Acetamide,N-(4,5-dichloro-2-nitrophenyl)- supplier

Name
N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
EINECS
CAS No. 5462-30-6
Article Data6
CAS DataBase
Density 1.573 g/cm³
Solubility
Melting Point 124-128 °C(lit.)
Formula C₈H₆Cl₂N₂O₃
Boiling Point 418.4 °C at 760 mmHg
Molecular Weight 249.053
Flash Point 206.8 °C
Transport Information
Appearance
Safety 26-36/37
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Acetanilide,4',5'-dichloro-2'-nitro- (8CI);NSC 17009;
PSA 74.92000
LogP 3.45620

Synthetic route

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; nitric acid at 3 - 13℃; for 6.5h;	95.23%
With sulfuric acid; nitric acid 1.) 0 deg C, 10 min, 2.) RT, 30 min;

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

A: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

B: 2-nitro-3,4-dichloroacetanilide

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; nitric acid at 3 - 13℃; for 6.5h;	A 92% B 6%

: 625-58-1
ethyl nitrate

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With sulfuric acid

: 108-24-7
acetic anhydride

: 95-76-1
m,p-dichloroaniline

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With nitric acid

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

A: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

B 3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide: 3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide

Conditions

Conditions	Yield
With nitric acid mann trennt durch fraktionierte Krystallisation aus Alkohol;

: 95-76-1
m,p-dichloroaniline

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: C8H8Cl2N2O

Conditions

Conditions	Yield
With hydrogen In tetrahydrofuran; water at 120℃; under 37503.8 Torr; for 15h; chemoselective reaction;	93%
With formic acid; triethylamine In tetrahydrofuran at 100℃; for 15h; Inert atmosphere; Sealed tube; chemoselective reaction;	93%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 99-96-7
4-hydroxy-benzoic acid

: 4-{5-[(5-acetylamino-2-chloro-4-nitrophenyl)amino]-2-chloro-4-nitrophenoxy}benzoic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 3h;	88%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 99-96-7
4-hydroxy-benzoic acid

: 1579231-58-5
4-(2'-Chloro-4'-nitro-5'-acetamidophenoxy)benzoic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 2.5h;	87%
Stage #1: 4-hydroxy-benzoic acid With potassium carbonate In dimethyl sulfoxide at 75℃; for 0.25h; Stage #2: N-(4,5-dichloro-2-nitrophenyl)acetamide In dimethyl sulfoxide at 110℃; for 6h;	3.1 g

: 2-S-ethylpiperazine hydrochloride

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 907181-48-0
C14H19ClN4O3

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; for 16h;	79%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

A: N-{4-chloro-5-[(4,5-dichloro-2-nitrophenyl)amino]-2-nitrophenyl}acetamide

B: N-(4-chloro-5-hydroxy-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 2h;	A 17% B 68%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 6641-64-1
4,5-dichloro-2-nitroaniline

Conditions

Conditions	Yield
With sulfuric acid at 120℃;
With sulfuric acid at 100℃; for 0.25h;

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 15862-04-1
4,5-Dichlor-2-nitro-N-nitroso-acetanilid

Conditions

Conditions	Yield
With nitrosylsulfuric acid; sodium acetate

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 71-43-2
benzene

: 15862-05-2
4.5-Dichlor-2-nitro-biphenyl

Conditions

Conditions	Yield
(i) NaOAc, P2O5, Ac2O, AcOH, NOHSO4, (ii) /BRN= 969212/; Multistep reaction;

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 170806-27-6
4,5-dichloro-2-nitrophenylazide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 4701-01-3
5,6-dichlorobenzofuroxan

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 3: toluene / 2 h / Heating View Scheme

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; nitric acid at 3 - 13℃; for 6.5h;	95.23%
With sulfuric acid; nitric acid 1.) 0 deg C, 10 min, 2.) RT, 30 min;

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

A: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

B: 2-nitro-3,4-dichloroacetanilide

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide; nitric acid at 3 - 13℃; for 6.5h;	A 92% B 6%

: 625-58-1
ethyl nitrate

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With sulfuric acid

: 108-24-7
acetic anhydride

: 95-76-1
m,p-dichloroaniline

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With nitric acid

: 2150-93-8
N-(3,4-dichlorophenyl)acetamide

A: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

B 3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide: 3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide

Conditions

Conditions	Yield
With nitric acid mann trennt durch fraktionierte Krystallisation aus Alkohol;

: 95-76-1
m,p-dichloroaniline

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: C8H8Cl2N2O

Conditions

Conditions	Yield
With hydrogen In tetrahydrofuran; water at 120℃; under 37503.8 Torr; for 15h; chemoselective reaction;	93%
With formic acid; triethylamine In tetrahydrofuran at 100℃; for 15h; Inert atmosphere; Sealed tube; chemoselective reaction;	93%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 99-96-7
4-hydroxy-benzoic acid

