Product Name

  • Name

    1-butylbiguanide

  • EINECS
  • CAS No. 692-13-7
  • Density 1.22g/cm3
  • Solubility
  • Melting Point
  • Formula C6H15 N5
  • Boiling Point 322.7°C at 760 mmHg
  • Molecular Weight 157.219
  • Flash Point 148.9°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 692-13-7 (1-butylbiguanide)
  • Hazard Symbols
  • Synonyms Biguanide,1-butyl- (6CI,8CI); 1-Butylbiguanide; Buformin; Buformine; Butformin;Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; H 224;N1-Butylbiguanide; W 37
  • PSA 97.78000
  • LogP 1.47550

Buformin [USAN:INN] Chemical Properties

Product Name: Buformin [USAN:INN] 
CAS Registry Number: 692-13-7 
Synonyms: 1-Butylbiguanide ; 1-Butyldiguanide ; 4-04-00-00582 (Beilstein Handbook Reference) ; BRN 0607037 ; Buformin ; Buformina ; Buformina [INN-Spanish] ; Buformine ; Buformine [INN-French] ; Buforminum ; Buforminum [INN-Latin] ; Butformin ; Butylbiguanide ; Butylbiguanidum ; Butyldiguanide ; DBV ; EINECS 211-726-4 ; Glybigid ; Glybigidum ; H 224 ; N-Butylbiguanide ; W 37 ; Biguanide, 1-butyl- ; Imidodicarbonimidic diamide, N-butyl- 
IUPAC Name: 2-butyl-1-(diaminomethylidene)guanidine 
Molecular Weight: 157.2168 [g/mol]
Molecular Formula: C6H15N5 
EINECS: 211-726-4
XLogP3-AA: -0.6
H-Bond Donor: 3
H-Bond Acceptor: 5
Surface Tension: 49.5 dyne/cm
Density: 1.22 g/cm3
Flash Point: 148.9 °C
Enthalpy of Vaporization: 56.45 kJ/mol
Boiling Point: 322.7 °C at 760 mmHg
Vapour Pressure: 0.000275 mmHg at 25°C 
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Following is the molecular structure of Buformin [USAN:INN] (CAS NO.692-13-7) is:

Buformin [USAN:INN] Uses

 Buformin [USAN:INN] (CAS NO.692-13-7) , clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.

Buformin [USAN:INN] Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 18mg/kg (18mg/kg)   Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 1521, 1981.
mouse LD50 oral 300mg/kg (300mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 1521, 1981.

Buformin [USAN:INN] Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.

Buformin [USAN:INN] Specification

Buformin [USAN:INN] (CAS NO.692-13-7) is an oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.

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