Product Name

  • Name

    aceprometazine

  • EINECS
  • CAS No. 13461-01-3
  • Density 1.154g/cm3
  • Solubility
  • Melting Point
  • Formula C19H22 N2 O S
  • Boiling Point 490.1°Cat760mmHg
  • Molecular Weight 326.462
  • Flash Point 250.2°C
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous route. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and SOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 13461-01-3 (aceprometazine)
  • Hazard Symbols
  • Synonyms Ketone,10-[2-(dimethylamino)propyl]phenothiazin-2-yl methyl (7CI,8CI); 1664CB;Aceprometazine; Acepromethazine
  • PSA 48.85000
  • LogP 4.50700

Aceprometazine Chemical Properties

Molecular Structure of Aceprometazine (CAS NO.13461-01-3): 

IUPAC Name: 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
Empirical Formula: C19H22N2OS 
Molecular Weight: 326.4558 
Index of Refraction: 1.608 
Surface Tension: 44.6 dyne/cm
Density: 1.154 g/cm3 
Flash Point: 250.2 °C
Enthalpy of Vaporization: 75.66 kJ/mol 
Boiling Point: 490.1 °C at 760 mmHg
Vapour Pressure: 9.4E-10 mmHg at 25°C 
Synonyms of Aceprometazine (CAS NO.13461-01-3): aceprometazine ; 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone ; Acepromethazine ; 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone ; Ethanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)- (9CI) ; Ketone, 10-(2-(dimethylamino)propyl)phenothiazin-2-yl methyl

Aceprometazine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 517mg/kg (517mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 21, Pg. 543, 1964.
mouse LD50 subcutaneous 240mg/kg (240mg/kg)   Anesthesie, Analgesie, Reanimation. Vol. 21, Pg. 543, 1964.

Aceprometazine Consensus Reports

Reported in AAREAV Anesthesie, Analgesie, Reanimation.

Aceprometazine Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and SOx.

Aceprometazine Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

Aceprometazine Specification

 Aceprometazine (CAS NO.13461-01-3) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

  Aceprometazine (CAS NO.13461-01-3) is a corrosive material, flammable,thermal decomposition would release toxic nitrogen oxides and sulfur oxide fumes,it should be stored in low temperature, ventilation, drying environmental conditions,separated with food and raw materials, besides water, carbon oxides and oxidation of toxic carbon dioxide, dry powder, sand, water mist fire extinguishing agent can be used if emergency.

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