-
Name
ZINC BACITRACIN
- EINECS 215-787-8
- CAS No. 92528-87-5
- Density
- Solubility
- Melting Point 250 °C
- Formula
- Boiling Point
- Molecular Weight 1486.06994628906
- Flash Point
- Transport Information
- Appearance
- Safety
- Risk Codes
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Molecular Structure
- Hazard Symbols
- Synonyms BACITRACIN ZINC;4-[2-[[2-(1-AMINO-2-METHYL-BUTYL)-4,5-DIHYDRO-1,3-THIAZOL-4-YL]CARBONYLAMINO]-4-METHYL-PENTANOYL]AMINO-5-[1-[[18-(3-AMINOPROPYL)-12-BENZYL-15-BUTAN-2-YL-3-(CARBAMOYLMETHYL)-6-(CARBOXYMETHYL)-9-(4H-IMIDAZOL-4-YLMETHYL)-2,5,8,11,14,17,20-HEPTAOXO-1,4,7,10,13,16,19-HEPTAZACYCLOPENTACOS-21-YL]CARBAMOYL]-2-METHYL-BUTYL]AMINO-5-OXO-PENTANOIC ACID, ZINC
- PSA
- LogP
Bacitracin zinc Chemical Properties
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, isolation of which was first reported in 1945.
As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Its action is on gram positive cell walls.
Formula :C66H103N17O16S
Mol. mass: 1422.69 g/mol
Bacitracin zinc History
One strain isolated from tissue debrided from a compound fracture of the tibia was particularly active. We named this growth-antagonistic strain for the patient, "Tracy I." When cell-free filtrates of broth cultures of this bacillus proved to possess strong antibiotic activity and to be non-toxic, further study seemed warranted. We have called this active principle "Bacitracin."
Bacitracin zinc Uses
Bactoprenol phosphate BACITRACIN interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane
which lowers chances of an allergic reaction.
In infants, it is sometimes administered intramuscularly for the treatment of pneumonias,but in most cases, it has been replaced by other antibiotics. This formulation is sold under the brand name Baciim.
Clinical note: This is a good alternative to SILVER sulfadiazine for burn patients with a sulfa allergy.
BACITRACIN can be used to distinguish Streptococcus pyogenes from Streptococcus agalactiae.
It was voted Allergen of the Year in 2003 by the American Contact Dermatitis Society.
which lowers chances of an allergic reaction.
In infants, it is sometimes administered intramuscularly for the treatment of pneumonias,but in most cases, it has been replaced by other antibiotics. This formulation is sold under the brand name Baciim.
Clinical note: This is a good alternative to SILVER sulfadiazine for burn patients with a sulfa allergy.
BACITRACIN can be used to distinguish Streptococcus pyogenes from Streptococcus agalactiae.
It was voted Allergen of the Year in 2003 by the American Contact Dermatitis Society.
Bacitracin zinc Toxicity Data With Reference
a toxic
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