Product Name

  • Name

    3,4-(METHYLENEDIOXY)PROPIOPHENONE

  • EINECS 248-937-6
  • CAS No. 28281-49-4
  • Article Data40
  • CAS DataBase
  • Density 1.198 g/cm3
  • Solubility
  • Melting Point 34-36 °C
  • Formula C10H10O3
  • Boiling Point 306.4 °C at 760 mmHg
  • Molecular Weight 178.188
  • Flash Point 130.1 °C
  • Transport Information
  • Appearance
  • Safety 26-37
  • Risk Codes 33
  • Molecular Structure Molecular Structure of 28281-49-4 (3,4-(METHYLENEDIOXY)PROPIOPHENONE)
  • Hazard Symbols Xn
  • Synonyms Propiophenone,3',4'-(methylenedioxy)- (6CI,7CI,8CI);1-(Benz[d][1,3]dioxol-5-yl)propan-1-one;3,4-Methylenedioxyphenyl ethyl ketone;3,4-Methylenedioxypropiophenone;5-Propanoyl-1,3-benzodioxole;NSC 29484;
  • PSA 35.53000
  • LogP 2.00800

Synthetic route

isosafrole
120-58-1

isosafrole

A

piperonal
120-57-0

piperonal

B

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With NaY-supported PhI(OAc)2 at 130℃; for 0.0833333h; Solvent; Concentration; Temperature; Time; Microwave irradiation;A 91%
B 9%
1-piperonyl-1-propanol
6890-30-8

1-piperonyl-1-propanol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With pyridinium chlorochromate In dichloromethane at 20℃; for 16h;89%
With pyridinium chlorochromate In dichloromethane at 20℃; for 16h;89%
With chromium(VI) oxide; sulfuric acid In water; acetone at 0 - 20℃; for 3h;64.06%
With potassium dichromate
With pyridinium chlorochromate In dichloromethane at 20℃; for 6h;
Methylenedioxybenzene
274-09-9

Methylenedioxybenzene

propionic acid anhydride
123-62-6

propionic acid anhydride

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With methanesulfonic acid at 0 - 5℃; for 4h; Concentration;89%
perchloric acid at 0 - 20℃; for 3h;34.5 g
With aluminum (III) chloride; carbonic acid dimethyl ester at 20℃; Friedel-Crafts Acylation;
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 24h;
piperonal
120-57-0

piperonal

C2H5BrMg*C2H6OZn*LiCl

C2H5BrMg*C2H6OZn*LiCl

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With pivalaldehyde In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;82%
piperonal
120-57-0

piperonal

diethylzinc
557-20-0

diethylzinc

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With pivalaldehyde; lithium chloride; magnesium bromide In tetrahydrofuran; toluene at 0 - 20℃; for 2h; Inert atmosphere;80%
2-Bromo-1-<3,4-(methylenedioxy)phenyl>-1-propanol
57961-85-0

2-Bromo-1-<3,4-(methylenedioxy)phenyl>-1-propanol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With potassium carbonate; palladium diacetate; tris-(o-tolyl)phosphine In benzene at 80℃; for 3h;75%
With potassium carbonate; palladium diacetate; tris-(o-tolyl)phosphine In benzene at 100℃; for 5h;75%
dihydrosafrole
94-58-6

dihydrosafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With formic acid; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 110 - 120℃; for 0.266667h; microwave irradiation;73%
ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

piperonylonitrile
4421-09-4

piperonylonitrile

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide; piperonylonitrile In tetrahydrofuran at 20℃; Cooling with ice;
Stage #2: With sulfuric acid; water In tetrahydrofuran Cooling with ice;		73%
isosafrole
4043-71-4

isosafrole

A

1-(1,3-benzodioxol-5-yl)-2-propanone
4676-39-5

1-(1,3-benzodioxol-5-yl)-2-propanone

B

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With oxygen; copper(l) chloride; palladium dichloride In water; N,N-dimethyl-formamide at 50℃; for 10h;A 18%
B 66%
With oxygen; copper(l) chloride; palladium dichloride In water; N,N-dimethyl-formamide at 50℃; for 10h; Product distribution; Reagents;A 60%
B 18%
1'-hydroxysafrole
5208-87-7

