Boc-L-Leucine supplier | CasNO.13139-15-6

Name
BOC-L-Leucine
EINECS 236-073-2
CAS No. 13139-15-6
Article Data169
CAS DataBase
Density 1.061 g/cm³
Solubility
Melting Point 82 - 87 °C
Formula C₁₁H₂₁NO₄
Boiling Point 356 °C at 760 mmHg
Molecular Weight 231.292
Flash Point 169.1 °C
Transport Information
Appearance White to off-white crystalline powder
Safety 26-36
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms N-((1,1-Dimethylethoxy)carbonyl)-L-leucine;N-(tert-Butoxycarbonyl)-L-leucine;N-tert-Butoxycarbonylleucine;N-tert-Butyloxycarbonyl-L-leucine;NSC 108690;tert-Butoxycarbonyl-L-leucine;tert-Butoxycarbonylleucine;
PSA 75.63000
LogP 2.40130

Synthetic route

: 61-90-5
L-leucine

: 24424-99-5
di-tert-butyl dicarbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 25℃; for 23h;	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 19h;	99%

: 108460-59-9
Boc-L-Leu-(Z)-ΔLeu-L-Ala-OMe

A: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

B: (S)-2-(4-Methyl-2-oxo-pentanoylamino)-propionic acid

Conditions

Conditions	Yield
With McIlvaine buffer; 2-hydroxyethanethiol; papain (EC 3.4.22.2) at 35℃; for 24h; pH=8.0; Hydrolysis;	A n/a B 100%

: 61-90-5
L-leucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 4h; Ambient temperature;	99%
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; pH=8 - 9;	89.1%

: 61-90-5
L-leucine

: 98015-52-2
1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 20℃; pH=9.75;	95%

: 61-90-5
L-leucine

: 105678-24-8
O-(tert-butyl) S-(pyridin-2-yl)carbonothioate

A: 2637-34-5
2-Mercaptopyridine

B: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 12h; Ambient temperature;	A n/a B 95%

...Expand

: 61-90-5
L-leucine

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

A: 142-08-5
2-hydroxypyridin

B: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 4h; Ambient temperature;	A n/a B 94%

...Expand

: 77163-64-5
Boc-Leu-ONbn

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature;	94%

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide In water; acetone at 20℃; for 6h;	92%

: 61-90-5
L-leucine

: 64205-15-8
(N-hydroxy-5-norbornene-2,3-diformylimino)tert-butyl ester

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With tertiary amine In 1,4-dioxane; water for 3h;	91%

: 2-tert-butoxycarbonylamino-4-methyl-pentanoic acid 3-methyl-but-2-enyl ester

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 1.5h; Heating;	91%

: 17790-87-3
Boc-Leu-NHNHPh

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With oxygen In acetonitrile for 16h; tyrosinase, phosphate buffer pH 7;	89%
With phosphate buffer; oxygen; tyrosinase In water; acetonitrile at 20℃; for 16h; pH=7.0;	89%

: 61-90-5
L-leucine

: tert-butyl (2,4-dioxo-3-azaspiro[5,5]undecan-3-yl) carbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water at 25℃; for 15h;	88%

: 178432-61-6
t-butyl (S)-2-tert-butoxycarbonylamino-4-methylpentanoate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 5h; Heating;	87%
With water; iodine In acetonitrile for 6h; Heating;	82%
With trifluoroacetic acid

: 61-90-5
L-leucine

: 75844-68-7
tert-butyl 2-oxo-1,3-oxazole-3(2H)-carboxylate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With dmap; triethylamine In 1,4-dioxane; water for 15h; Ambient temperature;	85%

: 61-90-5
L-leucine

: dimethylsulfonium methylsulfate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In water Ambient temperature;	75%

