Boc-glycine supplier | CasNO.4530-20-5

Name
Boc-Glycine
EINECS 224-864-5
CAS No. 4530-20-5
Article Data113
CAS DataBase
Density 1.159 g/cm³
Solubility Soluble in water
Melting Point 86-89 °C(lit.)
Formula C₇H₁₃NO₄
Boiling Point 315.9 °C at 760 mmHg
Molecular Weight 175.185
Flash Point 144.9 °C
Transport Information UN 2811 6.1/PG 3
Appearance white to off-white powder
Safety 26-36/37/39-39-36
Risk Codes 22-41-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Boc-Gly-OH;tert-Butoxycarbonylglycine;2-(tert-butoxycarbonylamino)acetate;Nalpha-tert-Butyloxycarbonylglycine;t-Butoxycarbonylglycine;N-(Carbo-tert-butoxy)glycine;Glycine, N-[ (1, 1-dimethylethoxy)carbonyl]-;tert-Butyloxycarbonylglycine;N-t-Butyloxycarbonyl glycine;N-[(1, 1-Dimethylethoxy)carbonyl]glycine;N(a)-tert-Butyloxycarbonylglycine;2-(tert-butoxycarbonylamino)acetic acid;N-(tert-butoxycarbonyl)glycine;Glycine, N-carboxy-, N-tert-butyl ester;Glycine, N-carboxy-, N-tert-butyl ester (8CI);N-((1,1-Dimethylethoxy)carbonyl)glycine;N-tert-Butyloxycarbonylglycine;N-t-BOC-Glycine;[(tert-butoxycarbonyl)amino]acetic acid;N-Boc-glycine;
PSA 75.63000
LogP 0.98660

Synthetic route

: 24424-99-5
di-tert-butyl dicarbonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 20℃; for 12h;	100%
Stage #1: glycine With sodium hydroxide In 1,4-dioxane; water at 0℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃;	100%
With sodium hydroxide In 1,4-dioxane	100%

: 83316-95-4
2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A: 4530-20-5
BOC-glycine

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With N,N,N',N'-tetramethyl-o-phenylenediamine In acetonitrile for 2h; Irradiation;	A 100% B n/a

: tert-butoxycarbonylamino-acetic acid 4-tert-butyl-benzyl ester

A: 4530-20-5
BOC-glycine

B: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal for 3h;	A 100% B n/a

: (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl (tert-butoxycarbonyl)glycinate

A: 4530-20-5
BOC-glycine

B: 1033736-87-6
C16H10O3S

Conditions

Conditions	Yield
In chloroform-d1 for 0.25h; Solvent; Photolysis; Inert atmosphere;	A 97% B n/a

: 56-40-6
glycine

BOC derivative: BOC derivative

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 20℃; for 8h;	95%

: tert-butyl (2,4-dioxo-3-azaspiro[5,5]undecan-3-yl) carbonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone at 25℃; for 12h;	94%

: 64205-15-8
(N-hydroxy-5-norbornene-2,3-diformylimino)tert-butyl ester

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With tertiary amine In 1,4-dioxane; water for 3h;	85%

: 909114-65-4
tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 0.5h;	85%

: 79113-14-7
4-nitrobenzyl N-(tert-butoxycarbonyl)glycinate

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium dithionite; sodium carbonate In acetonitrile	80%

: 56-40-6
glycine

: 89037-64-9
1-tert-butoxycarbonyloxybenzotriazole

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water for 0.166667h; Ambient temperature;	80%

: 83316-95-4
2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A: 4530-20-5
BOC-glycine

B: 6926-09-6
(tert-butoxycarbonyl)glycine hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In methanol Product distribution;	A 75% B 12%

: 618068-89-6
N-Boc-glycine 2-(2-acetylphenyl)-1-methylethyl ester

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
In acetonitrile for 3h; Photolysis;	73%

: 1080004-01-8
(E)-3-methoxyallyl 2-((tert-butoxycarbonyl)amino)acetate

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With zinc(II) chloride; lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	59%
With potassium hexamethylsilazane; zinc(II) chloride In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	54%

: 42721-06-2
tert-Butoxycarbonylamino-acetic acid (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl ester

: 5680-79-5
glycine ethyl ester hydrochloride

A: 4530-20-5
BOC-glycine

B: 53487-98-2
N-tert-butoxycarbonyl glycyl glycine methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine In N,N-dimethyl-formamide at 38℃; for 96h;	A n/a B 57%

...Expand

: 5680-79-5
glycine ethyl ester hydrochloride

: 35909-78-5
2,3,4,6-tetra-O-benzyl-1-O-(N-tert-butoxycarbonyl-glycyl)-β-D-glucopyranose