1'-hydroxysafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; Schlenk technique; Inert atmosphere;65%
1-(benzo[d][1,3]dioxol-6-yl)ethanone
3162-29-6

1-(benzo[d][1,3]dioxol-6-yl)ethanone

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With ammonium peroxydisulfate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In water at 110℃; for 3h; Inert atmosphere; Sealed tube;63%
Methylenedioxybenzene
274-09-9

Methylenedioxybenzene

propionyl chloride
79-03-8

propionyl chloride

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at 20℃; for 1h;58%
With zinc(II) oxide; zinc(II) chloride In dichloromethane at 0 - 5℃; for 5h; Reagent/catalyst; Solvent;311 g
With aluminum (III) chloride In dichloromethane Friedel-Crafts Acylation;
isosafrole
120-58-1

isosafrole

A

piperonal
120-57-0

piperonal

B

Piperonylic acid
94-53-1

Piperonylic acid

C

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With PhI(OAc)2/Al2O3 at 140℃; for 0.5h; Microwave irradiation;A 57%
B 31%
C 12%
...Expand
isosafrole
120-58-1

isosafrole

A

piperonal
120-57-0

piperonal

B

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

C

5-(3-methyl-oxiranyl)-benzo[1,3]dioxole
6333-38-6

5-(3-methyl-oxiranyl)-benzo[1,3]dioxole

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene In dichloromethane at 50℃; for 0.0833333h; Time; Temperature; Solvent; Microwave irradiation;A 29%
B 15%
C 55%
...Expand
dihydrosafrole
94-58-6

dihydrosafrole

acetic acid
64-19-7

acetic acid

A

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

B

1-(3,4-dioxymethylenephenyl)propyl acetate
73455-01-3

1-(3,4-dioxymethylenephenyl)propyl acetate

C

isosafrole
4043-71-4

isosafrole

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinoneA 17%
B 39%
C 10%
...Expand
dihydrosafrole
94-58-6

dihydrosafrole

acetic acid
64-19-7

acetic acid

A

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

B

1-(3,4-dioxymethylenephenyl)propyl acetate
73455-01-3

1-(3,4-dioxymethylenephenyl)propyl acetate

Conditions
ConditionsYield
With potassium permanganate sonication;A 32%
B 16%
...Expand
Diazoethan
1117-96-0

Diazoethan

piperonal
120-57-0

piperonal

diethyl ether
60-29-7

diethyl ether

ethanol
64-17-5

ethanol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

...Expand
piperonal
120-57-0

piperonal

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With Diazoethan; diethyl ether; ethanol
Multi-step reaction with 2 steps
1: tetrahydrofuran; diethyl ether / -78 - 20 °C
2: pyridinium chlorochromate / dichloromethane / 6 h / 20 °C
View Scheme
5-(1,2-dibromo-propyl)-benzo[1,3]dioxole
41103-34-8

5-(1,2-dibromo-propyl)-benzo[1,3]dioxole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With sodium methylate Erwaermen des Reaktionsprodukts mit Salzsaeure;
With sodium methylate Erwaermen des Reaktionsprodukts mit Salzsaeure;
3',4'-dihydroxypropiophenone
7451-98-1

3',4'-dihydroxypropiophenone

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With potassium hydroxide; dichloromethane at 120℃;
piperonylonitrile
4421-09-4

piperonylonitrile

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With diethyl ether; ethylmagnesium bromide Erwaermen des erhaltenen 1-Benzo<1,3>dioxol-5-yl-propan-1-on-imins mit wss. Salzsaeure;
isosafrole
120-58-1

isosafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With phosphorus pentachloride Zerlegung des Produkts mit Wasser und Kochen des mit Wasserdampf ueberdestillierten Oels mit alkoholischer Kalilauge;
α-<3.4-methylenedioxy-phenyl>-allylene

