Apraclonidine hydrochloride supplier

Name
Apraclonidine hydrochloride
EINECS
CAS No. 73218-79-8
Article Data2
CAS DataBase
Density 1.63 g/cm³
Solubility
Melting Point >230 °C
Formula C₉H₁₀Cl₂N₄.ClH
Boiling Point 395.5 °C at 760 mmHg
Molecular Weight 281.572
Flash Point 193 °C
Transport Information UN 2811 6.1/PG 1
Appearance crystalline solid
Safety 22-36/37/39-45
Risk Codes 23/24/25
Molecular Structure
Hazard Symbols T
Synonyms 2-(4-amino-2,6-dichlorophenylimino)imidazolidinehydrochloride;2,6-dichloro-n(sup1)-(4,5-dihydro-1h-imidazol-2-yl)-1,4-benzenediaminemonoh;3,5-dichloro-4-(2-imidazolidinylidenimino)anilinehydrochloride;4-benzenediamine,2,6-dichloro-n(sup1)-(4,5-dihydro-1h-imidazol-2-yl)-mono;alo-2145;iopidine;iopidineophthalmicsolution;nc14hydrochloride;apraclonidine hcl;apraclonidine hydrochloride;p-aminoclonidine hydrochloride;AL 02145;p-Aminoclonidine Monohydrochloride;Iopidine UD;2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride;
PSA 62.44000
LogP 3.16730

Synthetic route

: 66711-21-5
p-aminoclonidine

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 2h; Solvent; Reflux;	72.1%

: 99-30-9
4-nitro-2,6-dichloroaniline

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: acetic anhydride / 1 h / 70 - 80 °C 1.2: 3 h / Heating 2.1: sulfuryl dichloride; thionyl chloride / 4 h / Reflux 3.1: triethylamine / ethyl acetate / 6 h / 5 °C 4.1: hydrazine hydrate; 5%-palladium/activated carbon / methanol / 2 h / Heating 5.1: hydrogenchloride / methanol / 2 h / Reflux View Scheme

: 70106-94-4
N-(2,6-dichloro-4-nitrophenyl)formamide

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sulfuryl dichloride; thionyl chloride / 4 h / Reflux 2: triethylamine / ethyl acetate / 6 h / 5 °C 3: hydrazine hydrate; 5%-palladium/activated carbon / methanol / 2 h / Heating 4: hydrogenchloride / methanol / 2 h / Reflux View Scheme

: 73218-65-2
(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / ethyl acetate / 6 h / 5 °C 2: hydrazine hydrate; 5%-palladium/activated carbon / methanol / 2 h / Heating 3: hydrogenchloride / methanol / 2 h / Reflux View Scheme

: 26367-48-6
fumaric acid ethyl ester mono chloride

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

: 88307-13-5
(trans beta-carbethoxyacrylamido)-4-clonidine

Conditions

Conditions	Yield
In water at 50℃; for 0.25h;	55%

: 459-22-3
4-fluorophenylacetonitrile

: 73218-79-8
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride

: 2-[4-(4-Fluorobenzylamidino)-2,6-dichlorophenylimino]imidazolidine dihydrochloride

Conditions

Conditions	Yield
aluminium chloride

Apraclonidine hydrochloride Specification

The Apraclonidine hydrochloride with cas registry number of 73218-79-8, is also called 2-(4-amino-2,6-dichlorophenylimino)imidazolidinehydrochloride ; 2,6-dichloro-n(sup1)-(2-imidazolidinylidene)-1,4-benzenediaminehydrochlorid .The Apraclonidine hydrochloride belongs to the following product categories: (1)Heterocyclic Compounds; (2)Bases & Related Reagents; (3)Heterocycles; (4)Intermediates & Fine Chemicals; (5)Nucleotides; (6)Pharmaceuticals.

Physical properties of Apraclonidine hydrochloride :(1)ACD/LogP: 0.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.69; (4)ACD/LogD (pH 7.4): -1.12; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.31; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 22.08 Å²; (13)Index of Refraction: 1.719; (14)Molar Refractivity: 59.19 cm³; (15)Molar Volume: 150 cm³; (16)Polarizability: 23.46×10^-24cm³; (17)Surface Tension: 59.3 dyne/cm; (18)Enthalpy of Vaporization: 64.57 kJ/mol; (19)Vapour Pressure: 1.83E-06 mmHg at 25°C .

Its storage temperature is 2-8°C.

Uses of Apraclonidine hydrochloride : a-Adrenergic agonist; structural analog of clonidine. Used for treatment of post-surgical elevated intraocular pressure.

When you are using this chemical, please be cautious about it as the following:
The Apraclonidine hydrochloride is harmful and toxic by inhalation, in contact with skin and if swallowed. When use it, avoid contact with skin and eyes and do not breathe dust. When use it, wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure: (1)ACD/LogP: 0.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.69; (4)ACD/LogD (pH 7.4): -1.12; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.31; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 22.08 ?2; (13)Index of Refraction: 1.719; (14)Molar Refractivity: 59.19 cm3; (15)Molar Volume: 150 cm3; (16)Polarizability: 23.46 10-24cm3; (17)Surface Tension: 59.3 dyne/cm; (18)Enthalpy of Vaporization: 64.57 kJ/mol; (19)Vapour Pressure: 1.83E-06 mmHg at 25°C.

Product Name

Apraclonidine hydrochloride

Synthetic route

Apraclonidine hydrochloride Specification

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