3-Methyl-8-quinolinesulphonyl chloride supplier

Name
3-Methyl-8-quinolinesulphonyl chloride
EINECS -0
CAS No. 74863-82-4
Article Data3
CAS DataBase
Density 1.424 g/cm³
Solubility
Melting Point 158-159 °C
Formula C₁₀H₈ClNO₂S
Boiling Point 371.5 °C at 760 mmHg
Molecular Weight 241.698
Flash Point 178.5 °C
Transport Information
Appearance
Safety 26-24/25
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms 8-Quinolinesulfonylchloride,3-methyl-(9CI);3-Methyl Quinoline-8-Sulphonyl Chloride;8-Chlorosulfonyl-3-Methylquinoline;
PSA 55.41000
LogP 3.55150

Synthetic route

: 612-58-8
3-methylquinoline

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

Conditions

Conditions	Yield
With chlorosulfonic acid; thionyl chloride In water	1.58 g (18%)

: 153886-69-2
3-methyl-8-quinolinesulfonic acid

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; triethylamine In toluene at 25 - 40℃; for 3h; Reagent/catalyst; Temperature;	178 g

: C22H26N4O6

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: Nω,Nω'-bis((benzyloxy)carbonyl)-N2-((3-methylquinolin-8-yl)sulfon-yl)-L-arginine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 0 - 20℃; for 16h;	98%

: 2149-70-4
N-nitro-L-arginine

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C16H20N6O6S

Conditions

Conditions	Yield
With sodium carbonate; potassium hydroxide In methanol; water at 0 - 20℃; Concentration; Reagent/catalyst; Solvent;	96.12%

: (2R,4R)-1-[N-nitro-L-arginyl]-4-methyl-2-piperidinecarboxylic acid ethyl ester

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C25H35N7O7S

Conditions

Conditions	Yield
With potassium carbonate; potassium hydroxide In ethanol; water at 0 - 20℃; Concentration; Reagent/catalyst; Solvent;	96.09%

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: (3S,6S,9aS)-6-Carboxyamino-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carboxylic acid tert-butyl ester

: 188126-78-5
(3S,6S,9aS)-6-(3-Methyl-quinoline-8-sulfonylamino)-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane	89%

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C20H30N6O5*ClH

: 367952-84-9
C30H37N7O7S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	86%

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: 174699-02-6
(2R,4R)-1-((S)-2-Amino-5-benzyloxycarbonylamino-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester

: 174699-04-8
(2R,4R)-1-[(S)-5-Benzyloxycarbonylamino-2-(3-methyl-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2.75h; Acylation;	75%

: 74-79-3
L-arginine

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: 252985-90-3
5-guanidino-2(S)-[1-(3-methylquinolyl)sulfonylamino]pentanoic acid

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane; water at 20℃; for 2h; sulfonylation;	60%

: C15H28N4O4

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C25H35N5O6S

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	10.21%

: 177995-40-3
4-methoxy-3-amino-1,2-benzisoxazole

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: N-(4-methoxybenzo[d]isoxazol-3-yl)-3-methylquinoline-8-sulfonamide

Conditions

Conditions	Yield
Stage #1: 4-methoxy-3-amino-1,2-benzisoxazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.166667h; Stage #2: 8-(chlorosulphonyl)-3-methylquinoline In N,N-dimethyl-formamide; mineral oil for 16h;	8%

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: (2R,4R)-1-((S)-2-Amino-5-benzyloxycarbonylamino-4,4-difluoro-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester

: 183679-14-3
(2R,4R)-1-[(S)-5-Benzyloxycarbonylamino-4,4-difluoro-2-(3-methyl-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 2h; Acylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: (S)-2-Amino-4-hydroxy-butyric acid benzhydryl ester; compound with toluene-4-sulfonic acid

: 183679-06-3
(S)-4-Hydroxy-2-(3-methyl-quinoline-8-sulfonylamino)-butyric acid benzhydryl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; Acylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C13H25ClN6O3*ClH

: C23H32ClN7O5S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H30N6O4*ClH

: C25H37N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H30N6O4*ClH

: C25H37N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H30N6O4*ClH

: C25H37N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C14H26N6O5*ClH

: C24H33N7O7S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C17H34N6O4*ClH

: C27H41N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C16H32N6O4*ClH

: C26H39N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C17H34N6O4*ClH

: C27H41N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C16H32N6O4*ClH

: C26H39N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: 2(S)-amino-5-(3-nitroguanidino)-1-[4-(2-acetoxyethyl)piperidin-1-yl]pentan-1-one hydrochloride

: 252985-95-8
3-methylquinoline-8-sulfonic acid {4-(3-nitroguanidino)-1(S)-[4-(2-acetoxyethyl)piperidin-1-ylcarbonyl]butyl}amide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H28N6O5*ClH

: C25H35N7O7S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C17H34N6O4*ClH

: C27H41N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H29N7O4*ClH

: C25H36N8O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C15H28N6O5*ClH

: C25H35N7O7S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C18H36N6O4*ClH

: C28H43N7O6S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C19H36N6O6*ClH

: C29H43N7O8S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C20H38N6O5*ClH

: C30H45N7O7S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C18H33N7O6*ClH

: C28H40N8O8S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

: 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline

: C24H36N6O7*ClH

: C34H43N7O9S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; pH=9; sulfonylation;

3-Methyl-8-quinolinesulphonyl chloride Chemical Properties

Molecular structure of 3-Methyl-8-quinolinesulphonyl chloride (CAS NO.74863-82-4) is:

Product Name: 3-Methyl-8-quinolinesulphonyl chloride
CAS Registry Number: 74863-82-4
Systematic Name: 3-methylquinoline-8-sulfonyl chloride
Molecular Formula: C₁₀H₈ClNO₂S
Molecular Weight: 241.69
Melting Point: 158-159°C
Surface Tension: 54.4 dyne/cm
Density: 1.424 g/cm³
Flash Point: 178.5 °C
Enthalpy of Vaporization: 59.42 kJ/mol
Boiling Point: 371.5 °C at 760 mmHg
Vapour Pressure: 2.19E-05 mmHg at 25°C
Product Categories: Sulfonylhalide;Aromatics Compounds;Aromatics;Sulfonyl Chlorides;Sulfur & Selenium Compounds

3-Methyl-8-quinolinesulphonyl chloride Specification

3-Methyl-8-quinolinesulphonyl chloride , its cas register number is 74863-82-4. It also can be called 8-Chlorosulfonyl-3-Methylquinoline ; 3-Methyl Quinoline-8-Sulphonyl Chloride ; 8-Quinolinesulfonylchloride,3-methyl-(9CI) .It is a off-white to pale brown solid.

Product Name

3-Methyl-8-quinolinesulphonyl chloride

Synthetic route

3-Methyl-8-quinolinesulphonyl chloride Chemical Properties

3-Methyl-8-quinolinesulphonyl chloride Specification

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