5-Methyl-7-methoxyisoflavone supplier

Name
5-Methyl-7-methoxyisoflavone
EINECS 617-342-7
CAS No. 82517-12-2
Article Data3
CAS DataBase
Density 1.212 g/cm³
Solubility
Melting Point 116-120 °C
Formula C₁₇H₁₄O₃
Boiling Point 449.3 °C at 760 mmHg
Molecular Weight 266.296
Flash Point 217.5 °C
Transport Information
Appearance white crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 7-Methoxy-5-methylisoflavone;Methoxyvone;4H-1-Benzopyran-4-one,7-methoxy-5-methyl-3-phenyl-;
PSA 39.44000
LogP 3.77700

Synthetic route

: 860579-89-1
1-(2-hydroxy-4-methoxy-6-methylphenyl)-2-phenylethan-1-one

: 122-51-0
orthoformic acid triethyl ester

: 82517-12-2
5-methyl-7-methoxyisoflavone

Conditions

Conditions	Yield
With piperidine; pyridine Yield given;

: 4179-19-5
1,3-dimethoxy-5-methylbenzene

: 82517-12-2
5-methyl-7-methoxyisoflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 2: piperidine, pyridine View Scheme

: 103-80-0
phenylacetyl chloride

: 82517-12-2
5-methyl-7-methoxyisoflavone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 2: piperidine, pyridine View Scheme

: 64-67-5
diethyl sulfate

: 55338-30-2
7-hydroxy-5-methyl-3-phenyl-chromen-4-one

: 5-methyl-7-ethoxy-isoflavone

: 82517-12-2
5-methyl-7-methoxyisoflavone

Conditions

Conditions	Yield
With potassium carbonate In water

...Expand

: C11H9IO3

: 38111-44-3
phenylzinc(II) bromide

: 82517-12-2
5-methyl-7-methoxyisoflavone

Conditions

Conditions	Yield
at 20℃; Negishi Coupling;

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 3-(2-hydroxy-4-methoxy-6-methylphenyl)-4-phenyl-1H-pyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 2h; Reflux;	95%

: 934-32-7
1H-benzimidazol-2-amine

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1179998-26-5
2-(2-hydroxy-4-methoxy-5-methylphenyl)-3-phenyl-pyrimido[1,2-a]benzimidazole

Conditions

Conditions	Yield
With sodium methylate In methanol at 65℃; for 8h;	93%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 55338-30-2
7-hydroxy-5-methyl-3-phenyl-chromen-4-one

Conditions

Conditions	Yield
With aluminium trichloride In benzene	88%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1428876-28-1
9-methoxy-11-methyl-2H-phenanthro[9,10-c]pyrazole

Conditions

Conditions	Yield
Stage #1: 5-methyl-7-methoxyisoflavone With hydrazine hydrate In ethanol at 80℃; Stage #2: In ethanol; water at 20℃; for 4h; Inert atmosphere; Irradiation;	86%

: 50-01-1
guanidine hydrochloride

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1338784-55-6
2-amino-4-(2-hydroxy-4-methoxy-6-methylphenyl)-5-phenylpyrimidine

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride; 5-methyl-7-methoxyisoflavone With sodium hydroxide In ethanol for 4h; Reflux; Stage #2: With hydrogenchloride In ethanol; water	82%

: 7200-25-1
Arg

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 2-amino-5-[4-(2-hydroxy-4-methoxy-6-methylphenyl)-5-phenylpyrimidin-2-ylamino]pentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 5h; Reflux;	81%

: 1820-80-0
3-aminopyrazole

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1307770-03-1
6-phenyl-7-(2-hydroxy-4-methoxy-6-methylphenyl)pyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With sodium methylate In methanol at 70℃; for 13h;	79%

: 360-97-4
5-Aminoimidazole-4-carboxamide

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1380484-08-1
8-carbamoyl-4-(2-hydroxy-4-methoxy-6-methylphenyl)-3-phenylimidazo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 100℃; for 0.166667h; Microwave irradiation;	79%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 107-91-5
cyanoacetic acid amide

: 1456626-63-3
3-cyano-6-(4-methoxy-6-methyl-2-hydroxyphenyl)-5-phenylpyridin-2(1H)-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1.5h; Reflux;	78%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 53666-79-8
5-amino-2H-pyrazol-3-ol

: 1233690-15-7, 1351362-71-4
C20H17N3O3

Conditions

Conditions	Yield
With sodium methylate In methanol for 16h; Reflux; chemoselective reaction;	77%

: 2-cyanothioacetamide

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1427272-62-5
3-cyano-6-(4-methoxy-6-methyl-2-hydroxyphenyl)-5-phenylpyridine-2(1H)-thione

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 5h;	76%

: 31230-17-8
3-methyl-5-aminopyrazole

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1606136-74-6
2-methyl-6-phenyl-7-(2-hydroxyl-4-methoxy-6-methylphenyl)pyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With sodium methylate In ethanol for 24h; Reflux; chemoselective reaction;	75%

: 2114-02-5
amidinothiocarbamide

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1233943-89-9
1-[4-(2-hydroxy-4-methoxy-6-methylphenyl)-5-phenylpyrimidin-2-yl]thiourea

Conditions

Conditions	Yield
With sodium methylate In methanol for 3.5h; Reflux;	65%

: 1450-93-7, 36946-29-9, 42383-61-9
2-aminoimidazole hemisulfate

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1357294-47-3
5-(2-hydroxy-4-methoxy-6-methylphenyl)-6-phenylimidazo[1,2-a]pyrimidine

Conditions

Conditions	Yield
Stage #1: 2-aminoimidazole hemisulfate; 5-methyl-7-methoxyisoflavone With sodium hydroxide In water; dimethyl sulfoxide at 100℃; for 0.5h; Microwave irradiation; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide	65%

