5-Chloro-1-(4-piperidyl)-2-benzimidazolinone supplier

Name
5-Chloro-1-(4-piperidyl)-2-benzimidazolinone
EINECS 258-771-6
CAS No. 53786-28-0
Article Data8
CAS DataBase
Density 1.323 g/cm³
Solubility 549mg/L at 20℃
Melting Point 228-231 °C(lit.)
Formula C₁₂H₁₄ClN₃O
Boiling Point
Molecular Weight 251.716
Flash Point
Transport Information
Appearance
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-(6-Chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidine;5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one;5-Chloro-1-(piperidin-4-yl)-1H-benzimidazol-2(3H)-one;5-Chloro-1-piperidin-4-yl-1,3-dihydrobenzimidazol-2-one;R 29676;
PSA 49.82000
LogP 2.23630

Synthetic route

: 53786-46-2
4-(5-chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid ethyl ester

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
With sodium hydroxide for 8h; Heating;	96%
With sodium hydroxide at 100℃;
With ammonium chloride In water

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

2-phenylethyl halide: 2-phenylethyl halide

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: Na2CO3; KI / cyclohexanol / 0.17 h / 180 °C / microwave irradiation 2: Zn; aq. HCl / methanol / 50 °C 3: acetonitrile 4: aq. NaOH / 100 °C View Scheme

: 53786-45-1
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetonitrile 2: aq. NaOH / 100 °C View Scheme
Multi-step reaction with 2 steps 1: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 96 percent / 10percent NaOH / 8 h / Heating View Scheme

: 53786-44-0
4-(4-chloro-2-nitro-anilino)-piperidine-1-carboxylic acid ethyl ester

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Zn; aq. HCl / methanol / 50 °C 2: acetonitrile 3: aq. NaOH / 100 °C View Scheme
Multi-step reaction with 3 steps 1: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 2: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 3: 96 percent / 10percent NaOH / 8 h / Heating View Scheme

: 58859-46-4
ethyl 4-aminopiperidine-1-carboxylate

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 65 percent / Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 4: 96 percent / 10percent NaOH / 8 h / Heating View Scheme

: 89-61-2
2,5-dichloronitrobenzene

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 65 percent / Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 4: 96 percent / 10percent NaOH / 8 h / Heating View Scheme

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / dimethyl sulfoxide / 20 °C / Inert atmosphere 2: hydrazine hydrate / water; ethanol / 0.17 h / 45 °C 3: tetrahydrofuran / 20 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 345-18-6
2-fluoro-5-chloronitrobenzene

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / dimethyl sulfoxide / 20 °C / Inert atmosphere 2: hydrazine hydrate / water; ethanol / 0.17 h / 45 °C 3: tetrahydrofuran / 20 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 460047-89-6
tert-butyl 4-((4-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrazine hydrate / water; ethanol / 0.17 h / 45 °C 2: tetrahydrofuran / 20 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 1429415-80-4
tert-butyl 4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran / 20 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 460047-90-9
tert-butyl 4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)piperidine-1-carboxylate

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 5-chloro-6-nitro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
With nitric acid In o-xylene at 60℃;	95%
With nitric acid In 1,2-dichloro-benzene at 60℃; for 2h;	64%
With nitric acid In 1,2-dichloro-benzene at 20 - 60℃; for 2h;	64%
With nitric acid In o-xylene at 60℃; for 2h;

: 1146300-32-4
7-chloro-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1146300-60-8
7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	91%

: 1146300-33-5
1-tert-butyl-7-chloro-1-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1146300-77-7
1-tert-butyl-7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	89%

: 527-72-0
2-thiophenylcarboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 5-chloro-1-(1-(thiophene-2-carbonyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one

Conditions

Conditions	Yield
With pyridine; 1,3,5-trichloro-2,4,6-triazine In acetonitrile at 140℃; for 0.0833333h; Microwave irradiation;	89%

: 40133-08-2
5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 5-chloro-1-(1-(5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl) piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one

Conditions

Conditions	Yield
With pyridine; 1,3,5-trichloro-2,4,6-triazine In acetonitrile at 140℃; for 0.0833333h; Microwave irradiation;	85%

: 1146300-31-3
7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1146300-43-7
7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide Microwave irradiation;	82%

: 960313-86-4
1-(4-fluorophenyl)-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: C27H20ClFN6O6

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	78%

: 236743-93-4
(S)-9,10-difluoro-3-methyl-8-nitro-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: C25H21ClFN5O7

Conditions

Conditions	Yield
In dimethyl sulfoxide microwave irradiation;	78%

: 112811-77-5
1-cyclopropyl-6,7-difluoro-1,4-dihydro-5-nitro-8-methoxy-4-oxoquinoline-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1018937-91-1
C26H23ClFN5O7

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	78%

: 368839-20-7
7-chloro-1-(4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1119087-61-4
7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1-(4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	78%

: 1585-11-1
5-chloro-2,2-diphenylpentanenitrile

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 5-[4-(5-chloro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

Conditions

Conditions	Yield
With sodium carbonate; sodium iodide In acetonitrile at 160℃; under 12901 Torr; for 0.25h; microwave irradiation;	76%

: 960313-85-3
1-cyclopropyl-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: C24H21ClN6O6

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	76%

: 15936-81-9
5‑bromo‑7‑methylindole

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1248590-98-8
5-chloro-1-(1-(7-methyl-1H-indol-5-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial;	76%

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 2-(4-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)butyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetonitrile Reflux;	75.2%

: 102614-43-7
2-chloro-3-fluoro-5,12-dihydro-5-oxobenzothiazolo<3,2-a>quinoline-6-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1028203-07-7
C28H20ClFN4O4S

