Factory direct sales, accept customization. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical Ingredient), pharmaceutical intermediate, pesticide intermediate, additive and other chemical products, so it
Cas:79794-75-5
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiryItems Standard Result Appearance White or off-white crystalline powder Complies Solubility F
Cas:79794-75-5
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai P
Unique advantages for Loratadine Cas 79794-75-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg
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inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Loratadine English name: Loratadine Chemical name: Ethyl4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate Category involved: bulk ph
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:79794-75-5
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:79794-75-5
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TIANFUCHEM--79794-75-5--Loratadine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationsh
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryLoratadine Assay: 99% min CAS:79794-75-5 Molecular formula:C22H23ClN2O2 Molecular weight: 382.89 Purity: 99% Appearance: White crystalline powder Loratidine; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylid
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical inte
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inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Loratadine Structure: Formula: C22H23ClN2O2 Molecular Weight : 382.88 Synonyms: LORATADINE;LORATADINE-D5;LORATIDINE;CLARATYNE;CLARITIN;ethyl4-(8-chloro-5,6
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inquiryAppearance: White Crystalline Solid Storage:2 Years Package: according to customers' requirements Application:anti inflammatory, analgesic, antipyretic, analgesic, antipyretic Transportation:International express delivery Port: China main port
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryLoratadine CAS:79794-75-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In toluene at 60 - 75℃; for 1 - 2h; | 90% |
Stage #1: chloroformic acid ethyl ester; N-methyldesloratadine With N-ethyl-N,N-diisopropylamine In toluene at 60 - 75℃; for 1 - 2h; Stage #2: With hydrogenchloride In water; toluene | 73% |
With triethylamine In toluene for 3h; Reflux; | 72% |
diethyl N-ethoxycarbonylpiperidine-4-phosphonate
loratadine
Conditions | Yield |
---|---|
With hydrogenchloride In N,N-dimethyl acetamide; isopropyl alcohol at 20 - 140℃; under 760.051 Torr; for 2h; | 82% |
2-cyano-3-methylpyridine
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 20 g / BF3 / 4 h / 120 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 91 percent / hydrofluoric acid, BF3 / -35 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sulfuric acid / 0.5 h / 70 - 75 °C 2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 2.2: 1 h / -10 °C / Inert atmosphere 3.1: trichlorophosphate / 4 h / 110 °C 4.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 4.2: 1 h / 40 - 50 °C / Inert atmosphere 4.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 5.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 6.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
N-tert-butyl-3-methylpyridine-2-carboxamide
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 20 g / BF3 / 4 h / 120 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 91 percent / hydrofluoric acid, BF3 / -35 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux 4: CF3SO3H / Heating 5: Et3N / toluene / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 1.2: 1 h / -10 °C / Inert atmosphere 2.1: trichlorophosphate / 4 h / 110 °C 3.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 3.2: 1 h / 40 - 50 °C / Inert atmosphere 3.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 4.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 5.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 20 g / BF3 / 4 h / 120 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 91 percent / hydrofluoric acid, BF3 / -35 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: POCl3 / Heating 2: 2.) aq. HCl / 1.) THF, reflux 3: CF3SO3H / Heating 4: Et3N / toluene / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: trichlorophosphate / 4 h / 110 °C 2.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 2.2: 1 h / 40 - 50 °C / Inert atmosphere 2.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 3.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 4.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
