Product Name

  • Name

    Bunazosin hydrochloride

  • EINECS
  • CAS No. 52712-76-2
  • Density 1.221g/cm3
  • Solubility
  • Melting Point 280-282°
  • Formula C19H27 N5 O3 . Cl H
  • Boiling Point 620.6°Cat760mmHg
  • Molecular Weight 409.97
  • Flash Point 329.1°C
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • Risk Codes
  • Molecular Structure Molecular Structure of 52712-76-2 (Bunazosin hydrochloride)
  • Hazard Symbols
  • Synonyms 1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride (9CI); Bunazosin hydrochloride; DDQ; DDQ (pharmaceutical);Detantol; E 643
  • PSA 93.81000
  • LogP 3.45410

Bunazosin hydrochloride Chemical Properties

IUPAC Name: Bunazosin hydrochloride
Synonyms: Bunazosin hydrochloride ; Bunazosin hydrochloride ; Bunzaosin HCL ; Bunazosin HCL ; 1-(4-Amino-6，7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1，4-diazepine hydrochloride ; Detantol ; E-643 ; Detantol-R
Molecular Structure:
Molecular Formula : C19H27N5O3.HCl
Molecular Weight : 409.91
CAS NO: 52712-76-2
Flash Point: 329.1 °C
Melting point: 280 ~ 282 °C.
Enthalpy of Vaporization: 91.97 kJ/mol
Boiling Point: 620.6 °C at 760 mmHg
Vapour Pressure: 2.52E-15 mmHg at 25°C

Bunazosin hydrochloride Uses

 Bunazosin hydrochloride (CAS NO.52712-76-2) is a blocking agent to αl-receptor , almost does not affect heart rate. 
 Bunazosin hydrochloride (CAS NO.52712-76-2) is mainly for hypertension of primary, renal, pheochromocytoma-induced .

Bunazosin hydrochloride Production

1:4 - Amino--2 - chloro -6,7 - dimethoxy-quinazoline and 1 - A acyl-piperazine, which are refluxed in butanol ; generated compounds (I) in 9% hydrochloric acid reflux, get compound (Ⅱ), yield 80.4%. reaction with N-Butyl chloride in acetone , generating  Bunazosin hydrochloride (CAS NO.52712-76-2)
.

Bunazosin hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:980 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 17 (1983),843.
2.    

scu-rat LD50:365 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 17 (1983),843.
3.    

ivn-rat LD50:50 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 17 (1983),843.
4.    

ims-rat LD50:152 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 17 (1983),843.
5.    

orl-mus LD50:1201 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 17 (1983),843.

Bunazosin hydrochloride Safety Profile

Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.

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