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	75%

: 1028202-77-8
2-chloro-3-nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1028203-08-8
C28H20ClN5O6S

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	74%

: 960313-87-5
1-tert-butyl-1,4-dihydro-7-methoxy-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: C25H25ClN6O6

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide microwave irradiation;	72%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1018937-88-6
C26H24ClFN4O5

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	70%

: 129722-34-5
7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1314032-14-8
7-(4-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile Reflux; Inert atmosphere;	70%

: 494204-73-8
1-tert-butyl-7-chloro-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1119088-12-8
1-tert-butyl-7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	69%

: 100986-89-8
levofloxacin Q-acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: C25H22ClFN4O5

Conditions

Conditions	Yield
In dimethyl sulfoxide microwave irradiation;	67%

: 93107-29-0
1-cyclopropyl-6-nitro-4-oxo-7-chloro-1,4-dihydroquinoline-3-carboxylic acid

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1119087-10-3
7-(4-(6-chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidin-1-yl)-1-cyclopropyl-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide Microwave irradiation;	67%

: 1-(3-iodopropyl)-2,3-dihydro(4,5,6,7-D4)-1H-1,3-benzodiazol-2-one

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1-{3-[4-(5-chloro-2-oxo-2,3-dihydro-1 H-1,3-benzodiazol-1-yl)piperidin-1-yl]propyl}-2,3-dihydro(4,5,6,7-D4)-1H-1,3-benzodiazol-2-one

Conditions

Conditions	Yield
Stage #1: 1-(3-iodopropyl)-2,3-dihydro(4,5,6,7-D4)-1H-1,3-benzodiazol-2-one; 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one In tetrahydrofuran; N,N-dimethyl-formamide for 2.16667h; Inert atmosphere; Stage #2: With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h;	64%

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1-(1-(4-bromo-2-fluorobenzyl)piperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Inert atmosphere;	63%

: 2164-34-3
2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 85076-06-8
5-Chloro-1-[1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; sodium iodide In N,N-dimethyl-formamide for 60h; Ambient temperature;	60%

: 1089210-20-7
2,3-dihydro-2,2-dimethyl-5-chloro-7-(oxiranyl-methoxy)-benzofuran

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 1089209-50-6
1-((2,3-dihydro-2,2-dimethyl-5-chloro-benzofuran-7-yl)-oxy)-3-(4-(2,3-dihydro-2-oxo-5-chloro-benzoimidazol-1-yl)-piperidin-1-yl)-propan-2-ol

Conditions

Conditions	Yield
In ethanol at 20℃; for 72h;	58%

: 107617-97-0
7-fluoro-2-<(tosyloxy)methyl>-1,4-benzodioxan

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 107617-74-3
5-Chloro-1-[1-(7-fluoro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one

Conditions

Conditions	Yield
With triethylamine; potassium iodide In dimethyl sulfoxide at 80℃; for 20h;	57%

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 625446-22-2
4-bromo-2-fluoroacetophenone

: 1-(1-(1-(4-bromo-2-fluorophenyl)ethyl)piperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one; 4-bromo-2-fluoroacetophenone With titanium(IV) isopropylate at 60℃; for 2h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; Inert atmosphere;	56%

: 3635-70-9
6,7-dimethyl-2-(toluene-4-sulfonyloxymethyl)-2,3-dihydro-benzo[1,4]dioxine

: 53786-28-0
5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

: 85076-21-7
1-[(6,7-Dimethyl-benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chlorobenzimidazol-2-on-1-yl)-piperidine

Conditions

Conditions	Yield
With triethylamine; potassium iodide In dimethyl sulfoxide at 80℃; for 20h;	55%

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Chemical Properties

Molecule structure of 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone (CAS NO.53786-28-0):

IUPAC Name: 6-Chloro-3-piperidin-4-yl-1H-benzimidazol-2-one
Molecular Weight: 251.71206 [g/mol]
Molecular Formula: C₁₂H₁₄ClN₃O
Index of Refraction: 1.605
Molar Refractivity: 65.59 cm³
Molar Volume: 190.2 cm³
Polarizability: 26×10^-24cm³
Melting Point: 228-231 °C(lit.)
XLogP3: 2.6
H-Bond Donor: 2
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Tautomer Count: 2
Exact Mass: 251.08254
MonoIsotopic Mass: 251.08254
Topological Polar Surface Area: 44.4
Heavy Atom Count: 17
Complexity: 306
Canonical SMILES: C1CNCCC1N2C3=C(C=C(C=C3)Cl)NC2=O
InChI: InChI=1S/C12H14ClN3O/c13-8-1-2-11-10(7-8)15-12(17)16(11)9-3-5-14-6-4-9/h1-2,7,9,14H,3-6H2,(H,15,17)
InChIKey: DOAYWDKFDPSTSV-UHFFFAOYSA-N
EINECS: 258-771-6
Product Categories of 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone (CAS NO.53786-28-0): Benzimidazoles; BenzimidazolesHeterocyclic Building Blocks; Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Specification

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone (CAS NO.53786-28-0) is also named as 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one ; 2H-Benzimidazol-2-one,5-chloro-1,3-dihydro-1-(4-piperidinyl)- ; 4-(6-Chloro-1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)piperidine ; 5-Chloro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one ; 5-Chloro-1-(piperidin-4-yl)-1H-benzimidazol-2(3H)-one ; 5-Chloro-1-piperidin-4-yl-1,3-dihydrobenzimidazol-2-one ; R 29676 . 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone (CAS NO.53786-28-0) is white solid.

Product Name

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone

Synthetic route

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Chemical Properties

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Safety Profile

5-Chloro-1-(4-piperidyl)-2-benzimidazolinone Specification

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