2-Cyclopentylethanol supplier

Name
2-CYCLOPENTYLETHANOL
EINECS 212-156-9
CAS No. 766-00-7
Article Data25
CAS DataBase
Density 0.922g/cm³
Solubility
Melting Point
Formula C₇H₁₄O
Boiling Point 174.4 °C at 760 mmHg
Molecular Weight 114.188
Flash Point 70.4 °C
Transport Information
Appearance
Safety 23-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Cyclopentaneethanol;2-Cyclopentylethanol;2-Cyclopentylethyl alcohol;
PSA 20.23000
LogP 1.55900

Synthetic route

: 766-02-9
2-cyclopent-2-enyl-ethanol

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Stage #1: 2-cyclopent-2-enyl-ethanol With pyridinium p-toluenesulfonate In 1,2-dichloro-ethane at 80℃; for 20h; Stage #2: With triethylamine In dichloromethane at 20℃; for 6h; Stage #3: With trifluoroacetic acid In methanol; dichloromethane at 140℃; for 0.0666667h; microwave irradiation; Further stages.;	100%
With palladium Hydrogenation;
With platinum Hydrogenation;

: 1123-00-8
2-cyclopentylacetic acid

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With dimethylsulfide borane complex In tetrahydrofuran; toluene at 0 - 20℃; for 16h;	90%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 13h; Deacetylation;	86%
With lithium aluminium tetrahydride In tetrahydrofuran 1) 1h, 90 deg C 2) 3h, reflux;	78%

: 75-21-8
oxirane

: 32916-51-1
cyclopentylmagnesium chloride

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With diethyl ether at 5℃;

: 75-21-8
oxirane

: 33240-34-5
cyclopentylmagnesium bromide

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With diethyl ether

: 18322-54-8
ethyl cyclopentylacetate

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With ethanol; sodium
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In tetrahydrofuran

: 2723-38-8
cyclopentylacetic acid methyl ester

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With ethanol; sodium

: 75-21-8
oxirane

: 542-92-7
cyclopenta-1,3-diene

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
(i) KOtBu, tBuOH, (ii) /BRN= 102378/, (iii) H2, PtO2; Multistep reaction;

: 766-01-8
2-(cyclopent-3-en-1-yl)ethan-1-ol

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
With hydrogen

: 1903-22-6
ethyl cyclopentylideneacetate

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / 5percent Pd/C / ethanol / 760 Torr 2: LiAlH4 / tetrahydrofuran View Scheme

: 120-92-3
cyclopentanone

diluted alcoholic KOH: diluted alcoholic KOH

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaH / benzene 2: H2 / 5percent Pd/C / ethanol / 760 Torr 3: LiAlH4 / tetrahydrofuran View Scheme

: 104115-44-8
(2-oxocyclopent)acetic acid

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / KOH, hydrazine hydrate / ethane-1,2-diol / Heating; 1) 160-165 deg C 2) 4h, 195-200 deg C 2: 78 percent / 1) LAH / tetrahydrofuran / 1) 1h, 90 deg C 2) 3h, reflux View Scheme

: 137-43-9
Cyclopentyl bromide

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: xylene 2: ethanol 3: sodium; ethanol View Scheme

: 1540-32-5
ethyl 2-cyclopentyl-3-oxobutanoate

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: sodium; ethanol View Scheme

: 36367-85-8
toluene-4-sulfonic acid cyclopent-3-enyl ester

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: aq. KOH / ethanol 3: (i) Py, (ii) LiAlH4 4: H2 View Scheme

: 103095-34-7
<α-Cyan-α-(Δ3-cyclopentenyl)>-essigsaeure-ethylester

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. KOH / ethanol 2: (i) Py, (ii) LiAlH4 3: H2 View Scheme

: 771-00-6
2-(Δ3-Cyclopentyl)-malonsaeure

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Py, (ii) LiAlH4 2: H2 View Scheme

: 955017-60-4
bis(3-cyclopentylpropanoyl) peroxide

A: 3742-34-5
vinylcyclopentane

B: 766-00-7
2-cyclopentyl-ethanol

C: 2980-70-3
1,4-dicyclopentylbutane

D: 955017-64-8
2-cyclopentylethyl 3-cyclopentylpropanoate

Conditions

Conditions	Yield
In hexane at 80℃; Kinetics;	A 7.4 %Chromat. B 8 %Chromat. C 22 %Chromat. D 22 %Chromat.

