Ansamitocin P-4 supplier | CasNO.66547-10-2

Name
Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-O3-(3-methyl-1-oxobutyl)-
EINECS
CAS No. 66547-10-2
Density 1.28g/cm³
Solubility
Melting Point 178.5°C (rough estimate)
Formula C₃₃H₄₅N₂O₉Cl
Boiling Point 838.7°Cat760mmHg
Molecular Weight 649.25
Flash Point 461°C
Transport Information
Appearance
Safety Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. See also ESTERS.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Maytansinol isovalerate;ansamitocin P-4;Tam 340;
PSA 136.16000
LogP 5.10750

Ansamitocin P-4 Chemical Properties

Systematic Name: 11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 3-methylbutanoate
Synonyms of Ansamitocin P-4 (CAS NO.66547-10-2): 3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine isovalerate (ester) ; Maytansinol isovalerate ; Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, isovalerate (ester)
CAS NO: 66547-10-2
Molecular Formula: C₃₃H₄₅ClN₂O₉
Molecular Weight : 649.1714
Molecular Structure:
H bond acceptors: 11
H bond donors: 2
Freely Rotating Bonds: 7
Polar Surface Area: 116.37 Å²
Index of Refraction: 1.58
Molar Refractivity: 168.06 cm³
Molar Volume: 504.8 cm³
Surface Tension: 54.4 dyne/cm
Density: 1.28 g/cm3
Flash Point: 461 °C
Enthalpy of Vaporization: 127.74 kJ/mol
Boiling Point: 838.7 °C at 760 mmHg
Vapour Pressure: 7.44E-30 mmHg at 25°C

Ansamitocin P-4 Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	625ug/kg (0.625mg/kg)		Japanese Kokai Tokyo Koho Patents. Vol. #78-130495,

Ansamitocin P-4 Safety Profile

Poison by intraperitoneal route. Mutation data reported. When Ansamitocin P-4 (CAS NO.66547-10-2) is heated to decomposition, it emits toxic fumes of Cl⁻ and NO_x. See also ESTERS.

Product Name

Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-O3-(3-methyl-1-oxobutyl)-

Ansamitocin P-4 Chemical Properties

Ansamitocin P-4 Toxicity Data With Reference

Ansamitocin P-4 Safety Profile

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