• Name

  3-Methylpiperidin-4-one hydrochloride

• EINECS
• CAS No. 4629-78-1
• Article Data3
• CAS DataBase
• Density
• Solubility
• Melting Point 176.5-177 °C
• Formula C₆H₁₂ClNO
• Boiling Point 224.6 °C at 760 mmHg
• Molecular Weight 149.62
• Flash Point 89.7 °C
• Transport Information
• Appearance
• Safety 26-36/37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols
• Synonyms 4-Piperidinone,3-methyl-, hydrochloride (9CI);4-Piperidone, 3-methyl-, hydrochloride(6CI,7CI,8CI);
• PSA 29.10000
• LogP 1.31570

Synthetic route

17038-84-5

ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate

4629-78-1

3-methylpiperidine-4-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride for 72h; Heating;	72%

4451-86-9

ethyl 1-benzoyl-4-oxo-3-piperidinecarboxylate

4629-78-1

3-methylpiperidine-4-one hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 79 percent / NaH / 1,2-dimethoxy-ethane / 40 h / 60 °C 2: 72 percent / aq. HCl / 72 h / Heating View Scheme

181269-69-2

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

4629-78-1

3-methylpiperidine-4-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; dichloromethane at 0 - 25℃;

4629-78-1

3-methylpiperidine-4-one hydrochloride

6092-80-4

phenoxyamine hydrochloride

43213-62-3

4-methyl-1,2,3,4-tetrahydro-benzo[4,5]furo[3,2-c]pyridine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol

4629-78-1

3-methylpiperidine-4-one hydrochloride

rac-trans-3-methylpiperidin-4-ol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate 1) MeOH, r.t., 0.5 h, 2) MeOH, r.t., 4 h; Yield given; Multistep reaction;

4629-78-1

3-methylpiperidine-4-one hydrochloride

1-(4-hydroxy-3-methylpiperidino)cyclohexanecarbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) aq. NaOH, 2) NaBH4 / 1) MeOH, r.t., 0.5 h, 2) MeOH, r.t., 4 h 2: 93 percent / aq. HCl / 24 h / Ambient temperature View Scheme

4629-78-1

3-methylpiperidine-4-one hydrochloride

(3S,4S)-3-Methyl-1-(1-thiophen-2-yl-cyclohexyl)-piperidin-4-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1) aq. NaOH, 2) NaBH4 / 1) MeOH, r.t., 0.5 h, 2) MeOH, r.t., 4 h 2: 93 percent / aq. HCl / 24 h / Ambient temperature 3: 71 percent / diethyl ether / Heating View Scheme

4629-78-1

3-methylpiperidine-4-one hydrochloride

120737-98-6

1-[4,4'-difluorodiphenylmethoxy]-3-chloropropane

1-[1-(4,4'-difluorodiphenylmethoxy)-propyl]-3-methylpiperidine-4-one

Conditions

Conditions	Yield
With sodium iodide; potassium carbonate In water; acetonitrile

4629-78-1

3-methylpiperidine-4-one hydrochloride

75-36-5

acetyl chloride

1228450-13-2

1-acetyl-3-methyl-piperidin-4-one

Conditions

Conditions	Yield
Stage #1: 3-methylpiperidine-4-one hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 0℃; for 16h; Stage #3: With sodium hydrogencarbonate In dichloromethane; water

methyl 3-bromomethyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

4629-78-1

3-methylpiperidine-4-one hydrochloride

1335116-95-4

methyl 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 22h;

C13H12ClF3N2O3S

4629-78-1

3-methylpiperidine-4-one hydrochloride

3-ethyl-5-methyl-6-[(3-methyl-4-oxopiperidin-1-yl)carbonyl]-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidin-2,4-(1H,3H)dione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	236 mg

3-Methylpiperidin-4-one hydrochloride Chemical Properties

3-Methylpiperidin-4-one hydrochloride Safety Profile