DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh Quality Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Basic information Product Name: Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: difluorocarboylic acid este Synonyms: LEVOFLOXACIN ACID ESTER CAS: 106939-34-8 MF: C15H13F2NO4 Appearance:Colorless clear liquid Storage:Preserve in well-closed, light-resistant
Appearance:Off-White to Light Yellow powder Storage:Sealed in dry,2-8°C Package:25kg/drum Application:chemicals Transportation:Express/Sea/Air Port:any port in china
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white or off-white powder Storage:Store in sealed containers
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Synonyms: Ofloxacin Ethyl Ester;ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij]quinoline-6- ethyl car
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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Product name: Levofloxacin Acid Ester CAS No.:106939-34-8 Molecule Formula:C15H13F2NO4 Molecule Weight:309.27 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTIN
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inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Superior quality Appearance:Off-White Pale Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Levofloxacin intermediate Transportation:B
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Application:Pharmaceutical intermediate Port:Any port of China
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inquiry(S)-Alaninol
ethyl acetate
2,3,4,5-tetrafluorobenzoyl chloride
formic acid ethyl ester
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl acetate; formic acid ethyl ester With sodium hydride In toluene Stage #2: (S)-Alaninol; 2,3,4,5-tetrafluorobenzoyl chloride In toluene at 20℃; Reflux; Stage #3: With potassium fluoride In N,N-dimethyl-formamide Reflux; | 99.4% |
(-)-ethyl 9,10-difluoro-2,3-dihydro-3-iodomethyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With tri-n-butyl-tin hydride In ethanol at 50 - 60℃; for 1h; | 73% |
(S)-7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine
diethyl 2-ethoxymethylenemalonate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With ethyl phosphate In diethyl ether | 70% |
With sodium chloride; sulfuric acid; sodium hydrogencarbonate; potassium carbonate In ice-water; diethyl ether; acetic anhydride |
(+/-)-9,10-difluoro-3-hydroxymethyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid ethyl ester
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 75 percent / pyridine / tetrahydrofuran / 1.5 h / Heating 3: 91 percent / satd. NaHCO3 / ethanol / 2 h / 50 - 60 °C 4: 93 percent / triphenylphosphite methiodide / dimethylformamide / 1.5 h / Ambient temperature 5: 73 percent / tri-n-butyltin hydride / ethanol / 1 h / 50 - 60 °C View Scheme |
(-)-ethyl 9,10-difluoro-2,3-dihydro-3-hydroxymethyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / triphenylphosphite methiodide / dimethylformamide / 1.5 h / Ambient temperature 2: 73 percent / tri-n-butyltin hydride / ethanol / 1 h / 50 - 60 °C View Scheme |
(+/-)-ethyl 9,10-difluoro-2,3-dihydro-3-(3,5-dinitrobenzoyloxy)methyl-7-oxo-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 2: 91 percent / satd. NaHCO3 / ethanol / 2 h / 50 - 60 °C 3: 93 percent / triphenylphosphite methiodide / dimethylformamide / 1.5 h / Ambient temperature 4: 73 percent / tri-n-butyltin hydride / ethanol / 1 h / 50 - 60 °C View Scheme |
(S)-3-(3,5-Dinitro-benzoyloxymethyl)-8,9-difluoro-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid ethyl ester
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / satd. NaHCO3 / ethanol / 2 h / 50 - 60 °C 2: 93 percent / triphenylphosphite methiodide / dimethylformamide / 1.5 h / Ambient temperature 3: 73 percent / tri-n-butyltin hydride / ethanol / 1 h / 50 - 60 °C View Scheme |
(+)-ethyl 2-<<<(S)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 120℃; |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ammonia / toluene / 4 h / 50 °C 2: toluene / 50 - 100 °C / pH < 7 3: hydrogenchloride / toluene; water / pH < 7 4: potassium fluoride / N,N-dimethyl-formamide / Reflux View Scheme |
ethyl 3-(dimethylamino)acrylate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene / 8 h / 20 °C 2: ammonia / toluene / 4 h / 50 °C 3: toluene / 50 - 100 °C / pH < 7 4: hydrogenchloride / toluene; water / pH < 7 5: potassium fluoride / N,N-dimethyl-formamide / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 3 h / 40 °C / Green chemistry 2: 1 h / 40 - 90 °C / Green chemistry 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Green chemistry View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 6 h / 60 °C 2: toluene / 2 h / 60 - 90 °C 3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 150 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 50 - 100 °C / pH < 7 2: hydrogenchloride / toluene; water / pH < 7 3: potassium fluoride / N,N-dimethyl-formamide / Reflux View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With potassium fluoride In N,N-dimethyl-formamide Reflux; | |
