3-(METHYLTHIO)PROPYLAMINE supplier

Name
3-(METHYLTHIO)PROPYLAMINE
EINECS
CAS No. 4104-45-4
Article Data27
CAS DataBase
Density 0.938 g/mL at 25 °C(lit.)
Solubility Insoluble in water. Soluble in ethanol.
Melting Point
Formula C₄H₁₂NS+
Boiling Point 169 °C(lit.)
Molecular Weight 105.204
Flash Point 62 °C
Transport Information
Appearance CLEAR COLOURLESS LIQUID
Safety
Risk Codes R37/38; R41
Molecular Structure
Hazard Symbols Xi,C
Synonyms 3-Methylmercaptopropylamine;3-methylsulfanylpropan-1-amine;3-Aminopropyl Methyl Sulfide;3-(METHYLTHIO)PROPYLAMINE;3-MethylthiopropylaMine;3-Methylthio-1-propylamine;
PSA 51.32000
LogP 1.39850

Synthetic route

: 52096-79-4
2-<2-(Methylthio)propyl>-1H-isoindole-1,3(2H)-dione

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 1h; Wavelength; Microwave irradiation; Sonication; Reflux;	87.5%
With ethanol; hydrazine hydrate
With hydrazine

: 63-68-3
L-methionine

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
cyclohexenone In various solvent(s) at 154℃; for 2h;	72.8%
With cyclohexenone In cyclohexanol for 5h; Heating;
With 3,5,5-Trimethylcyclohex-2-en-1-one In isopropyl alcohol at 150℃; for 4h; Autoclave;	90 %Chromat.

: 52096-79-4
2-<2-(Methylthio)propyl>-1H-isoindole-1,3(2H)-dione

: furan-2,3,5(4H)-trione pyridine (1:1)

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
anschliessende Behandlung mit Salzsaeure;

: 54974-63-9
3-(methylthio)propionitrile

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In diethyl ether
With lithium aluminium tetrahydride
With sodium tetrahydroborate; nickel dichloride In N,N-dimethyl-formamide at 20℃;

: 59-51-8
DL-methionine

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
With nitrobenzene; 4-dimethylamino-benzaldehyde at 150 - 190℃;
With paraffin at 250℃;
With cyclohexenone In cyclohexanol for 5h; Heating;
With 1,10-Phenanthroline; copper hydroxide In 1-methyl-pyrrolidin-2-one at 210℃; for 4h; Inert atmosphere; Green chemistry;

: 52-90-4
L-Cysteine

: 86101-37-3
C4H10NS

A: 4104-45-4
3-methylthio-1-propanamine

B: cystine radical anion

Conditions

Conditions	Yield
In water Rate constant; pH=8.3;

...Expand

: 74-93-1
methylthiol

: 14753-26-5
3-chloropropan-1-amine

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
With sodium hydroxide

: 59-51-8
DL-methionine

paraffin: paraffin

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
at 250℃; (+-)-2-amino-4-methylsulfanyl-butyric acid;

methyl-<γ-phthalimido-propyl>-sulfide: methyl-<γ-phthalimido-propyl>-sulfide

: 4104-45-4
3-methylthio-1-propanamine

Conditions

Conditions	Yield
With sodium hydroxide folgende Behandlung mit Salzsaeure;

: 59-51-8
DL-methionine

A: 4104-45-4
3-methylthio-1-propanamine

B: 3268-49-3
3-(methylsulfenyl)propanal

C: 3226-65-1
methionine S-oxide

D: 2835-81-6
2-aminobutanoic acid

Conditions

Conditions	Yield
With water; dinitrogen monoxide Mechanism; Quantum yield; γ-irradiation;

...Expand

: 4104-45-4
3-methylthio-1-propanamine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: N-(3-(methylthio)propyl)formamide

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With bis(2-chlorophenyl)borinic acid; acetic acid at 20℃; for 0.25h; Inert atmosphere; Stage #2: 3-methylthio-1-propanamine at 20℃; for 72h; Inert atmosphere;	99%