A: 4530-20-5
BOC-glycine

B: 53487-98-2
N-tert-butoxycarbonyl glycyl glycine methyl ester

: 4132-28-9, 4291-69-4, 6386-24-9, 6564-72-3, 59531-24-7, 69257-52-9, 78184-89-1, 78609-16-2, 78609-17-3, 78609-18-4, 96553-53-6, 104111-61-7, 131347-08-5
2,3,4,6-tetra-O-benzyl-D-glucopyranose

Conditions

Conditions	Yield
With 4-methyl-morpholine In N,N-dimethyl-formamide at 38℃; for 96h;	A n/a B 55% C n/a

...Expand

: 541-16-2
t-butyl malonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium carbonate In water; acetonitrile at -5 - 20℃;	35%

: 6456-74-2
Glycine tert-butyl ester

: 83316-95-4
2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A: 4530-20-5
BOC-glycine

B: 5845-68-1
Boc-glycylglycine tert-butyl ester

Conditions

Conditions	Yield
In ethyl acetate for 24h; Product distribution; Ambient temperature;	A 10% B 30%

...Expand

: 13303-10-1
tert-Butyl 4-nitrophenyl carbonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium hydroxide; tert-butyl alcohol

: 75-44-5
phosgene

: 459-73-4
GlyOEt*HCl

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With toluene Erwaermen des Reaktionsprodukts mit tert-Butylalkohol und anschliessenden Hydrolyse;

: 75-65-0
tert-butyl alcohol

: 2949-22-6
Glycine ethyl ester isocyanate

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With triethylamine Behandeln des Reaktionsprodukts mit wss.NaOH und Dioxan;

: 24608-52-4
tert-butyl chloroformate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With sodium hydroxide

: 4530-20-5
BOC-glycine

: 100-46-9
benzylamine

: 19811-52-0
Boc-glycine-benzylamide

Conditions

Conditions	Yield
Stage #1: BOC-glycine; benzylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.0166667h; Stage #2: With HATU for 18h;	100%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	99%
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;	99%

: 4530-20-5
BOC-glycine

: 27894-50-4
methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

: 32689-62-6
Nα-tert-butoxycarbonylglycyl-Nε-benzyloxycarbonyl-L-lysine methyl ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at -20 - 20℃; for 4h; Acylation;	100%
Stage #1: BOC-glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.5h; Cooling with ice; Stage #2: methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	92.2%
(i) Et3N, ClCO2iBu, (ii) /BRN= 3578476/, Et3N; Multistep reaction;
With 4-methyl-morpholine; triethylamine; isobutyl chloroformate 1) THF, -10 deg C, 15 min, 2) THF, 12 h; Yield given. Multistep reaction;

: 4530-20-5
BOC-glycine

: 42854-62-6
L-alanine benzyl ester p-toluenesulfonate

: 63649-08-1
Boc-Gly-Ala-OBzl

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine	100%
With TEA; diphenyl phosphoryl azide In N,N-dimethyl-formamide 1.) 0 deg C, 4 h; 2.) r.t., overnight;	85%
Stage #1: BOC-glycine; L-alanine benzyl ester p-toluenesulfonate With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.166667h; Inert atmosphere; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;

: 4530-20-5
BOC-glycine

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 29776-78-1
(S)-1-(2-tert-butoxycarbonylaminoacetyl)pyrrolidine-2-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine In chloroform	100%
With benzotriazol-1-ol; triethylamine In chloroform	100%
With benzotriazol-1-ol; triethylamine In chloroform	100%

: 4530-20-5
BOC-glycine

: 16652-76-9
L-valine benzyl ester p-toluenesulfonate salt

: 66415-00-7
N-t-butoxycarbonylglycyl-L-valine benzyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine	100%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;	94%
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1.) 0 deg C, 2.) overnight, 4 deg C;	89%
With 4-methyl-morpholine; isobutyl chloroformate 1.) THF, -15 deg C, 2.) DMF, a) -15 deg C, 30 min, b) r.t., 30 min.; Yield given. Multistep reaction;

: 4530-20-5
BOC-glycine

: 65253-04-5
(-)-8-phenylmenthol

: 117681-86-4
(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 13h;	100%
Stage #1: BOC-glycine With dmap; dicyclohexyl-carbodiimide In dichloromethane at -30℃; for 0.166667h; Stage #2: (-)-8-phenylmenthol In dichloromethane for 20h; Heating;	96%
With dmap; dicyclohexyl-carbodiimide	93%

: 4530-20-5
BOC-glycine

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

Conditions

Conditions	Yield
Stage #1: BOC-glycine With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -15℃; for 0.25h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at -15℃; for 1h;	100%
With diisopropoxytitanium(III) tetrahydroborate In dichloromethane for 4h; Ambient temperature;	88%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran; toluene at 0℃; for 2h;	77.1%

