Product Name

  • Name

    3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

  • EINECS 145-896-5
  • CAS No. 31255-57-9
  • Article Data22
  • CAS DataBase
  • Density 1.23 g/cm3
  • Solubility
  • Melting Point 71-72 °C
  • Formula C14H11ClN2
  • Boiling Point 375.7 °C at 760 mmHg
  • Molecular Weight 242.708
  • Flash Point 181 °C
  • Transport Information
  • Appearance Light brown solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 31255-57-9 (3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile)
  • Hazard Symbols
  • Synonyms Picolinonitrile,3-(m-chlorophenethyl)- (8CI);
  • PSA 36.68000
  • LogP 3.39188

Synthetic route

3-[2-(3-chlorophenyl)vinyl]-2-pyridinecarbonitrile

3-[2-(3-chlorophenyl)vinyl]-2-pyridinecarbonitrile

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; under 760.051 Torr; for 24h; Reagent/catalyst; Solvent;96%
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
107285-30-3

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With trichlorophosphate In toluene for 4h; Reflux;74%
With trichlorophosphate at 80℃; for 2.5h;68.1%
With trichlorophosphate for 5h; Heating / reflux;63%
3-(3-chlorophenethyl)-pyridine N-oxide
31255-47-7

3-(3-chlorophenethyl)-pyridine N-oxide

sodium cyanide
143-33-9

sodium cyanide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-(3-chlorophenethyl)-pyridine N-oxide With N,N-Dimethylcarbamoyl chloride In acetonitrile at 35 - 40℃; for 1 - 3h;
Stage #2: sodium cyanide In water; acetonitrile at -5 - 0℃; for 3 - 4h;
Stage #3: With sodium hydroxide In water; acetonitrile for 2 - 3h;		73.5%
2-cyano-3-methylpyridine
20970-75-6

2-cyano-3-methylpyridine

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C
2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min
3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8
View Scheme
Multi-step reaction with 3 steps
1: N-chloro-succinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux
2: magnesium; iodine / tetrahydrofuran / 1 h / 35 - 40 °C / Inert atmosphere
3: palladium 10% on activated carbon / tetrahydrofuran / 12 h / 25 - 35 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 0.5 h / 70 - 75 °C
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere
2.2: 1 h / -10 °C / Inert atmosphere
3.1: trichlorophosphate / 4 h / 110 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid; water; acetic acid / 60 °C
1.2: 2.5 h / 70 - 80 °C
2.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 2 h / Inert atmosphere
3.1: trichlorophosphate / 2.5 h / 80 °C
View Scheme
N-tert-butyl-3-methylpyridine-2-carboxamide
32998-95-1

N-tert-butyl-3-methylpyridine-2-carboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min
2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8
View Scheme
Multi-step reaction with 2 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere
1.2: 1 h / -10 °C / Inert atmosphere
2.1: trichlorophosphate / 4 h / 110 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / Inert atmosphere
2.1: trichlorophosphate / 2.5 h / 80 °C
View Scheme
1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
View Scheme
3-[2-(3-Chlorophenyl)Ethyl]-1,1-Dimethylethyl)-2-Pyridine Carboxamide

3-[2-(3-Chlorophenyl)Ethyl]-1,1-Dimethylethyl)-2-Pyridine Carboxamide

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
107285-30-3

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol; trichlorophosphate118 g (HPLC purity 95.7%)
C7H5ClMgN2

C7H5ClMgN2

1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With palladium 10% on activated carbon In tetrahydrofuran at 25 - 35℃; for 12h;8.65 g
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With sulfuric acid; water at 120 - 122℃; for 10 - 12h;
Stage #2: With sodium hydroxide In water at 90℃;		94.4%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h;
Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux;		94%
With PPA at 200℃;45%
With PPA Heating;
4-chloro-1-methylpiperidine
5570-77-4

4-chloro-1-methylpiperidine

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran; ethylene dibromide at 75℃; for 1h; Inert atmosphere;
Stage #2: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile In tetrahydrofuran; ethylene dibromide at 40 - 50℃; for 1h; Inert atmosphere;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; ethylene dibromide at 20℃; for 1h; pH=< 2; Inert atmosphere;		83.3%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
In tetrahydrofuran at 30 - 60℃; for 1.5h;48.6%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
130642-50-1

{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone

Conditions
ConditionsYield
With hydrogenchloride 1.) THF, reflux; Multistep reaction;
In pyridine
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

Conditions
ConditionsYield
In tetrahydrofuran at 40 - 50℃; for 0.5h;
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
244122-88-1

10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
170727-68-1

8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol
170727-67-0

{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-[4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

1-[4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

loratadine
79794-75-5

loratadine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 20 g / BF3 / 4 h / 120 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 91 percent / hydrofluoric acid, BF3 / -35 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere
1.2: 1 h / 40 - 50 °C / Inert atmosphere
1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere
2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C
3.1: triethylamine / toluene / 2 h / 80 - 85 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine
119770-61-5

8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 0.85 g / polyphosphoric acid (PPA) / 8 h / 190 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene
119770-62-6

8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 0.3 g / BF3 / 4 h / 120 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

N-methyldesloratadine
38092-89-6

N-methyldesloratadine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 20 g / BF3 / 4 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 91 percent / hydrofluoric acid, BF3 / -35 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C
View Scheme
Multi-step reaction with 2 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere
1.2: 1 h / 40 - 50 °C / Inert atmosphere
1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere
2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-methyl-amine

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-methyl-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: PPA / Heating
2: tetrahydrofuran / -40 °C
3: H2SO4
4: Et3N / toluene / Heating
5: aq. KOH / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-dimethyl-amine

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-dimethyl-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PPA / Heating
2: tetrahydrofuran / -40 °C
3: H2SO4
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

descarboethoxyloratadine
100643-71-8

descarboethoxyloratadine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
4: aq. KOH / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone
130642-68-1

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PPA / Heating
2: diethyl ether; tetrahydrofuran
3: H2SO4 / H2O
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde
130642-70-5

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: PPA / Heating
2: diethyl ether; tetrahydrofuran
3: H2SO4 / H2O
4: tetrahydrofuran
5: H2SO4 / tetrahydrofuran; H2O
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

N-formyldesloratadine
117810-61-4

N-formyldesloratadine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
4: aq. KOH / Heating
5: C5H5N / CH2Cl2
View Scheme

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Chemical Properties

Molecular structure of 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile (CAS NO.31255-57-9) is:

Product Name: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile
CAS Registry Number: 31255-57-9
Systematic Name: 3-[2-(3-Chlorophenyl)ethyl]pyridine-2-carbonitrile
Empirical Formula: C14H11ClN2
Molecular Weight: 242.7035
Index of Refraction: 1.605
Molar Refractivity: 67.91 cm3
Molar Volume: 196.9 cm3
Surface Tension: 55.6 dyne/cm
Density: 1.23 g/cm3
Flash Point: 181 °C
Enthalpy of Vaporization: 62.32 kJ/mol
Boiling Point: 375.7 °C at 760 mmHg
Vapour Pressure: 7.65E-06 mmHg at 25°C
Product Categories: Pyridine

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Specification

 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile , its cas register number is 31255-57-9. It also can be called 2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]- ; 3-[2-(3-Chlorophenyl)-ethyl]-pyridine-2-carbonitrile ; 3-[2-(3-Chlorophenyl)-ethyl]-pyridine carbonitrile ; 3-[2-(3-Chlorophenyl)ethyl]-2-cyanopyridine .

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