Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:100986-85-4
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inquiryWelcome to visit our company and buy our products! Product Name: Levifloxacin Hemihydrate Specification: USP, EP Packing: 25kg/drum Certificate: GMP, WC Certificate MOQ: 25kg Origin: China Can provide sample if custo
Cas:100986-85-4
Min.Order:25 Kilogram
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:100986-85-4
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellowish-white to light yellowish-white crystals or crystalline powder Storage:Cool dry place
Cas:100986-85-4
Min.Order:0 Metric Ton
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Type:Trading Company
inquirySpecifications chemical materials levofloxacin powder Purity:99% Pack:25kg/drum 1kg/bag CAS No: 100986-85-4 Professional API Manufacturer Appearance:powder Storage:dry environment Package:25kg/drum or as your needs Application:Antibiotic
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:100986-85-4
Min.Order:1 Gram
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Type:Manufacturers
inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
ProName: Levofloxacin CasNo: 100986-85-4 Appearance: Slight yellow powder Application: Pharmaceutical intermediate DeliveryTime: in stock PackAge: 25kg/drum Port: Any port in China ProductionCapacity: 1000 Metric Ton/
Name:Levofloxacin hydrochloride CAS NO: 100986-85-4 Grade:Medical scientific research and export Molecular formula:C18H20FN3O4 Molecular weight:361.37 Product Quality 12 years of chemical raw materials Mature operation of the industry S
Cas:100986-85-4
Min.Order:25 Kilogram
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Type:Other
inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
Cas:100986-85-4
Min.Order:1 Metric Ton
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inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:100986-85-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:100986-85-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:100986-85-4
Min.Order:10 Kilogram
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Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:100986-85-4
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inquiryAppearance:white to faint yellow powder Storage:Keep in dark place,Sealed in dry,2-8°C Package:25kg/drum Application:Antibacterial. Transportation:Express/Sea/Air Port:any port in china
Cas:100986-85-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:100986-85-4
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:100986-85-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:100986-85-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:100986-85-4
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryEINECS No.:204-879-3 Place of Origin:Shaanxi, China (Mainland) Type:Anesthetic Agents, Anti-Allergic Agents, Antibiotic and Antimicrobial Agents, Antineoplastic Agents, Central Nervous System Agents Grade Standard:Cosmetic Grade, Feed Grade,
Cas:100986-85-4
Min.Order:1 Kilogram
FOB Price: $50.0 / 70.0
Type:Trading Company
inquiryLevofloxacin hydrochloride CAS:100986-85-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ
Cas:100986-85-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:100986-85-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:100986-85-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryCompany information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:100986-85-4
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryLevofloxacin hydrochloride CAS: 100986-85-4 Specification Items Specification Result Assay 98%-102% 99.67% Appearance Pale yellowish-w
Cas:100986-85-4
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available; 4) Reasonable & Compet
Cas:100986-85-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Conditions | Yield |
---|---|
With potassium hydroxide In water at 55℃; for 24h; Reagent/catalyst; Time; Temperature; Solvent; | 97.1% |
