2,6-Dichloropyrazine supplier

Name
2,6-Dichloropyrazine
EINECS 225-316-8
CAS No. 4774-14-5
Article Data13
CAS DataBase
Density 1.493 g/cm³
Solubility
Melting Point 53-56 °C
Formula C₄H₂Cl₂N₂
Boiling Point 187.466 °C at 760 mmHg
Molecular Weight 148.979
Flash Point 83.8 °C
Transport Information
Appearance White powder
Safety 26-37/39-36/37/39-22-36
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Pyrazine, 2,6-dichloro-;
PSA 25.78000
LogP 1.78340

Synthetic route

: 14508-49-7
2-chloropyrazin

: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With pyridine; chlorine at 110℃; for 2h; Reagent/catalyst;	87.3%
With sulfuryl dichloride at 120℃;

: 2423-84-9
Pyrazin-N.N'-dioxyd

: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 6h; Heating;	84%

: 6863-76-9
3-chloropyrazine 1-oxide

A: 19745-07-4
2,5-dichloropyrazine

B: 4858-85-9
2,3-dichloropyrazine

C: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given;
With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given;

...Expand

: 2423-84-9
Pyrazin-N.N'-dioxyd

A: 4858-85-9
2,3-dichloropyrazine

B: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 6863-76-9
3-chloropyrazine 1-oxide

A: 14508-49-7
2-chloropyrazin

B: 19745-07-4
2,5-dichloropyrazine

C: 4858-85-9
2,3-dichloropyrazine

D: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 16025-16-4
2-chloropyrazine 1-oxide

A: 14508-49-7
2-chloropyrazin

B: 4858-85-9
2,3-dichloropyrazine

C: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 14508-49-7
2-chloropyrazin

: 7782-50-5
chlorine

: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
at 120℃;

: 290-37-9
1,4-pyrazine

: 7732-18-5
water

: 7782-50-5
chlorine

A: 14508-49-7
2-chloropyrazin

B: 19745-07-4
2,5-dichloropyrazine

C: 4858-85-9
2,3-dichloropyrazine

D: 4774-14-5
2,6-dichloropyrazine

Conditions

Conditions	Yield
at 350℃; Product distribution;

...Expand

: 14508-49-7
2-chloropyrazin

A: 4774-14-5
2,6-dichloropyrazine

B 2,3-dichloro-pyrazine, 2,5-dichloro-pyrazine: 2,3-dichloro-pyrazine, 2,5-dichloro-pyrazine

Conditions

Conditions	Yield
With chlorine at 475℃;

: 290-37-9
1,4-pyrazine

A: 4774-14-5
2,6-dichloropyrazine

B 2,3-dichloro-pyrazine, chloropyrazine 2,5-dichloro-pyrazine: 2,3-dichloro-pyrazine, chloropyrazine 2,5-dichloro-pyrazine

Conditions

Conditions	Yield
With water; chlorine at 350℃;

: 290-37-9
1,4-pyrazine

A: 4774-14-5
2,6-dichloropyrazine

B 2,3-dichloro-pyrazine, chloropyrazine, 2,5-dichloro-pyrazine: 2,3-dichloro-pyrazine, chloropyrazine, 2,5-dichloro-pyrazine

Conditions

Conditions	Yield
With water; chlorine at 400 - 500℃;
With water; chlorine at 400 - 500℃;

: 4774-14-5
2,6-dichloropyrazine

: 5720-07-0
4-methoxyphenylboronic acid

: 135459-44-8
2,6-bis-(4-methoxy-phenyl)-pyrazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene for 14h; Suzuki coupling; Heating;	100%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 70℃; for 0.5h; Suzuki-Miyaura Coupling; Microwave irradiation;	97%

: 6093-68-1
6-hydroxycoumarin

: 4774-14-5
2,6-dichloropyrazine

: 894416-91-2
2-chloro-6-(7-coumarinyloxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h;	100%

: 93-35-6
7-hydroxy-2H-chromen-2-one

: 4774-14-5
2,6-dichloropyrazine

: 894416-91-2
2-chloro-6-(7-coumarinyloxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	100%

: 3470-49-3
5-hydroxy-2,3-dihydro-1H-indene-1-one

: 4774-14-5
2,6-dichloropyrazine

: 894417-08-4
2-chloro-6-(indanone-5-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	100%

: 3470-50-6
6-Hydroxy-1-tetralone

: 4774-14-5
2,6-dichloropyrazine

: 894416-93-4
2-chloro-6-(tetralon-1-yl-6-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	100%

: 28315-93-7
5-Hydroxy-1-tetralone

: 4774-14-5
2,6-dichloropyrazine

: 894416-92-3
2-chloro-6-(tetralon-1-yl-5-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	100%