: 4-{5-[(5-acetylamino-2-chloro-4-nitrophenyl)amino]-2-chloro-4-nitrophenoxy}benzoic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 3h;	88%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 99-96-7
4-hydroxy-benzoic acid

: 1579231-58-5
4-(2'-Chloro-4'-nitro-5'-acetamidophenoxy)benzoic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 2.5h;	87%
Stage #1: 4-hydroxy-benzoic acid With potassium carbonate In dimethyl sulfoxide at 75℃; for 0.25h; Stage #2: N-(4,5-dichloro-2-nitrophenyl)acetamide In dimethyl sulfoxide at 110℃; for 6h;	3.1 g

: 2-S-ethylpiperazine hydrochloride

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 907181-48-0
C14H19ClN4O3

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; for 16h;	79%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

A: N-{4-chloro-5-[(4,5-dichloro-2-nitrophenyl)amino]-2-nitrophenyl}acetamide

B: N-(4-chloro-5-hydroxy-2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 2h;	A 17% B 68%

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 6641-64-1
4,5-dichloro-2-nitroaniline

Conditions

Conditions	Yield
With sulfuric acid at 120℃;
With sulfuric acid at 100℃; for 0.25h;

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 15862-04-1
4,5-Dichlor-2-nitro-N-nitroso-acetanilid

Conditions

Conditions	Yield
With nitrosylsulfuric acid; sodium acetate

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 71-43-2
benzene

: 15862-05-2
4.5-Dichlor-2-nitro-biphenyl

Conditions

Conditions	Yield
(i) NaOAc, P2O5, Ac2O, AcOH, NOHSO4, (ii) /BRN= 969212/; Multistep reaction;

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 170806-27-6
4,5-dichloro-2-nitrophenylazide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 4701-01-3
5,6-dichlorobenzofuroxan

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 3: toluene / 2 h / Heating View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 163777-36-4
3-amino-6,7-dichloro-2-quinoxalinecarbonitrile 1,4-di-N-oxide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: conc. sulfuric acid / 0.25 h / 100 °C 2: 1.) aq. HCl, NaNO2, 2.) aq. NaN3, sodium acetate / 1.) 0 deg C, 15 min 3: toluene / 2 h / Heating 4: 48 percent / triethylamine / dimethylformamide / 24 h / 0 - 20 °C View Scheme

: 576-24-9
2,3-dichlorophenol

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 4-chloro-5-(2,3-dichlorophenoxy)-2-nitrophenyl acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; Industry scale;

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 118353-04-1
4-chloro-5-(2,3-dichlorophenoxy)-2-nitroaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 68786-66-3
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale 4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale 4.2: 4 h / 60 - 90 °C / Industry scale 5.1: sodium carbonate / water; methanol / 2 h / 60 °C View Scheme
Multi-step reaction with 7 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale 4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale 4.2: 4 h / 60 - 90 °C / Industry scale 5.1: methanol / 6 h / 40 - 65 °C / Industry scale 6.1: hydrogenchloride / water; methanol / 1 h / 20 °C 7.1: ammonia / water View Scheme

Yield

Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale
3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale
4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale
4.2: 4 h / 60 - 90 °C / Industry scale
5.1: sodium carbonate / water; methanol / 2 h / 60 °C
View Scheme

Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale
3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale
4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale
4.2: 4 h / 60 - 90 °C / Industry scale
5.1: methanol / 6 h / 40 - 65 °C / Industry scale
6.1: hydrogenchloride / water; methanol / 1 h / 20 °C
7.1: ammonia / water
View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 68828-69-3
6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazole-2-thiol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale 4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale 4.2: 4 h / 60 - 90 °C / Industry scale View Scheme
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 - 90 °C / Large scale 1.2: 4 h / 50 °C / Large scale 2.1: sodium hydroxide; hydrogen / methanol / 12 h / 100 °C / Inert atmosphere 3.1: methanol / 6 h / Reflux 3.2: 4 h / 60 - 90 °C View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 1378851-20-7
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale 4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale 4.2: 4 h / 60 - 90 °C / Industry scale 5.1: methanol / 6 h / 40 - 65 °C / Industry scale 6.1: hydrogenchloride / water; methanol / 1 h / 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale
3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale
4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale
4.2: 4 h / 60 - 90 °C / Industry scale
5.1: methanol / 6 h / 40 - 65 °C / Industry scale
6.1: hydrogenchloride / water; methanol / 1 h / 20 °C
View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 139369-42-9
4-chloro-5-(2,3-dichlorophenoxy)-1,2-phenylenediamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 1380167-24-7
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole methylsulfate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale 2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale 3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale 4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale 4.2: 4 h / 60 - 90 °C / Industry scale 5.1: methanol / 6 h / 40 - 65 °C / Industry scale View Scheme