: 193069-43-1
Boc-Leu-ΔLeu-Gly-OMe

A: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

B: (4-methyl-2-oxo-pentanoylamino)-acetic acid

Conditions

Conditions	Yield
With McIlvaine buffer; 2-hydroxyethanethiol; papain (EC 3.4.22.2) at 35℃; for 24h; pH=8.0; Hydrolysis;	A n/a B 75%

: (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid 2-trimethylsilanyl-ethoxymethyl ester

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With magnesium bromide In dichloromethane for 2.5h; Ambient temperature; addition at -20 deg C, 0.5 h;	71%

: 193069-44-2
Boc-Leu-ΔLeu-Val-OMe

A: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

B: (S)-3-Methyl-2-(4-methyl-2-oxo-pentanoylamino)-butyric acid

Conditions

Conditions	Yield
With McIlvaine buffer; 2-hydroxyethanethiol; papain (EC 3.4.22.2) at 35℃; for 24h; pH=8.0; Hydrolysis;	A n/a B 40%

Boc-Leu-ΔLeu-Leu-OMe: Boc-Leu-ΔLeu-Leu-OMe

A: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

B: (S)-4-Methyl-2-(4-methyl-2-oxo-pentanoylamino)-pentanoic acid

Conditions

Conditions	Yield
With McIlvaine buffer; 2-hydroxyethanethiol; papain (EC 3.4.22.2) at 35℃; for 24h; pH=8.0; Hydrolysis;	A n/a B 26%

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 61-90-5
L-leucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With 1,4-dioxane; magnesium oxide
With hydroxide
With N,N,N',N'-tetramethylguanidine In N,N-dimethyl-formamide

: 61-90-5
L-leucine

: 13303-10-1
tert-Butyl 4-nitrophenyl carbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide; tert-butyl alcohol

: Kohlensaeure-(2,2-dimethyl-propylester)-(N-hydroxysuccinimidester)

: 61-90-5
L-leucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane

: 18595-55-6
tert-butyl (quinolin-8-yl)carbonate

: 61-90-5
L-leucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide

: 61-90-5
L-leucine

: 18595-34-1
tert-butyl fluoroformate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane

: 61-90-5
L-leucine

: 16965-08-5
1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In tert-butyl alcohol

: 61-90-5
L-leucine

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water Ambient temperature;
With triethylamine In 1,4-dioxane; water for 4h; Ambient temperature;

: 61-90-5
L-leucine

: 53639-37-5
2,4-Dinitrophenyl-tert.-butylcarbonat

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 2743-60-4
L-Leucine ethyl ester

: 57022-34-1
tert-butyl cyanoformate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
(i) hexane, (ii) aq. NaOH; Multistep reaction;

: 110-89-4
piperidine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 78664-62-7
(S)-tert-butyl 4-methyl-1-oxo-1-(piperidin-1-yl)pentan-2-ylcarbamate

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1h;	100%
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran for 4h; Ambient temperature;	90%
	80%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 3392-09-4
Boc-Leu-ONSu

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 4℃;	100%
With dicyclohexyl-carbodiimide In 1,4-dioxane Ambient temperature;	93%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dichloromethane at 20℃; for 18h;	93%

: 115-20-8
1,1,1-trichloroethanol

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 162307-38-2
Nα-(tert-butoxycarbonyl)-L-leucine 2',2',2'-trichloroethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In tetrachloromethane; dichloromethane for 3h;	100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 18h; Ambient temperature;	93%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 87694-50-6
N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 0 - 25℃; for 14h; Inert atmosphere;	100%
Stage #1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With 4-methyl-morpholine In dichloromethane at 25℃; for 14h; Inert atmosphere;	100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 118792-26-0
(S)-2-Amino-1-(4-benzyl-piperidin-1-yl)-3-methyl-butan-1-one; hydrochloride

