IUPAC Name: 3-[bis(aziridin-1-yl)phosphoryl]-2-methyl-1,3-thiazolidine
Synonyms of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): Imiphos ; BRN 1214283 ; Imiphos ; Marcophan ; Marcophane ; Markofane ; 3-(Bis(1-aziridinyl)phosphinyl)-2-methylthiazolidine ; Phosphine oxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)-
CAS NO: 1078-79-1
Molecular Formula of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): C8H16N3OPS
Molecular Weight: 233.2709
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 61.44 Å2
Index of Refraction: 1.637
Molar Refractivity: 59.33 cm3
Molar Volume: 165.2 cm3
Surface Tension: 61.4 dyne/cm
Density of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): 1.41 g/cm3
Flash Point: 185.1 °C
Enthalpy of Vaporization: 63.08 kJ/mol
Boiling Point: 382.4 °C at 760 mmHg
Vapour Pressure: 4.72E-06 mmHg at 25°C
Molecular Structure:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 142mg/kg (142mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968. |
mouse | LD50 | oral | 225mg/kg (225mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968. |
rat | LD50 | intraperitoneal | 18700ug/kg (18.7mg/kg) | BLOOD: LEUKOPENIA | Farmakologiya i Toksikologiya Vol. 37, Pg. 464, 1974. |
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx.
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