Yield

Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 4 h / 50 °C / Industry scale
3.1: hydrogen; sodium hydroxide / Raney nickel / methanol / 12 h / 100 °C / Industry scale
4.1: sodium hydroxide / methanol / 6 h / Reflux; Industry scale
4.2: 4 h / 60 - 90 °C / Industry scale
5.1: methanol / 6 h / 40 - 65 °C / Industry scale
View Scheme

: 576-24-9
2,3-dichlorophenol

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 118353-04-1
4-chloro-5-(2,3-dichlorophenoxy)-2-nitroaniline

Conditions

Conditions	Yield
Stage #1: 2,3-dichlorophenol; N-(4,5-dichloro-2-nitrophenyl)acetamide With potassium carbonate In N,N-dimethyl-formamide at 20 - 90℃; for 12h; Large scale; Stage #2: With sodium hydroxide In methanol; water; N,N-dimethyl-formamide at 50℃; for 4h; Large scale;	2 kg

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: triclabendazole methanesulfonate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 - 90 °C / Large scale 1.2: 4 h / 50 °C / Large scale 2.1: sodium hydroxide; hydrogen / methanol / 12 h / 100 °C / Inert atmosphere 3.1: methanol / 6 h / Reflux 3.2: 4 h / 60 - 90 °C 4.1: methanol / 6 h / 40 - 65 °C / Large scale View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 68786-66-3
triclabendazole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 - 90 °C / Large scale 1.2: 4 h / 50 °C / Large scale 2.1: sodium hydroxide; hydrogen / methanol / 12 h / 100 °C / Inert atmosphere 3.1: methanol / 6 h / Reflux 3.2: 4 h / 60 - 90 °C 4.1: methanol; water / 0.5 h / 60 °C 4.2: 1.5 h / 60 °C View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 1579231-61-0
4-(2'-Chloro-4'-nitro-5'-aminophenoxy)benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 75 °C 1.2: 6 h / 110 °C 2.1: potassium hydroxide / water / 60 °C View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 2.5 h / 100 °C 2: potassium hydroxide; water / 1 h / 60 °C View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 1579231-63-2
4-(2'-Chloro-4',5'-diaminophenoxy)benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 75 °C 1.2: 6 h / 110 °C 2.1: potassium hydroxide / water / 60 °C 3.1: tin(II) chloride dihdyrate; hydrogenchloride / water / 1 h / 90 °C View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate / dimethyl sulfoxide / 2.5 h / 100 °C 2: potassium hydroxide; water / 1 h / 60 °C 3: tin(II) chloride dihdyrate; hydrogenchloride / water / 1 h / 90 °C View Scheme

: 5462-30-6
N-(4,5-dichloro-2-nitrophenyl)acetamide

: 99-96-7
4-hydroxy-benzoic acid

: C21H14Cl2N4O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 3 h / 100 °C 2: tin(II) chloride dihdyrate; hydrogenchloride; acetic acid / water / 1 h / 100 °C View Scheme

Acetamide,N-(4,5-dichloro-2-nitrophenyl)- Specification

The Acetamide,N-(4,5-dichloro-2-nitrophenyl)-, with the CAS registry number 5462-30-6, is also known as 4',5'-Dichloro-2'-nitroacetanilide. It belongs to the product categories of Anilines, Amides & Amines; Chlorine Compounds; Nitro Compounds. This chemical's molecular formula is C₈H₆Cl₂N₂O₃ and molecular weight is 249.05. Its systematic name is called N-(4,5-dichloro-2-nitrophenyl)acetamide.

Physical properties of Acetamide,N-(4,5-dichloro-2-nitrophenyl)-: (1)ACD/LogP: 2.72; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.72; (4)ACD/LogD (pH 7.4): 2.72; (5)ACD/BCF (pH 5.5): 68.25; (6)ACD/BCF (pH 7.4): 68.25; (7)ACD/KOC (pH 5.5): 715.28; (8)ACD/KOC (pH 7.4): 715.27; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.637; (13)Molar Refractivity: 56.86 cm³; (14)Molar Volume: 158.2 cm³; (15)Surface Tension: 58.7 dyne/cm; (16)Density: 1.573 g/cm³; (17)Flash Point: 206.8 °C; (18)Enthalpy of Vaporization: 67.19 kJ/mol; (19)Boiling Point: 418.4 °C at 760 mmHg; (20)Vapour Pressure: 3.29E-07 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful if swallowed. In addition, it is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc([N+]([O-])=O)c(cc1Cl)NC(=O)C
(2)InChI: InChI=1/C8H6Cl2N2O3/c1-4(13)11-7-2-5(9)6(10)3-8(7)12(14)15/h2-3H,1H3,(H,11,13)
(3)InChIKey: ZEGRPTYRAGSSBH-UHFFFAOYAW

Product Name

N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE

Synthetic route

Acetamide,N-(4,5-dichloro-2-nitrophenyl)- Specification

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