(1-methyl-4-piperidyl)magnesium chloride
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrahydrofuran / Reflux 2: sulfuric acid / 4.5 h / 20 °C 3: triethylamine / toluene / 3 h / Reflux View Scheme |
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 20 g / BF3 / 4 h / 120 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 91 percent / hydrofluoric acid, BF3 / -35 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme |
1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 20 g / BF3 / 4 h / 120 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / hydrofluoric acid, BF3 / -35 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme |
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CF3SO3H / Heating 2: Et3N / toluene / Heating View Scheme |
1-Chloro-3-chloromethyl-benzene
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux 4: CF3SO3H / Heating 5: Et3N / toluene / Heating View Scheme |
chloroformic acid ethyl ester
N-ethyl-N,N-diisopropylamine
N-methyldesloratadine
loratadine
Conditions | Yield |
---|---|
In toluene; acetonitrile | 42.4 g (HPLC purity 97.4%) |
In toluene; acetonitrile | 42.4 g (HPLC purity 97.4%) |
chloroformic acid ethyl ester
pyrographite
N-methyldesloratadine
loratadine
Conditions | Yield |
---|---|
In toluene; acetonitrile |
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / Reflux 2: sulfuric acid / 4.5 h / 20 °C 3: triethylamine / toluene / 3 h / Reflux View Scheme |
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux View Scheme |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 2h; |
4-chloro-1-methylpiperidine
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
loratadine
descarboethoxyloratadine
Conditions | Yield |
---|---|
In ethanol; water Reflux; Inert atmosphere; Alkaline conditions; | 98.5% |
With C22H40N4(2+)*2BF4(1-) In toluene at 80℃; for 0.666667h; | 98.5% |
With sodium hydroxide In ethanol; water at 100 - 105℃; for 5h; Concentration; Solvent; Time; Temperature; Autoclave; Inert atmosphere; Large scale; | 96% |
4-(aminomethyl)pyridine
loratadine
Conditions | Yield |
---|---|
With C47H70BrO4PPdSi; sodium t-butanolate In tetrahydrofuran at 20℃; for 1h; Schlenk technique; Inert atmosphere; Sealed tube; | 98% |
loratadine
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Schlenk technique; Inert atmosphere; | 91% |
bromo(2-ethoxy-2-oxoethyl)zinc
loratadine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); N,N,N,N,-tetramethylethylenediamine; C38H62P2 In tetrahydrofuran at 20℃; for 16h; Negishi Coupling; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; loratadine at -78℃; Inert atmosphere; Stage #2: triphenylphosphine Inert atmosphere; Cooling; Stage #3: Alkaline conditions; Inert atmosphere; regioselective reaction; | 88% |
at -78 - 20℃; Alkaline conditions; | 88% |
Stage #1: trifluoromethylsulfonic anhydride; loratadine In dichloromethane at -78℃; Inert atmosphere; Stage #2: triphenylphosphine In dichloromethane at -78 - 20℃; Inert atmosphere; regioselective reaction; |
loratadine
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 14h; Schlenk technique; Inert atmosphere; | 87% |
Conditions | Yield |
---|---|
With tris-(trimethylsilyl)silane; [Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]2(4,4′-di-t-Bu-2,2′-bipyridine)]PF6; oxygen; trifluoroacetic acid In acetone at 20℃; for 24h; Minisci Aromatic Substitution; Irradiation; regioselective reaction; | 83% |
loratadine
bis(pinacol)diborane
Conditions | Yield |
---|---|
With potassium acetate; palladium diacetate; XPhos In 1,4-dioxane at 80℃; for 10h; Schlenk technique; | 83% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos In 1,4-dioxane at 110℃; for 12h; Inert atmosphere; Sealed tube; | 705.4 mg |
Conditions | Yield |
---|---|
With chloro[(di(1-adamantyl)-N-butylphosphine)-2-(2-aminobiphenyl)]palladium(II); caesium carbonate In toluene at 100℃; for 14h; Schlenk technique; Inert atmosphere; | 82% |
trifluoromethylsulfonic anhydride
loratadine
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; 5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine; loratadine In dichloromethane at -50℃; for 1h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; for 0.333333 - 0.5h; Inert atmosphere; | 81% |
