-
Name
Amoscanate
- EINECS
- CAS No. 26328-53-0
- Article Data1
- CAS DataBase
- Density 1.3g/cm3
- Solubility
- Melting Point 196-198°
- Formula C13H9 N3 O2 S
- Boiling Point 469.7°Cat760mmHg
- Molecular Weight 271.299
- Flash Point 237.9°C
- Transport Information
- Appearance
- Safety Mutation data reported. An anthelmintic agent.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Isothiocyanicacid, p-(p-nitroanilino)phenyl ester (8CI);Diphenylamine,4-isothiocyanato-4'-nitro- (8CI);4-(4-Nitroanilino)phenyl isothiocyanate;4-Isothiocyanato-4'-nitrodiphenylamine;4-Nitro-4'-isothiocyanatodiphenylamine;Amoscanate;C 9333Go;CGP 4540;CIBA 9333Go;Nithiocyamine;p-(p-Nitroanilino)phenyl isothiocyanate;
- PSA 102.30000
- LogP 4.66890
Amoscanate Chemical Properties
IUPAC Name: N-(4-Isothiocyanatophenyl)-4-nitroaniline
Molecular Formula: C13H9N3O2S
Molecular Weight: 271.29g/mol
Density:1.3g/cm3
Boiling Point: 469.7°C at 760mmHg
Flash Point: 237.9°C
Freely Rotating Bonds: 4
Polar Surface Area: 93.51 Å2
Index of Refraction: 1.654
Molar Refractivity: 76.45 cm3
Molar Volume: 208.3 cm3
Polarizability: 30.3 ×10-24cm3
Surface Tension: 52.3 dyne/cm
Enthalpy of Vaporization: 73.21 kJ/mol
Vapour Pressure: 5.38E-09 mmHg at 25°C
The Cas Register Number of Amoscanate is 26328-53-0 .The chemical synonyms of Amoscanate (CAS No.26328-53-0) are Amoscanate ; Nithiocyanamine .The molecular structure of Amoscanate (CAS No.26328-53-0) is
.
Amoscanate Uses
Amoscanate (CAS No.26328 - 53 - 0) is widely used to treat schistosomiasis and de-worming drugs in the nematode. It also can be used as pharmaceutical intermediates and spices industry.
Amoscanate Production
There are three kinds of synthesis methods:
(1) with right Dinitrofluorobenzene condensation with p-phenylenediamine derived from 4 - amino -4 '- nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.
(2) with 2 - chloro -5 - nitro - benzene sulfonic acid with the diamine condensation, was 4 - amino -4 '- nitrobenzene sulfonic acid, and then concentrated sulfuric acid hydrolysis, was 4 - amino -4' Nitrodiphenylamine, and then with the reaction of sulfur derived phosgene.
(3) from 4 - nitro--2 - acid -4 '- acetyl-amino-2-aniline by the concentrated sulfuric acid hydrolysis, was 4 - amino -4' - nitro-diphenylamine, and then with the reaction of sulfur derived from phosgene.
Amoscanate Toxicity Data With Reference
| 1. | dnr-esc 1 g/L | MUREAV Mutation Research 164 (1986),9. | ||
| 2. | bfa-mus/omi 250 mg/kg | TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. 1 (1980),129. | ||
| 3. | hma-mus/esc 250 mg/kg/3 H | MUREAV Mutation Research 164 (1986),9. |
Amoscanate Consensus Reports
EPA Genetic Toxicology Program.
Amoscanate Safety Profile
Mutation data reported. An anthelmintic agent.
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