...Expand

: 18922-04-8
6-iodohex-1-ene

: 201230-82-2
carbon monoxide

: 766-00-7
2-cyclopentyl-ethanol

Conditions

Conditions	Yield
Stage #1: 6-iodohex-1-ene; carbon monoxide With diethoxymethylane; [CuCl(IPrMe)]; lithium methanolate In tetrahydrofuran at 60℃; under 2280.15 Torr; for 16h; Sealed tube; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran; diethyl ether at 20℃; for 2h;	68 %Spectr.

: 766-00-7
2-cyclopentyl-ethanol

: 5623-81-4
2-cyclopentylacetaldehyde

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane at 20℃; for 3h;	100%
With Dess-Martin periodane In dichloromethane at 0 - 20℃; for 4h;	50.9%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -61 - 20℃; Dehydration;	27.4%

: 766-00-7
2-cyclopentyl-ethanol

: 124-63-0
methanesulfonyl chloride

: 73779-38-1
2-cyclopentylethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 19h;	100%
With triethylamine In dichloromethane at 0℃; for 2h;	100%
With pyridine for 18h;
With triethylamine In dichloromethane at 5℃; for 1h;
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;

: 766-00-7
2-cyclopentyl-ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 786-33-4
2-cyclopentylethyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 16h;	98.2%
With dmap; triethylamine In dichloromethane at 20℃; for 16h;
In chloroform at 0 - 20℃; for 3.5h; Inert atmosphere;
With dmap; triethylamine
With pyridine at 0 - 20℃; for 36h;

: 766-00-7
2-cyclopentyl-ethanol

: 931410-28-5
sulfamic acid 2-cyclopentylethyl ester

Conditions

Conditions	Yield
Stage #1: With formic acid; isocyanate de chlorosulfonyle In dichloromethane at 0 - 20℃; for 1.33h; Stage #2: 2-cyclopentyl-ethanol With pyridine In dichloromethane at 7℃; for 2h; Stage #3: With sodium hydrogencarbonate In dichloromethane; water; ethyl acetate	95%

: 1189-71-5
isocyanate de chlorosulfonyle

: 766-00-7
2-cyclopentyl-ethanol

: 931410-28-5
sulfamic acid 2-cyclopentylethyl ester

Conditions

Conditions	Yield
Stage #1: isocyanate de chlorosulfonyle With formic acid at 0 - 20℃; for 1.33h; Inert atmosphere; Stage #2: 2-cyclopentyl-ethanol With pyridine In dichloromethane at 0 - 7℃; for 2h; Inert atmosphere;	95%

: 766-00-7
2-cyclopentyl-ethanol

: 5549-40-6, 18320-80-4, 32923-08-3
perhydrocyclopentafuran

Conditions

Conditions	Yield
With lead(IV) acetate; calcium carbonate In benzene for 48h; Heating;	93%

: 1160582-86-4
C16H19IN6O

: 766-00-7
2-cyclopentyl-ethanol

: 1160583-04-9
C23H32N6O2

Conditions

Conditions	Yield
With copper(l) iodide; Phenanthroline; caesium carbonate In 1,4-dioxane at 100℃; for 16h;	92%

: 1160582-80-8
C16H19BrN6O

: 766-00-7
2-cyclopentyl-ethanol

: 1160583-04-9
C23H32N6O2

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran for 16h; Reflux;	90%

: 1160582-90-0
C17H25BrN4O3

: 766-00-7
2-cyclopentyl-ethanol

: 1160582-92-2
C24H38N4O4

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran for 16h; Reflux;	88%

: 766-00-7
2-cyclopentyl-ethanol

: 195442-17-2
2-cyclopentyl-1-iodoethane

Conditions

Conditions	Yield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 2h;	84%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 2h; Inert atmosphere;	84%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 3h; Inert atmosphere;	75%

