6-Cyano-2-Naphthol supplier | CasNO.52927-22-7

Name
6-Cyano-2-naphthol
EINECS 628-663-7
CAS No. 52927-22-7
Article Data36
CAS DataBase
Density 1.28 g/cm³
Solubility
Melting Point 165.5-170.5 °C(lit.)
Formula C₁₁H₇NO
Boiling Point 383.1 °C at 760 mmHg
Molecular Weight 169.183
Flash Point 185.5 °C
Transport Information
Appearance brown crystalline solid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Cyano-6-hydroxynaphthalene;2-Hydroxy-6-naphthonitrile;6-Cyano-2-hydroxynaphthalene;6-Hydroxy-2-naphthalenecarbonitrile;
PSA 44.02000
LogP 2.41708

Synthetic route

: 939822-86-3
6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; triethylamine In dimethyl sulfoxide at 20℃; for 6h; Electrolysis; Green chemistry;	94%

: 67886-70-8
2-cyano-6-methoxynaphthalene

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
	91%
With tetrachlorosilane; borontrifluoride acetic acid; lithium iodide In toluene; acetonitrile at 70℃; for 10h;	83%
With boron tribromide In dichloromethane at -78 - 20℃; for 16h; Inert atmosphere;	69%
With sodium cyanide In dimethyl sulfoxide at 160 - 170℃; for 12h;	62%
With boron tribromide

: 145369-29-5
trifluoromethanesulfonic acid 6-cyano-naphthalen-2-yl ester

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; triethylamine In dimethyl sulfoxide at 20℃; for 9h; Electrolysis; Green chemistry;	91%

: 15231-91-1
6-bromo-naphthalen-2-ol

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With CuCN In N,N-dimethyl-formamide at 160 - 170℃; for 3h;	83%
	56%
In ethanol; N,N-dimethyl-formamide
In ethanol; N,N-dimethyl-formamide

: 15231-91-1
6-bromo-naphthalen-2-ol

: copper(l) cyanide

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 160 - 170℃; for 4h; Inert atmosphere;	83%
In N,N-dimethyl-formamide at 135℃; for 18h;	62%
In N,N-dimethyl-formamide at 150℃;	60%

: 78119-82-1
6-hydroxynaphthalene-2-carbaldehyde

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In dimethyl sulfoxide at 100℃; for 1h;	70%

: 860363-16-2
6-acetoxy-[2]naphthonitrile

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With potassium hydroxide

: 78119-72-9
acetate of α,α,α',α'-tetrabromo-3,4-xylenol

: 107-13-1
acrylonitrile

A: 52927-22-7
6-cyano-2-naphthol

B: 130200-58-7
7-hydroxynaphthalene-2-carbonitrile

Conditions

Conditions	Yield
1) NaI, DMF; 2) hydrolysis; Yield given. Multistep reaction. Title compound not separated from byproducts;

...Expand

: 78119-71-8
benzoate of α,α,α',α'-tetrabromo-3,4-xylenol

: 107-13-1
acrylonitrile

A: 52927-22-7
6-cyano-2-naphthol

B: 130200-58-7
7-hydroxynaphthalene-2-carbonitrile

Conditions

Conditions	Yield
1) NaI, DMF; 2) NaOH, CH3OH; Yield given. Multistep reaction;
1) NaI, DMF; 2) NaOH, CH3OH; Yield given. Multistep reaction. Title compound not separated from byproducts;

...Expand

: 6343-72-2
6-bromonaphthalen-2-yl acetate

: 544-92-3
copper(I) cyanide

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With pyridine; copper(II) sulfate In N,N-dimethyl-formamide

: 15231-91-1
6-bromo-naphthalen-2-ol

: 544-92-3
copper(I) cyanide

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone at 160℃; for 3h; Substitution;

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With boron tribromide demethylation;

