• Name

  ALPHA,ALPHA'-BIS(4-HYDROXYPHENYL)-1,4-DIISOPROPYLBENZENE

• EINECS 200-258-5
• CAS No. 2167-51-3
• Article Data14
• CAS DataBase
• Density 1.107±0.06 g/cm3(Predicted)
• Solubility
• Melting Point 193-195 °C(lit.)
• Formula C24H26 O2
• Boiling Point 246 °C(Press: 0.1 Torr)
• Molecular Weight 346.469
• Flash Point 230.1oC
• Transport Information
• Appearance
• Safety 26-36
• Risk Codes R36   
• Molecular Structure
• Hazard Symbols
• Synonyms Phenol,4,4'-(p-phenylenediisopropylidene)di- (7CI,8CI);1,4-Bis(1-(4-hydroxyphenyl)-1-methylethyl)benzene;1,4-Bis(4-hydroxycumyl)benzene; 1,4-Bis(p-hydroxycumyl)benzene;1,4-Bis[2-(4-hydroxyphenyl)-2-propyl]benzene; 1,4-Bis[a-methyl-a-(4-hydroxyphenyl)ethyl]benzene;4,4'-(p-Phenylenediisopropylidene)bisphenol;4,4'-(p-Phenylenediisopropylidene)diphenol; B 1563; Bisphenol P; a,a'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene; a,a'-Bis(4-hydroxyphenyl)-p-diisopropylbenzene
• PSA 40.46000
• LogP 5.74960

Synthetic route

2948-46-1

α,α,α',α'-tetramethyl-1,4-benzenedimethanol

108-95-2

phenol

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

Conditions

Conditions	Yield
With hydrogenchloride at 80℃; for 3.5h;	65%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

182318-36-1

α,α'-bis[(5-bromopentoxy)phenyl]-1,4-di(isopropyl)benzene

C58H68O4

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 168h;	99%
With caesium carbonate In N,N-dimethyl-formamide at 60 - 70℃; for 144h;	70%

109-04-6

2-bromo-pyridine

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

1020725-47-6

C34H32N2O2

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In sulfolane; toluene at 20℃; for 0.75h; Stage #2: 2-bromo-pyridine at 80℃; for 48h; Further stages.;	99%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

625084-41-5

α,α'-di[(4-bromo-1-butoxy)phenyl]-1,4-diisopropylbenzene

625084-44-8

C56H64O4

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 125h;	98%

110-52-1

1,4-dibromo-butane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

625084-41-5

α,α'-di[(4-bromo-1-butoxy)phenyl]-1,4-diisopropylbenzene

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In acetonitrile for 1.5h; Reflux; Stage #2: 1,4-dibromo-butane In [D3]acetonitrile for 30h; Reflux;	90%

612-62-4

2-Chloroquinoline

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

1020725-57-8

C42H36N2O2

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In sulfolane; toluene at 20℃; for 0.75h; Stage #2: 2-Chloroquinoline at 80℃; for 48h; Further stages.;	87%

2969-81-5

4-bromoethylbutanoate

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

153775-72-5

4-{4-[1-(4-{1-[4-(3-ethoxycarbonyl-propoxy)-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-phenoxy}-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	85%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

36530-06-0

subphthalocyanine

(B(N6C24H12))2O2C6H4C(CH3)2C6H4C(CH3)2C6H4

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 180.5℃; for 39h; Inert atmosphere;	85%
In 1,2-dichloro-benzene (Ar) chloro boron subphthalocyanine and bisphenol in 1,2-dichlorobenzenewere heated at reflux (180.5°C) for 39 h; react. mixt. was cooled, solvent was totary evapd., purification from hot toluene;	85%

31643-49-9

4-Nitrophthalonitrile

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

4,4′-bis[1,3-propylbenzene-2-p-phenoxy]phthalonitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 90℃; for 72h; Inert atmosphere;	84.44%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 48h; Inert atmosphere;	83.9%

4549-32-0

1,8-dibromooctane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

C40H56Br2O2

Conditions

Conditions	Yield
With potassium carbonate In acetone for 5h; Heating;	84%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

6959-48-4

3-chloromethylpyridinium chloride

1020725-72-7

C36H36N2O2

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydroxide In benzene at 80℃; for 48h;	82%

4549-31-9

1,7-dibromoheptane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

927403-48-3

C38H52Br2O2

Conditions

Conditions	Yield
With potassium carbonate In acetone for 5h; Heating;	81%

111-24-0

1,5-dibromo-pentane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

182318-36-1

α,α'-bis[(5-bromopentoxy)phenyl]-1,4-di(isopropyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h;	80%
With potassium carbonate In water; acetone for 48h; Heating;	71%
With potassium carbonate In water; acetone	65%
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In acetonitrile for 1.5h; Reflux; Stage #2: 1,5-dibromo-pentane In [D3]acetonitrile for 30h; Reflux;	60%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

