Product Name

  • Name

    4,4'-(Hexafluoroisopropylidene)diphthalic anhydride

  • EINECS 214-170-0
  • CAS No. 1107-00-2
  • Article Data15
  • CAS DataBase
  • Density 1.697 g/cm3
  • Solubility Insoluble in water
  • Melting Point 244-247 ºC
  • Formula C19H6F6O6
  • Boiling Point 494.5 ºC at 760 mmHg
  • Molecular Weight 444.243
  • Flash Point 243.7 ºC
  • Transport Information UN 3261 8/PG 2
  • Appearance White powder
  • Safety 26-36/37/39-45
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 1107-00-2 (4,4'-(Hexafluoroisopropylidene)diphthalic anhydride)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms Hexafluoroisopropylidene-2,2-bis(phthalic anhydride);[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]diphthalic anhydride;Phthalicanhydride, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]di- (7CI);Phthalic anhydride, 4,4'-[trifluoro-1-(trifluoromethyl)ethylidene]di- (8CI);2,2-Bis(3,4-dicarboxyphenyl)-1,1,1,3,3,3-hexafluoropropane dianhydride;2,2-Bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride;4,4'-(Hexafluoroisopropylidene)bis(phthalic anhydride);4,4'-(Hexafluoroisopropylidene)diphthalic dianhydride;4,4'-Hexafluoroisopropylidenebis(benzene-1,2-dicarboxylic acid dianhydride);4,4'-Hexafluoroisopropylidenebisphthalic dianhydride;4,4'-Hexafluoropropylidenebisphthalic acid dianhydride;
  • PSA 86.74000
  • LogP 3.71850

Synthetic route

1,1,1,3,3,3-hexafluoro-2,2-di(3,4-dicarboxyphenyl)-propane
3016-76-0

1,1,1,3,3,3-hexafluoro-2,2-di(3,4-dicarboxyphenyl)-propane

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
at 250℃; for 3h; Temperature;89%
With 2,6-bis[(2,2,6,6-tetramethylpiperidin-1-yl)methyl]phenylboronic acid In propyl cyanide for 12h; Reflux;85%
In o-xylene at 180℃; for 3h;3.5 g
acetic anhydride
108-24-7

acetic anhydride

4,4'-(perfluoropropane-2,2-diyl)bis(1,2-dimethylbenzene)
65294-20-4

4,4'-(perfluoropropane-2,2-diyl)bis(1,2-dimethylbenzene)

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Stage #1: 4,4'-(hexafluoroisopropylidene)-bis-(o-xylene) With pyridine; potassium permanganate In water at 100℃; for 3h;
Stage #2: acetic anhydride In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 0.666667h; Temperature;
79%
o-xylene
95-47-6

o-xylene

aluminium silicate

aluminium silicate

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: AlCl3 / 16 h / 110 °C
2: aq. KMnO4 / pyridine / 12 h / Heating
3: 3.5 g / o-xylene / 3 h / 180 °C
View Scheme
Multi-step reaction with 3 steps
1: 69 percent / HF / 18 h / 130 °C / 22065.2 Torr
2: aq. KMnO4 / pyridine / 12 h / Heating
3: 3.5 g / o-xylene / 3 h / 180 °C
View Scheme
4,4'-(perfluoropropane-2,2-diyl)bis(1,2-dimethylbenzene)
65294-20-4

4,4'-(perfluoropropane-2,2-diyl)bis(1,2-dimethylbenzene)

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. KMnO4 / pyridine / 12 h / Heating
2: 3.5 g / o-xylene / 3 h / 180 °C
View Scheme
phthalonitrile
91-15-6

phthalonitrile

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzenesulfonic acid / dichloromethane / 60 h / 150 - 160 °C / Inert atmosphere
2: water; potassium hydroxide / methanol / 40 h / 110 °C
3: acetic anhydride / toluene / 10 h / 120 °C
View Scheme
o-xylene
95-47-6

o-xylene

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Reflux
1.2: 17 h / 115 °C / 7980.54 Torr / Autoclave; Inert atmosphere
2.1: pyridine; potassium permanganate / water / 3 h / 100 °C / pH 1
3.1: 3 h / 250 °C
View Scheme
N-butylphthalimide
1515-72-6

N-butylphthalimide

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron(III) chloride; sulfuric acid / 80 h / 100 °C
2: water; potassium hydroxide / 18 h / 95 °C
3: 3 h / 250 °C
View Scheme
4,4'-(hexafluoroisopropylidene)bis(N-butylphthalimide)

4,4'-(hexafluoroisopropylidene)bis(N-butylphthalimide)

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; potassium hydroxide / 18 h / 95 °C
2: 3 h / 250 °C
View Scheme
2,2-bis(3-nitro-4-hydroxyphenyl)hexafluoropropane
73340-33-7