Conditions | Yield |
---|---|
Stage #1: 1,3-DIOXOLANE; loratadine With potassium phosphate; (1,2-dimethoxyethane)dichloronickel(II); 4,4'-di-tert-butyl-2,2'-bipyridine for 0.166667h; Glovebox; Stage #2: With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate at 23℃; for 72h; Sealed tube; Irradiation; Stage #3: With hydrogenchloride In water; acetone at 23℃; | A 78% B n/a |
loratadine
2-tri-n-butylstannylpyridine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube; | 78% |
trifluoromethylsulfonic anhydride
loratadine
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; loratadine In dichloromethane at -78℃; for 0.583333h; Inert atmosphere; Stage #2: 4-(diphenylphosphaneyl)-2,6-dimethylpyridine In dichloromethane at -50℃; for 0.5h; Inert atmosphere; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; Inert atmosphere; | 78% |
1,1,1-trifluoro-2-chloroethane
loratadine
Conditions | Yield |
---|---|
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique; | 78% |
loratadine
Conditions | Yield |
---|---|
With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 18h; Inert atmosphere; | 77% |
loratadine
Conditions | Yield |
---|---|
With sulfuric acid; potassium nitrate at -5℃; for 16h; | A 12% B 76% |
carbon dioxide
loratadine
8-cyano-11-(1-ethoxycarbonyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Conditions | Yield |
---|---|
With nickel(II) acetylacetonate; potassium fluoride; phenylsilane; ammonia; zinc; bis(2-diphenylphosphinoethyl)phenylphosphine In 1-methyl-pyrrolidin-2-one at 90 - 140℃; under 760.051 Torr; for 20h; Sealed tube; | 72% |
Conditions | Yield |
---|---|
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; | 70% |
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Inert atmosphere; Sealed tube; | 70% |
loratadine
A
ethyl 4-(5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With tert-Amyl alcohol; tetramethyl ammoniumhydroxide; 2-(2-ethylhexyl)-6,8,11-tris(4-methoxyphenyl)-1H-peryleno[1,12-efg]isoindole-1,3(2H)-dione In methanol at 20℃; for 48h; Birch Reduction; Sealed tube; Irradiation; | A 65% B 26% |
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; [2,2]bipyridinyl; nickel(II) bromide dimethoxyethane at 30℃; for 48h; Inert atmosphere; Irradiation; regioselective reaction; | 63% |
Conditions | Yield |
---|---|
Stage #1: loratadine; bis(pinacol)diborane With 10H-phenothiazine; caesium carbonate In acetonitrile at 45℃; for 72h; Irradiation; Sealed tube; Inert atmosphere; Stage #2: With hydrogenchloride; dihydroxy-methyl-borane In water; acetone Stage #3: potassium hydrogenfluoride Further stages; | 62% |
Conditions | Yield |
---|---|
With tris-(trimethylsilyl)silane; [Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]2(4,4′-di-t-Bu-2,2′-bipyridine)]PF6; oxygen; trifluoroacetic acid In acetone at 20℃; for 24h; Minisci Aromatic Substitution; Irradiation; regioselective reaction; | 61% |
loratadine
S-methyl-S-phenylsulfoximine
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 8h; Inert atmosphere; Sealed tube; Electrochemical reaction; | 60% |
4-chlorotetrahydro-2H-pyran
loratadine
Conditions | Yield |
---|---|
With 2,2'-biimidazole; (1,2-dimethoxyethane)dichloronickel(II); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; N-(adamantan-1-yl)-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-amine In tert-Amyl alcohol; N,N-dimethyl acetamide at 55℃; for 18h; Inert atmosphere; Irradiation; | 58% |
loratadine
trimethyl orthoformate
ethyl 4-(8-methyl-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: loratadine; trimethyl orthoformate With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube; Stage #2: With palladium on activated charcoal; hydrogen In methanol at 20℃; under 1551.49 Torr; for 10h; | 57% |
With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube; | 51% |
loratadine
S-(4-methoxyphenyl)-S-methylsulfoximine
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 8h; Inert atmosphere; Sealed tube; Electrochemical reaction; | 57% |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere; | 56% |
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere; Glovebox; | 56% |
Conditions | Yield |
---|---|
Stage #1: tetrahydroxydiboron; loratadine With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate; XPhos In ethanol at 80℃; Stage #2: 2,3-dimethyl-2,3-butane diol In dichloromethane at 20℃; for 16h; | 52% |
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