Product Name

  • Name

    Brofaromine

  • EINECS
  • CAS No. 63638-90-4
  • Density g/cm3
  • Solubility
  • Melting Point
  • Formula C14H16BrNO2•ClH
  • Boiling Point 404°Cat760mmHg
  • Molecular Weight 346.68
  • Flash Point 198.2°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion. When heated to decomposition it emits toxic fumes of Br−, NOx, and HCl.
  • Risk Codes
  • Molecular Structure Molecular Structure of 63638-90-4 (Brofaromine)
  • Hazard Symbols
  • Synonyms hydrochloride;4-(5-methoxy-7-bromo-benzofuranyl-2-) piperidine hydrochloride;BROFAREMINE HYDROCHLORIDE;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine;4-(7-Bromo-5-methoxy-benzofuran-2-yl)-piperidine;
  • PSA 34.40000
  • LogP 4.80170

BROFAREMINE HYDROCHLORIDE Chemical Properties

MF: C14-H16-Br-N-O2.Cl-H
MW: 346.6503

BROFAREMINE HYDROCHLORIDE Uses

It is an antidepressants, NEUROLOGIC DRUGS,PSYCHOPHARMACOLOGIC DRUGS,MAO-A Inhibitors.
is used for the treatment of Cognition Disorders, and Mood Disorders.

BROFAREMINE HYDROCHLORIDE Production

Bromination of 2-hydroxy-5-methoxybenzaldehyde (I) in acetic acid / sodium acetate mixture gives bromoaldehyde (II). Condensation to the benzofuranylpyridine (IV) is achieved by heating a solution of (II) and 4-(chloromethyl)pyridine hydrochloride (III) in polyethylene glycol-400 in the presence of potassium carbonate. Quaternization of (IV) with dimethylsulfate in dichloromethane affords (V), which upon reduction with sodium borohydride gives intermediate (VI). Reduction of (VI) with platinum on charcoal in methanol/HBr solution yields the N-methylpiperidine (VII). Degradation of the N-methyl group with ethylchloroformate in toluene affords the carbamate (VIII). Final treatment of (VIII) with potassium hydroxide in n-butanol yields the free base of brofaremine, which is converted to its hydrochloride salt by treatment with hydrochloric acid in methanol.

BROFAREMINE HYDROCHLORIDE Toxicity Data With Reference

1.   

orl-rat LD50:310 mg/kg

   DRFUD4    Drugs of the Future. 10 (1985),371.
2.   

orl-mus LD50:190 mg/kg

   DRFUD4    Drugs of the Future. 10 (1985),371.
3.   

orl-dog LD50:100 mg/kg

   DRFUD4    Drugs of the Future. 10 (1985),371.

BROFAREMINE HYDROCHLORIDE Safety Profile

Poison by ingestion. When heated to decomposition it emits toxic fumes of Br−, NOx, and HCl.

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