• Name

  BROMOPRIDE

• EINECS
• CAS No. 4093-35-0
• Article Data14
• CAS DataBase
• Density 1.313g/cm³
• Solubility
• Melting Point 148-150?C
• Formula C14H22 Br N3 O2
• Boiling Point 435.8°Cat760mmHg
• Molecular Weight 344.252
• Flash Point 217.3°C
• Transport Information
• Appearance
• Safety Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Br⁻.
• Risk Codes 20/21/22
• Molecular Structure
• Hazard Symbols
• Synonyms o-Anisamide,4-amino-5-bromo-N-[2-(diethylamino)ethyl]- (7CI,8CI); 2-Methoxy-4-amino-5-bromo-N,N-diethylaminoethylbenzamide;Bromopride; Emepride; Emoril;N-Diethylaminoethyl-2-methoxy-4-amino-5-bromobenzamide; Viadil
• PSA 67.59000
• LogP 3.08360

Synthetic route

201230-82-2

carbon monoxide

1285695-16-0

2-bromo-4-iodo-5-methoxyaniline

100-36-7

N,N-diethylethylenediamine

4093-35-0

bromopride

Conditions

Conditions	Yield
With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 80℃; Inert atmosphere; Sealed chamber;	74.7 mg

...Expand

5344-78-5

4-bromo-3-nitroanizole

4093-35-0

bromopride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride; iron / ethanol; water / 3 h / Reflux 2: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 3: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme

59557-92-5

2-bromo-5-methoxyaniline

4093-35-0

bromopride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 2: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme

96-96-8

4-methoxy-2-nitroaniline

4093-35-0

bromopride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sulfuric acid; acetic acid; sodium nitrite / water / 15 - 20 °C 1.2: 20 - 80 °C 2.1: hydrogenchloride; iron / ethanol; water / 3 h / Reflux 3.1: tetramethylammonium dichloroiodate(I) / ethyl acetate / 96 h 4.1: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme

4093-35-0

bromopride

Bromoprid-N-oxid

Conditions

Conditions	Yield
With dihydrogen peroxide In ethanol Ambient temperature;	11%

4093-35-0

bromopride

4-amino-5-bromo-N-(2-diethylamino-ethyl)-3-iodo-2-methoxy-benzamide

Conditions

Conditions	Yield
Stage #1: bromopride With trifluoroacetic acid; thallium(III) trifluoroacetate at 20℃; for 0.5h; thallation; Stage #2: With trifluoroacetic acid; sodium iodide at 20℃; for 5h; Iodination; Further stages.;

4093-35-0

bromopride

[131I]-iodo-Bromopride

Conditions

Conditions	Yield
Stage #1: bromopride With trifluoroacetic acid; thallium(III) trifluoroacetate for 0.166667h; thallation; Stage #2: With [131I]-sodium iodide; trifluoroacetic acid for 0.0833333h; Iodination; Further stages.;

4093-35-0

bromopride

6203-18-5

p-dimethylaminocinnamaldehyde

C25H34BrN4O2(1+)

Conditions

Conditions	Yield
With hydrogenchloride; sodium dodecyl-sulfate In water Reagent/catalyst; Flow reactor;

Bromopride Chemical Properties

Bromopride Uses

Bromopride Toxicity Data With Reference

Bromopride Safety Profile

Bromopride Specification