4-Aminophenol hydrochloride supplier

Name
4-Hydroxyaniline hydrochloride
EINECS 200-122-6
CAS No. 51-78-5
Article Data5
CAS DataBase
Density 1.21g/cm3
Solubility soluble in water
Melting Point 302 °C
Formula C₆H₇NO^.HCl
Boiling Point 282 °C at 760 mmHg
Molecular Weight 145.589
Flash Point 124.3 °C
Transport Information
Appearance Off white powder
Safety 28-36
Risk Codes 36/37/38-43
Molecular Structure
Hazard Symbols Xi
Synonyms Phenol,4-amino-, hydrochloride (9CI);Phenol, p-amino-, hydrochloride (8CI);4-Hydroxyanilinium chloride;C.I. 76551;C.I.Oxidation Base 6A;Durafur Brown R;Fouramine CP;Fourrine 83;Fourrine P;Furro P;Futramine P;Pelagol CP;Pelagol Grey CP;Peltol P;p-Aminophenolhydrochloride;p-Hydroxyaniline hydrochloride;
PSA 46.25000
LogP 2.35760

Synthetic route

: 100-02-7
4-nitro-phenol

: 51-78-5
p-aminophenol hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-nitro-phenol With sodium tetrahydroborate; water at 20℃; for 2h; Stage #2: With hydrogenchloride In ethyl acetate	93%

: 7647-01-0
hydrogenchloride

: 2835-04-3
5-amino-2-hydroxybenzenesulfonic acid

: 51-78-5
p-aminophenol hydrochloride

Conditions

Conditions	Yield
at 170℃; im geschlossenen Rohr;

: 7647-01-0
hydrogenchloride

: 78533-09-2
α-methylsuccinic di-p-anisidine

A: 74-87-3
methylene chloride

B: 498-21-5, 636-60-2
2-methylbutanedioic acid

C: 51-78-5
p-aminophenol hydrochloride

Conditions

Conditions	Yield
at 100℃;

...Expand

: 123-30-8
4-amino-phenol

: 51-78-5
p-aminophenol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol

: 108-95-2
phenol

: 51-78-5
p-aminophenol hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium azide / 5 h / 55 - 60 °C 2: hydrogenchloride / ethanol View Scheme

: 3913-17-5
2-chloro-4,8-dimethyl-quinoline

: 51-78-5
p-aminophenol hydrochloride

: 1436858-68-2
4-(4,8-dimethylquinolin-2-ylamino)phenol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water Heating;	94%

: 51-78-5
p-aminophenol hydrochloride

: 404586-94-3
1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline

A: 54840-15-2
4-N-tert-butoxycarbonylaminophenol

B: 95932-40-4
tert-butyl (4-((tert-butoxycarbonyl)oxy)phenyl)carbamate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 20℃;	A 93% B n/a
In 1,2-dimethoxyethane at 20℃; for 16h;	A 93% B 5%

...Expand

: 32314-39-9
4-chloro-2,8-dimethylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 4-(2,8-dimethylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	93%

: 3913-18-6
2-chloro-4,6-dimethylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 1436858-62-6
4-(4,6-dimethylquinolin-2-ylamino)phenol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water Heating;	92%

: 51-78-5
p-aminophenol hydrochloride

: 22042-71-3
(4-formylphenoxy)acetic acid

: 96865-80-4
4-<<(4-hydoxyanilino)carbonyl>methoxy>benzaldehyde

Conditions

Conditions	Yield
With TEA; dicyclohexyl-carbodiimide In tetrahydrofuran; N,N-dimethyl-formamide for 2h;	89%

: 1161733-88-5
4-methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydropyridine-3-carbonitrile

: 51-78-5
p-aminophenol hydrochloride

: 1397715-49-9
5-[(4-hydroxyphenyl)-hydrazono]-4-methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydropyridine-3-carbonitrile

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With sodium nitrite In water Cooling; Stage #2: 4-methyl-2,6-dioxo-1-propyl-1,2,5,6-tetrahydropyridine-3-carbonitrile With sodium acetate In ethanol; water at 20℃; for 1h; Cooling;	88%