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.366667h; Reflux; | 96% |
at 150℃; Microwave irradiation; | 89% |
N-methylpiperazine dihydrochloride
levofloxacin Q-acid
levofloxacin
Conditions | Yield |
---|---|
Stage #1: N-methylpiperazine dihydrochloride; levofloxacin Q-acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 24.5h; Stage #2: With methanol for 24h; Reflux; Stage #3: In ethanol at 20℃; for 16h; | 92% |
1-methyl-piperazine
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
levofloxacin
Conditions | Yield |
---|---|
With acetic acid In water; N,N-dimethyl-formamide at 70 - 105℃; for 10h; Temperature; Solvent; Reagent/catalyst; | 85.7% |
(S)-ethyl 6,8-difluoro-1-(1-hydroxypropan-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
levofloxacin
Conditions | Yield |
---|---|
Stage #1: (S)-ethyl 6,8-difluoro-1-(1-hydroxypropan-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate With potassium hydroxide; ethanol; water at 20℃; for 2.5h; Heating / reflux; Stage #2: With acetic acid In ethanol at 0 - 20℃; for 2h; pH=7; Product distribution / selectivity; | 78% |
levofloxacin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 83℃; for 36h; | 77.9% |
With hydrogenchloride In ethanol; water at 83℃; for 36h; | 75.3% |
(S)-6,8-difluoro-1-(1-hydroxypropan-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
levofloxacin
Conditions | Yield |
---|---|
Stage #1: (S)-6,8-difluoro-1-(1-hydroxypropan-2-yl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid With potassium hydroxide In ethanol; water for 3h; Heating / reflux; Stage #2: With acetic acid In ethanol; water at 0 - 20℃; Product distribution / selectivity; | 76% |
levofloxacin Q-acid
levofloxacin
Conditions | Yield |
---|---|
In pyridine; diethyl ether | 74.3% |
formaldehyd
S-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(1-piperazinyl)-7-oxo-7H-pyrido-<1,2,3-de><1,4>benzoxazine-6-carboxylic acid
levofloxacin
Conditions | Yield |
---|---|
With formic acid In water at 90℃; for 10h; Temperature; | 74.3% |
1-methyl-piperazine
(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid BF2-chelate
levofloxacin
Conditions | Yield |
---|---|
In dimethyl sulfoxide for 17h; Ambient temperature; | 52% |
Conditions | Yield |
---|---|
With Bis(2-ethylhexyl)phosphoric acid; sodium dodecyl-sulfate; O,O'-dibenzoyl-L-tartaric acid In octanol; water at 20℃; for 4h; pH=7; Reflux; Resolution of racemate; optical yield given as %ee; enantioselective reaction; | A 8.54% B 34.23% |
With (2-hydroxypropyl)-α-cyclodextrin In phosphate buffer pH=2.3; capillary electrophoresis; | |
With Bis(2-ethylhexyl)phosphoric acid; Di-p-toluoyl-L-tartaric acid; O,O'-dibenzoyl-L-tartaric acid In octanol; water at 25℃; for 0.5h; pH=6.86; Resolution of racemate; aq. phosphate buffer; enantioselective reaction; |
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic anhydride / 2 h / 110 °C 2: CH2Cl2 / 0.5 h / Ambient temperature 3: 59 percent / 50percent NaH / dimethylsulfoxide / 3 h / Ambient temperature 4: 70 percent / 10percent aq. KOH / tetrahydrofuran / 2 h / 65 - 70 °C 5: 83 percent / pyridine / 12 h / 120 °C View Scheme |
3-(2,3,4,5-tetrafluorophenyl)-3-oxo-2-(ethoxymethylene)-propanoic acid ethyl ester
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CH2Cl2 / 0.5 h / Ambient temperature 2: 59 percent / 50percent NaH / dimethylsulfoxide / 3 h / Ambient temperature 3: 70 percent / 10percent aq. KOH / tetrahydrofuran / 2 h / 65 - 70 °C 4: 83 percent / pyridine / 12 h / 120 °C View Scheme |
(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 59 percent / 50percent NaH / dimethylsulfoxide / 3 h / Ambient temperature 2: 70 percent / 10percent aq. KOH / tetrahydrofuran / 2 h / 65 - 70 °C 3: 83 percent / pyridine / 12 h / 120 °C View Scheme |
(-)-ethyl 1,4-dihydro-1-<1(S)-(hydroxymethyl)ethyl>-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / 10percent aq. KOH / tetrahydrofuran / 2 h / 65 - 70 °C 2: 83 percent / pyridine / 12 h / 120 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: 1-methyl-piperazine; (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid-boron difluoride chelate complex With triethylamine In dimethyl sulfoxide at 20℃; for 17h; Stage #2: With triethylamine In ethanol for 8h; Heating / reflux; Stage #3: With hydrogenchloride In water |
