• Name

  6-Fluoro-2-methylindole

• EINECS
• CAS No. 40311-13-5
• Article Data8
• CAS DataBase
• Density 1.219 g/cm³
• Solubility
• Melting Point 100
• Formula C₉H₈FN
• Boiling Point 269.24 °C at 760 mmHg
• Molecular Weight 149.168
• Flash Point 116.632 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 6-Fluoro-2-methylindole;
• PSA 15.79000
• LogP 2.61540

Synthetic route

39616-99-4

1-(4-fluoro-2-nitrophenyl)propan-2-one

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
With [2,2]bipyridinyl; carbon monoxide; dodecacarbonyltriruthenium(0) In toluene Product distribution / selectivity;	97%
With carbon monoxide; cyclopentadienyl iron(II) dicarbonyl dimer In toluene at 120℃; for 9h; Product distribution / selectivity;	95%
With carbon monoxide; tin(ll) chloride; bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 120℃; for 9h; Product distribution / selectivity;	91%

39616-99-4

1-(4-fluoro-2-nitrophenyl)propan-2-one

66-71-7

1,10-Phenanthroline

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
dodecacarbonyltriruthenium(0) In toluene Product distribution / selectivity;	94%

39616-99-4

1-(4-fluoro-2-nitrophenyl)propan-2-one

A

6-fluoro-2-methyl-2,3-dihydro-1H-indole

B

40311-13-5

6-fluoro-2-methyl-1H-indole

C

6-fluoro-1-hydroxy-2-methylindole

Conditions

Conditions	Yield
With hydrogen; 5%-palladium/activated carbon In butan-1-ol at 100℃; for 24h; Product distribution / selectivity;	A 25% B 70% C 3%
With hydrogen; 5%-palladium/activated carbon In 2-ethoxy-ethanol at 20℃; for 24h; Product distribution / selectivity;	A 11% B 17% C 55%

...Expand

5-fluoro-2-iodoaniline

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / -30 - 20 °C 2: copper(l) iodide / N,N-dimethyl-formamide / 1 h / Reflux View Scheme

1383976-65-5

5-fluoro-2-prop-1-ynylphenylamine

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
With copper(l) iodide In N,N-dimethyl-formamide for 1h; Reflux;	1.1 g

(E)-1-fluoro-4-(2-nitroprop-1-en-1-yl)benzene

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
With 1,10-Phenanthroline; [(1,10-phenanthroline)Pd](tetrafluoroborate)2; carbon monoxide; triethylamine In acetonitrile at 150℃; under 15001.5 Torr; for 2.5h; Schlenk technique; Inert atmosphere;	57 %Spectr.

446-09-3

2-bromo-5-fluoronitrobenzene

40311-13-5

6-fluoro-2-methyl-1H-indole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: caesium carbonate; palladium diacetate; triphenylphosphine / toluene / 5 h / 120 °C / Schlenk technique; Inert atmosphere 2: zinc; acetic acid / ethanol / 4 h / 70 °C / Inert atmosphere View Scheme

40311-13-5

6-fluoro-2-methyl-1H-indole

98-86-2

acetophenone

1621004-91-8

2-methyl-6-fluoro-3-(1-phenylethenyl)-1H-indole

Conditions

Conditions	Yield
With 4-n-butyl-4-(3-sulfopropyl)thiomorpholinium 1,1-dioxide trifluoromethane sulfonate In neat (no solvent) at 60℃; for 0.25h; Ionic liquid; Green chemistry;	95%

40311-13-5

6-fluoro-2-methyl-1H-indole

2,2,2-trifluoroethyl(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate

6-fluoro-2-methyl-3-(2,2,2-trifluoroethyl)-1H-indole

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-pyridine In dichloromethane at 25℃; for 0.166667h; regioselective reaction;	94%

617-35-6

2-oxo-propionic acid ethyl ester

40311-13-5

6-fluoro-2-methyl-1H-indole

ethyl 2-(6-fluoro-2-methyl-1H-indol-3-yl)acrylate

Conditions

Conditions	Yield
With 3-(1,1-dioxido-4-(3-(3-(3-sulfopropyl)-1H-imidazol-3-ium-1-yl)propyl)thiomorpholino-4-ium)propane-1-sulfonate trifluoromethanesulfonate In acetic acid butyl ester at 80℃; for 0.5h; Green chemistry;	93%