: 4104-45-4
3-methylthio-1-propanamine

: 247088-29-5
methyl 4-[(4-phenyl)thiazol-2-yl]benzoate

: 247088-31-9
methyl 3-{4-[(4-phenyl)thiazol-2-yl]benzamido}propyl sulfide

Conditions

Conditions	Yield
at 70 - 75℃; aminolysis;	98%

: 4104-45-4
3-methylthio-1-propanamine

: 1079-66-9
chloro-diphenylphosphine

: 951305-96-7
bis(diphenylphosphino)(N-(methylthio)propyl)amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane	97%
With triethylamine In dichloromethane at 20℃; for 20h;	97%

: 7113-08-8
methyl 2'-phenyl-2,4'-bithiazole-4-carboxylate

: 4104-45-4
3-methylthio-1-propanamine

: 85318-73-6
methyl 3-(2'-phenyl-2,4'-bithiazole-4-carboxamido)propyl sulfide

Conditions

Conditions	Yield
at 80℃; for 2h;	96%

: 4104-45-4
3-methylthio-1-propanamine

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1138324-18-1
C10H13BrN4S

Conditions

Conditions	Yield
With triethylamine In 1-methyl-pyrrolidin-2-one at 125 - 140℃;	96%

: 913090-51-4
5-[(2,5-difluorophenyl)[(4-fluorophenyl)sulfonyl]methyl]-4-methylpyridine-2-carboxylic acid

: 4104-45-4
3-methylthio-1-propanamine

: 913091-03-9
5-[(2,5-difluorophenyl)[(4-fluorophenyl)sulfonyl]methyl]-4-methyl-N-[3-(methylthio)propyl]pyridine-2-carboxamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h;	94%

: 4104-45-4
3-methylthio-1-propanamine

: 119014-47-0
2-amino-5-hydroxy-[1,4]benzoquinone-4-imine

: (6Z)-4-(3(methylthio)propylamino)-6-(3-(methylthio)propyliminio)-3-oxocyclohexa-1,4-dien-1-olate

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	94%

: 1120-82-7
pyrazole-1-methanol

: 4104-45-4
3-methylthio-1-propanamine

: N,N-bis((1H-pyrazol-1-yl)methyl)-3-(methylthio)propan-1-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 72h; Reflux;	93.8%

: 4104-45-4
3-methylthio-1-propanamine

: 68748-55-0, 83377-76-8
2-3'-2''-acetoxy-2'',3'',-dihydrofur-4''-ylacrylamido-3-hydroxy-2-cyclopenten-1-one

A: 85145-25-1
reductiline

B: acetate of 3-(methylthio)propylamine

Conditions

Conditions	Yield
for 17h; Ambient temperature;	A 92% B n/a

...Expand

: 4104-45-4
3-methylthio-1-propanamine

: 85318-71-4
methyl 2''-phenyl-2,4':2',4''-terthiazole-4-carboxylate

: 85318-74-7
methyl 3-(2''-phenyl-2,4':2',4''-terthiazole-4-carboxamido)propyl sulfide

Conditions

Conditions	Yield
at 60 - 70℃; for 6h;	92%

: 4104-45-4
3-methylthio-1-propanamine

: 142611-90-3
S-phenyl thiopantothenate

: 874304-40-2
N-(3-(methylthio)-propyl) pantothenamide

Conditions

Conditions	Yield
In acetonitrile at 30℃; for 3h;	92%

: 4104-45-4
3-methylthio-1-propanamine

: 16523-31-2
4,6-diaminoresorcin dihydrochloride

: (6Z)-4-(3(methylthio)propylamino)-6-(3-(methylthio)propyliminio)-3-oxocyclohexa-1,4-dien-1-olate

