Product Name

  • Name

    BLASTICIDIN S

  • EINECS
  • CAS No. 2079-00-7
  • Article Data46
  • CAS DataBase
  • Density 1.61 g/cm3
  • Solubility Solubility.: in water >30 g/l (20℃). In acetic acid >30 g/l (20℃). Practically insoluble in acetone, benzene, carbon tetrachloride, chloroform, cyclohexane, dioxane, ethanol diethyl ether, ethyl acetate, methanol, pyridine, xylene.
  • Melting Point 235-236ºC
  • Formula C17H26 N8 O5
  • Boiling Point °Cat760mmHg
  • Molecular Weight 422.444
  • Flash Point °C
  • Transport Information
  • Appearance Colourless needles
  • Safety Poison by ingestion, skin contact, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other blastomycin entries.
  • Risk Codes 28
  • Molecular Structure Molecular Structure of 2079-00-7 (BLASTICIDIN S)
  • Hazard Symbols VeryT+
  • Synonyms BlasticidinS (6CI,8CI);D-erythro-Hex-2-enopyranuronic acid,4-[3-amino-5-(1-methylguanidino)valeramido]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-(7CI);Bla-S;
  • PSA 215.67000
  • LogP 0.25370

Blasticidin S Chemical Properties

Molecular Formula: C17H26N8O5
Molar mass: 422.4389 g/mol
Density: 1.61 g/cm3
Index of Refraction: 1.707
Product categories of Blasticidin S (2079-00-7): Fungicide
Structure of Blasticidin S (2079-00-7):

XLogP3-AA: -5.2
H-Bond Donor: 6
H-Bond Acceptor: 10
Systematic Name: (2S,3S,6R)-3-[[3-Amino-5-(carbamimidoyl-methyl-amino)pentanoyl]amino]-6-(4-amino-2-oxo-pyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid 
SMILES: O=C1\N=C(\N)/C=C\N1[C@@H]\2O[C@H](C(=O)O)[C@H](/C=C/2)NC(=O)CC(N)CCN(C(=[N@H])N)C 
InChI: InChI=1/C17H26N8O5/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29)/t9?,10-,13+,14-/m0/s1 
InChIKey: CXNPLSGKWMLZPZ-LBLJTAPMBS 
Std. InChI: InChI=1S/C17H26N8O5/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29)/t9?,10-,13+,14-/m0/s1 
Std. InChIKey: CXNPLSGKWMLZPZ-LBLJTAPMSA-N

Blasticidin S Uses

 Blasticidin S (2079-00-7) is an antibiotic used to select transformed cells in genetic engineering.

Blasticidin S Toxicity Data With Reference

1.    

orl-rat LD50:16 mg/kg

     GUCHAZ    Guide to the Chemicals Used in Crop Protection 6 (1973),48.
2.    

skn-rat LD50:3100 mg/kg

     28ZEAL    Pesticide Index, 5 (1976),27.
3.    

orl-mus LD50:38 mg/kg

     JANTAJ    Journal of Antibiotics. 30 (1977),1022.
4.    

skn-mus LD50:220 mg/kg

     28ZEAL    Pesticide Index, 5 (1976),27.
5.    

ivn-mus LD50:2820 µg/kg

     JAJAAA    Journal of Antibiotics, Series A. 11 (1958),1.

Blasticidin S Safety Profile

Poison by ingestion, skin contact, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other blastomycin entries.
 

Hazard Codes: T+
Risk Statements:
28:  Very Toxic if swallowed
Safety Statements:
24:  Avoid contact with skin
25:  Avoid contact with eyes
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Blasticidin S Specification

After allowing time for recovery and for cells to begin transcribing and translating their new DNA, Blasticidin S (2079-00-7) is added. Now only the cells that have the new DNA can grow.

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