3-(3-Hydroxy-propylamino)-propan-1-ol supplier

Name
3-(3-HYDROXY-PROPYLAMINO)-PROPAN-1-OL
EINECS
CAS No. 14002-33-6
Article Data18
CAS DataBase
Density 1.014 g/cm³
Solubility
Melting Point
Formula C₆H₁₅NO₂
Boiling Point 268.858 °C at 760 mmHg
Molecular Weight 133.191
Flash Point 129.676 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Propanol,3,3'-iminodi- (6CI,7CI);3,3'-Iminodi-1-propanol;Bis(3-hydroxypropyl)amine;
PSA 52.49000
LogP -0.26830

Synthetic route

: 5279-23-2
3,3‘-(benzylazanediyl)bis(propan-1-ol)

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2280 Torr; for 2h;	92%
With hydrogen; palladium dihydroxide
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 775.743 Torr; for 6h;

: methyl 2-(3-hydroxypropylcarbamoyl)ethanoate

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In 1,4-dioxane for 24h; Heating;	88%

: 156-87-6
propan-1-ol-3-amine

: 627-30-5
1-chloro-3-hydroxypropane

A: 14002-33-6
bis-(3-hydroxypropyl)amine

B: 14002-34-7
tripropanolamine

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 24h; Heating;	A 8.23 g B 85%

...Expand

: 156-87-6
propan-1-ol-3-amine

: 627-30-5
1-chloro-3-hydroxypropane

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
Stage #1: propan-1-ol-3-amine; 1-chloro-3-hydroxypropane With water for 24h; Heating / reflux; Stage #2: With potassium hydroxide In water	80%
In water for 24h; Heating;	64%
In water for 24h; Reflux;	53%
Stage #1: propan-1-ol-3-amine; 1-chloro-3-hydroxypropane In water for 24h; Reflux; Stage #2: With potassium hydroxide In water
In water for 24h; Reflux;	12.5 g

: 3518-88-5
3,3'-imino-di-propionic acid diethyl ester

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 25℃; for 5h;	60%

: 3518-85-2
methylimine-N,N-dipropionate methyl ester

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether 1.) room temperature, 1 h, 2.) reflux, 24 h;	37%

: 70-55-3
toluene-4-sulfonamide

: 109-64-8
1,3-dibromo-propane

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With alkali Kochen des Reaktionsprodukts mit Natrium und Isoamylalkohol;

: 10494-79-8
methyl N-(3-hydroxypropyl)-β-alaninate

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran rt 30 min, reflux 2 h; Yield given;

: 70-55-3
toluene-4-sulfonamide

: 109-64-8
1,3-dibromo-propane

alkali: alkali

A: 14002-33-6
bis-(3-hydroxypropyl)amine

B: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
und Kochen der nicht naeher beschriebene p-Toluolsulfonylderivate mit Natrium und Isoamylalkohol; Produkt 5: 3-Hydroxy-propylamin;

...Expand

: 109-78-4
3-Hydroxypropionitrile

nickel kieselguhr: nickel kieselguhr

A: 14002-33-6
bis-(3-hydroxypropyl)amine

B: 14002-34-7
tripropanolamine

C: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
at 60 - 70℃; under 36775.4 Torr; Hydrogenation;

...Expand

: 109-78-4
3-Hydroxypropionitrile

A: 14002-33-6
bis-(3-hydroxypropyl)amine

B 3-hydroxy-propylamine and tris-<3-hydroxy-propyl>-amine: 3-hydroxy-propylamine and tris-<3-hydroxy-propyl>-amine

Conditions

Conditions	Yield
With nickel kieselguhr at 60 - 70℃; Hydrogenation.unter Druck;

: 793-19-1
bis(2-methoxycarbonylethyl)benzylamine

: 14002-33-6
bis-(3-hydroxypropyl)amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LAH 2: H2 / Pd(OH)2 View Scheme

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 881169-78-4
N-(p-nitrobenzyl)-dipropropanolamine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 55 - 60℃; for 2h;	100%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 102073-95-0
bis(3-chloropropyl)amine

Conditions

Conditions	Yield
With thionyl chloride In benzene 5 deg C then 4 h reflux;	97%
With thionyl chloride In chloroform at 0 - 20℃; for 24h;	92%
With thionyl chloride In dichloromethane 1.) room temp., overnight, 2.) reflux, 2 h;	80%
With sulfuryl dichloride In chloroform for 3h; Heating;	60%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 5720-07-0
4-methoxyphenylboronic acid

: 10-(4-methoxyphenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	97%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 1692-15-5
4-pyridylboronic acid

: 10-(4-pyridyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	97%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

