4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride supplier

Name
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride
EINECS 447-230-1
CAS No. 3945-69-5
Article Data36
CAS DataBase
Density g/cm³
Solubility Soluble in water, Methanol.
Melting Point 118-120 ºC
Formula C10H17 N4 O3 . Cl
Boiling Point °Cat760mmHg
Molecular Weight 276.723
Flash Point °C
Transport Information UN 3261
Appearance white powder
Safety S26;S36/37/39;S45
Risk Codes R20/21/22;R34;R40
Molecular Structure
Hazard Symbols
Synonyms 4-(4,6-Dimethoxy-s-triazin-2-yl)-4-methylmorpholiniumchloride (7CI);Morpholinium, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-,chloride (9CI);Morpholinium, 4-(4,6-dimethoxy-s-triazin-2-yl)-4-methyl-,chloride (8CI);4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholiniumchloride;DMTMM;
PSA 75.59000
LogP -3.10440

Synthetic route

: 109-02-4
4-methyl-morpholine

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h; Alkylation;	100%
In tetrahydrofuran at 20℃; for 0.5h; Substitution;	100%
In tetrahydrofuran at 0℃; for 0.5h;	100%

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran; methanol	97.4%
With 4-methyl-morpholine In tetrahydrofuran; methanol	96.9%
With 4-methyl-morpholine In ethyl acetate	94.6%

: 109-02-4
4-methyl-morpholine

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

A: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholine

B: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 17h; Substitution;	A 95% B 2%
In dichloromethane at 20℃; for 0.5h; Substitution;	A 21% B 78%

...Expand

: 109-02-4
4-methyl-morpholine

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 107-92-6
butyric acid

A: 1423116-02-2
C9H13N3O4

B: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Conditions

Conditions	Yield
In [D3]acetonitrile for 1h;

...Expand

: 109-02-4
4-methyl-morpholine

: 67-56-1
methanol

: 2-chloro-4,6-bis[3-(perfluorohexyl)propyloxy]-1,3,5-triazine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Conditions

Conditions	Yield
at 0 - 20℃; for 0.00416667h;

...Expand

: 116-53-0, 600-07-7
2-Methylbutanoic acid

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 2-methyl-butyric acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-(4,6-dimethoxy-[1,3,5]triazin-2-yl) ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13734-41-3
t-Boc-L-valine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 345911-01-5
2-tert-butoxycarbonylamino-3-methyl-butyric acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 345911-00-4
2-tert-butoxycarbonylamino-4-methyl-pentanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 15761-38-3
L-N-Boc-Ala

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 2-tert-butoxycarbonylamino-propionic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 124-07-2
Octanoic acid

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: octanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 646-30-0
nonadecanoic acid

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: nonadecanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 140-10-3
(E)-3-phenylacrylic acid

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 345910-94-3
(E)-3-Phenyl-acrylic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 4376-18-5
Monomethyl phthalate

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: phthalic acid 1-(4,6-dimethoxy-[1,3,5]triazin-2-yl) ester 2-methyl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13139-16-7, 35264-07-4, 55721-65-8, 55780-90-0, 116194-21-9
N-tert-butyloxy-isoleucine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 1026362-25-3
2-tert-butoxycarbonylamino-3-methyl-pentanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 7536-58-5
BOC-L-aspartic acid 4-benzyl ester

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 2-tert-butoxycarbonylamino-succinic acid 4-benzyl ester 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl) ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 1025839-59-1
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 65-85-0
benzoic acid

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 132353-23-2
2-(benzyloxy)-4,6-dimethoxy-1,3,5-triazin

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%
With 4-methyl-morpholine In water; acetone at 20℃; for 0.25h;
With 4-methyl-morpholine In 1,4-dioxane; water at 20℃; for 0.25h;

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 501-52-0
3-Phenylpropionic acid

: 3-phenyl-propionic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%
With 4-methyl-morpholine In 1,4-dioxane; water at 20℃; for 0.25h;

: C25H23NO6

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 718627-81-7
C30H28N4O8

Conditions

Conditions	Yield
In chloroform at 0 - 5℃; for 12h;	100%

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-morpholine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h; demethylation;	96%
In dichloromethane at 20℃; for 3h; Decomposition;	96%
In dichloromethane at 20℃; for 3h;	96%
In ethyl acetate at 23 - 29℃; for 0.5h; Conversion of starting material;

: 4530-18-1
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 13122-89-9
(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate

