

Conditions

Conditions	Yield
With [(1,3-bis(diphenylphosphino)propane)Pd(H2O)2](BF4)2 In tetrahydrofuran at 45℃; Molecular sieve;	A n/a B 100%

...Expand

: tert-butyl 1-(2-bromobenzyl)hydrazine-1-carboxylate

: 6334-18-5
2,3-dichlorobenzylaldehyde

: C19H19BrCl2N2O2

Conditions

Conditions	Yield
In ethanol at 20℃;	100%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 24155-32-6
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one

: (E)-1-(4-Chloro-phenyl)-3-(2,3-dichloro-phenyl)-2-imidazol-1-yl-propenone

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 2h; Heating;	99%

: 54-85-3
isoniazid

: 6334-18-5
2,3-dichlorobenzylaldehyde

: N'-[(E)-(2,3-dichloro-phenyl)methylidene]isonicotinohydrazide

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 0.0833333h; UV-irradiation;	99%
triethylamine In tetrahydrofuran for 6h; Heating;

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 357231-58-4
C12H9Cl2NO2

Conditions

Conditions	Yield
With poly(ethylene glycol) bridged dicationic ionic liquid PEG800-DPIL(Cl) In cyclohexane; isopropyl alcohol at 80℃; for 0.333333h; Knoevenagel Condensation;	99%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 4414-54-4
2,3-dichlorobenzaldehyde oxime

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In methanol at 20℃; for 2.5h;	99%
With hydroxylamine hydrochloride; potassium carbonate In water Reflux;	60%
With pyridine; hydroxylamine hydrochloride In methanol at 20℃; for 2.5h;

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 20830-75-5
digoxin

: 21-(2,3-dichloro)benzylidene digoxin

Conditions

Conditions	Yield
With potassium carbonate In methanol for 6h; Heating;	99%
With potassium carbonate In methanol at 70℃; for 6h;

: 923876-29-3
C16H14N4O2

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 6-(2,3-dichlorophenyl)-3-(4-methoxyphenyl)-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one

Conditions

Conditions	Yield
With acetic acid for 3h; Reflux;	99%

: 540-63-6
ethane-1,2-dithiol

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 2-(2,3-dichloro-phenyl)-[1,3]dithiolane

Conditions

Conditions	Yield
With iron(III) chloride at 20℃; for 0.583333h;	98%
With silica supported PCl5 In dichloromethane at 20℃; for 0.416667h; chemoselective reaction;	92%

: 54-85-3
isoniazid

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 314072-17-8
isonicotinic acid N2-(2,3-dichlorobenzylidene)hydrazide

Conditions

Conditions	Yield
In ethanol Reflux;	98%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 28144-70-9
anthranilic acid amide

: 923862-84-4
2,3-dihydro-2-(2,3-dichlorophenyl)quinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine at 80℃; for 0.5h; Ionic liquid; Inert atmosphere;	98%
With graphene oxide nanosheets In water at 20℃; for 0.333333h;	94%
In neat (no solvent) for 0.333333h; Microwave irradiation; Green chemistry;	84%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 95-54-5
1,2-diamino-benzene

: 1097786-96-3
2‐(2,3‐dichlorophenyl)‐1H‐benzo[d]imidazole

Conditions

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide In water; acetonitrile for 0.011h; Microwave irradiation;	98%
With iodine; sodium hydroxide In acetonitrile at 20℃; for 0.5h;	95%
With Thiocarbohydrazide/nickel-based nanocomposite supported on SBA-15 In ethanol at 20℃; for 0.0833333h;	90%
With dihydrogen peroxide In acetonitrile at 82℃; for 1h;	84%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 868-85-9
Dimethyl phosphite

: 1217702-69-6
C9H11Cl2O4P

Conditions

Conditions	Yield
With guanidine supported magnetic Fe3O4 nanoparticle In neat (no solvent) at 80℃; for 1.5h;	98%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 134-81-6
benzil

: 2-(2,3-dichlorophenyl)-4,5-diphenyl-1H-imidazole

Conditions

Conditions	Yield
With ammonium acetate In ethanol at 80℃; for 0.833333h; Green chemistry;	98%
With ammonium acetate at 110℃; for 0.166667h;	92%
With ammonium acetate In neat (no solvent) for 0.116667h; Microwave irradiation; Green chemistry;	89%

: C15H11FN4O

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 6-(2,3-dichlorophenyl)-3-(4-fluorophenyl)-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one

Conditions

Conditions	Yield
With acetic acid for 3h; Reflux;	98%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 945999-86-0
6-bromo-2,3-dichlorobenzaldehyde

Conditions

Conditions	Yield
With N-Bromosuccinimide; 4-chloro-2-(trifluoromethyl)aniline; palladium diacetate In 1,2-dichloro-ethane; trifluoroacetic acid at 60℃; for 24h;	98%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 21204-67-1
methyl (triphenylphosphoranylidene)acetate