: 3845-63-4
3,4-dimethylphenyl benzoate

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 91 percent / bromosuccinimide, azoisobutyronitrile / CCl4 / 12 h / Heating; Irradiation 2: 91 percent / NBS, azoisobutyronitrile / CCl4 / 12 h / Heating 3: 1) NaI, DMF; 2) NaOH, CH3OH View Scheme
Multi-step reaction with 2 steps 1: 88.5 percent / bromosuccinimide, azoisobutyronitrile / CCl4 / 25 h / Heating; Irradiation 2: 1) NaI, DMF; 2) NaOH, CH3OH View Scheme

: benzoate of α,α,α'-tribromo-3,4-xylenol

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / NBS, azoisobutyronitrile / CCl4 / 12 h / Heating 2: 1) NaI, DMF; 2) NaOH, CH3OH View Scheme

: 6343-72-2
6-bromonaphthalen-2-yl acetate

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper (II)-sulfate; pyridine / 180 - 190 °C 2: methanol. KOH-solution View Scheme

: 872-50-4
1-methyl-pyrrolidin-2-one

: 15231-91-1
6-bromo-naphthalen-2-ol

: iron(III) chloride

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With hydrogenchloride; CaCl2 In water

...Expand

: 1123760-79-1
C11H9NO2

A: 52927-22-7
6-cyano-2-naphthol

B: 91059-47-1
6-cyano-1-naphthol

Conditions

Conditions	Yield
With perchloric acid In water at 25℃; for 10h; Kinetics; Concentration;

: 135-19-3
β-naphthol

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine / acetic acid 1.2: 3 h / Reflux 2.1: N,N-dimethyl-formamide / 4 h / 160 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid; tin; bromine / 3 h / Reflux 2: N,N-dimethyl-formamide / 4 h / 160 - 170 °C / Inert atmosphere View Scheme

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C 1.2: 2 h / 20 °C 2.1: sodium azide; trifluorormethanesulfonic acid / acetonitrile / 1 h / 0 - 20 °C 3.1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C 4.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux 5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C 6.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C
1.2: 2 h / 20 °C
2.1: sodium azide; trifluorormethanesulfonic acid / acetonitrile / 1 h / 0 - 20 °C
3.1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C
4.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux
5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C
6.1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere
View Scheme

: 16252-53-2
6-Methoxy-2-hydroxymethylen-1-tetralon

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium azide; trifluorormethanesulfonic acid / acetonitrile / 1 h / 0 - 20 °C 2: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C 3: toluene-4-sulfonic acid / toluene / 16 h / Reflux 4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C 5: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere View Scheme

: 606494-99-9
1-hydroxy-2-cyano-6-methoxy-1,2,3,4-tetrahydronaphthalene

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 16 h / Reflux 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C 3: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere View Scheme

: 34093-07-7
6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonitrile

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C 2: toluene-4-sulfonic acid / toluene / 16 h / Reflux 3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C 4: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere View Scheme

: 79215-28-4
6-methoxy-3,4-dihydronaphthalene-2-carbonitrile

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 16 h / 90 °C 2: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere View Scheme

: 16712-64-4
6-Hydroxy-2-naphthoic acid

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 70 °C 2.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 25 °C 3.1: trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 - 25 °C 3.2: 16 h / 25 °C View Scheme

: 62529-01-5
6-hydroxynaphthalene-2-carboxamide

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Stage #1: 6-hydroxynaphthalene-2-carboxamide With trifluoroacetic anhydride In tetrahydrofuran at 0 - 25℃; for 0.5h; Stage #2: With pyridine In tetrahydrofuran at 25℃; for 16h;

: C11H7ClO2

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 25 °C 2.1: trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 - 25 °C 2.2: 16 h / 25 °C View Scheme

: 15231-91-1
6-bromo-naphthalen-2-ol

: 126747-14-6
4-cyanophenylboronic acid

: 52927-22-7
6-cyano-2-naphthol

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 8h; Suzuki-Miyaura Coupling; High pressure; Inert atmosphere;