: 4774-14-5
2,6-dichloropyrazine

: 86700-06-3
N-(5-hydroxynaphthalen-2-yl)acetamide

: 894416-96-7
2-chloro-6-(6-acetamido-naphthyl-1-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	100%

: 4774-14-5
2,6-dichloropyrazine

: 143900-43-0
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

: 1147998-31-9
tert-butyl (3R)-3-[(6-chloropyrazin-2-yl)oxy]piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 0 - 5℃; for 2h; Industry scale; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 0 - 30℃; for 3.5h;	100%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 4774-14-5
2,6-dichloropyrazine

: 1250740-85-2
2-(6-chloropyrazin-2-yl)oxy-N,N-dimethylethanamine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃;	100%
Stage #1: 2-(N,N-dimethylamino)ethanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	99%
Stage #1: 2-(N,N-dimethylamino)ethanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 2,6-dichloropyrazine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	87%
Stage #1: 2-(N,N-dimethylamino)ethanol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Microwave irradiation; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran for 0.166667h; Microwave irradiation;

: 3179-63-3
3-Dimethylamino-1-propanol

: 4774-14-5
2,6-dichloropyrazine

: 1609955-47-6
3-(6-chloropyrazin-2-yloxy)-N,N-diethylpropan-1-amine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃;	100%

: 3179-63-3
3-Dimethylamino-1-propanol

: 4774-14-5
2,6-dichloropyrazine

: 1247107-87-4
3-(6-chloropyrazin-2-yl)oxy-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃;	100%
Stage #1: 3-Dimethylamino-1-propanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 2,6-dichloropyrazine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	79%
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	77%
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Microwave irradiation; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran for 0.166667h; Microwave irradiation;

: 96-41-3
Cyclopentanol

: 4774-14-5
2,6-dichloropyrazine

: 2-chloro-6-(cyclopentyloxy)pyrazine

Conditions

Conditions	Yield
Stage #1: Cyclopentanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	100%
Stage #1: Cyclopentanol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran; mineral oil at 20℃; for 16h;	80%

: 4774-14-5
2,6-dichloropyrazine

: 108-93-0
cyclohexanol

: 1016681-36-9
2-chloro-6-(cyclohexyloxy)pyrazine

Conditions

Conditions	Yield
Stage #1: cyclohexanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	100%

: 106-52-5
N-methyl-4-hydroxypiperidine

: 4774-14-5
2,6-dichloropyrazine

: 2-chloro-6-((1-methylpiperidin-4-yl)oxy)pyrazine

Conditions

Conditions	Yield
Stage #1: N-methyl-4-hydroxypiperidine With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	100%

: 4774-14-5
2,6-dichloropyrazine

: 124-41-4
sodium methylate

: 4774-15-6
2,6-dimethoxypirazine

Conditions

Conditions	Yield
In methanol for 18h; Reflux;	99%
In methanol Heating / reflux;	98%
In methanol at 80℃; for 18h; Reflux;	97%

: 4774-14-5
2,6-dichloropyrazine

: 99-93-4
4-Hydroxyacetophenone

: 894417-06-2
2-chloro-6-(acetophenone-4-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	99%

: 4774-14-5
2,6-dichloropyrazine

: 621-42-1
meta-hydroxyacetanilide

: 894417-03-9
2-chloro-6-(3-acetamidophenyl-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	99%

: 4774-14-5
2,6-dichloropyrazine

: 100-37-8
2-(Diethylamino)ethanol

: 1247497-41-1
2-(6-chloropyrazin-2-yloxy)-N,N-diethylethanamine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃;	99%
Stage #1: 2-(Diethylamino)ethanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation;	95%

: 107-10-8
propylamine

: 4774-14-5
2,6-dichloropyrazine

: 6-Chloro-N-propylpyrazin-2-amine

Conditions

Conditions	Yield
With triethylamine In ethanol for 1.5h; Reflux;	99%

: 959833-70-6
tert-butyl [(2S)-1-aminopropan-2-yl]carbamate hydrochloride

: 4774-14-5
2,6-dichloropyrazine

: tert-butyl (S)-(1-((6-chloropyrazin-2-yl)amino)propan-2-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 115℃; for 8h;	99%

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 4774-14-5
2,6-dichloropyrazine

: 2-chloro-6-(3-methoxy-4-methylphenoxy)pyrazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;	99%

: 95-56-7
2-hydroxybromobenzene

: 4774-14-5
2,6-dichloropyrazine

: 2,6-bis(2-bromophenoxy)pyrazine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 160℃; for 16h; Inert atmosphere; Schlenk technique;	99%

