• Name

  3'-Amino-4'-methoxyacetanilide

• EINECS 228-938-8
• CAS No. 6375-47-9
• Article Data24
• CAS DataBase
• Density 1.211 g/cm³
• Solubility
• Melting Point 109 °C
• Formula C₉H₁₂N₂O₂
• Boiling Point 405.7 °C at 760 mmHg
• Molecular Weight 180.206
• Flash Point 199.2 °C
• Transport Information
• Appearance
• Safety 26-37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms p-Acetanisidide,3'-amino- (8CI);1-Methoxy-4-(N-acetylamino)-2-aminobenzene;2-Amino-4-(acetylamino)anisole;2-Amino-4-(acetylamino)phenyl methyl ether;2-Methoxy-5-(acetylamino)aniline;3'-Amino-4'-methoxyacetanilide;4-(Acetylamino)-2-aminoanisole;4-Acetamido-2-aminoanisole;4-Acetamido-2-anisidine;4'-Methoxy-3'-aminoacetanilide;5-(Acetylamino)-2-methoxyaniline;5-Acetamido-2-methoxyaniline;N-(3-Amino-4-methoxyphenyl)acetamide;m-Amino-p-methoxyacetanilide;
• PSA 64.35000
• LogP 1.89000

Synthetic route

50651-39-3

2-nitro-4-acetylamino-anisole

624-84-0

formic acid hydrazide

6375-47-9

3-amino-4-methoxyacetanilide

Conditions

Conditions	Yield
With palladium on activated charcoal In methanol at 20℃;	99.5%

615-05-4

2,4-Diaminoanisole

108-24-7

acetic anhydride

6375-47-9

3-amino-4-methoxyacetanilide

Conditions

Conditions	Yield
With sodium carbonate In methanol at 5℃; for 0.00416667h; Temperature; Concentration; Reagent/catalyst; Time;	99%
With sodium carbonate In methanol at 5℃; Reagent/catalyst; Temperature;	98.6%
In methanol at 0 - 5℃; for 1.16667h; Solvent; Large scale;	98.5%

3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 50℃; under 4500.45 Torr; for 0.416667h;	98.1%
With hydrogen In methanol at 60℃; under 11251.1 Torr;	96.52%
With hydrogen at 80℃; under 7500.75 Torr; Large scale;	96.52%

3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: PEG4000 / 60 °C / Large scale 2: hydrogen / methanol / 60 °C / 4500.45 Torr / pH 9 3: sodium carbonate / methanol / 5 °C View Scheme
Multi-step reaction with 4 steps 1: sodium hydroxide / 3 h / 60 °C 2: PdCu/graphene double-metal catalyst / 0.58 h / 60 °C / 7500.75 Torr 3: ammonium bicarbonate / methanol / -5 - 5 °C 4: palladium on activated charcoal; hydrogen / methanol / 0.42 h / 50 °C / 4500.45 Torr View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 35 - 65 °C 2: sodium disulfide / water / 80 °C 3: acetic acid; triethylamine / 2.5 h / 0 - 5 °C View Scheme
Multi-step reaction with 3 steps 1: PEG2000 / methanol / 60 °C 2: palladium on activated charcoal; formic acid hydrazide / methanol 3: magnesium oxide / methanol / -5 - 5 °C View Scheme
Multi-step reaction with 3 steps 1: PEG4000 (polyethyleneglycol 4000) / 60 °C 2: hydrogen / methanol / 40 °C / 30003 Torr / Autoclave 3: sodium carbonate / methanol / -5 - 5 °C View Scheme

3-amino-4-methoxyacetanilide

3-amino-4-methoxyacetanilide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon / methanol / 30 - 40 °C / 375.04 - 1500.15 Torr / Inert atmosphere 2: sulfuric acid; nitric acid / 3 h 3: palladium 10% on activated carbon / methanol / 30 - 40 °C / 375.04 - 1500.15 Torr / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1: hydrogen / methanol / 80 °C / 9000.9 Torr / Large scale 2: 8 h / 190 °C 3: nitric acid; sulfuric acid / water / 12 h / 0 - 5 °C 4: hydrogen / methanol / 60 °C / 11251.1 Torr View Scheme
Multi-step reaction with 4 steps 1: hydrogen; / methanol / 100 °C / 15001.5 Torr / Large scale 2: 200 °C / Large scale 3: sulfuric acid; nitric acid / 5 °C / Large scale 4: hydrogen; / 80 °C / 7500.75 Torr / Large scale View Scheme

3'-Amino-4'-methoxyacetanilide Chemical Properties

The molecular formula of 3'-Amino-4'-methoxyacetanilide(6375-47-9) is C₉H₁₂N₂O₂ and its formula weight is 180.2.
3'-Amino-4'-methoxyacetanilide(6375-47-9) has a melting point of  109°C.
The chemical synonyms of 3'-Amino-4'-methoxyacetanilide(6375-47-9) are 2-AMINO-4-ACETAMIDOANISOLE;2-AMINO-4-ACETYLAMINOANISOLE;3-AMINO-4-METHOXY ACETANILIDE;3'-AMINO-4'-METHOXYACETANILIDE;3-AMINO-4-METHOXYACETANILINE;3'-AMINO-4'-METHOXYACETOANILIDE;4-ACETOAMINO-2-AMINO METHOXYBENZENE;4-ACETAMINO-2-AMINOANISOLE
The molecular structure of 3'-Amino-4'-methoxyacetanilide(6375-47-9):

3'-Amino-4'-methoxyacetanilide Safety Profile