: 611-35-8
4-chloroquinoline

: 766-00-7
2-cyclopentyl-ethanol

: C16H18ClNO

Conditions

Conditions	Yield
With 4,5,6,7-tetrafluoro-1-hydroxybenzo[d][1,2]iodaoxol-3(1H)-one; Ru(bpy)3Cl2 at 30℃; for 24h; Minisci Aromatic Substitution; Inert atmosphere; Irradiation; regioselective reaction;	83%

: 766-00-7
2-cyclopentyl-ethanol

: 7411-18-9
3-methylsulfanyl-4H-[1,2,4]triazole

: 1626400-18-7
C10H16N4S

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 80℃; Mitsunobu Displacement; regioselective reaction;	77%

: 2380-86-1
6-hydroxy-1H-indole

: 766-00-7
2-cyclopentyl-ethanol

: 142535-22-6
6-(2-cyclopentylethoxy)indole

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran	75%

: 766-00-7
2-cyclopentyl-ethanol

: 18928-94-4
(2-bromo-ethyl)-cyclopentane

Conditions

Conditions	Yield
With sulfuric acid; hydrogen bromide for 6h; Heating;	72%
With sulfuric acid; hydrogen bromide
With phosphorus tribromide at -5 - 0℃; zuletzt bei 100grad;

: 1160582-78-4
C8H8Br2N2O

: 766-00-7
2-cyclopentyl-ethanol

: 1160582-98-8
C15H21BrN2O2

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In 1,4-dioxane at 50℃; for 2h;	70%

: 1003879-95-5
(2S)-2-(4-tert-butylphenoxy)-3-(4-{2-[(1α,5α,6α)-3-(2,4,5-trifluorobenzyl)-3-azabicyclo[3.1.0]hex-6-ylamino]ethoxy}phenyl)propionic acid

: 766-00-7
2-cyclopentyl-ethanol

: (2S)-2-(4-tert-butylphenoxy)-3-(4-{2-[(1α,5α,6α)-3-(2,4,5-trifluorobenzyl)-3-azabicyclo[3.1.0]hex-6-ylamino]ethoxy}phenyl)propionic acid 2-cyclopentylethyl ester

Conditions

Conditions	Yield
Stage #1: (2S)-2-(4-tert-butylphenoxy)-3-(4-{2-[(1α,5α,6α)-3-(2,4,5-trifluorobenzyl)-3-azabicyclo[3.1.0]hex-6-ylamino]ethoxy}phenyl)propionic acid; 2-cyclopentyl-ethanol With sulfuric acid In benzene for 6h; Heating / reflux; Stage #2: With ammonia In chloroform pH=8;	69%

: 193966-06-2
6-Benzyloxy-3-[3-methyl-4-[(1-pyrrolidinyl)methyl]-benzyl]-2-(4-hydroxyphenyl)benzo[b]thiophene

: 766-00-7
2-cyclopentyl-ethanol

: 215388-37-7
6-Benzyloxy-3-[3-methyl-4-[(1-pyrrolidinyl)methyl]-benzyl]-2-[4-(2-cyclopentylethoxy)phenyl]benzo[b]thiophene

Conditions

Conditions	Yield
With triethanolamine In tetrahydrofuran; SiO2	58%

: 766-00-7
2-cyclopentyl-ethanol

: triethylammonium N-tert-butylsulfamate

: 2-cyclopentylethyl tert-butylsulfamate

Conditions

Conditions	Yield
Stage #1: triethylammonium N-tert-butylsulfamate With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -78℃; for 0.25h; Inert atmosphere; Stage #3: 2-cyclopentyl-ethanol In dichloromethane at -78 - 22℃; for 18h; Inert atmosphere;	56%

: 916482-23-0
ethyl 2-((4,6-dihydroxypyrimidin-2-yl)thio)hexanoate

: 766-00-7
2-cyclopentyl-ethanol

: 1231734-03-4
ethyl 2-(4,6-bis(2-cyclopentylethoxy)pyrimidin-2-ylthio)hexanoate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction; Inert atmosphere; Cooling with ice;	55.3%

: 89-51-0
Homophthalic acid

: 766-00-7
2-cyclopentyl-ethanol

: 1034706-07-4
2-[2-(2-cyclopentylethoxy)-2-oxoethyl]benzoic acid

Conditions

Conditions	Yield
With sulfuric acid In benzene for 6h; Heating;	47%

: 766-00-7
2-cyclopentyl-ethanol

: 3-(2-fluoro-5-(methylsulfonyl)phenyl)-7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridine

