2-Methoxy-5-(methylsulfonyl)benzoic acid supplier

Name
2-Methoxy-5-(methylsulfonyl)benzoic acid
EINECS 256-573-4
CAS No. 50390-76-6
Article Data8
CAS DataBase
Density 1.372g/cm3
Solubility
Melting Point 190 °C
Formula C9H10 O5 S
Boiling Point 467.9oC at 760 mmHg
Molecular Weight 230.241
Flash Point 236.8oC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Methoxy-5-(methylsulfonyl)benzoicacid; 5-Methylsulfonyl-2-methoxybenzoic acid; 6-Methoxy-3-methylsulfonylbenzoicacid
PSA 89.05000
LogP 1.87770

Synthetic route

: 50390-78-8
1-methoxy-2-methyl-4-(methylthio)benzene

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
With potassium permanganate; potassium carbonate

: 61694-97-1
2-methoxy-5-(methylthio)benzoic acid

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
With potassium permanganate; potassium carbonate

: 51904-91-7
5-chlorosulfonyl-2-anisic acid

: 79-11-8
chloroacetic acid

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; sodium hydrogencarbonate; sodium sulfite 1) H2O, 75 deg C, 1 h, 2) 105 deg C, 47 h; Yield given. Multistep reaction;

: 50390-78-8
1-methoxy-2-methyl-4-(methylthio)benzene

KMnO4: KMnO4

aqueous K2CO3: aqueous K2CO3

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

...Expand

: 698-32-8
4-methoxy-3-methylbenzenethiol

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: potassium carbonate; aqueous potassium permanganate solution View Scheme

: 51904-91-7
5-chlorosulfonyl-2-anisic acid

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tin; aqueous hydrochloric acid 2: aq. NaOH solution 3: potassium carbonate; aqueous potassium permanganate solution View Scheme

: 80530-56-9
5-mercapto-2-methoxybenzoic acid

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH solution 2: potassium carbonate; aqueous potassium permanganate solution View Scheme

: 84910-98-5
4-methoxy-3-methylbenzene-1-sulfonyl chloride

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tin; aqueous HCl / zuletzt auf dem Dampfbad 2: aqueous NaOH 3: potassium carbonate; aqueous potassium permanganate solution View Scheme

aqueous potassium hydroxide: aqueous potassium hydroxide

: methyl 2-(methyloxy)-5-(methylsulfonyl)benzoate

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride
With hydrogenchloride
With hydrogenchloride

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 99281-88-6
(E)-methyl 4-aminobut-2-enoate trifluoroacetic acid salt

: (E)-methyl 4-(2-methoxy-5-(methylsulfonyl)benzamido)but-2-enoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Sealed tube;	74%

: 7β-amino-9-benzyl-9-aza-3-thiabicyclo[3.3.1]nonane

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 541-41-3
chloroformic acid ethyl ester

: 2-methoxy-5-methylsulphonyl-N-[9-benzyl-9-aza-3-thiabicyclo(3,3,1)nonan-7β-yl]benzamide

Conditions

Conditions	Yield
With triethylamine In N-methyl-acetamide	70%

...Expand

: 3-fluoro-4-piperazin-1-yl-benzonitrile hydrochloride

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 1229627-87-5
3-fluoro-4-[4-(5-methanesulfonyl-2-methoxy-benzoyl)-piperazin-1-yl]-benzonitrile

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	69%

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 541-41-3
chloroformic acid ethyl ester

: 94134-08-4
C12H14O7S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -40 - -10℃; for 0.5h;

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 61694-34-6
N-[2-(N'-benzyl-N'-methylamino)ethyl]-6-methoxy-3-methylsulfonylbenzamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / CH2Cl2 / 0.5 h / -40 - -10 °C 2: CH2Cl2 / 2 h / Ambient temperature View Scheme

: 896467-81-5
3-(pyridin-2-yl)-1H-pyrazol-4-amine

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 5-methanesulfonyl-2-methoxy-N-(3-pyridin-2-yl-1H-pyrazol-4-yl)benzamide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 2h;

: 192940-77-5
3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

: 1133464-33-1, 178371-24-9, 178371-26-1
(+)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine (R,R)-di-p-anisoyltartaric acid salt

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 1-(2-methoxy-5-methylsulfonylbenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine

...Expand

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 541-41-3
chloroformic acid ethyl ester

: 70180-92-6
4-Amino-1,2-diethyl-pyrazolidine

: N-(1.2-Diethyl-4-pyrazolidinyl)-2-methoxy-5-(methylsulfonyl)-benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane	1.03 g (29%)

...Expand

: 1-norbornyl-2-aminomethyl pyrrolidine

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 543-27-1
isobutyl chloroformate