levofloxacin
Conditions | Yield |
---|---|
Stage #1: (-) potassium N-(1-hydroxy-propy-2(S)-yl)-6-fluoro-7-(N-methylpiperazinyl)-8-nitro-quinol-4-one-3-carboxylate With potassium hydroxide In methanol for 2.5h; Heating / reflux; Stage #2: With acetic acid In methanol |
Conditions | Yield |
---|---|
In dimethyl sulfoxide | 5.63 g (87.6%) |
Conditions | Yield |
---|---|
In dimethyl sulfoxide | 11.8 g (92.4%) |
1-methyl-piperazine
1-methoxy-2-propanol
n-heptane
levofloxacin Q-acid
levofloxacin
Conditions | Yield |
---|---|
2.98 g (77.3%) |
levofloxacin Q-acid
levofloxacin
Conditions | Yield |
---|---|
In 1-methyl-piperazine; n-heptane |
1-methyl-piperazine
trifluoroborane diethyl ether
levofloxacin Q-acid
levofloxacin
Conditions | Yield |
---|---|
With triethylamine In hydrogenchloride; methanol; diethyl ether; dimethyl sulfoxide |
Conditions | Yield |
---|---|
In ethanol; dimethyl sulfoxide |
Conditions | Yield |
---|---|
pH=7; Reagent/catalyst; Resolution of racemate; |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid / water / 4 h / Reflux 2: triethylamine / dimethyl sulfoxide / 8 h / 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; acetic acid / N,N-dimethyl-formamide / 1 h / Reflux; Green chemistry 2: water / 10.5 h / 110 °C / Green chemistry View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; acetic acid / water / 3 h / 20 °C / Reflux 2: water / 15.5 h / 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; acetic acid / N,N-dimethyl-formamide / 1 h / Reflux 2: water / 10.5 h / 110 °C View Scheme |
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: ammonia / toluene / 4 h / 50 °C 2: toluene / 50 - 100 °C / pH < 7 3: hydrogenchloride / toluene; water / pH < 7 4: potassium fluoride / N,N-dimethyl-formamide / Reflux 5: acetic acid; sulfuric acid / water / 4 h / Reflux 6: triethylamine / dimethyl sulfoxide / 8 h / 90 °C View Scheme |
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene / 50 - 100 °C / pH < 7 2: hydrogenchloride / toluene; water / pH < 7 3: potassium fluoride / N,N-dimethyl-formamide / Reflux 4: acetic acid; sulfuric acid / water / 4 h / Reflux 5: triethylamine / dimethyl sulfoxide / 8 h / 90 °C View Scheme |
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / toluene; water / pH < 7 2: potassium fluoride / N,N-dimethyl-formamide / Reflux 3: acetic acid; sulfuric acid / water / 4 h / Reflux 4: triethylamine / dimethyl sulfoxide / 8 h / 90 °C View Scheme |
levofloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium fluoride / N,N-dimethyl-formamide / Reflux 2: acetic acid; sulfuric acid / water / 4 h / Reflux 3: triethylamine / dimethyl sulfoxide / 8 h / 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Green chemistry 2: sulfuric acid; acetic acid / N,N-dimethyl-formamide / 1 h / Reflux; Green chemistry 3: water / 10.5 h / 110 °C / Green chemistry View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 150 °C 2: sulfuric acid; acetic acid / water / 3 h / 20 °C / Reflux 3: water / 15.5 h / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C 2: sulfuric acid; acetic acid / N,N-dimethyl-formamide / 1 h / Reflux 3: water / 10.5 h / 110 °C View Scheme | |
Multi-step reaction with 3 steps 1: 24 h / 120 °C 2: potassium carbonate / 16 h / 140 °C 3: hydrogenchloride / ethanol; water / 36 h / 83 °C View Scheme |
levofloxacin
Conditions | Yield |
---|---|
With GLUTATHIONE In methanol at 23℃; pH=6.5; Kinetics; |
Conditions | Yield |
---|---|
In ethanol at 80℃; for 1h; Temperature; | 94.3% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; acetone at 20℃; for 24h; | 94% |
levofloxacin
Propargylamine
Conditions | Yield |
---|---|
Stage #1: levofloxacin With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: Propargylamine With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; | 90.7% |