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 4h; Temperature; Green chemistry; | |
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 8h; Temperature; |
2,3,4,5-tetrafluorobenzoyl chloride
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / toluene / 3 h / 40 °C / Green chemistry 2: 1 h / 40 - 90 °C / Green chemistry 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Green chemistry View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 6 h / 60 °C 2: toluene / 2 h / 60 - 90 °C 3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 150 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 6.42 h / 12 - 75 °C 2: 3 h / 20 - 45 °C 3: potassium fluoride / N,N-dimethyl-formamide / 4 h / 160 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 3 h / 55 °C 2: 1 h / 40 - 90 °C 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine; Phenyl acetate / toluene / 8 h / 5 - 55 °C 2: toluene / 5 °C 3: potassium carbonate; Phenyl acetate; potassium fluoride / N,N-dimethyl-formamide / 2 h / 140 °C View Scheme |
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1 h / 40 - 90 °C / Green chemistry 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Green chemistry View Scheme | |
Multi-step reaction with 2 steps 1: toluene / 2 h / 60 - 90 °C 2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1 h / 40 - 90 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: toluene / 5 °C 2: potassium carbonate; Phenyl acetate; potassium fluoride / N,N-dimethyl-formamide / 2 h / 140 °C View Scheme |
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 0.5 h / 140 °C 1.2: 40 h / 140 °C 1.3: 96 h / 20 °C 2.1: potassium carbonate / N,N-dimethyl acetamide / 0.42 h / 160 °C / Microwave irradiation View Scheme |
(-)-ethyl 2-<<<(R)-1-hydroxyprop-2-yl>amino>methylene>-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 160℃; for 0.416667h; Microwave irradiation; |
boric acid
acetic anhydride
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Stage #1: boric acid; acetic anhydride With zinc(II) chloride at 20℃; for 0.5h; Large scale; Stage #2: ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate at 60℃; for 2h; Large scale; | 94% |
Stage #1: boric acid; acetic anhydride With zinc(II) chloride at 20℃; for 0.5h; Stage #2: ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate at 60℃; for 2h; | 88% |
Stage #1: boric acid; acetic anhydride With zinc(II) chloride at 20℃; for 0.5h; Stage #2: ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate at 60℃; for 6h; | 83% |
acetic anhydride
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With boric acid; zinc(II) chloride | 93% |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With sulfuric acid; potassium nitrate at 0 - 25℃; for 2h; Reagent/catalyst; | 93% |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
levofloxacin Q-acid
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid | 91% |
In hydrogenchloride; acetic acid for 0.666667h; Heating; | 61% |
With hydrogenchloride; acetic acid |
nitromethane
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With sodium hydride In dimethyl sulfoxide at 50℃; for 4h; | 89% |
Stage #1: nitromethane With sodium hydride In dimethyl sulfoxide Stage #2: ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate In dimethyl sulfoxide at 65℃; for 4h; Further stages.; | 89% |
1-methyl-piperazine
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
levofloxacin
Conditions | Yield |
---|---|
With acetic acid In water; N,N-dimethyl-formamide at 70 - 105℃; for 10h; Temperature; Solvent; Reagent/catalyst; | 85.7% |
sodium cyanide
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 80℃; for 10h; Solvent; Temperature; | 60.8% |
In N,N-dimethyl-formamide at 0 - 80℃; for 10.5h; Temperature; | 60.8% |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
(S)-9-fluoro-3-methyl-10-formyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 89 percent / NaH / dimethylsulfoxide / 4 h / 50 °C 2.1: KOH / methanol / 0.5 h / -10 - 5 °C 2.2: 66 percent / KMnO4; MgSO4 / H2O View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl; AcOH 2: N-methylmorpoline / dimethylsulfoxide / 110 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere 4: sodium hydroxide; water / ethanol / 10 °C View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 90 - 95℃; for 8h; | 11.8 g |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere View Scheme |
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / 8 h / 90 - 95 °C 2: 5%-palladium/activated carbon; hydrogen / N,N-dimethyl-formamide / 70 °C 3: dmap; pyridine / toluene / 90 °C / Inert atmosphere View Scheme |
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