: N-(1-norbornyl-2-pyrrolidylmethyl)-2-methoxy-5-methylsulphonyl benzamide

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In water; ethyl acetate; isopropyl alcohol; acetone

...Expand

: 123-91-1
1,4-dioxane

4-methyl 2-chloro 1-3-2-dioxophosphorinane: 4-methyl 2-chloro 1-3-2-dioxophosphorinane

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 100-36-7
N,N-diethylethylenediamine

: 51012-32-9
tiapride

Conditions

Conditions	Yield
In water

...Expand

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 14165-18-5
N-benzyl-N-methylethylenediamine

: 61694-34-6
N-[2-(N'-benzyl-N'-methylamino)ethyl]-6-methoxy-3-methylsulfonylbenzamide

(-)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine(R,R)-di-p-anisoyltartaric acid salt: (-)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine(R,R)-di-p-anisoyltartaric acid salt

: 192940-77-5
3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 1-(2-methoxy-5-methylsulfonylbenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine

...Expand

: 1133464-33-1, 178371-24-9, 178371-26-1
(+)-3-phenyl-3-(2-hydroxy-ethyl)-pyrrolidine (R,R)-di-p-anisoyltartaric acid salt

: 3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 1-(2-methoxy-5-methylsulfonylbenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

...Expand

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 1297600-41-9
C2HF3O2*C15H24N2O4S3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide 2: tris-(2-carboxyethyl)-phosphine hydrochloride; triethylamine / water; N,N-dimethyl-formamide View Scheme

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 56-17-7
cystamine dihydrochioride

: C22H28N2O8S4

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water; N,N-dimethyl-formamide

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 2-chloro-N-(2-methoxy-5-(methylsulfonyl)benzyl)-5-methylpyrimidin-4-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: borane-THF / tetrahydrofuran / 16 h / 0 °C 2: phosphorus tribromide / dichloromethane / 18 h / 20 °C 3: potassium carbonate / acetonitrile / 100 °C View Scheme

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 294860-49-4
2-(bromomethyl)-1-methoxy-4-(methylsulfonyl)benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran / 16 h / 0 °C 2: phosphorus tribromide / dichloromethane / 18 h / 20 °C View Scheme

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: (2-methoxy-5-(methylsulfonyl)phenyl)methanol

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran at 0℃; for 16h;	4.9 g

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 2-(2-methoxy-5-(methylsulfonyl)phenyl)oxazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / 3 h / Reflux; Inert atmosphere 2: triethylamine / dichloromethane / 20 °C 3: hydrogenchloride / acetone; water / 5 h / Reflux 4: Burgess Reagent / tetrahydrofuran / 0.17 h / 70 °C / Microwave irradiation View Scheme

: 50390-76-6
2-methoxy-5-methylsulphonylbenzoic acid

: 4-(methylsulfonyl)-2-(oxazol-2-yl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: thionyl chloride / 3 h / Reflux; Inert atmosphere 2: triethylamine / dichloromethane / 20 °C 3: hydrogenchloride / acetone; water / 5 h / Reflux 4: Burgess Reagent / tetrahydrofuran / 0.17 h / 70 °C / Microwave irradiation 5: boron tribromide / dichloromethane / 0 - 20 °C View Scheme

2-Methoxy-5-(methylsulfonyl)benzoic acid Chemical Properties

The Molecular formula of 2-methoxyl-5-methysulfonyl benzoic acid(50390-76-6):C₉H₁₀O₅S
The Molecular Weight of 2-methoxyl-5-methysulfonyl benzoic acid(50390-76-6):230.24
The Molecular Structure of 2-Methyl-1,3-cyclopentanedione(765-69-5) is:
Melting point:189-197^°C
Appearance:white to off-white powder
Synonyms:5-METHANESULFONYL-2-METHOXY-BENZOIC ACID;2-Methoxy-5-(methylsulphonyl)benzoic acid;2-METHOXY-5-METHYL SULFONYLBENZOIC ACID;4-methox+c578y-3-carboxymethylbenzenesulponate;5-mesyl-o-anisic acid;2-methoxyl-5-methysulfonyl benzoic acid;2-Methoxy-5-methy1 sulfonylbenzoic acid;2-METHOXY-6-(METHYLSULPHONYL)BENZOIC ACID

Product Name

2-Methoxy-5-(methylsulfonyl)benzoic acid

Synthetic route

2-Methoxy-5-(methylsulfonyl)benzoic acid Chemical Properties

2-Methoxy-5-(methylsulfonyl)benzoic acid Uses

2-Methoxy-5-(methylsulfonyl)benzoic acid Safety Profile

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