• Name

  3,5-Dimethylpiperidine

• EINECS 252-730-6
• CAS No. 35794-11-7
• Article Data17
• CAS DataBase
• Density 0.794 g/cm³
• Solubility slightly soluble in Water
• Melting Point
• Formula C₇H₁₅N
• Boiling Point 141.2 °C at 760 mmHg
• Molecular Weight 113.203
• Flash Point 32.8 °C
• Transport Information UN 1993
• Appearance clear colorless to light yellow liquid
• Safety 16-26-37/39
• Risk Codes 10-36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 3,5-Lupetidine(7CI);3,5-Dimethylpiperidine;
• PSA 12.03000
• LogP 1.58070

Synthetic route

591-22-0

3,5-Lutidine

35794-11-7

3,5-dimethylpiperidine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; under 760.051 Torr; for 24h; Time;	100%
Stage #1: 3,5-Lutidine With hydrogen; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In octane at 120℃; under 15001.5 Torr; for 22h; Stage #2: With water Catalytic behavior; chemoselective reaction;	76 %Chromat.
With 5% active carbon-supported ruthenium; hydrogen; acetic acid In water at 90℃; under 22502.3 Torr; for 8h; Reagent/catalyst; Time; Autoclave;	99.5 %Chromat.
With palladium on activated charcoal; hydrogen In ethanol at 150℃; under 71257.1 Torr; for 5h; Temperature; Pressure; Solvent;

25115-68-8

3,5-dimethyl-piperidine-2,6-dione

35794-11-7

3,5-dimethylpiperidine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

4295-92-5, 7446-84-6, 35878-31-0, 50901-09-2, 82950-73-0, 118139-25-6

meso-2,4-dimethylglutaric anhydride

35794-11-7

3,5-dimethylpiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia 2: lithium alanate; diethyl ether View Scheme

35794-11-7

3,5-dimethylpiperidine

51064-65-4

1,4-di-o-tosyl-2,3-isopropylidene-D-threitol

C21H40N2O2

Conditions

Conditions	Yield
for 18h; Heating;	99%

35794-11-7

3,5-dimethylpiperidine

140-10-3

(E)-3-phenylacrylic acid

(E)-1-(3,5-dimethylpiperidin-1-yl)-3-phenylprop-2-en-1-one

Conditions

Conditions	Yield
With 3,4,5-trifluorophenylboronic acid In xylene for 29h; Heating;	99%

35794-11-7

3,5-dimethylpiperidine

1821-12-1

4-Phenylbutyric acid

1-(3,5-Dimethyl-piperidin-1-yl)-4-phenyl-butan-1-one

Conditions

Conditions	Yield
With 3,4,5-trifluorophenylboronic acid In toluene for 16h; Heating; other reagents;	99%
With 3,5-di-C10F21-C6H3-B(OH)2; 4 A molecular sieve In toluene for 15h; Heating;	95%
With boric acid In toluene for 15h; Dean-Stark; Reflux; Green chemistry; chemoselective reaction;	95%
With triethoxyantimony In toluene Acylation; Heating;	44%

35794-11-7

3,5-dimethylpiperidine

611-71-2, 611-72-3, 17199-29-0, 90-64-2

MANDELIC ACID

1445918-79-5

1-(3,5-dimethylpiperidin-1-yl)-2-hydroxy-2-phenylethanone

Conditions

Conditions	Yield
With butylboronic acid; water; benzoic acid In toluene for 14h; Reagent/catalyst; Solvent; Temperature; Reflux;	99%
With [2-[(2,2,6,6-tetramethylpiperidin-1-yl)methyl]phenyl]boronic acid; benzoic acid In toluene for 16h; Reagent/catalyst; Time; Concentration; Solvent; Reflux; Molecular sieve;	99%

35794-11-7

3,5-dimethylpiperidine

930-68-7

cyclohexenone

rac-N-phenyl-3,5-dimethylpiperidine

Conditions

Conditions	Yield
With PdCl2(PMePh2)2; oxygen; Potassium benzoate; benzoic acid In toluene at 20 - 100℃; for 18h; Sealed tube;	98%

35794-11-7

3,5-dimethylpiperidine

70132-91-1

2-chloro-5-nitro-4'-chlorobenzophenone

[2-(3,5-dimethyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl) methanone

Conditions

Conditions	Yield
With calcium carbonate In ethanol	97%

35794-11-7

3,5-dimethylpiperidine

32997-30-1

2-(3,5-dimethyl-piperidin-1-ylsulfanyl)-benzothiazole

Conditions

Conditions	Yield
	97%

35794-11-7

3,5-dimethylpiperidine

825-56-9

2-phenyl-1,3,4-oxadiazole

1323158-97-9

N'-[(3,5-dimethylpiperidin-1-yl)methylidene]benzohydrazide

Conditions

Conditions	Yield
at 80℃; for 5.5h;	97%

35794-11-7

3,5-dimethylpiperidine

77-78-1

dimethyl sulfate

N,N-dimethyl-3,5-dimethylpiperidinium hydroxide

Conditions

Conditions	Yield
Stage #1: 3,5-dimethylpiperidine; dimethyl sulfate In toluene at 0 - 70℃; for 1h; Large scale; Stage #2: dimethyl sulfate With sodium hydroxide In water; toluene at 5 - 50℃; Large scale; Further stages;	97%

35794-11-7

3,5-dimethylpiperidine

57381-34-7

5-chloro-2-fluorobenzonitrile

660831-14-1

5-chloro-2-(3,5-dimethyl-piperidin-1-yl)-benzonitrile

Conditions

Conditions	Yield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 12h;	96%

35794-11-7

3,5-dimethylpiperidine

65-85-0

benzoic acid

121882-68-6

(3,5-dimethylpiperidin-1-yl)(phenyl)methanone

Conditions

Conditions	Yield
With 3,4,5-trifluorophenylboronic acid In 1,3,5-trimethyl-benzene for 20h; Heating;	95%
With boric acid In o-xylene for 20h; Dean-Stark; Reflux; Green chemistry; chemoselective reaction;	85%
With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine In dichloromethane at 20℃; for 12h; Inert atmosphere; Sealed tube; Irradiation;	66%

35794-11-7

3,5-dimethylpiperidine

1-(3'-carboxy-2'-fluoro-biphenyl-3-yl)-5-cyclopropyl-1H-pyrazole-4-carboxylic acid methyl ester

5-cyclopropyl-1-[3'-(3,5-dimethyl-piperidine-1-carbonyl)-2'-fluoro-biphenyl-3-yl]-1H-pyrazole-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 16h;	95%

35794-11-7

3,5-dimethylpiperidine

42564-51-2

4-fluoro-3-nitrobenzaldehyde

4-(3,5-dimethylpiperidin-1-yl)-3-nitro-benzaldehyde

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 0.5h;	93.5%
With triethylamine In dichloromethane at 20℃; for 0.5h; Cooling with ice;	93%

35794-11-7

3,5-dimethylpiperidine

264879-17-6

ethyl 6-chloro-7-fluoro-2-(trifluoromethyl)-2H-1-benzopyran-3-carboxylate

ethyl 6-chloro-7-(3,5-dimethylpiperidin-1-yl)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 90℃; for 48h;	93%

3,5-Dimethylpiperidine Chemical Properties

3,5-Dimethylpiperidine Toxicity Data With Reference

3,5-Dimethylpiperidine Safety Profile

3,5-Dimethylpiperidine Specification