Bromoperidol supplier | CasNO.10457-90-6

Name
BROMPERIDOL
EINECS 233-943-3
CAS No. 10457-90-6
Article Data4
CAS DataBase
Density 1.367 g/cm³
Solubility insoluble in water
Melting Point 156-158 °C
Formula C₂₁H₂₃BrFNO₂
Boiling Point 543.598 °C at 760 mmHg
Molecular Weight 420.322
Flash Point 282.558 °C
Transport Information
Appearance Tan solid
Safety
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Butyrophenone,4-[4-(p-bromophenyl)-4-hydroxypiperidino]-4'-fluoro- (8CI);4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone;Azurene;4-[4-(4-Bromophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one;
PSA 40.54000
LogP 4.47260

Bromoperidol Chemical Properties

Chemistry informtion about Bromoperidol (CAS NO.10457-90-6) is:
IUPAC Name: 4-[4-(4-Bromophenyl)-4-Hydroxypiperidin-1-Yl]-1-(4-Fluorophenyl)Butan-1-One
Product Categories: Aromatics ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals
Empirical Formula: C₂₁H₂₃BrFNO₂
Molecular Weight: 420.3152
EINECS: 233-943-3
Density: 1.366 g/cm³
Melting Point: 156-158°C
Flash Point: 282.6 °C
Boiling Point: 543.6 °C at 760 mmHg
Vapour Pressure: 1.19E-12 mmHg at 25°C
Enthalpy of Vaporization: 86.51 kJ/mol
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 7
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.59
Molar Refractivity: 103.8 cm³
Molar Volume: 307.5 cm³
Surface Tension: 48.5 dyne/cm
SMILES: Fc1ccc(cc1)C(=O)CCCN3CCC(O)(c2ccc(Br)cc2)CC3
InChI: InChI=1/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Following is the molecular structure of Bromoperidol (CAS NO.10457-90-6):

Bromoperidol History

It was discovered at Janssen Pharmaceutica in 1966.

Bromoperidol Uses

Bromoperidol (CAS NO.10457-90-6) is used as Bromine analog of Haloperidol. Antipsychotic.Also it used as an antipsychotic in the treatment of schizophrenia.

Bromoperidol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	156mg/kg (156mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
mouse	LD50	intravenous	18900ug/kg (18.9mg/kg)	sense organs and special senses: ptosis: eye behavioral: tremor behavioral: somnolence (general depressed activity)	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
mouse	LD50	oral	174mg/kg (174mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
mouse	LD50	subcutaneous	114mg/kg (114mg/kg)	sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
rat	LD50	intraperitoneal	323mg/kg (323mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat	LD50	intravenous	10mg/kg (10mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat	LD50	oral	359mg/kg (359mg/kg)	sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.
rat	LD50	subcutaneous	84mg/kg (84mg/kg)	sense organs and special senses: ptosis: eye behavioral: somnolence (general depressed activity) behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 45, 1974.

Bromoperidol Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻, Br⁻ and NO_x.

Bromoperidol Specification

Bromoperidol , with CAS number of 10457-90-6, can be called 4-(4-(4-Bromophenyl)-4-Hydroxy-1-Piperidinyl)-1-(4-Fluorophenyl)-1-Butanon ; 4-(4-(4-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluorobutyrophenone ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluoro-Butyrophenon ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidino)-4’-Fluorobutyrophenone ; 4-(4-(P-Bromophenyl)-4-Hydroxypiperidinol)-4’-Fluorobutyrophenone ; Bromoperidol ; 4-[4-(4-Bromophenyl)-4-Hydroxy-1-Piperidinyl]-1-(4-Fluorophenyl)-1-Butanone . Bromoperidol (CAS NO.10457-90-6) is a tan solid. And it is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic.

Product Name

BROMPERIDOL