: 51-78-5
p-aminophenol hydrochloride

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 50994-51-9
N-(4-hydroxyphenyl)-4-nitrobenzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	88%

: 51-78-5
p-aminophenol hydrochloride

: 172531-37-2
11-azido-3,6,9-trioxaundecanoic acid

: 1096439-18-7
C14H20N4O5

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	87%

: 51-78-5
p-aminophenol hydrochloride

: 98-59-9
p-toluenesulfonyl chloride

: 1146-43-6
N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	87%

: 64951-58-2
4-chloro-8-methoxy-2-methylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 4-(8-methoxy-2-methylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	86%

: 1147550-11-5
ammonium thiocyanate

: 51-78-5
p-aminophenol hydrochloride

: 1520-27-0
1-(4-hydroxyphenyl)thiourea

Conditions

Conditions	Yield
Heating;	85%
Stage #1: p-aminophenol hydrochloride With hydrogenchloride In water for 0.5h; Reflux; Stage #2: ammonium thiocyanate In water at 20℃; for 4h; Reflux;

: 6270-08-2
4-chloro-2,6-dimethylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 4-(2,6-dimethylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	84%

: 634-47-9
2-chloro-4-methylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 1225153-42-3
4-(4-methylquinolin-2-ylamino)phenol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water Heating;	84%

: 51-78-5
p-aminophenol hydrochloride

: 13024-90-3
1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

: 2-(4-chloro-phenyl)-4-[(4-hydroxy-phenyl)-hydrazono]-5-methyl-2,4-dihydro-pyrazol-3-one

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling;	83%

: 50593-73-2
4-chloro-6-methoxy-2-methylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 4-(6-methoxy-2-methylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	83%

: 4295-06-1
4-chloro-2-methylquinoline

: 51-78-5
p-aminophenol hydrochloride

: 4-(2-methylquinolin-4-ylamino)phenol dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Heating;	82%

: 51-78-5
p-aminophenol hydrochloride

: 38695-92-0
5-hydroxy-3-methyl-1-(pyrid-2-yl)-1H-pyrazole

: 4-[(4-hydroxy-phenyl)-hydrazono]-5-methyl-2-pyridin-2-yl-2,4-dihydro-pyrazol-3-one

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 5-hydroxy-3-methyl-1-(pyrid-2-yl)-1H-pyrazole With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling;	81%

: 51-78-5
p-aminophenol hydrochloride

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: N-(4-hydroxyphenyl)-4-methoxybenzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	80%

: 51-78-5
p-aminophenol hydrochloride

: 60798-06-3
1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one

: 4-[(4-hydroxy-phenyl)-hydrazono]-2-(4-methoxy-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling;	79%

: 6579-54-0
2,6-dichlorobenzenesulfonyl chloride

: 51-78-5
p-aminophenol hydrochloride

: 19818-15-6
2,6-dichloro-N-(4-hydroxyphenyl)benzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	79%

: 51-78-5
p-aminophenol hydrochloride

: 93-11-8
2-Naphthalenesulfonyl chloride

: 51767-49-8
naphthalene-2-sulfonic acid (4-hydroxyl-phenyl)-amide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	78%

: 51-78-5
p-aminophenol hydrochloride

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 63301-13-3
4-chloro-N-(4-hydroxyphenyl)benzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	75%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 51-78-5
p-aminophenol hydrochloride

: 212248-51-6
N-(4-hydroxyphenyl)-2,4,6-triisopropylbenzenesulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	75%

: 51-78-5
p-aminophenol hydrochloride

: 122-04-3
4-nitro-benzoyl chloride

: 13160-56-0
N-(4-hydroxyphenyl)-4-nitrobenzamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 5h; Cooling with ice;	74%