: 175168-68-0
methyl (E)-3-(2,3-dichlorophenyl)acrylate

Conditions

Conditions	Yield
In dichloromethane at 20℃; Wittig Olefination;	98%

: 768-94-5
1-Adamantanamine

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1-<(2,3-dichlorobenzylidene)amino>adamantane

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	97%

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 356797-33-6
2,3:5,6-di-O-iso-propylidene-α-D-mannofuranose-1-acrylate

: 5-[2,2-dimethyl-(4R)-1,3-dioxolan-4-yl]-2,2-dimethyl-(3aR,6S,6aR)-perhydrofuro[2,3-d][1,3]-dioxol-6-yl 2-[2,3-dichlorophenyl(hydroxy)methyl]acrylate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In tetrahydrofuran at 20℃; for 48h; Baylis-Hillman reaction;	97%

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 109-77-3
malononitrile

: 2-amino-4-(2,3-dichlorophenyl)-4,5-dihydro-5-oxopyrano[3,2-c]chromene-3-carbonitrile

Conditions

Conditions	Yield
With copper chromite nanoparticles In water at 20℃; for 0.0666667h; Green chemistry;	97%
With silica gel (230-400 mesh) In ethanol at 20℃; for 4h;	91%
With diammonium phosphate In ethanol; water at 20℃; for 4h;	90%

...Expand

: 75-66-1
2-methylpropan-2-thiol

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 164791-48-4
2-tert-butylthio-3-chlorobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 96h; Reflux;	97%

: trimethylsilyl cyanide

: 6334-18-5
2,3-dichlorobenzylaldehyde

: C11H13Cl2NOS

Conditions

Conditions	Yield
With magnetic Fe3O4 nanoparticle-supported guanidine In dichloromethane at 20℃; for 0.0833333h;	97%

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 1522380-57-9
3,3'-((2,3-dichlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Conditions

Conditions	Yield
With Triton X-100 In water at 20℃; for 6.5h; Knoevenagel Condensation; Green chemistry;	97%

2,3-Dichlorobenzaldehyde Chemical Properties

Product Name: 2,3-Dichlorobenzaldehyde (CAS NO.6334-18-5)

Molecular Formula: C₇H₄Cl₂O
Molecular Weight: 175.01g/mol
Mol File: 6334-18-5.mol
EINECS: 228-711-3
Appearance: white crystalline powder
Melting Point: 64-67 °C(lit.)
Boiling point: 242.9 °C at 760 mmHg
Flash Point: 99.2 °C
Density: 1.4 g/cm³
Sensitive: Air Sensitive
Index of Refraction: 1.6
Molar Refractivity: 42.79 cm³
Molar Volume: 125 cm³
Surface Tension: 45.1 dyne/cm
Enthalpy of Vaporization: 47.99 kJ/mol
Vapour Pressure: 0.0331 mmHg at 25°C
XLogP3-AA: 3
H-Bond Donor: 0
H-Bond Acceptor: 1
Structure Descriptors of 2,3-Dichlorobenzaldehyde (CAS NO.6334-18-5):
IUPAC Name: 2,3-dichlorobenzaldehyde
Canonical SMILES: C1=CC(=C(C(=C1)Cl)Cl)C=O
InChI: InChI=1S/C7H4Cl2O/c8-6-3-1-2-5(4-10)7(6)9/h1-4H
InChIKey: LLMLNAVBOAMOEE-UHFFFAOYSA-N
Product Categories: Aromatic Aldehydes & Derivatives (substituted); Felodipine; Aldehydes; C7; Carbonyl Compounds

2,3-Dichlorobenzaldehyde Uses

2,3-Dichlorobenzaldehyde (CAS NO.6334-18-5) is the Pharmaceutical Intermediates,and 2,3-Dichlorobenzaldehyde is used in the synthesis of FELODIPINE, CHLORINE-dimensional, the synthesis of Lamotrigine.

2,3-Dichlorobenzaldehyde Safety Profile

Safety Information of 2,3-Dichlorobenzaldehyde (CAS NO.6334-18-5):
Hazard Codes: C Corrosive ,Xi Irritant
Risk Statements: 34-36/37/38
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-45-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 3261 8/PG 2
WGK Germany: 2
F: 10
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29130000

2,3-Dichlorobenzaldehyde Standards and Recommendations

Purity≥98.0% (GC)
Loss on drying ≤0.5%
Residue On Ignition≤0.5%

2,3-Dichlorobenzaldehyde Specification

2,3-Dichlorobenzaldehyde , its CAS NO. is 6334-18-5, the synonyms are Benzaldehyde, 2,3-dichloro- ; Benzaldehyde, dichloro- ; Benzaldehyde, 2,3-dichloro- .

Product Name

2,3-Dichlorobenzaldehyde

Synthetic route

2,3-Dichlorobenzaldehyde Chemical Properties

2,3-Dichlorobenzaldehyde Uses

2,3-Dichlorobenzaldehyde Safety Profile

2,3-Dichlorobenzaldehyde Standards and Recommendations

2,3-Dichlorobenzaldehyde Specification

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