7-Acetoxy-4-Methylcoumarin supplier

Name
7-Acetoxy-4-methylcoumarin
EINECS 220-386-6
CAS No. 2747-05-9
Article Data50
CAS DataBase
Density 1.263g/cm³
Solubility
Melting Point 149-150 ºC
Formula C12H10 O4
Boiling Point 371.4°Cat760mmHg
Molecular Weight 218.209
Flash Point 191.5°C
Transport Information
Appearance beige crystalline flakes and needles
Safety S26;S36
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols
Synonyms Coumarin,7-hydroxy-4-methyl-, acetate (7CI,8CI); Umbelliferone, 4-methyl-, acetate(6CI); 4-Methyl-7-acetoxycoumarin; 4-Methylumbelliferone 7-acetate;4-Methylumbelliferone acetate; 4-Methylumbelliferyl acetate;7-(Acetyloxy)-4-methyl-2H-1-benzopyran-2-one; 7-(Acetyloxy)-4-methylcoumarin;7-Acetoxy-4-methylcoumarin; 7-Hydroxy-4-methylcoumarin acetate; NSC 1059; NSC 31658;NSC 44763; NSC 688806; b-Methylumbelliferone acetate
PSA 56.51000
LogP 2.02670

7-Acetoxy-4-Methylcoumarin Chemical Properties

MF: C₁₂H₁₀O₄
MW: 218.21
EINECS: 220-386-6
Storage temp: −20°C
Density: 1.263 g/cm³
Flash Point: 191.5 °C
Product Categories: Coumarin
Index of Refraction: 1.559
Melting Point: 149-150 °C(lit.)
Enthalpy of Vaporization: 61.85 kJ/mol
Boiling Point: 371.4 °C at 760 mmHg
Vapour Pressure: 1.03E-05 mmHg at 25°C
Appearance: beige crystalline flakes and needles
IUPAC Name: (4-methyl-2-oxochromen-7-yl) acetate
Synonyms: MUB Acetate ; MU-AC ; Muacetate ; 2H-1-benzopyran-2-one, 7-(acetyloxy)-4-methyl- ; 4-Methyl-2-oxo-2h-chromen-7-yl acetate ; 7-Acetoxy-4-methylcoumarin ; 7-(Acetyloxy)-4-methyl-2-benzopyrone ; Acetic acid 4-methylumbelliferyl ester
Following is the molecular structure of 7-Acetoxy-4-Methylcoumarin (CAS NO.2747-05-9):

7-Acetoxy-4-Methylcoumarin Uses

As a Pharmaceutical intermediates,7-Acetoxy-4-Methylcoumarin (CAS NO.2747-05-9) is used for the production of anti-allergy cromolyn sodium.

7-Acetoxy-4-Methylcoumarin Production

Resorcinol derived 7-Acetoxy-4-Methylcoumarin (CAS NO.2747-05-9) by cyclization, acetylation . In the reaction tank by adding ethyl acetoacetate and resorcinol, stirring heated to 50 ℃ dissolved, then add sulfuric acid (to prevent the red material), heating reflux 1h. Vacuum evaporated, add acetyl ethyl acetate, reflux 1h, vacuum evaporated. Adding acetic anhydride, reflux 1h. Cooling to 80 ℃, slowly adding ethanol and cooling to 10 ℃, rejection filter, filter cake washed with ethanol to neutral, drying was 7 - Acetoxy -4 - methyl-coumarin. Melting point 150-153 ℃ (ethanol liquor evaporated and resorcinol can be used for post-cast material).

7-Acetoxy-4-Methylcoumarin Safety Profile

Safety Information of 7-Acetoxy-4-Methylcoumarin (CAS NO.2747-05-9):
Hazard Codes: Xi Harmful
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3

Product Name

7-Acetoxy-4-methylcoumarin

7-Acetoxy-4-Methylcoumarin Chemical Properties

7-Acetoxy-4-Methylcoumarin Uses

7-Acetoxy-4-Methylcoumarin Production

7-Acetoxy-4-Methylcoumarin Safety Profile

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