: 118792-33-9
{(S)-1-[(S)-1-(4-Benzyl-piperidine-1-carbonyl)-2-methyl-propylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 4℃;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran 1.) 0 deg C, 1 h; 2.) RT; 3.) 0 deg C, 1 h;	100%
Stage #1: N-tert-butoxycarbonyl-L-leucine With 4-methyl-morpholine; tert-butyl chloroformate In 1,2-dimethoxyethane Stage #2: With sodium tetrahydroborate In 1,2-dimethoxyethane; water at -15℃; Further stages.;	96%
With borane-THF In tetrahydrofuran for 1h; Ambient temperature;	91%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 345911-00-4
2-tert-butoxycarbonylamino-4-methyl-pentanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 157547-47-2
3-(2'-Hydroxy-5'-benzyloxy-4',6'-dimethylphenyl)-3,3-dimethyl-1-propanol

: 264888-34-8
2-tert-butoxycarbonylamino-4-methyl-pentanoic acid 3-(3-benzyloxy-6-hydroxy-2,4-dimethyl-phenyl)-3-methyl-butyl ester

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 5h; Acylation;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 80182-99-6
β-hydroxyphenylalanine methyl ester hydrochloride

: 896735-84-5
Boc-L-Leu-DL-Phe(β-OH)-OMe

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;	100%
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 191593-14-3
4,6-O-di(tert-butyl)silanediyl-D-glucal

: 3-O-(N-tert-butoxycarbonyl-L-leucyl)-4,6-O-di-tert-butylsilanediyl-D-glucal

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	100%

: 1006030-39-2
(S)-Pyrrolidine-2-carboxylic acid (3-carbamoyl-phenyl)-amide

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 886847-55-8
{(S)-1-[(S)-2-(3-Carbamoyl-phenylcarbamoyl)-pyrrolidine-1-carbonyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane; N,N-dimethyl-formamide	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 168777-81-9
(3S,4R)-1-[(tert-butyldimethylsilyl)oxy]-4-methylhex-5-en-3-ol

: 916452-48-7
(1S,2R)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-2-(methyl)but-3-enyl (2S)-2-tert-butoxycarbonylamino-4-methylpentanoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 502482-25-9
(3S)-1-benzyl-3-isobutylpiperazine-2,5-dione

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-leucine; ethyl 2-(benzylamino)acetate With dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; for 3.25h; Stage #2: With hydrogenchloride In dichloromethane for 4h;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With water at 170℃; for 0.05h; Microwave irradiation;	100%
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	98%
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 82732-07-8, 108524-68-1, 142926-43-0, 100564-78-1
Boc-L-homophenylalanine

: 1187223-35-3
H-Hphe-Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-OH

Conditions

Conditions	Yield
Stage #1: Boc-L-homophenylalanine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; N-tert-butoxycarbonyl-L-phenylalanine Further stages;	100%

...Expand

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 82732-07-8, 108524-68-1, 142926-43-0, 100564-78-1
Boc-L-homophenylalanine

: 1187223-36-4
H-Ile-Ile-Leu-Val-Pro-Pro-Hphe-Hphe-Leu-OH

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-leucine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-phenylalanine; Boc-L-homophenylalanine Further stages;	100%

...Expand

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 1219603-58-3
6-ethynyl-3,3-dimethoxyhexahydrofuro[3,2-b]pyrrole-4-carboxylic acid tert-butyl ester

: 1219603-61-8
C21H34N2O6

Conditions

Conditions	Yield
Stage #1: 6-ethynyl-3,3-dimethoxyhexahydrofuro[3,2-b]pyrrole-4-carboxylic acid tert-butyl ester With methanol; acetyl chloride at 20℃; Cooling in ice; Stage #2: N-tert-butoxycarbonyl-L-leucine With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 3.25h;	100%

: 931120-51-3
2,4-bis(docosyloxy)benzyl alcohol

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 1258442-24-8
C62H115NO6

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 955095-32-6
3,5-di(docosyloxy)benzyl alcohol

: 1258442-25-9
C62H115NO6

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 233281-31-7
(3,4,5-trioctadecyloxyphenyl)methan-1-ol