2,2-bis(3-nitro-4-hydroxyphenyl)hexafluoropropane

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: palladium on activated charcoal; hydrogen / 2-methyl-propan-1-ol; acetic acid butyl ester
2: ammonia
3: nitrosylsulfuric acid / acetic acid
4: water
5: Heating; Acidic conditions
6: Heating
View Scheme
Multi-step reaction with 6 steps
1: hydrogen; palladium on activated charcoal / butan-1-ol; acetic acid butyl ester
2: ammonia
3: nitrosyl sulphuric acid / acetic acid
4: urea
5: Heating; Acidic conditions
6: Heating
View Scheme
2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane
83558-87-6

2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ammonia
2: nitrosylsulfuric acid / acetic acid
3: water
4: Heating; Acidic conditions
5: Heating
View Scheme
Multi-step reaction with 5 steps
1: ammonia
2: nitrosyl sulphuric acid / acetic acid
3: urea
4: Heating; Acidic conditions
5: Heating
View Scheme
2,2-bis(3,4-di-o-aminophenyl)hexafluoropropane
61005-79-6

2,2-bis(3,4-di-o-aminophenyl)hexafluoropropane

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nitrosylsulfuric acid / acetic acid
2: water
3: Heating; Acidic conditions
4: Heating
View Scheme
Multi-step reaction with 4 steps
1: nitrosyl sulphuric acid / acetic acid
2: urea
3: Heating; Acidic conditions
4: Heating
View Scheme
C15H6F6N8(4+)*4HO4S(1-)

C15H6F6N8(4+)*4HO4S(1-)

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water
2: Heating; Acidic conditions
3: Heating
View Scheme
Multi-step reaction with 3 steps
1: urea
2: Heating; Acidic conditions
3: Heating
View Scheme
[(m-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile
439385-19-0

[(m-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

polyimide, Mw = 51000; monomer(s): [(m-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile; 4,4'-hexafluoroisopropylidene diphthalic anhydride

polyimide, Mw = 51000; monomer(s): [(m-aminophenylamino)-4-aminophenylmethylidene]propanedinitrile; 4,4'-hexafluoroisopropylidene diphthalic anhydride

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one; chlorobenzene at 20 - 190℃;100%
3,3'-bis(N-aminophthalimide)
916066-54-1

3,3'-bis(N-aminophthalimide)

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

polymer, Mn/Mw = 1.1, Mn = 30370 g/mol, Mw = 32910 g/mol, inherent viscosity = 0.35 dL/g; monomer(s): 3,3\-bis(N-aminophthalimide); 4,4\-(hexafluoroisopropylidene)diphthalic anhydride

polymer, Mn/Mw = 1.1, Mn = 30370 g/mol, Mw = 32910 g/mol, inherent viscosity = 0.35 dL/g; monomer(s): 3,3\-bis(N-aminophthalimide); 4,4\-(hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
With 4-chloro-phenol; benzoic acid at 100 - 190℃;98%
N-(4-aminophenyl)-N-phenyl-1-aminopyrene
1446316-97-7

N-(4-aminophenyl)-N-phenyl-1-aminopyrene

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

4,4'-hexafluoroisopropylidenebis[4-(N-phenyl-N-pyren-1-ylamino)phenylphthalimide]
1446316-98-8

4,4'-hexafluoroisopropylidenebis[4-(N-phenyl-N-pyren-1-ylamino)phenylphthalimide]

Conditions
ConditionsYield
Stage #1: N-(4-aminophenyl)-N-phenyl-1-aminopyrene; 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In tetrahydrofuran at 20℃; for 1h;
Stage #2: for 4h; Reflux;
98%
2-methyl-2-propenoic acid 2-hydroxyethyl ester
868-77-9

2-methyl-2-propenoic acid 2-hydroxyethyl ester

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C31H26F6O12

C31H26F6O12

Conditions
ConditionsYield
With dmap; 2,6-di-tert-butyl-4-methyl-phenol; 4-methoxy-phenol at 90℃; for 1h; Concentration;98%
2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-hydroxychalcone) ester

2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-hydroxychalcone) ester

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Reaxys ID: 11558107

Reaxys ID: 11558107

Conditions
ConditionsYield
Stage #1: 2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-hydroxychalcone) ester; 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: With 3-Methylpyridine; acetic anhydride In N,N-dimethyl-formamide at 20 - 120℃; for 2h;
97.4%
3.5-diaminobenzoic acid
535-87-5

3.5-diaminobenzoic acid

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

polymer, inherent viscosity 0.76 dl/g; monomer(s): 3,5-diaminobenzoic acid; 4,4\-(hexafluoroisopropylidene)diphthalic anhydride

polymer, inherent viscosity 0.76 dl/g; monomer(s): 3,5-diaminobenzoic acid; 4,4\-(hexafluoroisopropylidene)diphthalic anhydride