: 4530-20-5
BOC-glycine

: 100-39-0
benzyl bromide

: 54244-69-8
tert-butoxycarbonylamino-acetic acid benzyl ester

Conditions

Conditions	Yield
Stage #1: BOC-glycine With caesium carbonate In methanol pH=7; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 5h; Further stages.;	100%
Stage #1: BOC-glycine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 0℃; for 18h; Further stages;	100%
With triethylamine In N,N-dimethyl-formamide at 25℃; for 5h;	54%
With caesium carbonate 1) MeOH, water, pH 7.0, 2) DMF, 5 h; Yield given. Multistep reaction;
With sodium iodide In acetone for 2h; Reflux; Inert atmosphere;

: 4530-20-5
BOC-glycine

: 75-03-6
ethyl iodide

: 149794-10-5
N-(tert-buytoxycarbonyl)-N-ethylglycine

Conditions

Conditions	Yield
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: In tetrahydrofuran at 0℃;	100%
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: With citric acid In water pH=2 - 3;	100%
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: With citric acid In water pH=2 - 3;	100%

: 4530-20-5
BOC-glycine

: 106-95-6
allyl bromide

: 124373-83-7
allyl 2-(tert-butoxycarbonylamino)acetate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50℃; for 16h;	100%
With N-ethyl-N,N-diisopropylamine for 0.666667h; Reflux;	91%
With caesium carbonate In acetonitrile	90%

: 4530-20-5
BOC-glycine

: 62-53-3
aniline

: 27904-92-3
N-glycyl>aniline

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 25℃; for 5h;	100%
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	99%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 6h;	96.9%

: 4530-20-5
BOC-glycine

: 543-27-1
isobutyl chloroformate

: 66866-43-1
N-(t-butoxycarbonyl)glycyl i-butyl carbonate

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran at -15℃; for 0.0833333h;	100%
With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 0.05h;

: 4530-20-5
BOC-glycine

: 52199-35-6
tetrakis-5,10,15,20-(o-aminophenyl)porphyrin

: α,α,α,α-5,10,15,20-tetrakis-(2-(N-[(2-t-butylcarbamoyl)ethanamide]phenyl))porphyrin

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 20℃; for 50h; Condensation;	100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Inert atmosphere; Cooling with ice;	62%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane

: 4530-20-5
BOC-glycine

: H-Ala-Glu(OBzl)-OBzl hydrochloride

: 125274-43-3
Boc-Gly-Ala-Glu(OBzl)-OBzl

Conditions

Conditions	Yield
Stage #1: H-Ala-Glu(OBzl)-OBzl hydrochloride With triethylamine In dichloromethane Hydrolysis; Stage #2: BOC-glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; for 14h; Condensation;	100%

: 4530-20-5
BOC-glycine

: 64-04-0
phenethylamine

: 613675-75-5
tert-butyl N-{[(2-phenylethyl)carbamoyl]methyl}carbamate

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 0 - 20℃; Acylation;	100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 72h;	94%
Stage #1: BOC-glycine With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h; Stage #2: phenethylamine In dichloromethane for 16h;	81%
Stage #1: BOC-glycine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: phenethylamine In N,N-dimethyl-formamide at 20℃;	72%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 23℃; for 4h; Inert atmosphere;	71%

: 33941-15-0
1-aza-18-crown-6

: 4530-20-5
BOC-glycine

: 394208-14-1
[2-oxo-2-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-ethyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; lutidine In tetrahydrofuran at 25 - 50℃; for 2h;	100%
With 2,6-dimethylpyridine; bis(trichloromethyl) carbonate In tetrahydrofuran Inert atmosphere;

: 4530-20-5
BOC-glycine

: 172611-73-3
4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol

: tert-butoxycarbonylamino-acetic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;	100%

: 4530-20-5
BOC-glycine

: 191593-14-3
4,6-O-di(tert-butyl)silanediyl-D-glucal

: 848359-00-2
3-O-(N-tert-butoxycarbonyl-2'-amino-ethanoyl)-4,6-O-di-tert-butylsilanediyl-D-glucal

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	100%

: 4530-20-5
BOC-glycine

: 2450-71-7
Propargylamine

: 847490-49-7
tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 6h; Inert atmosphere;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;	99%
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In acetonitrile at 20℃;	96%

: 4530-20-5
BOC-glycine

: 118-92-3
anthranilic acid

: 109-85-3
2-methoxyethylamine

: 2-aminomethyl-3-(2-methoxyethyl)-3H-quinazolin-4-one

Conditions

Conditions	Yield
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation; Stage #2: 2-methoxyethylamine at 220℃; for 0.0666667h; microwave irradiation;	100%