α-<3.4-methylenedioxy-phenyl>-allylene

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With sulfuric acid
α-ethyl-piperonyl alcohol

α-ethyl-piperonyl alcohol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With chromium(III) oxide; sulfuric acid
11-ethoxy-isosafrole

11-ethoxy-isosafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With hydrogenchloride
11-methoxy-isosafrole

11-methoxy-isosafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
With hydrogenchloride
5-(prop-1-yn-1-yl)benzo[d][1,3]dioxole
140472-50-0

5-(prop-1-yn-1-yl)benzo[d][1,3]dioxole

sulfuric acid
7664-93-9

sulfuric acid

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

isosafrole
120-58-1

isosafrole

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Conditions
ConditionsYield
Zerlegung des Reaktionsprodukts mit Wasser und Kochen des mit Wasserdampf destillierten Oels mit alkoh. Kalilauge;
hydrogenchloride
7647-01-0

hydrogenchloride

1ξ-ethoxy-1ξ-benzo[1,3]dioxol-5-yl-propene
108757-52-4

1ξ-ethoxy-1ξ-benzo[1,3]dioxol-5-yl-propene

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

1-piperonyl-1-propanol
6890-30-8

1-piperonyl-1-propanol

chromic acid

chromic acid

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

1-piperonyl-1-propanol
6890-30-8

1-piperonyl-1-propanol

Conditions
ConditionsYield
With sodium tetrahydroborate In isopropyl alcohol at 20℃; for 18h;97.1%
With lithium aluminium tetrahydride In diethyl ether for 0.5h; Heating;90%
With lithium aluminium tetrahydride In diethyl ether for 24h; Heating;90 mg
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol
235792-16-2

(S)-(-)-α-ethyl-3,4-methylenedioxybenzyl alcohol

Conditions
ConditionsYield
With dimethylsulfide; dimethylsulfide borane complex; (R)-2-methyl-(CBS)-oxazaborolidine In dichloromethane; toluene at 20℃; for 4h;97%
With dimethylsulfide; dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane; toluene at 20℃; for 4h; Corey-Bakshi-Shibata reduction;97%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

C11H9ClO3

C11H9ClO3

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 15 - 20℃; for 2.5h; Vilsmeier Formylation;
Stage #2: 3,4-methylenedioxypropiophenone In DMF (N,N-dimethyl-formamide) at 35℃; for 6h; Vilsmeier Formylation;
Stage #3: With sodium hydroxide; water In DMF (N,N-dimethyl-formamide); toluene at 20 - 25℃; for 7h; Product distribution / selectivity;		97%
methanol
67-56-1

methanol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

(±)-1-(benzo[d][1,3]dioxol-5-yl)-2-methylpropan-1-one
67292-69-7

(±)-1-(benzo[d][1,3]dioxol-5-yl)-2-methylpropan-1-one

Conditions
ConditionsYield
With C34H27IrN2P(1+)*C32H12BF24(1-); caesium carbonate at 65℃; for 24h; Inert atmosphere;91%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

1-(3,4-(methylenedioxy)phenyl)-2-bromopropan-1-one
52190-28-0

1-(3,4-(methylenedioxy)phenyl)-2-bromopropan-1-one

Conditions
ConditionsYield
With bromine In chloroform at 0℃;87%
With bromine In diethyl ether for 0.5h; Inert atmosphere;82%
With dichloromethane; bromine
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

1-(4-(benzyloxy)-3-methoxyphenyl)-2-bromopropan-1-one
1835-16-1

1-(4-(benzyloxy)-3-methoxyphenyl)-2-bromopropan-1-one

1-(benzo[d][1,3]dioxol-5-yl)-4-(4-benzyloxy-3-methoxyphenyl)-2,3-dimethylbutane-1,4-dione