: N,N-Bis(3-hydropropyl)dansylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	96%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: C15H22BNO4

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	96%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 149104-90-5
4-acetylphenylboronic acid

: 10-(4-ethane-1-onephenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	92%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 126747-14-6
4-cyanophenylboronic acid

: 10-(4-cyanophenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	92%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 13292-87-0
dimethylsulfide borane complex

: hexahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinine

Conditions

Conditions	Yield
In toluene at 20℃; for 3h; Inert atmosphere; Schlenk technique;	92%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 101251-09-6
(4-acetylaminophenyl)boronic acid

: C14H21BN2O3

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	90%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 98-80-6
phenylboronic acid

: 10-phenyloctahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	89%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 16419-60-6
2-Methylphenylboronic acid

: 10-(o-tolyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	89%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 98-59-9
p-toluenesulfonyl chloride

: 56187-12-3
N-tosyl-bis(3-hydroxypropyl)amine

Conditions

Conditions	Yield
With sodium carbonate In water 1.) 95 deg C, 1 h; 2.) 25 deg C, 2 h;	85%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 5720-05-8
4-methylphenylboronic acid

: 10-(p-tolyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	84%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 13922-41-3
1-Naphthylboronic acid

: 10-(1-naphthyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	84%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 2156-04-9
4-Vinylphenylboronic acid

: 10-(4-vinylphenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	84%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 98-59-9
p-toluenesulfonyl chloride

: 75321-10-7
3-propyl tosylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	83%
With triethylamine In dichloromethane at 20℃;	80%
In dichloromethane	50%
In dichloromethane	45%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 73852-19-4
3,5-bis-trifluromethylphenylboronic acid

: 10-(3,5-bis(trifluoromethyl)phenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	83%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 24067-17-2
4-nitrophenylboronic acid

: 10-(4-nitrophenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	83%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 98-59-9
p-toluenesulfonyl chloride

: 4-(p-toluenesulfonyl)-4-azaheptane-1,7-di-p-toluenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	82%
With triethylamine In dichloromethane	82%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 244205-40-1
(2-bromophenyl)boronic acid

: 10-(2-bromophenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	82%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 907625-54-1
3,3'-iminobis-1-propanol dinitrate nitrate

Conditions

Conditions	Yield
With nitric acid; acetic anhydride In tetrahydrofuran; ethyl acetate at 0 - 20℃; for 1h;	78%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 1000290-09-4
phenyl(oxo)borane

: Perhydro-2-phenyl-1,3,7,2-dioxazaborecin

Conditions

Conditions	Yield
	76%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 380430-49-9
[4-(tert-butoxycarbonylamino)phenyl]boronic acid

: C17H27BN2O4

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	76%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 17933-03-8
m-tolylboronic acid

: 10-(m-tolyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	74%

: 14002-33-6
bis-(3-hydroxypropyl)amine

: 55499-43-9
3,4-dimethyl phenylboronic acid

: 10-(3,4-dimethylphenyl)octahydro-[1,3,2]oxazaborinino[2,3-b][1,3,2]oxazaborinin-5-ium-10-uide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	72%

3-(3-Hydroxy-propylamino)-propan-1-ol Specification

This chemical is called 1-Propanol, 3,3'-iminobis-, and its systematic name is 3,3'-iminodipropan-1-ol. With the molecular formula of C₆H₁₅NO₂, its molecular weight is 133.19. The CAS registry number of this chemical is 14002-33-6.

Other characteristics of the 1-Propanol, 3,3'-iminobis- can be summarised as followings: (1)ACD/LogP: -1.25; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.34; (4)ACD/LogD (pH 7.4): -3.79; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 21.7 Å²; (13)Index of Refraction: 1.467; (14)Molar Refractivity: 36.51 cm³; (15)Molar Volume: 131.4 cm³; (16)Polarizability: 14.47×10^-24cm³; (17)Surface Tension: 40.8 dyne/cm; (18)Density: 1.013 g/cm³; (19)Flash Point: 129.7 °C; (20)Enthalpy of Vaporization: 58.86 kJ/mol; (21)Boiling Point: 268.9 °C at 760 mmHg; (22)Vapour Pressure: 0.001 mmHg at 25°C.

You can still convert the following datas into molecular structure:
1.SMILES: OCCCNCCCO
2.InChI: InChI=1/C6H15NO2/c8-5-1-3-7-4-2-6-9/h7-9H,1-6H2
3.InChIKey: CXMYWOCYTPKBPP-UHFFFAOYAP

Product Name

3-(3-HYDROXY-PROPYLAMINO)-PROPAN-1-OL

Synthetic route

3-(3-Hydroxy-propylamino)-propan-1-ol Specification

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