: 3-[2-(2-cyclopentylethoxy)-5-(methylsulfonyl)phenyl]-1-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Conditions

Conditions	Yield
Stage #1: 2-cyclopentyl-ethanol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.0833333h; Stage #2: 3-(2-fluoro-5-(methylsulfonyl)phenyl)-7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridine In tetrahydrofuran; mineral oil at 60℃; for 12h; Stage #3: With hydrogenchloride In 1,4-dioxane at 70℃; for 12h;	34.5%

: 3112-88-7
Benzyl phenyl sulfone

: 766-00-7
2-cyclopentyl-ethanol

: C27H28O2S

Conditions

Conditions	Yield
With ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); potassium hexamethylsilazane In toluene at 120℃; for 12h; Schlenk technique; Inert atmosphere; Glovebox;	31%

: 766-00-7
2-cyclopentyl-ethanol

: 1257243-77-8
N-{3-[5-(3-hydroxyphenyl)[1,3]dioxan-2-yl]propyl}acetamide

: 1257243-97-2
N-(3-{5-[3-(2-cyclopentylethoxy)phenyl][1,3]dioxan-2-yl}propyl)acetamide

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 2h; Mitsunobu reaction;	14%

: 766-00-7
2-cyclopentyl-ethanol

: 10310-21-1
2-Amino-6-chloropurin

: 2-amino-6-[(cyclopentylethyl)oxy]purine

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane for 4h; Reflux;	7%

: 766-00-7
2-cyclopentyl-ethanol

: 4-nitro-benzoic acid-(2-cyclopentyl-ethyl ester)

2-Cyclopentylethanol Specification

The Cyclopentaneethanol, with CAS registry number 766-00-7, has the systematic name of 2-cyclopentylethanol. Besides this, it is also called 2-Cyclopentylethan-1-ol. And the chemical formula of this chemical is C₇H₁₄O. What's more, its EINECS is 212-156-9. When use this chemical, do not breathe vapour and avoid contact with skin and eyes.

Physical properties of Cyclopentaneethanol: (1)ACD/LogP: 1.84; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.84; (4)ACD/LogD (pH 7.4): 1.84; (5)ACD/BCF (pH 5.5): 14.72; (6)ACD/BCF (pH 7.4): 14.72; (7)ACD/KOC (pH 5.5): 238.51; (8)ACD/KOC (pH 7.4): 238.51; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 9.23 Å²; (13)Index of Refraction: 1.46; (14)Molar Refractivity: 33.92 cm³; (15)Molar Volume: 123.7 cm³; (16)Polarizability: 13.44×10^-24cm³; (17)Surface Tension: 34.9 dyne/cm; (18)Density: 0.922 g/cm³; (19)Flash Point: 70.4 °C; (20)Enthalpy of Vaporization: 47.81 kJ/mol; (21)Boiling Point: 174.4 °C at 760 mmHg; (22)Vapour Pressure: 0.376 mmHg at 25°C.

Preparation: this chemical can be prepared by cyclopentylacetic acid. This reaction will need reagent LiAlH4 and solvent tetrahydrofuran.

Cyclopentaneethanol can be prepared by cyclopentylacetic acid.

Uses of Cyclopentaneethanol: it can be used to produce (2-bromo-ethyl)-cyclopentane. This reaction will need reagent concentrated aqueous HBr.

Uses of Cyclopentaneethanol: it can be used to produce (2-bromo-ethyl)-cyclopentane.

You can still convert the following datas into molecular structure:
(1)SMILES: OCCC1CCCC1
(2)InChI: InChI=1/C7H14O/c8-6-5-7-3-1-2-4-7/h7-8H,1-6H2
(3)InChIKey: JEXQWCBPEWHFKC-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C7H14O/c8-6-5-7-3-1-2-4-7/h7-8H,1-6H2
(5)Std. InChIKey: JEXQWCBPEWHFKC-UHFFFAOYSA-N

Product Name

2-CYCLOPENTYLETHANOL

Synthetic route

2-Cyclopentylethanol Specification

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