: 52927-22-7
6-cyano-2-naphthol

: 199387-77-4
6-(aminomethyl)naphthalen-2-ol

Conditions

Conditions	Yield
With ammonia; hydrogen; nickel In methanol; water	100%

: 52927-22-7
6-cyano-2-naphthol

: 32443-99-5
D-cysteine hydrochloride

: 122364-82-3
(S)-2-(6-hydroxynaphthalen-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 80℃; for 5h;	100%

: 52927-22-7
6-cyano-2-naphthol

: 100-39-0
benzyl bromide

: 66217-29-6
6-(benzyloxy)-2-cyanonaphthalene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	100%

: 52927-22-7
6-cyano-2-naphthol

: 104-81-4
4-Methylbenzyl bromide

: 6-((4-methylbenzyl)oxy)-2-naphthonitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	98%

: 110-53-2
1-Bromopentane

: 52927-22-7
6-cyano-2-naphthol

: 6-(pentyloxy)-2-naphthonitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	98%

: 52927-22-7
6-cyano-2-naphthol

: (Z)-tert-butyl (3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene) carbamate

: tert-butyl ((7aS,10aS)-3-cyano-7a-methyl-10-oxo-9-phenyl-7a,8,9,10-tetrahydro-10aHnaphtho[1',2':4,5]furo[2,3-c]pyrazol-10a-yl)carbamate

Conditions

Conditions	Yield
With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione In dichloromethane at 20℃; for 1h; stereoselective reaction;	98%

: 52927-22-7
6-cyano-2-naphthol

: (Z)-tert-butyl (3-methyl-5-oxo-1-(p-tolyl)-1H-pyrazol-4(5H)-ylidene) carbamate

: tert-butyl ((7aS,10aS)-3-cyano-7a-methyl-10-oxo-9-(p-tolyl)-7a,8,9,10-tetrahydro-10aHnaphtho[1',2':4,5]furo[2,3-c]pyrazol-10a-yl)carbamate

Conditions

Conditions	Yield
With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione In dichloromethane at 20℃; for 1h; stereoselective reaction;	98%

: 52927-22-7
6-cyano-2-naphthol

: 5720-05-8
4-methylphenylboronic acid

: 944042-22-2
6-p-tolyl-2-naphthonitrile

Conditions

Conditions	Yield
Stage #1: 6-cyano-2-naphthol With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 100℃; for 3h; Inert atmosphere; Stage #2: 4-methylphenylboronic acid With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In 1,4-dioxane at 100 - 110℃; Suzuki-Miyaura coupling; Inert atmosphere;	97%

: 91-01-0
1,1-Diphenylmethanol

: 52927-22-7
6-cyano-2-naphthol

: 5-benzhydryl-6-hydroxy-2-naphthonitrile

Conditions

Conditions	Yield
With stannic bromide In dichloromethane at 20℃; for 24h; Friedel-Crafts Alkylation; Inert atmosphere;	97%

: 358-23-6
trifluoromethylsulfonic anhydride

: 52927-22-7
6-cyano-2-naphthol

: 145369-29-5
trifluoromethanesulfonic acid 6-cyano-naphthalen-2-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 48h;	95%
With triethylamine In dichloromethane at 20℃;	93%
With pyridine In dichloromethane at 20℃;	79.1%

: 52927-22-7
6-cyano-2-naphthol

: 62921-76-0
2,5,8,11-tetraoxatridecan-13-ol tosylate

: tetraethylene glycol methyl 6-cyano-2-naphthyl ether

Conditions

Conditions	Yield
With potassium hydroxide In 1,2-dimethoxyethane at 80℃; for 16h; Williamson etherification;	95%

: 52927-22-7
6-cyano-2-naphthol

: 98-59-9
p-toluenesulfonyl chloride

: 939822-86-3
6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	95%
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	95%
Stage #1: 6-cyano-2-naphthol With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h;	90%
With dmap; triethylamine In dichloromethane at 20℃;