6959-47-3

2-chloromethylpyridine hydrochloride

1020725-67-0

C36H36N2O2

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydroxide In benzene at 80℃; for 48h;	80%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

684-16-2

Hexafluoroacetone

1422464-20-7

C27H20F18O4

Conditions

Conditions	Yield
With methanesulfonic acid at 20 - 55℃; for 8h; Autoclave;	80%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

108-24-7

acetic anhydride

1107651-70-6

C26H28O3

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 1.75h; Inert atmosphere;	72%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

α,α'-di[(3-bromo-1-propoxy)phenyl]-1,4-diisopropylbenzene

199340-65-3

C54H60O4

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 120h;	71%

515136-37-5

3-iodopropyl methyl diisopropoxy silane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

C44H70O6Si2

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium isopropoxide In isopropyl alcohol at 20℃; Stage #2: 3-iodopropyl methyl diisopropoxy silane In N,N-dimethyl-formamide at 70℃; for 1h; Stage #3: With potassium iodide In N,N-dimethyl-formamide at 25℃; for 1h;	70%

14508-49-7

2-chloropyrazin

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

1020725-52-3

C32H30N4O2

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In sulfolane; toluene at 20℃; for 0.75h; Stage #2: 2-chloropyrazin at 80℃; for 48h; Further stages.;	69%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

1822-51-1

4-picolylchloride hydrochloride

1020725-77-2

C36H36N2O2

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydroxide In benzene at 80℃; for 48h;	68%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

110-56-5

1,4-dichlorobutane

C32H40Cl2O2

Conditions

Conditions	Yield
With sodium hydroxide In butan-1-ol	66%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

6068-70-8

triphenylacetyl chloride

169179-44-6

11'-(tert-butyl)-5',17',23',35',38',40'43',45'-octamethyldispiro[cyclohexane-1,2'-[7,15,25,33]tetraazaheptacyclo[32.2.2.2.2(3,6).2(16,19).2(21,24).1(3,13).1(27,31)]hexatetraconta[3,5,9,11,13(44),16,18,21,23,27,29,31(39),34,36,37,40,42,45]octadecaene..].

C64H72N4O4*C64H54O4

Conditions

Conditions	Yield
With dibenzo-18-crown-6; potassium carbonate In dichloromethane at 20℃; for 168h; Acylation; Threading synthesis;	65%

...Expand

50-00-0

formaldehyd

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

124-40-3

dimethyl amine

912474-61-4

2,5,2',5'-tetra(dimethylaminemethylene)-α,α'-bis(4-hydroxyphenyl)-1,4-diisopropylbenzene

Conditions

Conditions	Yield
In ethanol; water for 3h; Mannich reaction; Heating;	63%

...Expand

506-68-3

bromocyane

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

133685-37-7

1,4-bis(2-(4-cyanatophenyl)propan-2-yl)benzene

Conditions

Conditions	Yield
With triethylamine In acetone at -5 - 20℃; for 2h;	63%

74-96-4

ethyl bromide

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

α,α'-bis(4-ethoxyphenyl)-1,4-di(isopropyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	62%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

109-64-8

1,3-dibromo-propane

α,α'-di[(3-bromo-1-propoxy)phenyl]-1,4-diisopropylbenzene

Conditions

Conditions	Yield
Stage #1: 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol With potassium carbonate In acetonitrile for 1.5h; Reflux; Stage #2: 1,3-dibromo-propane In [D3]acetonitrile for 30h; Reflux;	61%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

1107651-69-3

tri(p-bromomethylphenyl)phosphane oxide

A

C69H67O5P

B

C114H108O8P2

C

C228H216O16P4

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; for 60h; Inert atmosphere;	A 1% B 58% C 8%

...Expand

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

106-94-5

propyl bromide

α,α'-bis(4-propyloxyphenyl)-1,4-di(isopropyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	55%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

106-96-7

propargyl bromide

134127-88-1

[1,4-C6H4(CMe2-4-C6H4OCH2CCH)2]

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	48%

2167-51-3

4,4'-(1,4-phenylene-diisopropylidene)-bisphenol

789-54-8

2,6-di-tert-butyl-4-methylphenoxydichlorophosphine

C78H94O6P2

Conditions

Conditions	Yield
With triethylamine In toluene at 25℃; for 24h;	46%

Bisphenol P Chemical Properties

Bisphenol P Safety Profile