...Expand

: 4530-20-5
BOC-glycine

: 118-92-3
anthranilic acid

: 109-85-3
2-methoxyethylamine

: [3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazolin-2-yl-methyl]carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation; Stage #2: 2-methoxyethylamine at 180℃; for 0.05h; microwave irradiation;	100%

...Expand

: 916452-54-5
(3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

: 4530-20-5
BOC-glycine

: 916452-55-6
tert-butoxycarbonylamino-acetic acid 4-{3-[3-isobutyl-10-(4-methoxy-benzyl)-2,5,9,12-tetraoxo-1-oxa-4,8,11-triaza-cyclohexadec-13-en-16-yl]-but-1-enyl}-benzyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;	100%

: 4530-20-5
BOC-glycine

: trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-amine

: [[[(trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)amino]carbonyl]methyl]carbamic acid 1,1-dimethylethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 3h; pH=9;	100%

: 4530-20-5
BOC-glycine

: 89226-13-1
2-(N-t-butoxycarbonylamino)thioacetamide

Conditions

Conditions	Yield
With Lawessons reagent In dichloromethane at 25℃; for 16h;	100%
Stage #1: BOC-glycine With ammonium hydroxide; triethylamine; isobutyl chloroformate In tetrahydrofuran Stage #2: With tetraphosphorus decasulfide; sodium carbonate In tetrahydrofuran	83%
Multi-step reaction with 3 steps 1: Et3N / tetrahydrofuran / 0.42 h / -10 °C 2: aq. MH3 / tetrahydrofuran / 0.75 h / -10 °C 3: 85 percent / Lawesson's reagent / CH2Cl2 / 16 h / Ambient temperature View Scheme

: 4530-20-5
BOC-glycine

: 540-37-4
p-aminoiodobenzene

: 216774-64-0
[(4-iodophenylcarbamoyl)methyl]carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dacarbazine; dmap In dichloromethane	100%
With dmap; diisopropyl-carbodiimide In dichloromethane for 20h; Inert atmosphere;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 5h;	98%

: 4530-20-5
BOC-glycine

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: (R*)-N-[[2-[N-[(1,1-Dimethylethoxy)carbonyl]glycyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-L-methionine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	100%

: 4530-20-5
BOC-glycine

: 3007-31-6
N,N-didodecylamine

: 879004-97-4
C31H62N2O3

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h;	100%

Boc-glycine Chemical Properties

Molecular structure of Boc-glycine (CAS NO.4530-20-5) is:

Product Name: Boc-glycine
CAS Registry Number: 4530-20-5
IUPAC Name: 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
Molecular Weight: 175.18242 [g/mol]
Molecular Formula: C₇H₁₃NO₄
XLogP3-AA: 0.5
H-Bond Donor: 2
H-Bond Acceptor: 4
EINECS: 224-864-5
Melting Point: 86-89 °C(lit.)
Water Solubility: soluble
Surface Tension: 40.1 dyne/cm
Density: 1.159 g/cm³
Flash Point: 144.9 °C
Enthalpy of Vaporization: 61.27 kJ/mol
Boiling Point: 315.9 °C at 760 mmHg
Vapour Pressure: 9.08E-05 mmHg at 25°C
Product Categories: Protected Amino Acids;Aminoacids Derivatives;Amino Acid Derivatives;Protected Amino Acid & Peptides;Amino Acids;Glycine [Gly, G];Boc-Amino Acids and Derivative;Amino Acids 13C, 2H, 15N;Absolute Configuration Determination (Exciton Chirality CD Method);Amino Acids (N-Protected);Analytical Chemistry;Biochemistry;Boc-Amino Acids;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Methodfor (for Monofunctional Compounds);Boc-Amino acid series;Amino Acids & Derivatives

Boc-glycine Safety Profile

Safty information about Boc-glycine (CAS NO.4530-20-5) is:
Hazard Codes: Harmful Xn,Xi
Risk Statements: 22-41-36/37/38-20/21/22
R22:Harmful if swallowed.
R41:Risk of serious damage to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37/39-39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S39:Wear eye / face protection.
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

Boc-glycine Specification

Boc-glycine , its cas register number is 4530-20-5. It also can be called 2-[(2-Methylpropan-2-yl)oxycarbonylamino]acetic acid ; Glycine, N-[(1,1-dimethylethoxy)carbonyl]- ; N-(tert-Butoxycarbonyl)glycine ; Nalpha-tert-Butyloxycarbonylglycine ; t-Butoxycarbonylglycine ; Glycine, N-carboxy-, N-tert-butyl ester (8CI) .It is a white to off-white powder.

Product Name

Boc-Glycine

Synthetic route

Boc-glycine Chemical Properties

Boc-glycine Safety Profile

Boc-glycine Specification

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