: 1258442-23-7
C72H135NO7

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 2450-71-7
Propargylamine

: 1268671-03-9
tert-Butyl [(2S)-1-(thynylamino)-4-methyl-1-oxopentan-2-yl]carbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane for 2h; Inert atmosphere; Reflux;	100%
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20℃; for 2h;	90%
Stage #1: N-tert-butoxycarbonyl-L-leucine With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane for 0.166667h; Cooling with ice; Stage #2: Propargylamine With triethylamine In dichloromethane at 20℃; for 24h;	82%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 44565-27-7, 44565-28-8, 64070-19-5, 88390-32-3
(R)-4-amino-2-methyl-1-butanol

: 1265404-73-6
[1-(4-hydroxy-3-methylbutylcarbamoyl)-3-methylbutyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1160927-49-0
3-(2-tert-butoxycarbonylamino-4-methylpentanoylamino)-propionic acid methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 5h; Inert atmosphere;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 1312545-25-7
3-(1-[3-ammoniopropyl]-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-maleinimide-chloride

: 1383842-05-4
tert-butyl 1-(3-(3-(2,5-dioxo-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propylamino)-4-methyl-1-oxopentan-2-ylcarbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 2-methoxy-5-(2,3,4-trimethoxy-7-oxo-6,7-dihydro-5H-benzo[7]annulen-9-yl)benzenaminium chloride

: tert-butyl 1-(5-(6,7-dihydro-2,3,4-trimethoxy-7-oxo-5H-benzo[7]annulen-9-yl)-2-methoxyphenylcarbamoyl)-3-methylbutylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 8,9-dihydro-5-(3-hydroxy-4-methoxyphenyl)-1,2,3-trimethoxybenzo[7]annulen-7-one

: C32H41NO9

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: (3S)-3-Amino-N-ethyl-2-hydroxy-4-phenylbutanamide hydrochloride

: tert-butyl ((2S)-1-((4-(ethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	100%

: methyl Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-argininate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: Boc-Leu-Arg(Pbf)-OMe

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran Cooling with ice;	100%

Boc-L-Leucine Specification

The Boc-Leu-OH, with the CAS registry number 13139-15-6, is also known as N-((1,1-Dimethylethoxy)carbonyl)-L-leucine. It belongs to the product categories of Aminoacids Derivatives; Leucine [Leu, L]; Boc-Amino Acids and Derivative; Amino Acids; Amino Acids (N-Protected); Biochemistry; Boc-Amino Acids; Boc-Amino Acid Series. Its EINECS registry number is 236-073-2. This chemical's molecular formula is C₁₁H₂₁NO₄ and molecular weight is 231.28874. Its IUPAC name is called (2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid. The product should be sealed and stored in cool, dry place at temperature of 4 °C. In addition, it is used as pharmaceutical Intermediate.

Physical properties of Boc-Leu-OH: (1)ACD/LogP: 2.51; (2)ACD/LogD (pH 5.5): 0.6; (3)ACD/LogD (pH 7.4): -0.97; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 6.87; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.461; (12)Molar Refractivity: 59.82 cm³; (13)Molar Volume: 217.8 cm³; (14)Surface Tension: 36.1 dyne/cm; (15)Density: 1.061 g/cm³; (16)Flash Point: 169.1 °C; (17)Enthalpy of Vaporization: 66.05 kJ/mol; (18)Boiling Point: 356 °C at 760 mmHg; (19)Vapour Pressure: 4.98E-06 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes and may cause damage to health. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)OC(C)(C)C
(2)Isomeric SMILES: CC(C)C[C@@H](C(=O)O)NC(=O)OC(C)(C)C
(3)InChI: InChI=1S/C11H21NO4/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14)/t8-/m0/s1
(4)InChIKey: MDXGYYOJGPFFJL-QMMMGPOBSA-N

Product Name

BOC-L-Leucine

Synthetic route

Boc-L-Leucine Specification

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