levofloxacin
Conditions | Yield |
---|---|
In water; ethyl acetate for 1h; Purification / work up; Heating / reflux; | 90% |
In 2,8-dimethylnonan-5-one; water for 1h; Purification / work up; Heating / reflux; | 89.6% |
In acetic acid methyl ester; water for 1h; Purification / work up; Heating / reflux; | 85.6% |
di(pyridin-2-yl)amine
levofloxacin
Conditions | Yield |
---|---|
Stage #1: copper(II) choride dihydrate; levofloxacin With potassium hydroxide In methanol at 20℃; for 0.5h; Stage #2: di(pyridin-2-yl)amine In methanol at 60℃; for 2h; | 83% |
4-amino-N-(diaminomethylene) benzenesulfonamide
levofloxacin
Conditions | Yield |
---|---|
With acetic acid In methanol for 2h; Microwave irradiation; Reflux; | 82.94% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; acetone at 20℃; for 24h; | 81.4% |
octadecanoic acid chloromethyl ester
levofloxacin
A
C37H72O4
B
(3S)-6-[(octadecanoyloxy)methyl] 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Conditions | Yield |
---|---|
Stage #1: levofloxacin With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.333333h; Stage #2: octadecanoic acid chloromethyl ester In N,N-dimethyl-formamide at 90℃; for 1h; | A n/a B 81% |
Stage #1: levofloxacin With potassium carbonate In acetonitrile for 8h; Reflux; Stage #2: octadecanoic acid chloromethyl ester With tetra-(n-butyl)ammonium iodide In acetonitrile for 168h; Reflux; |
isoniazid
levofloxacin
Conditions | Yield |
---|---|
With trichlorophosphate Reflux; | 81% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 80% |
sulfanilamide
levofloxacin
Conditions | Yield |
---|---|
With acetic acid In methanol for 2h; Microwave irradiation; Reflux; | 80% |
chloromethyl n-dodecanoate
levofloxacin
A
C25H48O4
B
(3S)-6-[(dodecanoyloxy)methyl] 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Conditions | Yield |
---|---|
Stage #1: levofloxacin With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.333333h; Stage #2: chloromethyl n-dodecanoate In N,N-dimethyl-formamide at 90℃; for 1h; | A n/a B 79% |
Stage #1: levofloxacin With potassium carbonate In acetonitrile for 8h; Reflux; Stage #2: chloromethyl n-dodecanoate With tetra-(n-butyl)ammonium iodide In acetonitrile for 168h; Reflux; |
levofloxacin
chloromethyl n-hexadecanoate
A
C33H64O4
B
(3S)-6-[(hexadecanoyloxy)methyl] 9-fluoro-3,7-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2H-[1,4]oxazino-[2,3,4-ij]quinoline-6-carboxylate
Conditions | Yield |
---|---|
Stage #1: levofloxacin With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.333333h; Stage #2: chloromethyl n-hexadecanoate In N,N-dimethyl-formamide at 90℃; for 1h; | A n/a B 79% |
Stage #1: levofloxacin With potassium carbonate In acetonitrile for 8h; Reflux; Stage #2: chloromethyl n-hexadecanoate With tetra-(n-butyl)ammonium iodide In acetonitrile for 168h; Reflux; |
levofloxacin
decanoyloxymethyl chloride
A
(3S)-6-[(decanoyloxy)methyl] 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
B
Methylendidecanoat
Conditions | Yield |
---|---|
Stage #1: levofloxacin With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.333333h; Stage #2: decanoyloxymethyl chloride In N,N-dimethyl-formamide at 90℃; for 1h; | A 79% B n/a |
1,2,3-Benzotriazole
levofloxacin
(S)-6-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7(3H)-one
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane at 20℃; | 79% |
Conditions | Yield |
---|---|
Stage #1: levofloxacin With sodium hydrogencarbonate In water at 25℃; for 0.5h; Stage #2: dimethyltin dichloride In toluene Reflux; | 79% |
Conditions | Yield |
---|---|
Stage #1: copper(II) choride dihydrate; levofloxacin With potassium hydroxide In methanol at 20℃; for 0.5h; Stage #2: bathophenanthroline In methanol at 60℃; for 2h; | 79% |
sulfamerazina
levofloxacin
Conditions | Yield |
---|---|
With acetic acid In methanol for 2h; Microwave irradiation; Reflux; | 78.91% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; acetone at 20℃; for 24h; | 78.6% |
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