: 52927-22-7
6-cyano-2-naphthol

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1290542-49-2
methyl 4-(2-cyanonaphthalen-6-yl)benzoate

Conditions

Conditions	Yield
Stage #1: 6-cyano-2-naphthol With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 100℃; for 3h; Inert atmosphere; Stage #2: 4-methoxycarbonylphenylboronic acid With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In 1,4-dioxane at 100 - 110℃; Suzuki-Miyaura coupling; Inert atmosphere;	95%

: 52927-22-7
6-cyano-2-naphthol

: 4559-70-0
Diphenylphosphine oxide

: 1378042-96-6
6-(diphenylphosphoryl)-2-naphthonitrile

Conditions

Conditions	Yield
Stage #1: 6-cyano-2-naphthol With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In acetonitrile at 100℃; for 3h; Inert atmosphere; Stage #2: Diphenylphosphine oxide With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In acetonitrile at 100℃; for 18h; Inert atmosphere;	95%

: 52927-22-7
6-cyano-2-naphthol

: [(1,10-phenanthroline)2Cu][O2CCF2Cl]

: 1261682-37-4
6-(difluoromethoxy)-2-naphthonitrile

Conditions

Conditions	Yield
With sodium hydroxide; phenol In N,N-dimethyl-formamide at 75℃; for 4h; Sealed tube; Inert atmosphere;	95%

: 2446-83-5
di-isopropyl azodicarboxylate

: 52927-22-7
6-cyano-2-naphthol

: C19H21N3O5

Conditions

Conditions	Yield
With 1,3,4-triphenyl-1,2,4-triazolium hexafluorophosphate; potassium tert-butylate In chloroform at 20℃; for 4h; Inert atmosphere;	95%

: 52927-22-7
6-cyano-2-naphthol

: 1-bromo-7-(4-bromophenylthio)heptane

: 1-(4-bromophenylthio)-7-(6-cyano-2-naphthyloxy)heptane

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetonitrile for 12h; Williamson Ether Synthesis; Reflux;	95%

: 52927-22-7
6-cyano-2-naphthol

: 124-63-0
methanesulfonyl chloride

: 939822-84-1
6-cyanonaphthalen-2-yl methanesulfonate

Conditions

Conditions	Yield
Stage #1: 6-cyano-2-naphthol With triethylamine In toluene at 0℃; for 0.166667h; Stage #2: methanesulfonyl chloride In toluene at 20℃; for 12h;	93%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	91%

: 52927-22-7
6-cyano-2-naphthol

: 106-95-6
allyl bromide

: 6-(allyloxy)-2-naphthonitrile

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 70℃; for 4h;	93%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;

: 109-65-9
1-bromo-butane

: 52927-22-7
6-cyano-2-naphthol

: 66217-27-4
6-(butyloxy)-2-naphthonitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	93%
With potassium carbonate In acetonitrile at 80℃; Williamson Ether Synthesis;	93%
With potassium carbonate In acetonitrile at 80℃;	93%

: 766-47-2
1-ethynyl-2-methylbenzene

: 52927-22-7
6-cyano-2-naphthol

: 2-(o-tolyl)naphtho[2,1-b]furan-7-carbonitrile

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; 2,3-dicyano-5,6-dichloro-p-benzoquinone In chloroform; toluene at 80℃; for 2h; Inert atmosphere; Schlenk technique;	93%

: 1493-13-6
trifluorormethanesulfonic acid

: 52927-22-7
6-cyano-2-naphthol

: 145369-29-5
trifluoromethanesulfonic acid 6-cyano-naphthalen-2-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	93%

: 100-42-5
styrene

: 52927-22-7
6-cyano-2-naphthol

: 6-isocyano-1-(1-phenylethyl)naphthalen-2-ol

Conditions

Conditions	Yield
With phosphorous acid In water; 1,2-dichloro-ethane at 100℃; for 18h; Schlenk technique; regioselective reaction;	93%

