• Name

  A 769662

• EINECS
• CAS No. 844499-71-4
• Density 1.56 g/cm³
• Solubility
• Melting Point
• Formula C₂₀H₁₂N₂O₃S
• Boiling Point 556.6 °C at 760 mmHg
• Molecular Weight 360.393
• Flash Point 290.4 °C
• Transport Information
• Appearance
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;A 769662;
• PSA 125.35000
• LogP 4.20648

Synthetic route

844499-71-4

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

75-16-1

methylmagnesium bromide

5-ethanimidoyl-4-hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)thieno[2,3-b]pyridin-6(7H)-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 4h;

844499-71-4

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

4-hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)thieno[2,3-b]pyridin-6(7H)-one

Conditions

Conditions	Yield
Stage #1: 4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile With sulfuric acid for 16h; Heating / reflux; Stage #2: With sodium hydroxide pH=2;

844499-71-4

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

844501-29-7

3-[4-(2-hydroxyphenyl)-phenyl]-4-hydroxy-5-iminomethyl-6-oxo-7H-thieno[2,3-b]-pyridine-6-one

Conditions

Conditions	Yield
aluminum nickel In formic acid for 24h; Heating / reflux;

844499-71-4

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

105-36-2

ethyl bromoacetate

{[4'-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-1,1'-biphenyl-2-yl]oxy}acetic acid

Conditions

Conditions	Yield
Stage #1: 4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: ethyl bromoacetate In acetone at 20℃; for 16h;

A-769662 Specification