Albendazole supplier | CasNO.54965-21-8

Name
Albendazole
EINECS 259-414-7
CAS No. 54965-21-8
Article Data19
CAS DataBase
Density 1.3 g/cm³
Solubility 0.75mg/L(209 oC)
Melting Point 208-210 °C
Formula C₁₂H₁₅N₃O₂S
Boiling Point
Molecular Weight 265.336
Flash Point
Transport Information
Appearance Colourless crystalline solid
Safety 53-45-37/39-26
Risk Codes 61-36/37/38
Molecular Structure
Hazard Symbols
Synonyms Albendazole Bolus/tablet;O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate;Albendazole (CP/USP);Albenza (TN);Eskazole;Vermitan;(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;Carbamic acid,[5-(propylthio)-1Hbenzimidazol- 2-yl]-,methyl ester;Methyl 5-(propylthio)-2-benzimidazolecarbamate;SKF-62979;Albendazole [USAN:BAN:INN:JAN];Albendazol [INN-Spanish];Bilutac;Carbamic acid, [5- (propylthio)-1H-benzimidazol-2-yl]-, methyl ester;Albenza;methyl N-(5-propylsulfanyl-3H-benzoimidazol-2-yl)carbamate;Zental;Albendazole (JAN/USP);((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French];Proftril;[5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester;SKF 62979;Prestwick_675;SKandF 62979;Zentel;Albendazole cp2005;
PSA 92.31000
LogP 3.31630

Synthetic route

: 6-(propylthio)-1H-benzo[d]imidazol-2-amine

: 79-22-1
methyl chloroformate

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 0.216667h; Sealed tube; Microwave irradiation;	86%
With sodium hydroxide	26.95 g

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 40943-37-1
O-methyl-N-(methoxycarbonyl)-isourea

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; acetic acid In methanol at 110℃; for 5h; Inert atmosphere; Reflux;	65.1%

: 106-94-5
propyl bromide

: 40483-97-4
methyl 5-nitrobenzoimidazole-2-carbamate

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With potassium carbonate; sodium thiosulfate; copper dichloride In water at 135℃; for 20h;	58%

: 54029-12-8, 122063-20-1, 122063-21-2
ricobendazole

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With aluminum (III) chloride; tetrabutyl-ammonium chloride; aluminium In 1,2-dichloro-ethane at 20℃; for 6h; Electrolysis; Inert atmosphere; Green chemistry;	74%
With 1,2,3-trimethoxybenzene; oxalyl dichloride In chloroform at 0℃; for 0.00166667h; Inert atmosphere; chemoselective reaction;	73%

: 21729-98-6
methyl-N-cyano carbamate

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
With hydrogenchloride In water; acetone at 85℃; Large scale;	520 kg
With hydrogenchloride In water at 80℃; for 0.5h; pH=4 - 5;	26.05 g

: sodium salt of cyanocarbamic acid methyl ester

: 66608-52-4
4-(propylthio)-1,2-phenylenediamine

: 54965-21-8
Albendazole

Conditions

Conditions	Yield
Stage #1: 4-(propylthio)-1,2-phenylenediamine With hydrogenchloride In water; acetone at 80 - 85℃; Industry scale; Stage #2: sodium salt of cyanocarbamic acid methyl ester at 20 - 85℃; pH=4 - 4.5;

Albendazole Chemical Properties

IUPAC Name: Methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
Molecular Formula: C₁₂H₁₅N₃O₂S
Molecular Weight: 265.33
EINECS : 259-414-7
Product Category: Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Miscellaneous Compounds
Melting point: 208-210 °C
Storage tempreture: 0-6 °C
Index of Refraction: 1.634
Molar Refractivity: 72.69 cm³
Molar Volume: 203.1 cm³
Surface Tension: 61.9 dyne/cm
Density of Albendazole (CAS NO.54965-21-8): 1.3 g/cm³

Albendazole Uses

Albendazole (CAS NO.54965-21-8) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. It is effective against: flatworms, flukes/trematodes, tapeworm/cestodes, echinococcosis, nematodes, hookworms, roundworms, whipworms, and threadworms or pinworms. In Africa, albendazole is being used to treat lymphatic filariasis as part of efforts to stop transmission of the disease. In Brazil and other countries it is used against giardiasis.

Albendazole Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
hamster	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 99, 1995.
mouse	LD50	oral	1500mg/kg (1500mg/kg)		Acta Leidensia. Vol. 57, Pg. 201, 1989.
rat	LD50	intravenous	265mg/kg (265mg/kg)		Drugs in Japan Vol. -, Pg. 99, 1995.
rat	LD50	oral	2400mg/kg (2400mg/kg)		Annales Pharmaceutiques Francaises. Vol. 40, Pg. 55, 1982.
women	TDLo	oral	256mg/kg/16D (256mg/kg)	BLOOD: APLASTIC ANEMIA	American Journal of Hematology. Vol. 53, Pg. 53, 1996.

Albendazole Safety Profile

Hazard Codes: Toxic T
Risk Statements: 61-36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
R61:May cause harm to the unborn child.
Safety Statements: 53-45-37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany 2
RTECS FD1100000

Albendazole Specification

Albendazole , its cas register number is 54965-21-8. It also can be called Methyl 5-propylthio-2-benzimidazolecarbamate . It may cause dizziness, headache, fever, nausea, vomiting, or temporary hair loss. It is colourless crystalline solid.

Product Name

Albendazole

Synthetic route

Albendazole Chemical Properties

Albendazole Uses

Albendazole Toxicity Data With Reference

Albendazole Safety Profile

Albendazole Specification

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