: 16617-46-2
3-Amino-4-cyanopyrazole

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1365659-26-2
3-cyano-6-phenyl-7-(2-hydroxyl-4-methoxy-6-methylphenyl)pyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With sodium methylate In methanol at 70℃; for 16h;	59%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 61-82-5
4H-1,2,4-triazol-3-amine

: 1232561-85-1
6-phenyl-7-(2-hydroxy-4-methoxy-6-methylphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

Conditions

Conditions	Yield
With sodium methylate In dimethyl sulfoxide at 100℃; for 0.2h; Microwave irradiation;	54%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 1003-35-6
3-amino-5-hydroxy-1,2,4-triazole

: 1232562-06-9
3-hydroxy-6-phenyl-7-(2-hydroxy-4-methoxy-6-methylphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

Conditions

Conditions	Yield
With sodium methylate In dimethyl sulfoxide at 100℃; for 0.25h; Microwave irradiation;	50%

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 112953-45-4
[(5-Methyl-4-oxo-3-phenyl-4H-1-benzopyran-7-yl)oxy]acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 88 percent / AlCl3 / benzene 2: 78.5 percent / K2CO3 3: 76.2 percent / NaOH View Scheme

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 112953-75-0
(5-Methyl-4-oxo-3-phenyl-4H-chromen-7-yloxy)-acetic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / AlCl3 / benzene 2: 78.5 percent / K2CO3 View Scheme

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 4-methoxy-6-methyl-7a-phenyl-1a,7a-dihydrobenzopyrano[2,3-b]azirin-7-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; hydroxylamine hydrochloride / ethanol / Reflux 2: ethanol; water / 1 h / 20 °C / Inert atmosphere; Irradiation View Scheme

: 82517-12-2
5-methyl-7-methoxyisoflavone

: C17H15NO3

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; triethylamine In ethanol Reflux;

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 860579-89-1
1-(2-hydroxy-4-methoxy-6-methylphenyl)-2-phenylethan-1-one

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 60℃;

: 82517-12-2
5-methyl-7-methoxyisoflavone

: 7-hydroxy-3-methoxy-1-methyl-6H-naphtho[2,3-c]chromen-6-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 60 °C 2: toluene-4-sulfonic acid / toluene; para-xylene / 150 °C View Scheme

5-Methyl-7-methoxyisoflavone Chemical Properties

IUPAC Name: 7-Methoxy-5-methyl-3-phenylchromen-4-one
Molecular Formula: C₁₇H₁₄O₃
Molecular Weight: 266.29 g/mol
Canonical SMILES: CC1=CC(=CC2=C1C(=O)C(=CO2)C3=CC=CC=C3)OC
InChI: InChI=1S/C17H14O3/c1-11-8-13(19-2)9-15-16(11)17(18)14(10-20-15)12-6-4-3-5-7-12/h3-10H,1-2H3
Product Categories: Iso-Flavones
XLogP3-AA: 3.5
H-Bond Acceptor: 3
Surface Tension: 46.2 dyne/cm
Density: 1.212 g/cm³
Flash Point: 217.5 °C
Enthalpy of Vaporization: 70.79 kJ/mol
Boiling Point: 449.3 °C at 760 mmHg
Melting Point: 116-120 °C
Vapour Pressure of 5-Methyl-7-methoxyisoflavone (CAS NO.82517-12-2): 2.9E-08 mmHg at 25 °C

5-Methyl-7-methoxyisoflavone History

During the search for new anabolics in the 1970's, researchers strived to develop a compound that didn't have the pharmaceutical steroid status. The patent for methoxyflavone was first filed in 1977 by Chinoin, a Hungarian pharmaceutical company and leader in flavonoid research and knowledge. Then, in the 1980's, livestock producers introduced it as a new compound to increase lean mass in animals. Now, some 20 years later, with the end of its patent protection (which means anyone can copy the product, which is easy, since patents have to list exact manufacturing techniques), a new supplement, called methoxyisoflavone, popped onto the performance-supplement market... with no real science to back its claims.Unfortunately, patents don't mean a product works. They just mean the product is patented. In addition, methoxyflavones appear to have negative effects on important testosterone-conversion enzymes, whereby it inhibits the enzyme responsible for converting precursor hormones into testosterone. And, due to its similar structure to ipriflavone, it may even enhance the effects of estrogen in certain parts of the body (which isn't in the least bit beneficial for men trying to put on muscle mass).

5-Methyl-7-methoxyisoflavone Uses

5-Methyl-7-methoxyisoflavone (CAS NO.82517-12-2) is used for sports and fitness support (Enhancing Performance) and it is a chemical derivative of Ipriflavone, but it is marketed as a bodybuilding aid.

5-Methyl-7-methoxyisoflavone Safety Profile

Safety Statements of 5-Methyl-7-methoxyisoflavone (CAS NO.82517-12-2): 24/25
S24/25: Avoid contact with skin and eyes.

5-Methyl-7-methoxyisoflavone Specification

5-Methyl-7-methoxyisoflavone (CAS NO.82517-12-2), its Synonyms are Methyl-7-methoxy-isoflavone, 5- ; 7-Methoxy-5-methylisoflavone ; 5-Methyl-7-methoxyisoflavone 99+% . It is white crystalline powder.

Product Name

5-Methyl-7-methoxyisoflavone

Synthetic route

5-Methyl-7-methoxyisoflavone Chemical Properties

5-Methyl-7-methoxyisoflavone History

5-Methyl-7-methoxyisoflavone Uses

5-Methyl-7-methoxyisoflavone Safety Profile

5-Methyl-7-methoxyisoflavone Specification

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