: 617-89-0
furan-2-ylmethanamine

: 4774-14-5
2,6-dichloropyrazine

: 629658-05-5
6-chloro-N-(2-furylmethyl)pyrazin-2-amine

Conditions

Conditions	Yield
	98%

: 722538-29-6
1-benzenesulfonyl-6-methoxy-2-tributylstannyl-1H-indole

: 4774-14-5
2,6-dichloropyrazine

: 1346163-38-9
1-benzensulfonyl-2-(6-chloro-pyrazin-2-yl)-6-methoxy-1H-indole

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 100℃; for 0.333333h; Stille cross-coupling; Inert atmosphere; Microwave irradiation;	98%

: 4774-14-5
2,6-dichloropyrazine

: 16419-60-6
2-Methylphenylboronic acid

: C18H16N2

Conditions

Conditions	Yield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%

: 6165-69-1
Thien-3-ylboronic acid

: 4774-14-5
2,6-dichloropyrazine

: C12H8N2S2

Conditions

Conditions	Yield
With C84H64Cl3N3Pd; potassium carbonate In ethanol at 80℃; for 2h; Suzuki-Miyaura Coupling;	98%

: 109-00-2
3-HYDROXYPYRIDINE

: 4774-14-5
2,6-dichloropyrazine

: 477960-95-5
2,6-bis(3-pyridyloxy)pyrazine

Conditions

Conditions	Yield
With CsCO3 In N,N-dimethyl-formamide at 110℃; for 20h;	97%

: 4774-14-5
2,6-dichloropyrazine

: 100-53-8
phenylmethanethiol

: 33870-91-6
2-(benzylthio)-6-chloropyrazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	97%
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 13h;
With sodium hydroxide In ethanol at 20℃; for 6h;

: 4774-14-5
2,6-dichloropyrazine

: 60-34-4
methylhydrazine

: 1567389-01-8
2,6-dimethylhydrazinopyrazine

Conditions

Conditions	Yield
for 1h; Reflux; Inert atmosphere;	97%
Reflux;

: 121-71-1
3-Hydroxyacetophenone

: 4774-14-5
2,6-dichloropyrazine

: 894417-05-1
2-chloro-6-(acetophenone-3-oxy)-pyrazine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 5h; Inert atmosphere;	96%

2,6-Dichloropyrazine Chemical Properties

IUPAC name: 2,6-Dichloropyrazine
Molecular Structure of 2,6-Dichloropyrazine (CAS NO.4774-14-5):

Molecular formula: C₄H₂Cl₂N₂
Molecular Weight: 148.98 g/mol
EINECS: 225-316-8
Melting point: 55-58 °C(lit.)
Molar Refractivity: 32.22 cm³
Molar Volume: 99.7 cm³
Flash Point: 83.8 °C
Density: 1.493 g/cm³
Index of Refraction: 1.559
Surface Tension: 51.5 dyne/cm
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 187.5 °C at 760 mmHg
Vapour Pressure: 0.867 mmHg at 25 °C
Appearance of 2,6-Dichloropyrazine (CAS NO.4774-14-5) White Powder
Canonical SMILES: C1=C(N=C(C=N1)Cl)Cl
InChI: InChI=1S/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H
InChIKey: LSEAAPGIZCDEEH-UHFFFAOYSA-N

2,6-Dichloropyrazine Uses

2,6-Dichloropyrazine (CAS NO.4774-14-5) is used for medicine, pesticide intermediates and mainly used as livestock's health medicine intermediate.

2,6-Dichloropyrazine Toxicity Data With Reference

2,6-Dichloropyrazine (CAS NO.4774-14-5) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

2,6-Dichloropyrazine Safety Profile

Hazard Symbols: Harmful Xn
Risk Codes: R20/21/22;R36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description: S22;S26;S36/37/39
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
HazardClass: Irritant

2,6-Dichloropyrazine Specification

2,6-Dichloropyrazine , its cas register number is 4774-14-5. It also can be called 2,6-Dichlor-pyrazin ; Pyrazine, 2,6-dichloro- ; and 2,6-Dichloropyrazine,99% .
2,6-Dichloropyrazine (CAS NO.4774-14-5) is stable under normal temperatures and pressures. And it should avoid the condition like incompatible materials, ignition sources. It is also incompatibilities with other materials strong oxidizing agents, strong reducing agents, strong acids, strong bases. while, its hazardous decomposition products are hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. And its hazardous polymerization has not been reported.
2,6-Dichloropyrazine (CAS NO.4774-14-5) is harmful and irritant. It is irritating to eyes, respiratory system and skin and harmful by inhalation, in contact with skin and if swallowed. So you should in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and wear suitable protective clothing, gloves and eye/face protection and do not empty into drains.

Product Name

2,6-Dichloropyrazine

Synthetic route

2,6-Dichloropyrazine Chemical Properties

2,6-Dichloropyrazine Uses

2,6-Dichloropyrazine Toxicity Data With Reference

2,6-Dichloropyrazine Safety Profile

2,6-Dichloropyrazine Specification

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