Conditions
ConditionsYield
In various solvent(s) at 200℃;97.3%
3.5-diaminobenzoic acid
535-87-5

3.5-diaminobenzoic acid

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Reaxys ID: 11558590

Reaxys ID: 11558590

Conditions
ConditionsYield
In 3-methyl-phenol at 60 - 200℃;97%
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

2-amino-3-(4-chlorophenyl)-1,8-naphthyridine
439277-53-9

2-amino-3-(4-chlorophenyl)-1,8-naphthyridine

C47H22Cl2F6N6O4

C47H22Cl2F6N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.15h; Milling; Green chemistry;97%
2-amino-3-(4-fluorophenyl)-1,8-naphthyridine
60467-61-0

2-amino-3-(4-fluorophenyl)-1,8-naphthyridine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C47H22F8N6O4

C47H22F8N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.141667h; Milling; Green chemistry;97%
2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-cinnamoyloxyethyl) ester

2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-cinnamoyloxyethyl) ester

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

Reaxys ID: 11558106

Reaxys ID: 11558106

Conditions
ConditionsYield
Stage #1: 2,5-bis(m-aminobenzoyloxy)terephthalic acid bis(2-cinnamoyloxyethyl) ester; 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: With 3-Methylpyridine; acetic anhydride In N,N-dimethyl-formamide at 20 - 120℃; for 2h;
96.5%
3-amino-5-ethynylbenzoic acid
1639866-72-0

3-amino-5-ethynylbenzoic acid

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C37H16F6N2O8

C37H16F6N2O8

Conditions
ConditionsYield
With acetic acid at 118℃; for 24h; Inert atmosphere;96.09%
N-Methyldiethanolamine
105-59-9

N-Methyldiethanolamine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

di(4-isocyanatophenyl)methane
101-68-8

di(4-isocyanatophenyl)methane

polymer, product of diol-diisocyanate condensation followed by polycondensation with dianhydride and heating; monomer(s): 4,4\-methylenebis(phenyl isocyanate); N-methyldiethanolamine; 4,4\-(hexafluoroisopropylidene)bis(phthalic anhydride)

polymer, product of diol-diisocyanate condensation followed by polycondensation with dianhydride and heating; monomer(s): 4,4\-methylenebis(phenyl isocyanate); N-methyldiethanolamine; 4,4\-(hexafluoroisopropylidene)bis(phthalic anhydride)

Conditions
ConditionsYield
Stage #1: N-Methyldiethanolamine; di(4-isocyanatophenyl)methane In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In N,N-dimethyl-formamide at 60 - 80℃;
Stage #3: for 15h; Heating; vacuum;
96%
L-phenylalanine
63-91-2

L-phenylalanine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C37H24F6N2O8
1267449-01-3

C37H24F6N2O8

Conditions
ConditionsYield
With acetic acid at 20℃; Reflux;95%
C15H14N4

C15H14N4

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C49H30F6N8O4

C49H30F6N8O4

Conditions
ConditionsYield
With N,N-dimethyl-formamide for 0.0916667h; Solvent; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;95%
2-hydrazino-3-(4-fluorophenyl)-1,8-naphthyridine
1153668-78-0

2-hydrazino-3-(4-fluorophenyl)-1,8-naphthyridine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C47H24F8N8O4

C47H24F8N8O4

Conditions
ConditionsYield
With N,N-dimethyl-formamide for 0.1h; Solvent; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;95%
3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine
1082325-94-7

3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C49H22F12N6O4

C49H22F12N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.133333h; Milling; Green chemistry;95%
C15H10F3N3
1233246-25-7

C15H10F3N3

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C49H22F12N6O4

C49H22F12N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.15h; Milling; Green chemistry;95%
C18H13N3

C18H13N3

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C55H28F6N6O4

C55H28F6N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.141667h; Milling; Green chemistry;95%
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

2,2'-(4,4'-hexafluoroisopropylidene)-bis(5-aminobenzimidazole)
313505-03-2

2,2'-(4,4'-hexafluoroisopropylidene)-bis(5-aminobenzimidazole)

polymer; monomer(s): 4,4-(hexafluoroisopropylidene)diphthalic anhydride; 2,2-{4,4-[di(trifluoromethyl)]diphenylmethyl}-bis(5-aminobenzimidazole)

polymer; monomer(s): 4,4-(hexafluoroisopropylidene)diphthalic anhydride; 2,2-{4,4-[di(trifluoromethyl)]diphenylmethyl}-bis(5-aminobenzimidazole)

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one In toluene at 140 - 190℃;94%
L-alanin
56-41-7

L-alanin

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C25H16F6N2O8
1267448-97-4

C25H16F6N2O8

Conditions
ConditionsYield
With acetic acid at 20℃; Reflux;94%
C15H11F3N4
1153668-81-5