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 2h;	92%

: 4104-45-4
3-methylthio-1-propanamine

: 2892-62-8
3,4-dibutoxy-3-cyclobutene-1,2-dione

: 3,4-bis{[3-(methylsulfanyl)propyl]amino}cyclobut-3-ene-1,2-dione

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 1h;	91%

: 4104-45-4
3-methylthio-1-propanamine

: 16947-80-1
N-(tert-butoxycarbonyl)-S-methyl-L-cysteine

: 142721-46-8
N-(tert-butoxycarbonyl)-S-methyl-(S)-cysteine <3-(methylthio)propyl>amide

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetonitrile for 72h; Ambient temperature;	90%

: 4104-45-4
3-methylthio-1-propanamine

: 76275-91-7
2'-<2-(trifluoroacetamido)ethyl>-2,4'-bithiazole-4-carboxylic acid

: 76275-93-9
methyl 3-<2'-<2-(trifluoroacetamido)ethyl>-2,4'-bithiazole-4-carboxamido>propyl sulfide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride	90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 14h;	90%

: 4104-45-4
3-methylthio-1-propanamine

: 598-21-0
2-Bromoacetyl bromide

: 1258542-48-1
N-(3-(methylthio)propyl)-2-(3-(methylthio)propylamino)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃;	89%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 4104-45-4
3-methylthio-1-propanamine

: 6-chloro-N2,N4-bis(3-(methylthio)propyl)-1,3,5-triazine-2,4-diamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 96h;	89%

: 4104-45-4
3-methylthio-1-propanamine

: 325990-92-9
2'-(2-benzyloxy-ethyl)-[2,4']bithiazolyl-4-carboxylic acid

: 325990-89-4
2'-(2-benzyloxy-ethyl)-[2,4']bithiazolyl-4-carboxylic acid (3-methylsulfanyl-propyl)-amide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃;	88%

: 10025-99-7
potassium tetrachloroplatinate(II)

: 4104-45-4
3-methylthio-1-propanamine

: C4H11Cl2NPtS

Conditions

Conditions	Yield
In methanol; water at 20℃; for 1.5h; Inert atmosphere;	88%

: 4104-45-4
3-methylthio-1-propanamine

: 1096156-35-2
homopantothenic acid phenyl thioester

: 2,4-dihydroxy-3,3-dimethyl-N-[2-(3-methylsulfanylpropylcarbamoyl)ethyl]-butyramide

Conditions

Conditions	Yield
In acetonitrile at 30℃; for 3h;	87%

: 4104-45-4
3-methylthio-1-propanamine

: C59H86ClFeN4O16

: C63H95ClFeN5O15S

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h; Cooling with ice;	87%

: 7647-01-0
hydrogenchloride

: 4104-45-4
3-methylthio-1-propanamine

: 7646-79-9
cobalt(II) chloride

: C4H11Cl3CoNS(1-)*H(1+)

Conditions

Conditions	Yield
Stage #1: hydrogenchloride; 3-methylthio-1-propanamine In dichloromethane; water Inert atmosphere; Schlenk technique; Stage #2: cobalt(II) chloride In dichloromethane; water for 2h; Schlenk technique; Inert atmosphere;	86%

...Expand

: 4104-45-4
3-methylthio-1-propanamine

: 1096156-34-1
S-phenyl thio-α-pantothenate

: 1096156-87-4
N-(3-(methylthio)-propyl) α-pantothenamide

Conditions

Conditions	Yield
In acetonitrile at 30℃; for 3h;	85%

: 4104-45-4
3-methylthio-1-propanamine

: 1190044-83-7
4-(cyclopropylethynyl)-N-(3-formyl-8-methylquinolin-7-yl)benzamide

: 1190044-85-9
4-(cyclopropylethynyl)-N-[8-methyl-3-({[3-(methylthio)propyl]amino}methyl)quinolin-7-yl]benzamide

Conditions

Conditions	Yield
Stage #1: 3-methylthio-1-propanamine; 4-(cyclopropylethynyl)-N-(3-formyl-8-methylquinolin-7-yl)benzamide With acetic acid In N,N-dimethyl acetamide at 15 - 30℃; for 0.166667h; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In N,N-dimethyl acetamide at 5 - 30℃; Stage #3: With sodium hydroxide In N,N-dimethyl acetamide; water at 5℃;	85%