: 26153-38-8
3,5-dihydroxybenzaldehyde

: 51-78-5
p-aminophenol hydrochloride

: (E)-5{(4-hydroxyphenylimino)methyl}benzene-1,3-diol

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With triethylamine In ethanol at 20℃; for 0.0833333h; Stage #2: 3,5-dihydroxybenzaldehyde With acetic acid In ethanol for 8h; Reflux;	73%

: 207742-88-9
3,4,5-trihydroxybenzaldehyde monohydrate

: 51-78-5
p-aminophenol hydrochloride

: 1448846-11-4
(E)-5{(4-hydroxyphenylimino)methyl}benzene-1,2,3-triol

Conditions

Conditions	Yield
Stage #1: p-aminophenol hydrochloride With triethylamine In ethanol at 20℃; for 0.0833333h; Stage #2: 3,4,5-trihydroxybenzaldehyde monohydrate With acetic acid In ethanol Reflux;	70%

: 51-78-5
p-aminophenol hydrochloride

: 151121-34-5
di-tert-butyl (2S,4E)-4-[(dimethylamino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate

: 1252661-52-1
di-tert-butyl (2S,4E)-4-[(4-hydroxyanilino)methylidene]-5-oxopyrrolidine-1,2-dicarboxylate

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 24h;	69%

: 85-46-1
1-Naphthalenesulfonyl chloride

: 51-78-5
p-aminophenol hydrochloride

: 50994-44-0
N-(4-hydroxyphenyl)naphthalene-1-sulfonamide

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	68%

: 51-78-5
p-aminophenol hydrochloride

: 124-63-0
methanesulfonyl chloride

: 51767-39-6
4-(methylsulfonylamino)phenol

Conditions

Conditions	Yield
In pyridine at 20℃; for 5h; Cooling with ice;	68%

4-Aminophenol hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

4-Aminophenol hydrochloride Specification

The CAS register number of 4-Aminophenol hydrochloride is 51-78-5. It also can be called as 4-Hydroxyaniline hydrochloride and the IUPAC name about this chemical is 4-aminophenol hydrochloride. The molecular formula about this chemical is C₆H₇NO^.HCl and the molecular weight is 145.59 . Classification code about this chemical is Mutation data. This chemical can be used for the photographic imaging agent, synthetic dyes, fur dyes, etc. It is mainly used for fur dyeing, but also can be used for sulfur dyes and pharmaceutical intermediates. This chemical is stable, but it is hygroscopic, air and light sensitive. It is incompatible with strong oxidizing agents.

Physical properties about 4-Aminophenol hydrochloride are: (1)ACD/LogP: -0.29; (2)ACD/LogD (pH 5.5): -0.5; (3)ACD/LogD (pH 7.4): -0.29; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 10.29; (7)ACD/KOC (pH 7.4): 16.47; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 12.47Å²; (12)Flash Point: 124.3 °C; (13)Enthalpy of Vaporization: 54.17 kJ/mol; (14)Boiling Point: 282 °C at 760 mmHg; (15)Vapour Pressure: 0.00202 mmHg at 25°C.

Uses of 4-Aminophenol hydrochloride: it can be used to produce methyl-carbamic acid 4-amino-phenyl ester with methyl-carbamic acid methyl ester at temperature of 60 ℃. This reaction will need reagent POCl₃ with reaction time of 10 hours. The yield is about 39%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin, it may cause sensitization by skin contact. When you are using it, wear suitable protective clothing. After contact with skin, wash immediately with plenty of soap-suds.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.Oc1ccc(N)cc1
(2)InChI: InChI=1/C6H7NO.ClH/c7-5-1-3-6(8)4-2-5;/h1-4,8H,7H2;1H
(3)InChIKey: RVGOBWDGAVAVPJ-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C6H7NO.ClH/c7-5-1-3-6(8)4-2-5;/h1-4,8H,7H2;1H
(5)Std. InChIKey: RVGOBWDGAVAVPJ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)		National Technical Information Service. Vol. AD691-490,

Product Name

4-Hydroxyaniline hydrochloride

Synthetic route

4-Aminophenol hydrochloride Consensus Reports

4-Aminophenol hydrochloride Specification

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