C15H11F3N4

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C49H24F12N8O4

C49H24F12N8O4

Conditions
ConditionsYield
With N,N-dimethyl-formamide for 0.0916667h; Solvent; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;94%
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

2-hydrazino-3-(2-chlorophenyl)-1,8-naphthyridine
519153-80-1

2-hydrazino-3-(2-chlorophenyl)-1,8-naphthyridine

C47H24Cl2F6N8O4

C47H24Cl2F6N8O4

Conditions
ConditionsYield
With N,N-dimethyl-formamide for 0.0916667h; Solvent; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;94%
2-hydrazino-3-(2-fluorophenyl)-1,8-naphthyridine
1153668-72-4

2-hydrazino-3-(2-fluorophenyl)-1,8-naphthyridine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C47H24F8N8O4

C47H24F8N8O4

Conditions
ConditionsYield
With N,N-dimethyl-formamide for 0.0833333h; Solvent; Time; Reagent/catalyst; Microwave irradiation; Green chemistry;94%
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

2-amino-3-(o-chlorophenyl)-1,8-naphthyridine
845533-60-0

2-amino-3-(o-chlorophenyl)-1,8-naphthyridine

C47H22Cl2F6N6O4

C47H22Cl2F6N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.133333h; Milling; Green chemistry;94%
2-amino-3-(2-fluorophenyl)-1,8-naphthyridine
1082583-45-6

2-amino-3-(2-fluorophenyl)-1,8-naphthyridine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C47H22F8N6O4

C47H22F8N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.141667h; Milling; Green chemistry;94%
2-amino-3-(3-fluorophenyl)-1,8-naphthyridine
1082419-13-3

2-amino-3-(3-fluorophenyl)-1,8-naphthyridine

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

C47H22F8N6O4

C47H22F8N6O4

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.133333h; Milling; Green chemistry;94%
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride
1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

2-amino-3-phenyl-1,8-naphthyridine
5174-94-7

2-amino-3-phenyl-1,8-naphthyridine

2-(3-phenyl[1,8]naphthyridin-2-yl)-5-[1-[1,3-dioxo-2,3-dihydro-1H-5-isoindolyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-phenyl[1,8]naphthyridin-2-yl)-1,3-isoindolinedione

2-(3-phenyl[1,8]naphthyridin-2-yl)-5-[1-[1,3-dioxo-2,3-dihydro-1H-5-isoindolyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-phenyl[1,8]naphthyridin-2-yl)-1,3-isoindolinedione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In neat (no solvent, solid phase) at 20℃; for 0.116667h; Milling; Green chemistry;94%

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Chemical Properties

The Molecular Structure of 1,3-Isobenzofurandione, 5,5'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis- (CAS NO.1107-00-2):

Empirical Formula: C19H6F6O6
Molecular Weight: 444.2378 
IUPAC: 5-[2-(1,3-dioxo-2-benzofuran-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-benzofuran-1,3-dione
Product Categories: Aromatic Tetracarboxylic Dianhydrides (for High-Performance Polymer Research);Bisphenol AF type Compounds (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;Anhydride Monomers;Monomers;Polymer Science
Nominal Mass: 444 Da
Average Mass: 444.2378 Da
Monoisotopic Mass: 444.006857 Da 
Index of Refraction: 1.556
Molar Refractivity: 84.17 cm3
Molar Volume: 261.7 cm3
Surface Tension: 50.2 dyne/cm
Density: 1.697 g/cm3
Flash Point: 243.7 °C
Enthalpy of Vaporization: 76.19 kJ/mol
Boiling Point: 494.5 °C at 760 mmHg
Vapour Pressure: 6.4E-10 mmHg at 25°C 
Sensitive: Moisture Sensitive
InChI
InChI=1/C19H6F6O6/c20-18(21,22)17(19(23,24)25,7-1-3-9-11(5-7)15(28)30-13(9)26)8-2-4-10-12(6-8)16(29)31-14(10)27/h1-6H
Smiles
C(C(F)(F)F)(C(F)(F)F)(c1cc2c(cc1)C(=O)OC2=O)c1cc2C(OC(=O)c2cc1)=O

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Safety Profile

Hazard Codes: CorrosiveCIrritantXi
Risk Statements: 34 
R34: Causes burns
Safety Statements: 26-36/37/39-45 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 2
WGK Germany: 1
F 21: Sensitive to humidity
Hazard Note: Irritant
TSCA: T
HazardClass: 8
PackingGroup: II

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride Specification

 1,3-Isobenzofurandione, 5,5'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis- (CAS NO.1107-00-2) is also called as 2,2'-Bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride ; 4,4'-(Hexafluoroisopropylidene)bis(phthalic anhydride) ; EINECS 214-170-0 ; 4,4'-(2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene)diphthalic anhydride .

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