formaldehyd
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one
dimethyl sulfate
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
With sodium carbonate at 40℃; Neutralisieren und Erhitzen mit NaHSO3; |
4-methylaminoantipyrine
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
With sodium hydrogensulfite dann Behandeln mit Formaldehyd-Loesung und anschliessendem Erwaermen; |
3-oxo-N-o-tolylbutanamide
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.; | 69% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
N-phenylacetoacetamide
Conditions | Yield |
---|---|
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.; | 68% |
2'-methoxyacetoacetanilide
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.; | 67% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
N-phenylacetoacetamide
Conditions | Yield |
---|---|
In ethanol mixing stoichiometric quantities of HgCl2, acetoacetanilide and pyrazoline-5-one derivative in ethanol, refluxing for 15-20 min over a hot plate at 80°C to yield a transparent soln., further refluxing for 1-3 h, pptn.; filtn. by suction, washing several times with EtOH, drying in a desiccator over anhyd. CaCl2 at room temp. to a constant weight, elem. anal.; | 60% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In water; acetic acid byproducts: CH3COOK, HCN; aq. acetic acid; addn. of aq. soln. of ligand to aq. soln. of K3(Cr(NO)(CN)5), pptn. (heating, 80°C, 35 min), liberating of HCN (purged with CO2, 3 h); sepn. (filtration off), washing (dil. CH3COOH, water), drying (room temp., vac., to const. wt.); elem. anal.; | 58% |
o-hydroxyacetophenone
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol mixing stoichiometric quantities of HgCl2, o-hydroxyacetophenone and pyrazoline-5-one derivative in ethanol, refluxing for 15-20 min over a hot plate at 80°C to yield a transparent soln., further refluxing for 1-3 h, pptn.; filtn. by suction, washing several times with EtOH, drying in a desiccator over anhyd. CaCl2 at room temp. to a constant weight, elem. anal.; | 58% |
4-benzoyloxime-3-methyl-1-phenyl-2-pyrazoline-5-one
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol; water mixt. of aq. soln. of NiCl2 and ethanolic soln. of ligands refluxed for 30-60 min; ppt. filtered by suction, washed (ethanol), dried in vac.; elem. anal.; | 56% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
potassium succinimide
Conditions | Yield |
---|---|
In ethanol; water to mixt. of aq. soln. of VOSO4 and KN(C(O)CH2)2 ethanolic soln. of pyrazoline derivative added, soln. refluxed for 30-40 min at 80 °C, stand for 30 min; ppt. filtered, washed (1:1 H2O/C2H5OH), dried (dessicator over anhydrousCaCl2); elem. anal.; | 56% |
sodium tungstate (VI) dihydrate
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In hydrogenchloride; water room temp., pptn.; filtration, washing (HCl(aq.)); elem. anal.; | 55% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In acetic acid aq. acetic acid; to Mo-comp. pyrazoline-comp. in H2O-CH3COOH mixture 1:1 added with shaking, refluxed for 3 h; filtered by suction, washed with 5% dilute CH3COOH and H2O, dried in vac. at room temp., elem. anal.; | 52% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
2-(salicylideneamino)thiophenol
Conditions | Yield |
---|---|
In ethanol byproducts: HNO3, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.; | 50% |
zinc(II) thiocyanate
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol refluxing (6 h); filtn., washing (EtOH), drying (vac., room temp.); elem anal.; | 50% |
salicylaldehyde anthranilic acid
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol byproducts: HCl, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.; | 48% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
2-(salicylideneamino)thiophenol
Conditions | Yield |
---|---|
In ethanol byproducts: HCl, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.; | 47% |
salicylaldehyde anthranilic acid
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol byproducts: HNO3, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.; | 45% |
mercury(II) thiocyanate
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol refluxing (4 h); filtn., washing (EtOH), drying (vac., room temp.); elem anal.; | 30% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol; water addn. of alcoholic soln. of ligand to aq. soln. of Co-complex, shaking, refluxing (4 - 5 h, 80°C, pptn.); filtration, washing (alcohol), drying (vac., over CaCl2, room temp.); elem. anal.; | 28% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol; chloroform molar ratio V-complex (in chloroform) / ligand (in ethanol) = 1:1, refluxing (3 h); washing (chloroform), drying (over CaCl2, room temp.); elem. anal.; | 20% |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
cadmium(II) chloride
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)cobalt(II)
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)copper(II)
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)nickel(II)
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)zinc(II)
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one
Conditions | Yield |
---|---|
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.; |
Molecular Formula of Analgin (CAS NO.5907-38-0): C13H18N3NaO5S
Molecular Weight: 351.35
storage temp.: 2-8 °C
Appearance: White or light yellow crystalline powder, odorless, tiny bitter
Structure of Analgin (CAS NO.5907-38-0):
IUPAC Name: Sodium[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate
Analgin (CAS NO.5907-38-0) is antipyretic analgesics of pyrazolones. It is indicated for treatment diseases caused by high fever and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal ect.
Analgin , its cas register number is 5907-38-0. It also can be called Dipyron ; Metamizol ; Methapyrone ; Sulpyrine ; and Sodium [(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-methyl-amino]methanesulfonate .
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