606092-05-1

3-bromo-6-fluoro-2-methyl indole

40311-13-5

6-fluoro-2-methyl-1H-indole

3-chlorosuffonyl-1-(N,N-dimethylsulfamoyl)-3-chlorosulfonyl-1,2,4-triazole

3-chlorosuffonyl-1-(N,N-dimethylsulfamoyl)-3-chlorosulfonyl-1,2,4-triazole

1643-19-2

tetrabutylammomium bromide

348635-87-0

3-[(3-bromo-6-fluoro-2-methyl-1H-indol-1-yl)sulfonyl]-N,N-dimethyl-1H-1,2,4-triazole-1-sulfonamide

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene	91.2%

...Expand

40311-13-5

6-fluoro-2-methyl-1H-indole

(S)-6-fluoro-2-methylindoline

Conditions

Conditions	Yield
With hydrogenchloride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (S,R)-ZhaoPhos; hydrogen; acetic acid In dichloromethane at 25℃; under 30402 Torr; for 48h; Autoclave; enantioselective reaction;	90%

40311-13-5

6-fluoro-2-methyl-1H-indole

117-34-0

2,2-diphenylacetic acid

C23H18FN

Conditions

Conditions	Yield
With aluminium(III) triflate; Co(acac)3; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 130℃; under 22502.3 Torr; for 18h; Autoclave; Sealed tube;	88%

103-82-2

phenylacetic acid

40311-13-5

6-fluoro-2-methyl-1H-indole

C17H16FN

Conditions

Conditions	Yield
With aluminium(III) triflate; Co(acac)3; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 160℃; under 22502.3 Torr; for 18h; Autoclave; Sealed tube;	70%

40311-13-5

6-fluoro-2-methyl-1H-indole

99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0

fullerene-C60

C69H5FN2

Conditions

Conditions	Yield
With trifluoroacetic acid; sodium nitrite In dimethyl sulfoxide; 1,2-dichloro-benzene at 25℃; for 1h; Sealed tube; regioselective reaction;	63%

40311-13-5

6-fluoro-2-methyl-1H-indole

102-96-5

(2-nitroethenyl)benzene

C17H15FN2O2

Conditions

Conditions	Yield
With C66H64Ag2N8O4(2+)*2F6P(1-); palladium diacetate In isopropyl alcohol at 30℃; for 24h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique;	61%

40311-13-5

6-fluoro-2-methyl-1H-indole

606092-05-1

3-bromo-6-fluoro-2-methyl indole

Conditions

Conditions	Yield
With hydrogen bromide; dimethyl sulfoxide In water; toluene at 18 - 22℃; for 8 - 9h; Product distribution / selectivity;

40311-13-5

6-fluoro-2-methyl-1H-indole

3-bromo-6-fiuoro-2-methylindole

3-bromo-6-fiuoro-2-methylindole

606092-05-1

3-bromo-6-fluoro-2-methyl indole

Conditions

Conditions	Yield
With hydrogen bromide In water; dimethyl sulfoxide; toluene

40311-13-5

6-fluoro-2-methyl-1H-indole

N-(2-((6-fluoro-2-methyl-1H-indol-3-yl)methyl)phenyl)benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 1,2-dichloro-ethane / 12 h / 50 °C 2: pyridine / dichloromethane / 12 h / 0 - 20 °C View Scheme

40311-13-5

6-fluoro-2-methyl-1H-indole

6-fluoro-2-methyl-1'-(phenylsulfonyl)spiro[indole-3,2'-indoline]

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: trifluoroacetic acid / 1,2-dichloro-ethane / 12 h / 50 °C 2: pyridine / dichloromethane / 12 h / 0 - 20 °C 3: [bis(acetoxy)iodo]benzene / 0.5 h / 20 °C View Scheme

5344-90-1

2-Aminobenzyl alcohol

40311-13-5

6-fluoro-2-methyl-1H-indole

C16H15FN2

Conditions

Conditions	Yield
With trifluoroacetic acid In 1,2-dichloro-ethane at 50℃; for 12h;

6-Fluoro-2-methylindole Specification