1-(benzo[d][1,3]dioxol-5-yl)-4-(4-benzyloxy-3-methoxyphenyl)-2,3-dimethylbutane-1,4-dione

Conditions
ConditionsYield
Stage #1: 3,4-methylenedioxypropiophenone With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at -45℃; for 1h;
Stage #2: 1-(4-(benzyloxy)-3-methoxyphenyl)-2-bromopropan-1-one In N,N-dimethyl-formamide; toluene at -45℃;		86%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

5-propionyloxy-benzo[1,3]dioxole
112579-46-1

5-propionyloxy-benzo[1,3]dioxole

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide In dichloromethane; water for 6h;85%
With formic acid; dihydrogen peroxide In dichloromethane; water at 47℃; for 12h; Heating / reflux;94.5 %Chromat.
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

C18H16O5

C18H16O5

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; copper diacetate; cesium fluoride In toluene at 120℃; for 24h; Inert atmosphere;85%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

anthranil
271-58-9

anthranil

benzo[d][1,3]dioxol-5-yl(quinolin-3-yl)methanone

benzo[d][1,3]dioxol-5-yl(quinolin-3-yl)methanone

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper diacetate In 1,2-dichloro-benzene at 110℃; for 12h; Molecular sieve; Inert atmosphere;83%
methanol
67-56-1

methanol

3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

5-(1-methoxypropyl)-1,3-benzodioxolane
73455-03-5

5-(1-methoxypropyl)-1,3-benzodioxolane

Conditions
ConditionsYield
With sodium tetrahydroborate at 20℃; for 0.5h;81%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

3-amino-1-phenylbut-2-en-1-one
23652-90-6, 80012-15-3, 1128-85-4

3-amino-1-phenylbut-2-en-1-one

[6-(benzo[d][1,3]dioxol-5-yl)-2-methylpyridin-3-yl](phenyl)-methanone

[6-(benzo[d][1,3]dioxol-5-yl)-2-methylpyridin-3-yl](phenyl)-methanone

Conditions
ConditionsYield
With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper diacetate In N,N-dimethyl-formamide at 120℃; for 20h; Sealed tube; regioselective reaction;79%
With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper diacetate In N,N-dimethyl-formamide at 120℃; for 20h; Sealed tube;79%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

aniline
62-53-3

aniline

N-phenylbenzo[d][1,3]dioxole-5-carboxamide
40141-72-8

N-phenylbenzo[d][1,3]dioxole-5-carboxamide

Conditions
ConditionsYield
With copper(II) choride dihydrate; oxygen; triphenylphosphine In dimethyl sulfoxide at 120℃; for 20h; Schlenk technique;79%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

Methanesulfonyl azide
624-90-8, 1516-70-7

Methanesulfonyl azide

1-(benzo[d][1,3]dioxol-5-yl)-2-diazopropan-1-one

1-(benzo[d][1,3]dioxol-5-yl)-2-diazopropan-1-one

Conditions
ConditionsYield
Stage #1: 3,4-methylenedioxypropiophenone With sodium hydride; formic acid ethyl ester In diethyl ether; ethanol; mineral oil at 0 - 20℃; for 15h; Inert atmosphere;
Stage #2: Methanesulfonyl azide In diethyl ether; ethanol; mineral oil for 2h; Inert atmosphere;		74%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

benzamidine monohydrochloride
1670-14-0

benzamidine monohydrochloride

4-(benzo[d][1,3]dioxol-5-yl)-2-phenylpyrimidine

4-(benzo[d][1,3]dioxol-5-yl)-2-phenylpyrimidine

Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In N,N-dimethyl-formamide at 120℃; for 12h; Sealed tube;73%
With ferrous(II) sulfate heptahydrate; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N,N-dimethyl-formamide at 120℃; for 24h; regioselective reaction;73%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