: 4104-45-4
3-methylthio-1-propanamine

: 67393-83-3, 67393-84-4, 67663-02-9, 91603-21-3, 91603-22-4, 118759-60-7, 118759-61-8
2-((2RS,3RS)-3-ethyloxiran-2-yl)ethan-1-ol

: rac-N-(2-((2R,3R)-3-ethyloxiran-2-yl)ethyl)-3-(methylthio)propan-1-amine

Conditions

Conditions	Yield
Stage #1: 2-((2RS,3RS)-3-ethyloxiran-2-yl)ethan-1-ol With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 0.166667h; Inert atmosphere; Stage #2: 3-methylthio-1-propanamine With sodium iodide In dimethyl sulfoxide at 20℃; for 48h; Inert atmosphere;	85%

: 4104-45-4
3-methylthio-1-propanamine

: 686-69-1
diethylchlorophosphine

: C12H29NP2S

Conditions

Conditions	Yield
With triethylamine In dichloromethane	84%
With triethylamine In dichloromethane at 20℃; for 20h;	84%

: 57120-54-4
4-(oxiran-2-yl)-2,8-bis(trifluoromethyl)quinoline

: 4104-45-4
3-methylthio-1-propanamine

: 1223578-26-4
1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(3-(methylthio)propylamino)ethanol

Conditions

Conditions	Yield
In ethanol at 130℃; under 14221.9 Torr; Microwave irradiation;	84%

: 4104-45-4
3-methylthio-1-propanamine

: 114214-49-2
1-tert-butoxycarbonyl-3,4-epoxypyrrolidine

: (3S,4S)-3-Hydroxy-4-(3-methylsulfanyl-propylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In ethanol Heating;	83.5%

: 1003-29-8
2-pyrrole aldehyde

: 4104-45-4
3-methylthio-1-propanamine

: N-((1H-pyrrol-2-yl)methylene)-3-(methylthio)propan-1-amine

Conditions

Conditions	Yield
In dichloromethane at 20℃;	83.4%

3-(METHYLTHIO)PROPYLAMINE Chemical Properties

The molecular formula of 3-(methylthio)propylamine(4104-45-4) is C₄H₁₁NS and its formula weight is 105.2.
The density of 3-(methylthio)propylamine(4104-45-4) is 0.938 g/mL at 25 °C(lit.) and it has a boiling point of 169 °C(lit.). The refractive index is about 1.4940(lit.). Its flash point is 62 °C .
The chemical synonyms of 3-(methylthio)propylamine(4104-45-4) are 3-(methylthio)-1-propanamin;3-(methylthio)-1-Propanamine;Methylmercaptopropylamine;3-METHYLMERCAPTOPROPYLAMINE;3-(METHYLTHIO)PROPYLAMINE;3-AMINOPROPYL METHYL SULFIDE;1-Propanamine, 3-(methylthio)-;3-(Methylmercapto)-prop
The molecular structure of 3-(methylthio)propylamine(4104-45-4):

3-(METHYLTHIO)PROPYLAMINE Toxicity Data With Reference

RTECS#: CAS# 4104-45-4: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: 3-(Methylthio)propylamine - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.

3-(METHYLTHIO)PROPYLAMINE Safety Profile

Hazard Codes Xi,C
Risk Statements 37/38-41
Safety Statements 26-36/37/39
RIDADR UN2735
WGK Germany 3
HazardClass 8
PackingGroup III

3-(METHYLTHIO)PROPYLAMINE Specification

Chemical Stability: Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Hazardous Polymerization

Product Name

3-(METHYLTHIO)PROPYLAMINE

Synthetic route

3-(METHYLTHIO)PROPYLAMINE Chemical Properties

3-(METHYLTHIO)PROPYLAMINE Toxicity Data With Reference

3-(METHYLTHIO)PROPYLAMINE Safety Profile

3-(METHYLTHIO)PROPYLAMINE Specification

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