Conditions

Conditions	Yield
In dichloromethane; water	95%

...Expand

: 894789-27-6
(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetic acid

: C16H18FN3

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

A: C21H23FN6O2

B: C33H46FN5O4

C: C33H46FN5O4

Conditions

Conditions	Yield
In ethyl acetate at -20 - 20℃;	A n/a B n/a C 95%

...Expand

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide In methanol; diethyl ether; water	93%
With 4-methyl-morpholine; hydrogenchloride In methanol; dichloromethane; water

: 2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranose

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 4,6-dimethoxy-1,3,5-triazine-2-yl-2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranoside

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 0 - 20℃; for 8h; Inert atmosphere;	93%

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 62-23-7
4-nitro-benzoic acid

: 132353-24-3
4-Nitro-benzoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃;	92%

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: triethylammonium (SP)-5'-O-DMT-thymidine-3'-O-methylphosphonothioate

: 959156-15-1
(RP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

Conditions

Conditions	Yield
In acetonitrile at 20℃;	90%

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: triethylammonium (RP)-5'-O-DMT-thymidine-3'-O-methylphosphonothioate

: 959156-14-0
(SP)-5'-O-DMT-thymidine-3'-O-((4,6-dimethoxy-1,3,5-triazin-2-yl)methylphosphonothioate)

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h;	88%

: 4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid 1-(1,1-dimethylethyl) sodium salt

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

A: 709031-38-9
(5S)-5-aminocarbonyl-4,5-dihydro-1H-pyrrole-1-carboxylic acid 1-(1,1-dimethylethyl) ester

B: 4, 6-DIMEO-1, 3,5-triazene ether (DMT-ether)

Conditions

Conditions	Yield
With sodium hydroxide; sodium dihydrogenphosphate; ammonium chloride at 20℃; for 4h; pH=6.20; Conversion of starting material;	A 87% B 12%

...Expand

: C32H34N2O9P(1-)

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

A: C37H40N5O11P

B: C64H68N4O17P2

Conditions

Conditions	Yield
In acetonitrile at 20℃;	A 5% B 85%

...Expand

: 10036-64-3
N-acetyl-D-glucosamine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 1337923-38-2
4,6-dimethoxy-1,3,5-triazin-2-yl α-N-acetylglucosaminide

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In water at 20℃; for 24h; regioselective reaction;	84%

: 894789-27-6
(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetic acid

: 1005342-91-5
3-(4-fluoro-phenoxy)-5-(S)-pyrrolidin-2-yl-pyridine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

A: C20H20FN5O3

B: C32H43FN4O5

C: 1005342-92-6
C32H43FN4O5

Conditions

Conditions	Yield
In ethyl acetate at -20 - 20℃;	A n/a B n/a C 82%

...Expand

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Chemical Properties

Systematic Name: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride
Synonyms of Morpholinium,4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-, chloride (1:1) (CAS NO.3945-69-5): DMTMM ; 4-(4,6-Dimethoxy-[1,3,5]triazin-2-yl)-4-methylmorpholin-4-ium chloride ; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4
-methylmorpholinium Chloride ; Morpholinium, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl- ; Morpholinium, 4-(4,6-dimethoxy-1,3,5-triazin
-2-yl)-4-methyl-, chloride (1:1)
Molecular Structure:
Molecular Formula: C₁₀H₁₇ClN₄O₃
Molecular Weight: 276.72
CAS NO: 3945-69-5
H bond acceptors: 7
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 66.36 Å²
Melting point: 110-114 °C
Flash Point: 92.5 °C
Storage temp: -20°C
Appearance: White powder or chunks
Product Categories of Morpholinium,4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-, chloride (1:1) (CAS NO.3945-69-5): API intermediates;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Synthetic Organic Chemistry
SMILES: [Cl-].n1c(nc(OC)nc1OC)[N+]2(C)CCOCC2
InChI: InChI=1/C10H17N4O3.ClH/c1-14(4-6-17-7-5-14)8-11-9(15-2)13-10(12-8)16-3;/h4-7H2,1-3H3;1H/q+1;/p-1
InChIKey: BMTZEAOGFDXDAD-REWHXWOFAF
Std. InChI: InChI=1S/C10H17N4O3.ClH/c1-14(4-6-17-7-5-14)8-11-9(15-2)13-10(12-8)16-3;/h4-7H2,1-3H3;1H/q+1;/p-1
Std. InChIKey: BMTZEAOGFDXDAD-UHFFFAOYSA-M

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Safety Profile

Safety information of Morpholinium,4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-, chloride (1:1) (CAS NO.3945-69-5):
Hazard Codes: Corrosive C
Risk Statements: 34-40-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN: 3261 8/PG 2
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup: III

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Store in a dry area. Corrosives area. Deep freeze (below -20°C). Store under nitrogen.

Product Name

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride

Synthetic route

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Chemical Properties

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Safety Profile

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Specification

Related Products

Hot Products