1-benzo[1,3]dioxol-5-yl-2-chloro-propan-1-one

1-benzo[1,3]dioxol-5-yl-2-chloro-propan-1-one

Conditions
ConditionsYield
With lithium chloride In N,N-dimethyl-formamide at 80℃; for 6h; Chlorination;66%
3,4-methylenedioxypropiophenone
28281-49-4

3,4-methylenedioxypropiophenone

2,4-dichlorophenyl hydrazine hydrochloride
5446-18-4

2,4-dichlorophenyl hydrazine hydrochloride

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

1-(2,4-dichlorophenyl)-4-methyl-5-(3,4-methylenedioxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
501426-49-9

1-(2,4-dichlorophenyl)-4-methyl-5-(3,4-methylenedioxyphenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 3,4-methylenedioxypropiophenone; oxalic acid diethyl ester With lithium hexamethyldisilazane In diethyl ether at -78 - 0℃;
Stage #2: 2,4-dichlorophenyl hydrazine hydrochloride In ethanol at 20℃;
Stage #3: With acetic acid Heating; Further stages.;		57%
...Expand

3,4-(Methylenedioxy)propiophenone Specification

The 1-Propanone,1-(1,3-benzodioxol-5-yl)- is an organic compound with the formula C10H10O3. The IUPAC name of this chemical is 1-(1,3-benzodioxol-5-yl)propan-1-one. With the CAS registry number 28281-49-4, it is also named as 3',4'-Methylenedioxypropiophenone. The product's categories are Adehydes, Acetals & Ketones. Besides, it should be stored in a closed cool and dry place.

Physical properties about 1-Propanone,1-(1,3-benzodioxol-5-yl)- are: (1)ACD/LogP: 2.31; (2)ACD/LogD (pH 5.5): 2.31; (3)ACD/LogD (pH 7.4): 2.31; (4)ACD/BCF (pH 5.5): 33.43; (5)ACD/BCF (pH 7.4): 33.43; (6)ACD/KOC (pH 5.5): 429.1; (7)ACD/KOC (pH 7.4): 429.1; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 35.53 Å2; (11)Index of Refraction: 1.546; (12)Molar Refractivity: 47.07 cm3; (13)Molar Volume: 148.6 cm3; (14)Polarizability: 18.66×10-24cm3; (15)Surface Tension: 46.2 dyne/cm; (16)Density: 1.198 g/cm3; (17)Flash Point: 130.1 °C; (18)Enthalpy of Vaporization: 54.7 kJ/mol; (19)Boiling Point: 306.4 °C at 760 mmHg; (20)Vapour Pressure: 0.000771 mmHg at 25°C.

Preparation: this chemical can be prepared by benzo[1,3]dioxole and propaionyl chloride. This reaction will need reagent SnCl4 and solvent CH2Cl2. The reaction time is 60 min with reaction temperature of 20 °C. The yield is about 58%.

Uses of 1-Propanone,1-(1,3-benzodioxol-5-yl)-: it can be used to produce 5-(1-methoxy-propyl)-benzo[1,3]dioxole at temperature of 20 °C. It will need reagent NaBH4 with reaction time of 30 min. The yield is about 81%.

When you are using this chemical, please be cautious about it as the following:
This chemical is danger of cumulative effects. When you are using it, wear suitable gloves. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccc2OCOc2c1)CC
(2)InChI: InChI=1/C10H10O3/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5H,2,6H2,1H3
(3)InChIKey: RVBJGSPBFIUTTR-UHFFFAOYAB
(4)Std. InChI: InChI=1S/C10H10O3/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5H,2,6H2,1H3
(5)Std. InChIKey: RVBJGSPBFIUTTR-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 2150mg/kg (2150mg/kg)   Pharmaceutical Chemistry Journal Vol. 21, Pg. 341, 1987.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View