: 52927-22-7
6-cyano-2-naphthol

: 1192026-57-5
5-bromo-6-hydroxy-2-naphthonitrile

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃;	92%
With bromine; acetic acid at 25℃; for 2.5h;
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 4h; Inert atmosphere;
With pyridinium perbromide hydrobromide In acetonitrile at 0℃;
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere; Schlenk technique;

: 866562-23-4
1-phenyl-3-(trimethylsilyl)prop-2-yn-1-yl acetate

: 52927-22-7
6-cyano-2-naphthol

: (R)-2-methylene-1-phenyl-1,2-dihydronaphtho[2,1-b]furan-7-carbonitrile

Conditions

Conditions	Yield
With (S)-N-[(3,5-dimethylphenyl)(pyridin-2-yl)methylene]-1-[2-(diphenylphosphino)phenyl]ethanamine; copper(II) acetate monohydrate; N-ethyl-N,N-diisopropylamine In methanol at -20℃; for 12h; Schlenk technique; Inert atmosphere; enantioselective reaction;	92%
Stage #1: 1-phenyl-3-(trimethylsilyl)prop-2-yn-1-yl acetate; 6-cyano-2-naphthol With (S)-N-[(3,5-dimethylphenyl)(pyridin-2-yl)methylene]-1-[2-(diphenylphosphino)phenyl]ethanamine; copper(II) acetate monohydrate In methanol for 1h; Inert atmosphere; Stage #2: With N-ethyl-N,N-diisopropylamine In methanol for 24h; Inert atmosphere;	90%

: 52927-22-7
6-cyano-2-naphthol

: C10H9BrOS2

: 1-(3-bromobenzoyl)-2-(methylthio)-4,5-dioxo-4,5-dihydronaphtho[2,1-b]thiophene-8-carbonitrile

Conditions

Conditions	Yield
Stage #1: 6-cyano-2-naphthol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) bis(trifluoromethanesulfonate) In acetic acid at 100℃; for 0.166667h; Stage #2: C10H9BrOS2 In acetic acid at 100℃; for 4h; chemoselective reaction;	92%

: 52927-22-7
6-cyano-2-naphthol

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 1231261-78-1
6-cyanonaphthalen-2-yl bis(2-oxo-3-oxazolidinyl)phosphoramide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; Inert atmosphere;	91%

6-Cyano-2-Naphthol Chemical Properties

Molecular Structure of 6-Cyano-2-Naphthol (CAS NO.52927-22-7):

Molecular Formula: C₁₁H₇NO
Molar mass: 169.17938g/mol
Density: 1.28 g/cm³
Flash Point: 185.5 °C
Melting point: 165.5-170.5 °C
Appearance: Brown Crystalline Solid
Boiling Point: 383.1 °C at 760 mmHg
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 33.02Å²
Index of Refraction: 1.692
Molar Refractivity: 50.4 cm³
Molar Volume: 131.5 cm³
Surface Tension: 64.7 dyne/cm
Enthalpy of Vaporization: 65.64 kJ/mol
Vapour Pressure: 2.04E-06 mmHg at 25°C
Product Categoriy: Aromatics and Nitrogen Compounds; Cyanides/Nitriles; Chalcones; Functional Materials

6-Cyano-2-Naphthol Safety Profile

Hazard Codes: Xi
Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3

6-Cyano-2-Naphthol Specification

6-Cyano-2-Naphthol , with CAS number of 52927-22-7, can be called 6-Hydroxy-2-naphthalenecarbonitrile ; 2-Cyano-6-hydroxynaphthalene ; 2-Hydroxy-6-naphthonitrile . 6-Cyano-2-Naphthol (CAS NO.52927-22-7) is functional Material,and can be used for building blocks forliquid crystals.

Product Name

6-Cyano-2-naphthol

Synthetic route

6-Cyano-2-Naphthol Chemical Properties

6-Cyano-2-Naphthol Safety Profile

6-Cyano-2-Naphthol Specification

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